The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component... See more...

Aliases for RIPK3 Gene

Aliases for RIPK3 Gene

  • Receptor Interacting Serine/Threonine Kinase 3 2 3 5
  • RIP3 2 3 4
  • Receptor-Interacting Serine/Threonine-Protein Kinase 3 3 4
  • RIP-Like Protein Kinase 3 3 4
  • RIP-3 3 4
  • Receptor-Interacting Serine-Threonine Kinase 3 2
  • Receptor Interacting Protein 3 3
  • Receptor-Interacting Protein 3 4
  • EC 2.7.11.1 4
  • RIPK3 5

External Ids for RIPK3 Gene

Previous GeneCards Identifiers for RIPK3 Gene

  • GC14M022177
  • GC14M018592
  • GC14M022795
  • GC14M023875
  • GC14M024811
  • GC14M004920

Summaries for RIPK3 Gene

Entrez Gene Summary for RIPK3 Gene

  • The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIPK3 Gene

RIPK3 (Receptor Interacting Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with RIPK3 include Caspase 8 Deficiency and Zika Virus Congenital Syndrome. Among its related pathways are Activated TLR4 signalling and IKK complex recruitment mediated by RIP1. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is RIPK2.

UniProtKB/Swiss-Prot Summary for RIPK3 Gene

  • Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Gene Wiki entry for RIPK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RIPK3 Gene

Genomics for RIPK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RIPK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J024339 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 619 +0.4 410 2 PRDM10 POLR2A EZH2 NR2F2 ELF1 NBN NR2F1 MAZ SIN3A TBP RIPK3 ENSG00000258973 lnc-ADCY4-4 ADCY4
GH14J024331 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 26.8 +6.3 6262 3.9 CEBPG HNRNPL GATAD2A CTCF ATF7 PRDM10 TFE3 NFKBIZ KDM1A RCOR2 ADCY4 RIPK3 LTB4R SDR39U1 ENSG00000258973 piR-57098-005
GH14J024364 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.8 -28.0 -27984 6.1 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 RFX1 KDM1A ZNF692 NFATC4 lnc-RIPK3-1 SDR39U1 KHNYN ADCY4 RIPK3 RNA5SP383 ENSG00000259321 LOC102724814 NYNRIN
GH14J024397 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -60.8 -60794 6.7 PRDM10 ZNF692 ZNF7 PATZ1 ZNF600 ZNF341 CEBPA KLF9 ZBTB20 SP2 NYNRIN KHNYN ADCY4 NGDN RIPK3 CBLN3 NFATC4 LTB4R
GH14J024328 Promoter/Enhancer 0.9 Ensembl ENCODE 22.4 +10.4 10361 1.5 MGA EGR1 CREB1 ZNF282 SPI1 NBN POLR2A USF2 EGR2 L3MBTL2 piR-57098-005 RIPK3 KHNYN RNF31 ADCY4 RNA5SP383 CIDEB LOC102724814 LTB4R DHRS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIPK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RIPK3

Top Transcription factor binding sites by QIAGEN in the RIPK3 gene promoter:
  • AML1a
  • STAT3

Genomic Locations for RIPK3 Gene

Genomic Locations for RIPK3 Gene
chr14:24,336,025-24,340,022
(GRCh38/hg38)
Size:
3,998 bases
Orientation:
Minus strand
chr14:24,805,227-24,809,251
(GRCh37/hg19)
Size:
4,025 bases
Orientation:
Minus strand

Genomic View for RIPK3 Gene

Genes around RIPK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPK3 Gene

Proteins for RIPK3 Gene

  • Protein details for RIPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y572-RIPK3_HUMAN
    Recommended name:
    Receptor-interacting serine/threonine-protein kinase 3
    Protein Accession:
    Q9Y572
    Secondary Accessions:
    • B4DJL9
    • C4AM87
    • Q5J795
    • Q5J796
    • Q6P5Y1

