MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008] See more...

Aliases for RIOX2 Gene

Aliases for RIOX2 Gene

  • Ribosomal Oxygenase 2 2 3 4 5
  • MINA53 2 3 4
  • NO52 2 3 4
  • Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MINA 3 4
  • 60S Ribosomal Protein L27a Histidine Hydroxylase 3 4
  • Histone Lysine Demethylase MINA 3 4
  • MYC Induced Nuclear Antigen 2 3
  • Ribosomal Oxygenase MINA 3 4
  • Nucleolar Protein 52 3 4
  • JMJD10 2 3
  • MDIG 3 4
  • MINA 3 4
  • ROX 3 4
  • Myc-Induced Nuclear Antigen, 53 KDa 3
  • Mineral Dust Induced Gene Protein 3
  • Mineral Dust-Induced Gene Protein 4
  • MYC-Induced Nuclear Antigen 53 3
  • MYC-Induced Nuclear Antigen 4
  • EC 1.14.11.- 4
  • FLJ14393 2
  • RIOX2 5
  • Mdig 2

External Ids for RIOX2 Gene

Previous HGNC Symbols for RIOX2 Gene

  • MINA

Summaries for RIOX2 Gene

Entrez Gene Summary for RIOX2 Gene

  • MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

GeneCards Summary for RIOX2 Gene

RIOX2 (Ribosomal Oxygenase 2) is a Protein Coding gene. Diseases associated with RIOX2 include Squamous Cell Carcinoma and Lung Cancer. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is RIOX1.

UniProtKB/Swiss-Prot Summary for RIOX2 Gene

  • Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Gene Wiki entry for RIOX2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RIOX2 Gene

Genomics for RIOX2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RIOX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J097969 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 255.8 +1.0 972 4 MYC ZNF600 ZNF592 ATF2 CEBPA ZNF223 YY1 MXD4 CEBPB SIN3A RIOX2 ENSG00000285614 CRYBG3 HSALNG0027468
GH03J097974 Enhancer 0.2 Ensembl 250.7 -1.8 -1844 1 ENSG00000285614 RIOX2 HSALNG0027470 GABRR3
GH03J097820 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 +150.0 149956 3.4 BCLAF1 ZNF600 POLR2A YY1 REST ZNF341 KLF7 CTCF ZNF513 KMT2B CRYBG3 ENSG00000282527 LOC101929298 RIOX2
GH03J097882 Enhancer 0.6 Ensembl ENCODE 15.1 +89.2 89180 1.8 NFIC FEZF1 JUND NFIB EP300 HMBOX1 RIOX2 HSALNG0027459 HSALNG0027460 CRYBG3
GH03J097910 Enhancer 0.8 ENCODE 11.4 +61.3 61332 1.6 NCOR1 NFIC HES1 ARNT FOXA2 TAL1 STAT5A SMARCA4 SPI1 MYC RIOX2 CRYBG3 HSALNG0027460 HSALNG0027463
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIOX2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RIOX2

Genomic Locations for RIOX2 Gene

Latest Assembly
chr3:97,941,818-97,972,457
(GRCh38/hg38)
Size:
30,640 bases
Orientation:
Minus strand

Previous Assembly
chr3:97,660,662-97,691,275
(GRCh37/hg19 by Entrez Gene)
Size:
30,614 bases
Orientation:
Minus strand

chr3:97,660,662-97,691,301
(GRCh37/hg19 by Ensembl)
Size:
30,640 bases
Orientation:
Minus strand

Genomic View for RIOX2 Gene

Genes around RIOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOX2 Gene

Proteins for RIOX2 Gene

  • Protein details for RIOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUF8-RIOX2_HUMAN
    Recommended name:
    Ribosomal oxygenase 2
    Protein Accession:
    Q8IUF8
    Secondary Accessions:
    • D3DN35
    • Q6AHW4
    • Q6SKS0
    • Q8IU69
    • Q8IUF6
    • Q8IUF7
    • Q96C17
    • Q96KB0

    Protein attributes for RIOX2 Gene

    Size:
    465 amino acids
    Molecular mass:
    52800 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH10679.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIOX2 Gene

    Alternative splice isoforms for RIOX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIOX2 Gene

Post-translational modifications for RIOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIOX2 Gene

Domains & Families for RIOX2 Gene

Gene Families for RIOX2 Gene

Protein Domains for RIOX2 Gene

InterPro:
Blocks:
  • Transcription factor jumonji, jmjC
  • Cupin 4

Suggested Antigen Peptide Sequences for RIOX2 Gene

GenScript: Design optimal peptide antigens:
  • Nucleolar protein 52 (MINA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IUF8

UniProtKB/Swiss-Prot:

RIOX2_HUMAN :
  • Belongs to the ROX family. MINA53 subfamily.
Family:
  • Belongs to the ROX family. MINA53 subfamily.
genes like me logo Genes that share domains with RIOX2: view

Function for RIOX2 Gene

Molecular function for RIOX2 Gene

UniProtKB/Swiss-Prot Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate; Xref=Rhea:RHEA:54024, Rhea:RHEA-COMP:13760, Rhea:RHEA-COMP:13761, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29979, ChEBI:CHEBI:30031, ChEBI:CHEBI:138021; Evidence={ECO:0000269|PubMed:23103944};.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells.

