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Aliases for RIPK2 Gene

Aliases for RIPK2 Gene

  • Receptor Interacting Serine/Threonine Kinase 2 2 3 5
  • CARD-Containing IL-1 Beta ICE-Kinase 3 4
  • Receptor-Interacting Protein 2 3 4
  • Tyrosine-Protein Kinase RIPK2 3 4
  • CARDIAK 3 4
  • RIP-2 3 4
  • RICK 3 4
  • RIP2 3 4
  • Receptor-Interacting Protein (RIP)-Like Interacting Caspase-Like Apoptosis Regulatory Protein (CLARP) Kinase 3
  • CARD-Containing Interleukin-1 Beta-Converting Enzyme (ICE)-Associated Kinase 3
  • CARD-Containing Interleukin-1 Beta-Converting Enzyme-Associated Kinase 4
  • Receptor-Interacting Serine/Threonine-Protein Kinase 2 3
  • Receptor-Interacting Serine-Threonine Kinase 2 2
  • RIP-Like-Interacting CLARP Kinase 4
  • Growth-Inhibiting Gene 30 3
  • CARD-Carrying Kinase 3
  • EC 2.7.11.1 4
  • EC 2.7.10.2 4
  • CARD3 3
  • GIG30 3
  • CCK 3

External Ids for RIPK2 Gene

Previous GeneCards Identifiers for RIPK2 Gene

  • GC08P089201
  • GC08P090502
  • GC08P090726
  • GC08P090839
  • GC08P085980
  • GC08P090769

Summaries for RIPK2 Gene

Entrez Gene Summary for RIPK2 Gene

  • This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIPK2 Gene

RIPK2 (Receptor Interacting Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with RIPK2 include Lymphoproliferative Syndrome, X-Linked, 2 and Human Granulocytic Anaplasmosis. Among its related pathways are Activated TLR4 signalling and Canonical NF-kappaB pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is RIPK4.

UniProtKB/Swiss-Prot for RIPK2 Gene

  • Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes Lys-63-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces Lys-63-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

Gene Wiki entry for RIPK2 Gene

Additional gene information for RIPK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPK2 Gene

Genomics for RIPK2 Gene

GeneHancer (GH) Regulatory Elements for RIPK2 Gene

Promoters and enhancers for RIPK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J089755 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 656.1 +0.3 329 5.8 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B LOC101929709 RIPK2 COX6B1P6
GH08J089725 Enhancer 1.5 FANTOM5 Ensembl ENCODE 31.9 -29.5 -29529 5.7 HDGF PKNOX1 ATF1 SIN3A IRF4 YY1 POLR2B ZNF766 ZNF143 ATF7 LOC101929709 RIPK2 DECR1 NBN OSGIN2 PIR62642
GH08J089780 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 25.7 +24.1 24137 2.1 BMI1 BATF NFATC1 ATF7 ETV6 FOS IKZF2 RUNX3 SRF ZNF687 RIPK2 LOC101929709 OSGIN2 COX6B1P6
GH08J089835 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +79.1 79074 2.9 HDGF STAT5A BATF KLF5 IRF4 ATF7 FOS ETV6 BCLAF1 IKZF2 RIPK2 LOC101929709 NBN OSGIN2 ENSG00000275103 RNU6-925P GC08M089901
GH08J089841 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 25.8 +83.8 83768 1 ATF4 CEBPB CEBPG RIPK2 DECR1 NBN LOC101929709 OSGIN2 ENSG00000275103 GC08M089901 RNU6-925P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIPK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RIPK2 gene promoter:
  • AP-1
  • NF-kappaB1
  • NF-kappaB
  • c-Jun
  • ATF-2
  • LCR-F1
  • Msx-1
  • FOXL1
  • RORalpha2
  • AML1a

Genomic Locations for RIPK2 Gene

Genomic Locations for RIPK2 Gene
chr8:89,757,733-89,791,064
(GRCh38/hg38)
Size:
33,332 bases
Orientation:
Plus strand
chr8:90,769,975-90,803,292
(GRCh37/hg19)
Size:
33,318 bases
Orientation:
Plus strand

