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Aliases for RIIAD1 Gene

Aliases for RIIAD1 Gene

  • Regulatory Subunit Of Type II PKA R-Subunit (RIIa) Domain Containing 1 2 3 5
  • C1orf230 3 4
  • RIIa Domain-Containing Protein ENSP00000357824 3
  • RIIa Domain-Containing Protein C1orf230 3
  • Chromosome 1 Open Reading Frame 230 2
  • RIIa Domain-Containing Protein 1 3
  • Non-Protein Coding RNA 166 2
  • NCRNA00166 3

External Ids for RIIAD1 Gene

Previous HGNC Symbols for RIIAD1 Gene

  • NCRNA00166
  • C1orf230

Previous GeneCards Identifiers for RIIAD1 Gene

  • GC01P151684

Summaries for RIIAD1 Gene

GeneCards Summary for RIIAD1 Gene

RIIAD1 (Regulatory Subunit Of Type II PKA R-Subunit (RIIa) Domain Containing 1) is a Protein Coding gene. Among its related pathways are Endothelin Pathways.

Additional gene information for RIIAD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIIAD1 Gene

Genomics for RIIAD1 Gene

GeneHancer (GH) Regulatory Elements for RIIAD1 Gene

Promoters and enhancers for RIIAD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J151710 Enhancer 0.9 ENCODE dbSUPER 650.7 -0.1 -53 0.2 MEIS2 MXI1 PKNOX1 ATF1 JUN MAX BMI1 ZBTB40 RFX5 ZFHX2 RIIAD1 ENSG00000227045 CELF3
GH01J151610 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 -98.3 -98334 3.5 HDGF PKNOX1 SMAD1 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SNX27 ENSG00000250734 SETDB1 PIP5K1A ZNF687 ARNT CTSK PI4KB C1orf56 UBE2D3P3
GH01J151537 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 -170.2 -170227 7.3 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 TUFT1 ENSG00000232536 PIP5K1A SETDB1 MRPL9 POGZ CGN LYSMD1 PRUNE1 SNX27
GH01J151608 Enhancer 1.1 Ensembl ENCODE 15.9 -101.8 -101840 1 HDAC1 ZNF2 RAD21 ZNF335 ZNF121 ZNF366 ZSCAN5C RCOR1 FOS THAP11 RIIAD1 RPS10P6 MIR554 TUFT1 ENSG00000252840 ENSG00000227045 CGN CELF3 ENSG00000232536 OAZ3
GH01J151712 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 7.6 +4.8 4844 6.3 PKNOX1 ARNT SIN3A ZBTB7B YY1 E2F8 ZNF143 KLF13 ZNF263 SP3 CELF3 SETDB1 PIP5K1A ZNF687 PI4KB UBE2D3P3 SNX27 GABPB2 MRPL9 ARNT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIIAD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RIIAD1 Gene

Genomic Locations for RIIAD1 Gene
chr1:151,710,433-151,729,805
(GRCh38/hg38)
Size:
19,373 bases
Orientation:
Plus strand
chr1:151,682,909-151,702,281
(GRCh37/hg19)
Size:
19,373 bases
Orientation:
Plus strand

Genomic View for RIIAD1 Gene

Genes around RIIAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIIAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIIAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIIAD1 Gene

Proteins for RIIAD1 Gene

  • Protein details for RIIAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNX1-RIAD1_HUMAN
    Recommended name:
    RIIa domain-containing protein 1
    Protein Accession:
    A6NNX1

    Protein attributes for RIIAD1 Gene

    Size:
    92 amino acids
    Molecular mass:
    10810 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RIIAD1 Gene

Post-translational modifications for RIIAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIIAD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIIAD1 Gene

Domains & Families for RIIAD1 Gene

Gene Families for RIIAD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RIIAD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RIIAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RIIAD1: view

No data available for UniProtKB/Swiss-Prot for RIIAD1 Gene

Function for RIIAD1 Gene

Phenotypes for RIIAD1 Gene

genes like me logo Genes that share phenotypes with RIIAD1: view

Animal Models for RIIAD1 Gene

MGI Knock Outs for RIIAD1:
  • Riiad1 Riiad1<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for RIIAD1 Gene

miRTarBase miRNAs that target RIIAD1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIIAD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIIAD1 Gene

Localization for RIIAD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIIAD1 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RIIAD1 Gene

Pathways & Interactions for RIIAD1 Gene

SuperPathways for RIIAD1 Gene

SuperPathway Contained pathways
1 Endothelin Pathways
genes like me logo Genes that share pathways with RIIAD1: view

Pathways by source for RIIAD1 Gene

1 BioSystems pathway for RIIAD1 Gene

Interacting Proteins for RIIAD1 Gene

Gene Ontology (GO) - Biological Process for RIIAD1 Gene

None

No data available for SIGNOR curated interactions for RIIAD1 Gene

Drugs & Compounds for RIIAD1 Gene

No Compound Related Data Available

Transcripts for RIIAD1 Gene

mRNA/cDNA for RIIAD1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(17) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RIIAD1 Gene

Regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIIAD1

Alternative Splicing Database (ASD) splice patterns (SP) for RIIAD1 Gene

No ASD Table

Relevant External Links for RIIAD1 Gene

GeneLoc Exon Structure for
RIIAD1
ECgene alternative splicing isoforms for
RIIAD1

Expression for RIIAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIIAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIIAD1 Gene

This gene is overexpressed in Pituitary (x6.3), Brain - Amygdala (x6.1), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for RIIAD1 Gene

This gene is overexpressed in Kidney (31.8), Lymph node (12.2), and Gallbladder (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RIIAD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of RIIAD1 Gene:

RIIAD1

SOURCE GeneReport for Unigene cluster for RIIAD1 Gene:

Hs.297967
genes like me logo Genes that share expression patterns with RIIAD1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIIAD1 Gene

Orthologs for RIIAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIIAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIIAD1 34 33
  • 98.91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RIIAD1 34 33
  • 88.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RIIAD1 34 33
  • 85.87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Riiad1 16 34 33
  • 77.54 (n)
rat
(Rattus norvegicus)
Mammalia Riiad1 33
  • 77.17 (n)
oppossum
(Monodelphis domestica)
Mammalia RIIAD1 34
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100536995 33
  • 60.68 (n)
RIIAD1 34
  • 57 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToOne
Species where no ortholog for RIIAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIIAD1 Gene

ENSEMBL:
Gene Tree for RIIAD1 (if available)
TreeFam:
Gene Tree for RIIAD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RIIAD1: view image

Paralogs for RIIAD1 Gene

No data available for Paralogs for RIIAD1 Gene

Variants for RIIAD1 Gene

Sequence variations from dbSNP and Humsavar for RIIAD1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000065736 -- 151,725,824(+) T/C intron_variant
rs1000573281 -- 151,720,923(+) T/C upstream_transcript_variant
rs1000876036 -- 151,724,886(+) G/A intron_variant
rs1000905845 -- 151,724,452(+) A/G intron_variant
rs1001144648 -- 151,727,544(+) A/G intron_variant

Variation tolerance for RIIAD1 Gene

Gene Damage Index Score: 1.71; 32.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIIAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIIAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RIIAD1 Gene

Disorders for RIIAD1 Gene

Additional Disease Information for RIIAD1

No disorders were found for RIIAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIIAD1 Gene

Publications for RIIAD1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. (PMID: 20564261) Erlbruch A … Bossemeyer D (Proteomics 2010) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for RIIAD1 Gene

Sources for RIIAD1 Gene

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