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RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008] See more...
Aliases for RICTOR Gene
Aliases for RICTOR Gene
External Ids for RICTOR Gene
- HGNC: 28611
- NCBI Entrez Gene: 253260
- Ensembl: ENSG00000164327
- OMIM®: 609022
- UniProtKB/Swiss-Prot: Q6R327
Previous GeneCards Identifiers for RICTOR Gene
- GC05M038977
- GC05M038939
Summaries for RICTOR Gene
-
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
GeneCards Summary for RICTOR Gene
RICTOR (RPTOR Independent Companion Of MTOR Complex 2) is a Protein Coding gene. Diseases associated with RICTOR include Premature Menopause and Tuberous Sclerosis. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include binding and ribosome binding.
UniProtKB/Swiss-Prot Summary for RICTOR Gene
-
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Additional gene information for RICTOR Gene
- HGNC (28611)
- NCBI Entrez Gene (253260)
- Ensembl (ENSG00000164327)
- OMIM® (609022)
- UniProtKB/Swiss-Prot (Q6R327)
- Open Targets Platform(ENSG00000164327)
- Monarch Initiative
- Alliance of Genome Resources
- Search for RICTOR at DataMed
- Search for RICTOR at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RICTOR Gene
Genomics for RICTOR Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RICTOR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RICTOR on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RICTOR
- Top Transcription factor binding sites by QIAGEN in the RICTOR gene promoter:
-
- AML1a
- C/EBPbeta
- FOXF2
- GATA-2
- HSF1 (long)
- HSF1short
- Meis-1
- Meis-1a
- Meis-1b
- Sox9
Genomic Locations for RICTOR Gene
Latest Assembly
- chr5:38,937,920-39,074,421
- (GRCh38/hg38)
- Size:
- 136,502 bases
- Orientation:
- Minus strand
Previous Assembly
- chr5:38,938,022-39,074,501
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 136,480 bases
- Orientation:
- Minus strand
Genomic View for RICTOR Gene
Genes around RICTOR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.1 by HGNC
- 5p13.1 by Entrez Gene
- 5p13.1 by Ensembl
RICTOR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RICTOR Gene
Proteins for RICTOR Gene
-
Protein details for RICTOR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6R327-RICTR_HUMAN
- Recommended name:
- Rapamycin-insensitive companion of mTOR
- Protein Accession:
- Q6R327
- B2RNX0
- B7ZMF7
- Q68DT5
- Q86UB7
- Q8N3A0
- Q8NCM6
Protein attributes for RICTOR Gene
- Size:
- 1708 amino acids
- Molecular mass:
- 192218 Da
- Quaternary structure:
-
- Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex (PubMed:15268862, PubMed:17461779, PubMed:17599906). Interacts with CCDC28B (PubMed:23727834). Interacts with NBN (PubMed:23762398). Interacts with PRR5L (PubMed:17461779, PubMed:21964062). Interacts with SIK3 (PubMed:30232230).
- (Microbial infection) Interacts with vaccinia virus protein F17; this interaction dysregulates mTOR.
- SequenceCaution:
-
- Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for RICTOR Gene
Post-translational modifications for RICTOR Gene
- Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
-
Ubiquitination at Lys1391
- NX_Q6R327 (NX_Q6R327-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RICTOR Gene
Antibodies for research
- LifeSpan BioSciences RICTOR Monoclonal Antibody and RICTOR Antibody
- G Biosciences Immunotag™ RICTOR Antibody and Immunotag™ Phospho-Rictor (Thr1135) Antibody
- NSJ Bioreagents RICTOR Antibody
-
Custom Antibody ServicesOriGene Antibodies for RICTOR
- Novus Biologicals Antibodies for RICTOR
-
Abcam antibodies for RICTOR
- Invitrogen Antibodies for RICTOR (AFLGC-Rictor)
- antibodies-online: Show 65 available RICTOR Antibodies ranked by validation data
- Compare Top RICTOR Antibodies
-
Recommended
- 157 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 76 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 10 WB Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for RICTOR
- RPTOR independent companion of MTOR, complex 2 [22-021]
- RPTOR independent companion of MTOR, complex 2 [46-299]
- RPTOR independent companion of MTOR, complex 2 [70-186]
- Rapamycin-insensitive companion of mTOR [62-768]
- Rapamycin-insensitive companion of mTOR [62-769]
- Rapamycin-insensitive companion of mTOR [62-770]
- Rapamycin-insensitive companion of mTOR [62-771]
-
Santa Cruz Biotechnology (SCBT) Antibodies for RICTOR
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RICTOR
- Origene Custom Protein Services for RICTOR
-
Abcam proteins for RICTOR
Assay products for research
No data available for DME Specific Peptides for RICTOR Gene
Domains & Families for RICTOR Gene
Gene Families for RICTOR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RICTOR Gene
Suggested Antigen Peptide Sequences for RICTOR Gene
- GenScript: Design optimal peptide antigens:
-
- RICTOR protein (Q8N6M7_HUMAN)
- AVO3 homolog (RICTR_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6R327- Family:
-
- Belongs to the RICTOR family.