Genomic View for RIPK2 Gene

Genes around RIPK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPK2 Gene

Proteins for RIPK2 Gene

  • Protein details for RIPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43353-RIPK2_HUMAN
    Recommended name:
    Receptor-interacting serine/threonine-protein kinase 2
    Protein Accession:
    O43353
    Secondary Accessions:
    • B7Z748
    • Q6UWF0

    Protein attributes for RIPK2 Gene

    Size:
    540 amino acids
    Molecular mass:
    61195 Da
    Quaternary structure:
    • Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2. Interacts with ARHGEF2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex. Interacts with NOD1. Interacts (via CARD domain) with NOD2 (via CARD domain). Interacts with MAP3K4; this interaction sequesters RIPK2 from the NOD2 signaling pathway. Interacts with IKBKG/NEMO. The polyubiquitinated protein interacts with MAP3K7/TAK1. Interacts with XIAP/BIRC4. Interacts with NLRP10. Interacts with CARD9. Interacts with INAVA; the interaction takes place upon PRR stimulation (PubMed:28436939).

    Three dimensional structures from OCA and Proteopedia for RIPK2 Gene

    Alternative splice isoforms for RIPK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPK2 Gene

Post-translational modifications for RIPK2 Gene

  • Autophosphorylated. Autophosphorylation at Tyr-474 is necessary for effective NOD2 signaling. Phosphorylated. Phosphorylation at Tyr-381 by Src kinase CSK occurs in a ARHGEF2-dependent manner and is required for NOD2-dependent innate immune activation.
  • Ubiquitinated on Lys-209; undergoes Lys-63-linked polyubiquitination catalyzed by ITCH. Polyubiquitinated with Lys-48 and Lys-63-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. Also undergoes Met-1-linked polyubiquitination; the head-to-tail linear polyubiquitination is mediated by the LUBAC complex in response to NOD2 stimulation. Linear polyubiquitination is restricted by FAM105B/otulin, probably to limit NOD2-dependent proinflammatory signaling activation of NF-kappa-B.
  • Ubiquitination at Lys209
  • Modification sites at PhosphoSitePlus

Other Protein References for RIPK2 Gene

No data available for DME Specific Peptides for RIPK2 Gene

Domains & Families for RIPK2 Gene

Gene Families for RIPK2 Gene

Suggested Antigen Peptide Sequences for RIPK2 Gene

Graphical View of Domain Structure for InterPro Entry

O43353

UniProtKB/Swiss-Prot:

RIPK2_HUMAN :
  • Contains an N-terminal kinase domain and a C-terminal caspase activation and recruitment domain (CARD) that mediates the recruitment of CARD-containing proteins.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • Contains an N-terminal kinase domain and a C-terminal caspase activation and recruitment domain (CARD) that mediates the recruitment of CARD-containing proteins.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with RIPK2: view

Function for RIPK2 Gene

Molecular function for RIPK2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes Lys-63-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces Lys-63-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
GENATLAS Biochemistry:
receptor interacting serine-threonine kinase 2,widely expressed with two transcripts due to differential polyadenylation,regulator of TNFRSF6 (CD95)-mediated

Enzyme Numbers (IUBMB) for RIPK2 Gene

Phenotypes From GWAS Catalog for RIPK2 Gene

Gene Ontology (GO) - Molecular Function for RIPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
GO:0004871 obsolete signal transducer activity TAS --
genes like me logo Genes that share ontologies with RIPK2: view
genes like me logo Genes that share phenotypes with RIPK2: view

Animal Models for RIPK2 Gene

MGI Knock Outs for RIPK2:

miRNA for RIPK2 Gene

miRTarBase miRNAs that target RIPK2

Clone Products

  • Addgene plasmids for RIPK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIPK2 Gene

Localization for RIPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPK2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIPK2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RIPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21887730
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IDA 21887730
GO:0031982 vesicle IDA 21887730
GO:0032991 protein-containing complex IMP 11432859
genes like me logo Genes that share ontologies with RIPK2: view

Pathways & Interactions for RIPK2 Gene

genes like me logo Genes that share pathways with RIPK2: view

SIGNOR curated interactions for RIPK2 Gene

Activates:
Other effect:

