The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component... See more...

Aliases for RIPK3 Gene

Aliases for RIPK3 Gene

  • Receptor Interacting Serine/Threonine Kinase 3 2 3 5
  • RIP3 2 3 4
  • Receptor-Interacting Serine/Threonine-Protein Kinase 3 3 4
  • RIP-Like Protein Kinase 3 3 4
  • RIP-3 3 4
  • Receptor-Interacting Serine-Threonine Kinase 3 2
  • Receptor Interacting Protein 3 3
  • Receptor-Interacting Protein 3 4
  • EC 2.7.11.1 4
  • RIPK3 5

External Ids for RIPK3 Gene

Previous GeneCards Identifiers for RIPK3 Gene

  • GC14M022177
  • GC14M018592
  • GC14M022795
  • GC14M023875
  • GC14M024811
  • GC14M004920

Summaries for RIPK3 Gene

Entrez Gene Summary for RIPK3 Gene

  • The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIPK3 Gene

RIPK3 (Receptor Interacting Serine/Threonine Kinase 3) is a Protein Coding gene. Diseases associated with RIPK3 include Caspase 8 Deficiency and Zika Virus Congenital Syndrome. Among its related pathways are IKK complex recruitment mediated by RIP1 and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is RIPK1.

UniProtKB/Swiss-Prot Summary for RIPK3 Gene

  • Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109).

Gene Wiki entry for RIPK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RIPK3 Gene

Genomics for RIPK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RIPK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J024339 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 269 +0.4 410 2 SIN3A ELF1 TAF1 ZBTB33 NR2F1 POLR2A IKZF1 RXRA PRDM10 NBN RIPK3 ENSG00000258973 lnc-ADCY4-4 ADCY4
GH14J024331 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 26.8 +6.3 6262 3.9 ZNF207 ZNF654 MYC SSRP1 KLF9 CEBPA BRCA1 CHD4 MXD4 NONO ADCY4 RIPK3 LTB4R SDR39U1 ENSG00000258973 piR-57098-005
GH14J024364 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.8 -28.0 -27984 6.1 BCLAF1 SP1 ZNF207 ZNF654 ZNF600 SSRP1 ZNF580 KLF9 POLR2A CEBPA NFATC4 lnc-RIPK3-1 NGDN SDR39U1 ENSG00000259321 RNA5SP383 KHNYN RNF31 ADCY4 RIPK3
GH14J024397 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -60.8 -60794 6.7 ZNF600 CEBPA PLRG1 ZNF341 KLF9 MAFF SMAD4 SP2 NBN GABPB1 NYNRIN KHNYN ADCY4 NGDN RIPK3 CBLN3 NFATC4 LTB4R HSALNG0100141
GH14J024328 Promoter/Enhancer 0.9 Ensembl ENCODE 22.4 +10.4 10361 1.5 NBN SPI1 POLR2A EGR1 L3MBTL2 EGR2 CREB1 ZNF282 MGA piR-57098-005 RIPK3 KHNYN RNF31 ADCY4 RNA5SP383 CIDEB AP1G2-AS1 LTB4R DHRS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIPK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RIPK3

Top Transcription factor binding sites by QIAGEN in the RIPK3 gene promoter:
  • AML1a
  • STAT3

Genomic Locations for RIPK3 Gene

Latest Assembly
chr14:24,336,025-24,340,022
(GRCh38/hg38)
Size:
3,998 bases
Orientation:
Minus strand

Previous Assembly
chr14:24,805,231-24,809,197
(GRCh37/hg19 by Entrez Gene)
Size:
3,967 bases
Orientation:
Minus strand

chr14:24,805,227-24,809,251
(GRCh37/hg19 by Ensembl)
Size:
4,025 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr14(PATCHES):637,003-640,969 (-)

Genomic View for RIPK3 Gene

Genes around RIPK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPK3 Gene

Proteins for RIPK3 Gene

  • Protein details for RIPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y572-RIPK3_HUMAN
    Recommended name:
    Receptor-interacting serine/threonine-protein kinase 3
    Protein Accession:
    Q9Y572
    Secondary Accessions:
    • B4DJL9
    • C4AM87
    • Q5J795
    • Q5J796
    • Q6P5Y1