    Protein attributes for RIPK3 Gene

    Size:
    518 amino acids
    Molecular mass:
    56887 Da
    Quaternary structure:
    • Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts with MLKL; the interaction is direct. Binds TRAF2 and is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with ARHGEF2. Interacts with PELI1 (via atypical FHA domain); the phosphorylated form at Thr-182 binds preferentially to PELI1 (PubMed:29883609). Interacts with BUB1B, TRAF2 and STUB1 (PubMed:29883609). Interacts with ZBP1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RIPK3 Gene

    Alternative splice isoforms for RIPK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPK3 Gene

Post-translational modifications for RIPK3 Gene

  • RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3. Phosphorylation at Ser-227 is required for binding MLKL (PubMed:11734559, PubMed:19524512, PubMed:22265413). Phosphorylation at Thr-182 is important for its kinase activity, interaction with PELI1 and PELI1-mediated 'Lys-48'-linked polyubiquitination and for its ability to mediate TNF-induced necroptosis (PubMed:29883609).
  • Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B (PubMed:21931591). Polyubiquitinated with 'Lys-48'-linked chains by PELI1 leading to its subsequent proteasome-dependent degradation. Ubiquitinated by STUB1 leading to its subsequent proteasome-dependent degradation (PubMed:29883609).
  • Ubiquitination at Lys363
  • Modification sites at PhosphoSitePlus

Other Protein References for RIPK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RIPK3
  • Boster Bio Antibodies for RIPK3

No data available for DME Specific Peptides for RIPK3 Gene

Domains & Families for RIPK3 Gene

Gene Families for RIPK3 Gene

Protein Domains for RIPK3 Gene

Suggested Antigen Peptide Sequences for RIPK3 Gene

GenScript: Design optimal peptide antigens:
  • Receptor-interacting protein 3 (RIPK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y572

UniProtKB/Swiss-Prot:

RIPK3_HUMAN :
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with RIPK3: view

Function for RIPK3 Gene

Molecular function for RIPK3 Gene

UniProtKB/Swiss-Prot Function:
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for RIPK3 Gene

Phenotypes From GWAS Catalog for RIPK3 Gene

Gene Ontology (GO) - Molecular Function for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003713 transcription coactivator activity TAS 10339433
GO:0004672 protein kinase activity TAS,IMP 22265414
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004704 NF-kappaB-inducing kinase activity IEA --
genes like me logo Genes that share ontologies with RIPK3: view
genes like me logo Genes that share phenotypes with RIPK3: view

Animal Models for RIPK3 Gene

MGI Knock Outs for RIPK3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIPK3

Clone Products

  • Addgene plasmids for RIPK3

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RIPK3 Gene

Localization for RIPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPK3 Gene

Cytoplasm, cytosol. Cell membrane. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIPK3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
mitochondrion 4
nucleus 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RIPK3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RIPK3 Gene

Pathways & Interactions for RIPK3 Gene

genes like me logo Genes that share pathways with RIPK3: view

Pathways by source for RIPK3 Gene

1 GeneGo (Thomson Reuters) pathway for RIPK3 Gene
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
1 Qiagen pathway for RIPK3 Gene
  • Toll-Like Receptors Pathway
2 Cell Signaling Technology pathways for RIPK3 Gene

SIGNOR curated interactions for RIPK3 Gene

Activates:

Gene Ontology (GO) - Biological Process for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001914 regulation of T cell mediated cytotoxicity ISS --
GO:0002819 regulation of adaptive immune response ISS --
GO:0006464 cellular protein modification process TAS 10358032
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 10339433
genes like me logo Genes that share ontologies with RIPK3: view

Drugs & Compounds for RIPK3 Gene

(2) Drugs for RIPK3 Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
Pulmonary Surfactants Pharma 163

(1) Additional Compounds for RIPK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with RIPK3: view

Transcripts for RIPK3 Gene

mRNA/cDNA for RIPK3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIPK3

Clone Products

  • Addgene plasmids for RIPK3

Alternative Splicing Database (ASD) splice patterns (SP) for RIPK3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for RIPK3 Gene

GeneLoc Exon Structure for
RIPK3

Expression for RIPK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RIPK3 Gene

mRNA differential expression in normal tissues according to GTEx for RIPK3 Gene

This gene is overexpressed in Whole Blood (x9.7).