Gene Ontology (GO) - Biological Process for RIPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA --
GO:0000187 activation of MAPK activity TAS --
GO:0001961 positive regulation of cytokine-mediated signaling pathway IEA --
GO:0002250 adaptive immune response IBA,ISS --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with RIPK2: view

Drugs & Compounds for RIPK2 Gene

(7) Drugs for RIPK2 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
SRC KINASE INHIBITOR I Pharma 0

(1) Additional Compounds for RIPK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with RIPK2: view

Transcripts for RIPK2 Gene

mRNA/cDNA for RIPK2 Gene

Unigene Clusters for RIPK2 Gene

Receptor-interacting serine-threonine kinase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for RIPK2

Alternative Splicing Database (ASD) splice patterns (SP) for RIPK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - - -
SP3:

Relevant External Links for RIPK2 Gene

GeneLoc Exon Structure for
RIPK2
ECgene alternative splicing isoforms for
RIPK2

Expression for RIPK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RIPK2 Gene

This gene is overexpressed in Plasma (24.0), Peripheral blood mononuclear cells (10.1), Placenta (6.5), and Islet of Langerhans (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RIPK2 Gene



Protein tissue co-expression partners for RIPK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RIPK2 Gene:

RIPK2

SOURCE GeneReport for Unigene cluster for RIPK2 Gene:

Hs.103755

mRNA Expression by UniProt/SwissProt for RIPK2 Gene:

O43353-RIPK2_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.

Evidence on tissue expression from TISSUES for RIPK2 Gene

  • Heart(4.3)
  • Liver(4.3)
  • Skin(4.3)
  • Blood(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with RIPK2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIPK2 Gene

Orthologs for RIPK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIPK2 34 33
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RIPK2 34 33
  • 89.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RIPK2 34 33
  • 89.08 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ripk2 16 34 33
  • 85.16 (n)
rat
(Rattus norvegicus)
Mammalia Ripk2 33
  • 84.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 78 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RIPK2 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIPK2 34 33
  • 70.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIPK2 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ripk2 33
  • 62.02 (n)
zebrafish
(Danio rerio)
Actinopterygii ripk2 34 33 33
  • 56.31 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
ManyToMany
Species where no ortholog for RIPK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIPK2 Gene

ENSEMBL:
Gene Tree for RIPK2 (if available)
TreeFam:
Gene Tree for RIPK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RIPK2: view image

Paralogs for RIPK2 Gene

Paralogs for RIPK2 Gene

genes like me logo Genes that share paralogs with RIPK2: view

Variants for RIPK2 Gene

Sequence variations from dbSNP and Humsavar for RIPK2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs71268283 benign, not specified 89,784,142(+) AAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAA/AAAAAAAAAAAA/AAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAAAAAAA intron_variant
rs1000021635 -- 89,772,543(+) G/C intron_variant
rs1000058498 -- 89,763,085(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000071789 -- 89,777,936(+) A/G intron_variant
rs1000074293 -- 89,772,216(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RIPK2 Gene

Variant ID Type Subtype PubMed ID
esv3576595 CNV gain 25503493

Variation tolerance for RIPK2 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.09; 69.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIPK2 Gene

Human Gene Mutation Database (HGMD)
RIPK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIPK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPK2 Gene

Disorders for RIPK2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RIPK2 Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search RIPK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RIPK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RIPK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIPK2 Gene

Publications for RIPK2 Gene

  1. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. (PMID: 9575181) Inohara N … Núñez G (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. (PMID: 9705938) Thome M … Tschopp J (Current biology : CB 1998) 2 3 4 22 58
  3. ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. (PMID: 19592251) Tao M … Abbott DW (Current biology : CB 2009) 3 4 22 58
  4. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. (PMID: 18079694) Hasegawa M … Inohara N (The EMBO journal 2008) 3 4 22 58
  5. Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. (PMID: 17054981) Manon F … Cusack S (Journal of molecular biology 2007) 3 4 22 58

Products for RIPK2 Gene

  • Addgene plasmids for RIPK2

Sources for RIPK2 Gene

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