    Protein attributes for RIPK3 Gene

    Size:
    518 amino acids
    Molecular mass:
    56887 Da
    Quaternary structure:
    • Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex (PubMed:10339433, PubMed:11734559, PubMed:19524512, PubMed:29681455). Interacts with MLKL; the interaction is direct and triggers necroptosis (PubMed:22265413, PubMed:22421439). Interacts with ZBP1 (via RIP homotypic interaction motif); interaction with ZBP1 activates RIPK3, triggering necroptosis (By similarity). Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439). Binds TRAF2 and is recruited to the TNFR-1 signaling complex (PubMed:29883609). Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes (PubMed:19498109). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4 (PubMed:21931591). Interacts with ARHGEF2 (PubMed:21887730). Interacts with PELI1 (via atypical FHA domain); the phosphorylated form at Thr-182 binds preferentially to PELI1 (PubMed:29883609). Interacts with BUB1B, TRAF2 and STUB1 (PubMed:29883609). Interacts with CASP6 (PubMed:32298652).
    • (Microbial infection) Interacts (via RIP homotypic interaction motif) with herpes simplex virus 1/HHV-1 protein RIR1/ICP6 (via RIP homotypic interaction motif); this interaction prevents necroptosis activation.
    • (Microbial infection) Interacts (via RIP homotypic interaction motif) with herpes simplex virus 2/HHV-2 protein RIR1/ICP10 (via RIP homotypic interaction motif); this interaction prevents necroptosis activation.

    Three dimensional structures from OCA and Proteopedia for RIPK3 Gene

    Alternative splice isoforms for RIPK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPK3 Gene

Post-translational modifications for RIPK3 Gene

  • RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Autophosphorylated following interaction with ZBP1 (By similarity). Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3 (PubMed:11734559, PubMed:19524512). Autophosphorylates at Ser-227 following activation by ZBP1: phosphorylation at these sites is a hallmark of necroptosis and is required for binding MLKL (PubMed:22265413). Phosphorylation at Thr-182 is important for its kinase activity, interaction with PELI1 and PELI1-mediated 'Lys-48'-linked polyubiquitination and for its ability to mediate TNF-induced necroptosis (PubMed:29883609).
  • Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B (PubMed:21931591). Polyubiquitinated with 'Lys-48'-linked chains by PELI1 leading to its subsequent proteasome-dependent degradation. Ubiquitinated by STUB1 leading to its subsequent proteasome-dependent degradation (PubMed:29883609).
  • Ubiquitination at Lys363
  • Modification sites at PhosphoSitePlus

Other Protein References for RIPK3 Gene

Antibodies for research

  • Abcam antibodies for RIPK3

No data available for DME Specific Peptides for RIPK3 Gene

Domains & Families for RIPK3 Gene

Gene Families for RIPK3 Gene

Suggested Antigen Peptide Sequences for RIPK3 Gene

GenScript: Design optimal peptide antigens:
  • Receptor-interacting protein 3 (RIPK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y572

UniProtKB/Swiss-Prot:

RIPK3_HUMAN :
  • The RIP homotypic interaction motif (RHIM) mediates interaction with the RHIM motif of RIPK1. Both motifs form a hetero-amyloid serpentine fold, stabilized by hydrophobic packing and featuring an unusual Cys-Ser ladder of alternating Ser (from RIPK1) and Cys (from RIPK3).
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • The RIP homotypic interaction motif (RHIM) mediates interaction with the RHIM motif of RIPK1. Both motifs form a hetero-amyloid serpentine fold, stabilized by hydrophobic packing and featuring an unusual Cys-Ser ladder of alternating Ser (from RIPK1) and Cys (from RIPK3).
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with RIPK3: view

Function for RIPK3 Gene

Molecular function for RIPK3 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is stimulated by ZBP1, which senses double-stranded Z-RNA structures (By similarity). RIPK3-dependent necroptosis is inhibited by RIPK1: RIPK1 prevents the ZBP1-induced activation of RIPK3 via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (By similarity).

Enzyme Numbers (IUBMB) for RIPK3 Gene

Phenotypes From GWAS Catalog for RIPK3 Gene

Gene Ontology (GO) - Molecular Function for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003713 transcription coactivator activity TAS 10339433
GO:0004672 protein kinase activity IBA,IMP 22265414
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004704 NF-kappaB-inducing kinase activity IEA --
genes like me logo Genes that share ontologies with RIPK3: view
genes like me logo Genes that share phenotypes with RIPK3: view

Animal Models for RIPK3 Gene

MGI Knock Outs for RIPK3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIPK3

Clone products for research

  • Addgene plasmids for RIPK3

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RIPK3 Gene

Localization for RIPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPK3 Gene

Cytoplasm, cytosol. Nucleus. Note=Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection. {ECO:0000250 UniProtKB:Q9QZL0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIPK3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
mitochondrion 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0032991 protein-containing complex IDA 22817896
genes like me logo Genes that share ontologies with RIPK3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RIPK3 Gene

Pathways & Interactions for RIPK3 Gene

genes like me logo Genes that share pathways with RIPK3: view

Pathways by source for RIPK3 Gene

1 GeneGo (Thomson Reuters) pathway for RIPK3 Gene
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
1 Qiagen pathway for RIPK3 Gene
  • Toll-Like Receptors Pathway
2 Cell Signaling Technology pathways for RIPK3 Gene