Protein differential expression in normal tissues from HIPED for RIPK3 Gene

This gene is overexpressed in CD8 Tcells (25.7), Monocytes (9.1), Peripheral blood mononuclear cells (8.5), and NK cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RIPK3 Gene



Protein tissue co-expression partners for RIPK3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RIPK3

SOURCE GeneReport for Unigene cluster for RIPK3 Gene:

Hs.268551

mRNA Expression by UniProt/SwissProt for RIPK3 Gene:

Q9Y572-RIPK3_HUMAN
Tissue specificity: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.

Evidence on tissue expression from TISSUES for RIPK3 Gene

  • Blood(4.5)
  • Nervous system(4.4)
  • Lung(3.1)
  • Intestine(2.8)
  • Spleen(2.7)
  • Lymph node(2.6)
  • Skin(2.5)
  • Heart(2.3)
  • Bone marrow(2.3)
  • Liver(2.3)
  • Kidney(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with RIPK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIPK3 Gene

Orthologs for RIPK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RIPK3 30 31
  • 98.91 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RIPK3 30 31
  • 80.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RIPK3 30 31
  • 74.84 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ripk3 30 17 31
  • 71.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ripk3 30
  • 70.89 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 28 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 13 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 34 (a)
OneToMany
-- 31
  • 32 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490493 30
  • 49.01 (n)
Zebrafish
(Danio rerio)
Actinopterygii ripk3l 30 31
  • 50.54 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 15 (a)
ManyToMany
Species where no ortholog for RIPK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RIPK3 Gene

ENSEMBL:
Gene Tree for RIPK3 (if available)
TreeFam:
Gene Tree for RIPK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RIPK3: view image

Paralogs for RIPK3 Gene

genes like me logo Genes that share paralogs with RIPK3: view

Variants for RIPK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RIPK3 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs114872465 Uncertain Significance: not specified 24,337,408(-) G/A MISSENSE_VARIANT
rs3212254 - p.Pro492Gln
rs34106261 - p.Thr300Met
rs7153640 - p.Glu260Val

Additional dbSNP identifiers (rs#s) for RIPK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RIPK3 Gene

Variant ID Type Subtype PubMed ID
nsv564060 CNV loss 21841781

Variation tolerance for RIPK3 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIPK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIPK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPK3 Gene

Disorders for RIPK3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RIPK3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
caspase 8 deficiency
  • ceds
zika virus congenital syndrome
  • zikv congenital infection
retinal detachment
  • retinal detachments
autoimmune lymphoproliferative syndrome
  • css
- elite association - COSMIC cancer census association via MalaCards
Search RIPK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RIPK3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RIPK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIPK3 Gene

Publications for RIPK3 Gene

  1. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. (PMID: 20354226) Vandenabeele P … Vanden Berghe T (Science signaling 2010) 3 4 23
  2. RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. (PMID: 15896315) Yang Y … Wu M (Biochemical and biophysical research communications 2005) 3 4 23
  3. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PMID: 11734559) Sun X … Dixit VM (The Journal of biological chemistry 2002) 3 4 23
  4. RIP3, a novel apoptosis-inducing kinase. (PMID: 10358032) Sun X … Dixit VM (The Journal of biological chemistry 1999) 2 3 4
  5. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. (PMID: 10339433) Yu PW … Luo Y (Current biology : CB 1999) 2 3 4

Products for RIPK3 Gene

Sources for RIPK3 Gene