Enzyme Numbers (IUBMB) for RIOX2 Gene

Gene Ontology (GO) - Molecular Function for RIOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 32296183
GO:0016491 oxidoreductase activity IEA --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA,IBA 21873635
genes like me logo Genes that share ontologies with RIOX2: view
genes like me logo Genes that share phenotypes with RIOX2: view

Animal Models for RIOX2 Gene

MGI Knock Outs for RIOX2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIOX2

Clone products for research

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIOX2 Gene

Localization for RIOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIOX2 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIOX2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RIOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IBA,IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RIOX2: view

Pathways & Interactions for RIOX2 Gene

genes like me logo Genes that share pathways with RIOX2: view

Pathways by source for RIOX2 Gene

Gene Ontology (GO) - Biological Process for RIOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034720 histone H3-K4 demethylation IBA 21873635
GO:0042254 ribosome biogenesis IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0070544 histone H3-K36 demethylation IBA 21873635
genes like me logo Genes that share ontologies with RIOX2: view

No data available for SIGNOR curated interactions for RIOX2 Gene

Drugs & Compounds for RIOX2 Gene

(3) Drugs for RIOX2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Succinic acid Approved Nutra 0
Oxogluric acid Experimental, Investigational Nutra 0
genes like me logo Genes that share compounds with RIOX2: view

Transcripts for RIOX2 Gene

mRNA/cDNA for RIOX2 Gene

4 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIOX2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for RIOX2 Gene

No ASD Table

Relevant External Links for RIOX2 Gene

GeneLoc Exon Structure for
RIOX2

Expression for RIOX2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RIOX2

mRNA Expression by UniProt/SwissProt for RIOX2 Gene:

Q8IUF8-RIOX2_HUMAN
Tissue specificity: Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.

Evidence on tissue expression from TISSUES for RIOX2 Gene

  • Nervous system(3.2)

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIOX2 Gene

Orthologs for RIOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIOX2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MINA 29 30
  • 99.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MINA 29 30
  • 85.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mina 29
  • 82.15 (n)
Mouse
(Mus musculus)
Mammalia Mina 29 30
  • 80.93 (n)
OneToOne
Riox2 16
Dog
(Canis familiaris)
Mammalia MINA 29 30
  • 80.13 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MINA 30
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MINA 30
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MINA 29 30
  • 70.78 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 64 (a)
OneToMany
-- 30
  • 64 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mina 29
  • 59.19 (n)
Str.7087 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.14893 29
Zebrafish
(Danio rerio)
Actinopterygii minal 29 30
  • 59.7 (n)
OneToOne
zgc63873 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG2982 30
  • 18 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea jmjc-1 30
  • 17 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8544 30
  • 36 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.10438 29
Species where no ortholog for RIOX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RIOX2 Gene

ENSEMBL:
Gene Tree for RIOX2 (if available)
TreeFam:
Gene Tree for RIOX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RIOX2: view image
Alliance of Genome Resources:
Additional Orthologs for RIOX2

Paralogs for RIOX2 Gene

Paralogs for RIOX2 Gene

genes like me logo Genes that share paralogs with RIOX2: view

Variants for RIOX2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RIOX2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs2172257 -- p.Ala386Thr
rs35391656 -- p.Ala17Pro
rs56183666 -- p.Pro201Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RIOX2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RIOX2 Gene

Variant ID Type Subtype PubMed ID
nsv1012322 CNV gain 25217958
nsv1013060 CNV gain 25217958
nsv520553 CNV gain 19592680

Variation tolerance for RIOX2 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.87; 93.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIOX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIOX2
Leiden Open Variation Database (LOVD)
RIOX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIOX2 Gene

Disorders for RIOX2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RIOX2 Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
squamous cell carcinoma
  • epidermoid carcinoma
lung cancer
  • lung cancer, susceptibility to
gastric cancer
  • gastric cancer, somatic
hepatocellular carcinoma
  • hcc
familial isolated hypoparathyroidism
  • fih
- elite association - COSMIC cancer census association via MalaCards
Search RIOX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RIOX2

genes like me logo Genes that share disorders with RIOX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIOX2 Gene

Publications for RIOX2 Gene

  1. A novel myc target gene, mina53, that is involved in cell proliferation. (PMID: 12091391) Tsuneoka M … Kimura H (The Journal of biological chemistry 2002) 2 3 4 22
  2. Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. (PMID: 19502796) Lu Y … Chen F (Cell cycle (Georgetown, Tex.) 2009) 3 4
  3. Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66. (PMID: 15819408) Eilbracht J … Schmidt-Zachmann MS (European journal of cell biology 2005) 3 4
  4. The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. (PMID: 15897898) Zhang Y … Chen F (Oncogene 2005) 3 4
  5. Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma. (PMID: 15534111) Tsuneoka M … Kimura H (Clinical cancer research : an official journal of the American Association for Cancer Research 2004) 3 4

Products for RIOX2 Gene

Sources for RIOX2 Gene