SIGNOR curated interactions for RIPK3 Gene

Activates:

Gene Ontology (GO) - Biological Process for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001914 regulation of T cell mediated cytotoxicity ISS --
GO:0002819 regulation of adaptive immune response ISS --
GO:0006464 cellular protein modification process TAS 10358032
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with RIPK3: view

Drugs & Compounds for RIPK3 Gene

(2) Drugs for RIPK3 Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra 0
Pulmonary Surfactants Pharma 187

(1) Additional Compounds for RIPK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with RIPK3: view

Transcripts for RIPK3 Gene

mRNA/cDNA for RIPK3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIPK3

Clone products for research

  • Addgene plasmids for RIPK3

Alternative Splicing Database (ASD) splice patterns (SP) for RIPK3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for RIPK3 Gene

GeneLoc Exon Structure for
RIPK3

Expression for RIPK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RIPK3 Gene

mRNA differential expression in normal tissues according to GTEx for RIPK3 Gene

This gene is overexpressed in Whole Blood (x9.7).

Protein differential expression in normal tissues from HIPED for RIPK3 Gene

This gene is overexpressed in CD8 Tcells (25.7), Monocytes (9.1), Peripheral blood mononuclear cells (8.5), and NK cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RIPK3 Gene



Protein tissue co-expression partners for RIPK3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RIPK3

SOURCE GeneReport for Unigene cluster for RIPK3 Gene:

Hs.268551

mRNA Expression by UniProt/SwissProt for RIPK3 Gene:

Q9Y572-RIPK3_HUMAN
Tissue specificity: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney.

Evidence on tissue expression from TISSUES for RIPK3 Gene

  • Blood(4.5)
  • Nervous system(4.4)
  • Lung(2.9)
  • Intestine(2.7)
  • Spleen(2.5)
  • Lymph node(2.5)
  • Skin(2.4)
  • Bone marrow(2.1)
  • Heart(2.1)
  • Liver(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RIPK3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIPK3 Gene

Orthologs for RIPK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RIPK3 29 30
  • 98.91 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RIPK3 29 30
  • 80.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RIPK3 29 30
  • 74.84 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ripk3 29 16 30
  • 71.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ripk3 29
  • 70.89 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 28 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 13 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 34 (a)
OneToMany
-- 30
  • 32 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490493 29
  • 49.01 (n)
Zebrafish
(Danio rerio)
Actinopterygii ripk3l 29 30
  • 50.54 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 15 (a)
ManyToMany
Species where no ortholog for RIPK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RIPK3 Gene

ENSEMBL:
Gene Tree for RIPK3 (if available)
TreeFam:
Gene Tree for RIPK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RIPK3: view image
Alliance of Genome Resources:
Additional Orthologs for RIPK3

Paralogs for RIPK3 Gene

genes like me logo Genes that share paralogs with RIPK3: view

Variants for RIPK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RIPK3 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs114872465 Uncertain Significance: not specified 24,337,408(-) G/A
NM_006871.4(RIPK3):c.953C>T (p.Pro318Leu)
MISSENSE
rs3212254 -- p.Pro492Gln
rs34106261 -- p.Thr300Met
rs7153640 -- p.Glu260Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RIPK3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RIPK3 Gene

Variant ID Type Subtype PubMed ID
nsv564060 CNV loss 21841781

Variation tolerance for RIPK3 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIPK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIPK3
Leiden Open Variation Database (LOVD)
RIPK3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPK3 Gene

Disorders for RIPK3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RIPK3 Gene - From: COP

Disorder Aliases PubMed IDs
caspase 8 deficiency
  • ceds
zika virus congenital syndrome
  • zikv congenital infection
autoimmune lymphoproliferative syndrome
  • alps
hypersensitivity reaction type iv disease
  • immunoproliferative disease
- elite association - COSMIC cancer census association via MalaCards
Search RIPK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RIPK3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RIPK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIPK3 Gene

Publications for RIPK3 Gene

  1. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. (PMID: 20354226) Vandenabeele P … Vanden Berghe T (Science signaling 2010) 3 4 22
  2. RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. (PMID: 15896315) Yang Y … Wu M (Biochemical and biophysical research communications 2005) 3 4 22
  3. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PMID: 11734559) Sun X … Dixit VM (The Journal of biological chemistry 2002) 3 4 22
  4. RIP3, a novel apoptosis-inducing kinase. (PMID: 10358032) Sun X … Dixit VM (The Journal of biological chemistry 1999) 2 3 4
  5. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. (PMID: 10339433) Yu PW … Luo Y (Current biology : CB 1999) 2 3 4

Products for RIPK3 Gene

Sources for RIPK3 Gene