Aliases for RILP Gene
External Ids for RILP Gene
Previous GeneCards Identifiers for RILP Gene
This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]
GeneCards Summary for RILP Gene
RILP (Rab Interacting Lysosomal Protein) is a Protein Coding gene. Diseases associated with RILP include Retinitis Pigmentosa. Among its related pathways are Phagosome and wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF). Gene Ontology (GO) annotations related to this gene include Rab GTPase binding. An important paralog of this gene is RILPL1.
UniProtKB/Swiss-Prot Summary for RILP Gene
Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.