Aliases for RIN1 Gene
Aliases for RIN1 Gene
External Ids for RIN1 Gene
- HGNC: 18749
- Entrez Gene: 9610
- Ensembl: ENSG00000174791
- OMIM: 605965
- UniProtKB: Q13671
Previous GeneCards Identifiers for RIN1 Gene
- GC11M068633
- GC11M067780
- GC11M066349
- GC11M065874
- GC11M065856
- GC11M066099
- GC11M062436
Summaries for RIN1 Gene
GeneCards Summary for RIN1 Gene
RIN1 (Ras And Rab Interactor 1) is a Protein Coding gene. Diseases associated with RIN1 include Bladder Urothelial Carcinoma. Among its related pathways are Vesicle-mediated transport and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Ras GTPase binding. An important paralog of this gene is RIN2.
UniProtKB/Swiss-Prot for RIN1 Gene
-
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIN1 Gene
Genomics for RIN1 Gene
GeneHancer (GH) Regulatory Elements for RIN1 Gene
Promoters and enhancers for RIN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RIN1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RIN1 gene promoter:
-
- AP-1
- c-Myb
- GATA-2
- PPAR-alpha
- SREBP-1a
Genomic Locations for RIN1 Gene
Genomic Locations for RIN1 Gene
- chr11:66,330,241-66,337,133
- (GRCh38/hg38)
- Size:
- 6,893 bases
- Orientation:
- Minus strand
- chr11:66,097,713-66,104,311
- (GRCh37/hg19)
- Size:
- 6,599 bases
- Orientation:
- Minus strand
Genomic View for RIN1 Gene
Genes around RIN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.2 by HGNC
- 11q13.2 by Entrez Gene
- 11q13.2 by Ensembl
RIN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RIN1 Gene
Proteins for RIN1 Gene
-
Protein details for RIN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13671-RIN1_HUMAN
- Recommended name:
- Ras and Rab interactor 1
- Protein Accession:
- Q13671
- O15010
- Q00427
- Q96CC8
Protein attributes for RIN1 Gene
- Size:
- 783 amino acids
- Molecular mass:
- 84099 Da
- Quaternary structure:
-
- Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.
Protein Expression for RIN1 Gene
Post-translational modifications for RIN1 Gene
- Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RIN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-RIN1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for RIN1
- Novus Biologicals Antibodies for RIN1
-
Abcam antibodies for RIN1
- Invitrogen Antibodies for RIN1 (AFLGC-RIN1)
-
Boster Bio Antibodies for RIN1
Protein Products
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- antibodies-online: Search results for 5 available RIN1 Proteins ranked by validation data
- Compare Top RIN1 Proteins
-
Quality Products:
-
Abcam proteins for RIN1
No data available for DME Specific Peptides for RIN1 Gene
Domains & Families for RIN1 Gene
Gene Families for RIN1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RIN1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RIN1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ras interaction/interference protein 1 (RIN1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13671- Family:
-
- Belongs to the RIN (Ras interaction/interference) family.
Function for RIN1 Gene
Molecular function for RIN1 Gene
- UniProtKB/Swiss-Prot Function:
- Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Phenotypes From GWAS Catalog for RIN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 9144171 |
| GO:0017016 | Ras GTPase binding | IEA | -- |
Phenotypes for RIN1 Gene
- MGI mutant phenotypes for RIN1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RIN1:
Animal Models for RIN1 Gene
- MGI Knock Outs for RIN1:
-
- Rin1 Rin1<tm1Colc>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RIN1
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RIN1 - Now 50% OFF >
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-
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- genomics-online: gRNA clones - Search results for 82 available RIN1 gene related products
- Overview of 82 available RIN1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for RIN1
miRNA for RIN1 Gene
- miRTarBase miRNAs that target RIN1
miRNA Products
Inhibitory RNA Products
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- Overview of 82 available RIN1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for RIN1 - Now 50% OFF >
- * RIN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * RIN1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG210527
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- RC204147
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- RC204147L3
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- RG204147
- RR210421
- RR210421L1
- RR210421L1V
- RR210421L2
- RR210421L2V
- RR210421L3
- RR210421L3V
- RR210421L4
- RR210421L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RIN1
- Addgene plasmids for RIN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RIN1
Cell Line Products
-
Horizon Cell Lines for RIN1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIN1 Gene
Localization for RIN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RIN1 Gene
- Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| nucleus | 3 |
| endosome | 1 |
- Nuclear membrane (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 12574403 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | TAS,IDA | 12574403 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for RIN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | Ras signaling pathway | ||
| 3 | RAB GEFs exchange GTP for GDP on RABs | ||
| 4 | EGF/EGFR Signaling Pathway | ||
| 5 | ErbB1 downstream signaling | ||
Pathways by source for RIN1 Gene
2 BioSystems pathways for RIN1 Gene
3 Reactome pathways for RIN1 Gene
1 KEGG pathway for RIN1 Gene
Interacting Proteins for RIN1 Gene
Selected Interacting proteins:
Q13671-RIN1_HUMAN
ENSP00000310406
for RIN1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RIN1
SIGNOR curated interactions for RIN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007613 | memory | IEA | -- |
| GO:0008306 | associative learning | IEA | -- |
| GO:0031914 | negative regulation of synaptic plasticity | IEA | -- |
