Aliases for RIPK3 Gene
External Ids for RIPK3 Gene
Previous GeneCards Identifiers for RIPK3 Gene
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
GeneCards Summary for RIPK3 Gene
RIPK3 (Receptor Interacting Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with RIPK3 include Caspase 8 Deficiency and Autoimmune Lymphoproliferative Syndrome. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is RIPK2.
UniProtKB/Swiss-Prot Summary for RIPK3 Gene
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.