Aliases for RINL Gene

Aliases for RINL Gene

  • Ras And Rab Interactor Like 2 3 5
  • Ras And Rab Interactor-Like Protein 3 4
  • FLJ45909 2
  • RINL 5

External Ids for RINL Gene

Previous GeneCards Identifiers for RINL Gene

  • GC19M044052
  • GC19M039358
  • GC19M035805

Summaries for RINL Gene

GeneCards Summary for RINL Gene

RINL (Ras And Rab Interactor Like) is a Protein Coding gene. Diseases associated with RINL include Intracranial Berry Aneurysm. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIN1.

UniProtKB/Swiss-Prot Summary for RINL Gene

  • Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).

Additional gene information for RINL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RINL Gene

Genomics for RINL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RINL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RINL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RINL

Top Transcription factor binding sites by QIAGEN in the RINL gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • ITF-2
  • LyF-1
  • MEF-2A
  • Tal-1beta

Genomic Locations for RINL Gene

Genomic Locations for RINL Gene
chr19:38,867,825-38,878,275
(GRCh38/hg38)
Size:
10,451 bases
Orientation:
Minus strand
chr19:39,358,470-39,368,919
(GRCh37/hg19)
Size:
10,450 bases
Orientation:
Minus strand

Genomic View for RINL Gene

Genes around RINL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RINL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RINL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RINL Gene

Proteins for RINL Gene

  • Protein details for RINL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS11-RINL_HUMAN
    Recommended name:
    Ras and Rab interactor-like protein
    Protein Accession:
    Q6ZS11
    Secondary Accessions:
    • B4DPG5

    Protein attributes for RINL Gene

    Size:
    566 amino acids
    Molecular mass:
    62466 Da
    Quaternary structure:
    • Interacts with RAB5A, RAB22A and MUSK.

    Alternative splice isoforms for RINL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RINL Gene

Post-translational modifications for RINL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RINL Gene

Domains & Families for RINL Gene

Gene Families for RINL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RINL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RINL Gene

GenScript: Design optimal peptide antigens:
  • Ras and Rab interactor-like protein (RINL_HUMAN)
genes like me logo Genes that share domains with RINL: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RINL Gene

Function for RINL Gene

Molecular function for RINL Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).

Phenotypes From GWAS Catalog for RINL Gene

Gene Ontology (GO) - Molecular Function for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA,ISS --
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with RINL: view
genes like me logo Genes that share phenotypes with RINL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RINL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RINL Gene

Localization for RINL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RINL Gene

Cell projection, ruffle. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RINL gene
Compartment Confidence
cytosol 3
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0015629 actin cytoskeleton IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with RINL: view

Pathways & Interactions for RINL Gene

genes like me logo Genes that share pathways with RINL: view

Pathways by source for RINL Gene

Gene Ontology (GO) - Biological Process for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis ISS --
GO:0015031 protein transport IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RINL: view

No data available for SIGNOR curated interactions for RINL Gene

Drugs & Compounds for RINL Gene

No Compound Related Data Available

Transcripts for RINL Gene

mRNA/cDNA for RINL Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RINL

Alternative Splicing Database (ASD) splice patterns (SP) for RINL Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:

Relevant External Links for RINL Gene

GeneLoc Exon Structure for
RINL

Expression for RINL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RINL Gene

mRNA differential expression in normal tissues according to GTEx for RINL Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for RINL Gene

This gene is overexpressed in Pancreatic juice (36.6) and Peripheral blood mononuclear cells (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RINL Gene



Protein tissue co-expression partners for RINL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RINL

SOURCE GeneReport for Unigene cluster for RINL Gene:

Hs.446933

Evidence on tissue expression from TISSUES for RINL Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with RINL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RINL Gene

Orthologs for RINL Gene

This gene was present in the common ancestor of animals.

Orthologs for RINL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RINL 30 31
  • 99.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RINL 30 31
  • 81.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RINL 30 31
  • 81.55 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rinl 30 17 31
  • 77.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rinl 30
  • 75.63 (n)
Oppossum
(Monodelphis domestica)
Mammalia RINL 31
  • 49 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 14 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia RINL 31
  • 19 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CABZ01056375.1 31
  • 20 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta spri 31
  • 5 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rin-1 31
  • 5 (a)
OneToMany
Species where no ortholog for RINL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RINL Gene

ENSEMBL:
Gene Tree for RINL (if available)
TreeFam:
Gene Tree for RINL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RINL: view image

Paralogs for RINL Gene

Paralogs for RINL Gene

(2) SIMAP similar genes for RINL Gene using alignment to 3 proteins:

  • RINL_HUMAN
  • M0QY08_HUMAN
  • M0QZ15_HUMAN
genes like me logo Genes that share paralogs with RINL: view

Variants for RINL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RINL Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
777530 Benign: not provided 38,871,637(-) C/T INTRON_VARIANT
rs8110393 - p.Pro402Leu

Additional dbSNP identifiers (rs#s) for RINL Gene

Structural Variations from Database of Genomic Variants (DGV) for RINL Gene

Variant ID Type Subtype PubMed ID
nsv1160616 CNV duplication 26073780

Variation tolerance for RINL Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.18; 92.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RINL Gene

Human Gene Mutation Database (HGMD)
RINL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RINL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RINL Gene

Disorders for RINL Gene

MalaCards: The human disease database

(1) MalaCards diseases for RINL Gene - From: DISEASES

Disorder Aliases PubMed IDs
intracranial berry aneurysm
  • aneurysm, intracranial berry, 1
- elite association - COSMIC cancer census association via MalaCards
Search RINL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RINL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RINL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RINL Gene

Publications for RINL Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The human cytoplasmic dynein interactome reveals novel activators of motility. (PMID: 28718761) Redwine WB … Reck-Peterson SL (eLife 2017) 3
  4. RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin. (PMID: 22291991) Kajiho H … Katada T (PloS one 2012) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3

Products for RINL Gene

Sources for RINL Gene