Drugs & Compounds for RIN1 Gene
Drug Products
- Atlas Antibodies PrEST Antigen RIN1
Transcripts for RIN1 Gene
mRNA/cDNA for RIN1 Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (95) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000526246 4416 bps (ENST00000526246.5)
- ENST00000311320 4419 bps (ENST00000311320.8)
- ENST00000534824 1834 bps (ENST00000534824.5)
- ENST00000530056 2122 bps (ENST00000530056.1)
- ENST00000524804 847 bps (ENST00000524804.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RIN1 - Now 50% OFF >
- * RIN1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * RIN1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for RIN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RIN1
- genomics-online: gRNA clones - Search results for 82 available RIN1 gene related products
- Overview of 82 available RIN1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for RIN1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for RIN1
- Browse OriGene Inhibitory RNA Products For RIN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIN1
- genomics-online: shRNA clones - Search results for 82 available RIN1 gene related products
- Overview of 82 available RIN1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for RIN1 - Now 50% OFF >
- * RIN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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-
- MG210527
- MR210527
- MR210527L1
- MR210527L1V
- MR210527L2
- MR210527L2V
- MR210527L3
- MR210527L3V
- MR210527L4
- MR210527L4V
- RC204147
- RC204147L1
- RC204147L1V
- RC204147L2
- RC204147L2V
- RC204147L3
- RC204147L3V
- RC204147L4
- RC204147L4V
- RG204147
- RR210421
- RR210421L1
- RR210421L1V
- RR210421L2
- RR210421L2V
- RR210421L3
- RR210421L3V
- RR210421L4
- RR210421L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RIN1
- Addgene plasmids for RIN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RIN1
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: |
Expression for RIN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Urine (25.6), Breast (24.6), and Bone (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RIN1 Gene
NURSA nuclear receptor signaling pathways regulating expression of RIN1 Gene:
RIN1SOURCE GeneReport for Unigene cluster for RIN1 Gene:
Hs.1030mRNA Expression by UniProt/SwissProt for RIN1 Gene:
Q13671-RIN1_HUMAN
Tissue specificity:
Expressed in all tissues examined with high levels in brain, placenta and pancreas.
Evidence on tissue expression from TISSUES for RIN1 Gene
- Nervous system(4.3)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for RIN1
-
OriGene qPCR primer pairs and template standards for RIN1
- genomics-online: primer clones - Search results for 82 available RIN1 gene related products
- Overview of 82 available RIN1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIN1 Gene
Orthologs for RIN1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RIN1 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RIN1 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RIN1 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rin1 17 35 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RIN1 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RIN1 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | rin1a 35 |
|
OneToMany | |
| BX511131.1 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | spri 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | rin-1 35 |
|
OneToMany |
- Species where no ortholog for RIN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for RIN1 Gene
- ENSEMBL:
- Gene Tree for RIN1 (if available)
- TreeFam:
- Gene Tree for RIN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RIN1: view image
Paralogs for RIN1 Gene
Variants for RIN1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000154130 | -- | 66,337,457(-) | C/G | upstream_transcript_variant | |
| rs1000810804 | -- | 66,332,135(-) | C/G | 3_prime_UTR_variant | |
| rs1000835117 | -- | 66,339,081(-) | G/A | upstream_transcript_variant | |
| rs1001484719 | -- | 66,333,063(-) | T/C | intron_variant | |
| rs1001682340 | -- | 66,337,565(-) | C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.67;
72.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RIN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RIN1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RIN1 Gene
Disorders for RIN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bladder urothelial carcinoma |
|
|
Search RIN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RIN1
No data available for UniProtKB/Swiss-Prot and Genatlas for RIN1 Gene
Publications for RIN1 Gene
- Protein binding and signaling properties of RIN1 suggest a unique effector function. (PMID: 9144171) Han L … Colicelli J (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 23 58
- The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. (PMID: 11784866) Wang Y … Colicelli J (Molecular and cellular biology 2002) 3 4 23 58
- Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. (PMID: 11703925) Tall GG … Horazdovsky BF (Developmental cell 2001) 3 4 23 58
- Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. (PMID: 9208849) Afar DE … Colicelli J (Immunity 1997) 3 4 23 58
- Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. (PMID: 1849280) Colicelli J … Wigler M (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 58
ExternalLinks
Products for RIN1 Gene
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- MG210527
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- RC204147
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- RR210421
- RR210421L1
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- Quality Products:
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- genomics-online: cdna clones - Search results for 82 available RIN1 gene related products
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Sources for RIN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
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