Aliases for RILPL1 Gene
External Ids for RILPL1 Gene
Previous GeneCards Identifiers for RILPL1 Gene
GeneCards Summary for RILPL1 Gene
RILPL1 (Rab Interacting Lysosomal Protein Like 1) is a Protein Coding gene. Diseases associated with RILPL1 include Epidermolysis Bullosa Simplex, Ogna Type and Alzheimer Disease 3. An important paralog of this gene is RILP.
UniProtKB/Swiss-Prot Summary for RILPL1 Gene
Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (PubMed:14668488). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (PubMed:30398148).