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RIN1 (Ras And Rab Interactor 1) is a Protein Coding gene. Diseases associated with RIN1 include Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease and Bladder Urothelial Carcinoma. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Ras GTPase binding. An important paralog of this gene is RIN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005096 | GTPase activator activity | IEA | -- |
GO:0005515 | protein binding | IPI | 9144171 |
GO:0017016 | Ras GTPase binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 12574403 |
GO:0005829 | cytosol | TAS | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005886 | plasma membrane | TAS,IDA | 12574403 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | Ras signaling pathway | ||
3 | RAB GEFs exchange GTP for GDP on RABs | ||
4 | EGF/EGFR Signaling Pathway | ||
5 | ErbB1 downstream signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006897 | endocytosis | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007613 | memory | IEA | -- |
GO:0008306 | associative learning | IEA | -- |
GO:0031914 | negative regulation of synaptic plasticity | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RIN1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RIN1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RIN1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rin1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RIN1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RIN1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | rin1a 31 |
|
OneToMany | |
BX511131.1 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | spri 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | rin-1 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
720437 | Benign: not provided | 66,333,614(-) | C/T | MISSENSE_VARIANT | |
775092 | Benign: not provided | 66,332,699(-) | G/C | SYNONYMOUS_VARIANT | |
776629 | Benign: not provided | 66,332,558(-) | G/A | SYNONYMOUS_VARIANT | |
785361 | Benign: not provided | 66,332,417(-) | C/T | SYNONYMOUS_VARIANT | |
785362 | Benign: not provided | 66,332,530(-) | C/T | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
polycystic kidney disease 3 with or without polycystic liver disease |
|
|
bladder urothelial carcinoma |
|
|