Function for RICTOR Gene
Molecular function for RICTOR Gene
- UniProtKB/Swiss-Prot Function:
- Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Phenotypes From GWAS Catalog for RICTOR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15467718 |
| GO:0019901 | protein kinase binding | IPI | 21177249 |
| GO:0043022 | ribosome binding | IEA | -- |
| GO:0043539 | protein serine/threonine kinase activator activity | IBA | 21873635 |
Phenotypes for RICTOR Gene
- MGI mutant phenotypes for RICTOR:
-
inferred from 8 alleles
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- immune system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for RICTOR:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased OCT4 protein expression
- Decreased POU5F1-GFP protein expression
- Decreased NANOG protein expression
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased cell migration
Animal Models for RICTOR Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RICTOR - Starting at $85 >
- * RICTOR CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RICTOR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RICTOR
-
Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
miRNA for RICTOR Gene
- miRTarBase miRNAs that target RICTOR
-
- hsa-miR-218-5p (MIRT006105)
- mmu-miR-340-5p (MIRT010514)
- mmu-miR-15a-5p (MIRT011782)
- mmu-miR-34b-5p (MIRT012770)
- mmu-miR-24-3p (MIRT013890)
- mmu-miR-149-5p (MIRT014710)
- mmu-miR-9-5p (MIRT015326)
- hsa-miR-335-5p (MIRT018260)
- hsa-miR-155-5p (MIRT020841)
- hsa-miR-31-3p (MIRT038935)
- hsa-miR-18a-5p (MIRT050668)
- mmu-miR-155-5p (MIRT053264)
- hsa-miR-34a-5p (MIRT054810)
- hsa-miR-6747-5p (MIRT166223)
- hsa-miR-3124-3p (MIRT391490)
- hsa-let-7c-5p (MIRT437348)
- hsa-miR-16-5p (MIRT437349)
- hsa-miR-142-3p (MIRT439769)
- hsa-miR-4665-5p (MIRT469189)
- hsa-miR-1275 (MIRT469190)
- hsa-miR-4472 (MIRT469191)
- hsa-miR-4447 (MIRT469192)
- hsa-miR-6769b-5p (MIRT469193)
- hsa-miR-6769a-5p (MIRT469194)
- hsa-miR-92a-2-5p (MIRT469195)
- hsa-miR-654-5p (MIRT469196)
- hsa-miR-541-3p (MIRT469197)
- hsa-miR-7110-5p (MIRT469198)
- hsa-miR-6842-5p (MIRT469199)
- hsa-miR-6752-5p (MIRT469200)
- hsa-miR-5010-5p (MIRT469201)
- hsa-miR-4525 (MIRT469202)
- hsa-miR-7111-5p (MIRT469203)
- hsa-miR-6870-5p (MIRT469204)
- hsa-miR-4723-5p (MIRT469205)
- hsa-miR-5698 (MIRT469206)
- hsa-miR-6825-5p (MIRT469207)
- hsa-miR-625-5p (MIRT469208)
- hsa-miR-6883-5p (MIRT469209)
- hsa-miR-6785-5p (MIRT469210)
- hsa-miR-4728-5p (MIRT469211)
- hsa-miR-149-3p (MIRT469212)
- hsa-miR-8069 (MIRT469213)
- hsa-miR-8062 (MIRT469214)
- hsa-miR-8079 (MIRT469215)
- hsa-miR-1245a (MIRT469216)
- hsa-miR-6841-5p (MIRT469217)
- hsa-miR-6732-5p (MIRT469218)
- mmu-miR-194-5p (MIRT581314)
- mmu-miR-132-3p (MIRT581315)
- mmu-miR-212-3p (MIRT581316)
- mmu-miR-362-5p (MIRT581317)
- mmu-miR-212-5p (MIRT581318)
- mmu-miR-377-3p (MIRT589030)
- mmu-miR-362-3p (MIRT589031)
- mmu-miR-329-3p (MIRT589032)
- hsa-miR-384 (MIRT654255)
- hsa-miR-3685 (MIRT654256)
- hsa-miR-6509-5p (MIRT654257)
- hsa-miR-202-5p (MIRT654258)
- hsa-miR-337-3p (MIRT654259)
- hsa-miR-3160-5p (MIRT654260)
- hsa-miR-3927-5p (MIRT654261)
- hsa-miR-500b-5p (MIRT654262)
- hsa-miR-362-5p (MIRT654263)
- hsa-miR-128-3p (MIRT733520)
- hsa-miR-153-5p (MIRT735419)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RICTOR
- Browse OriGene Inhibitory RNA Products For RICTOR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RICTOR
Clone products for research
- Applied Biological Materials (abm): Clones for RICTOR - Starting at $45 >
- * RICTOR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RICTOR
- Addgene plasmids for RICTOR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RICTOR
Cell Lines for research
-
Horizon Cell Lines for RICTOR
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RICTOR Gene
Localization for RICTOR Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0031932 | TORC2 complex | IEA,IDA | 15268862 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RICTOR Gene
Pathways & Interactions for RICTOR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | PI3K/AKT activation |
.89
|
|
| 3 | CD28 co-stimulation | ||
| 4 | mTOR signaling pathway (KEGG) | ||
| 5 | Constitutive Signaling by AKT1 E17K in Cancer | ||
Pathways by source for RICTOR Gene
10 BioSystems pathways for RICTOR Gene
35 Reactome pathways for RICTOR Gene
1 KEGG pathway for RICTOR Gene
2 R&D Systems pathways for RICTOR Gene
1 Qiagen pathway for RICTOR Gene
- mTOR Pathway
1 Cell Signaling Technology pathway for RICTOR Gene
1 GeneTex pathway for RICTOR Gene
Interacting Proteins for RICTOR Gene
Selected Interacting proteins:
Q6R327-RICTR_HUMAN
ENSP00000296782
for RICTOR Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RICTOR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009792 | embryo development ending in birth or egg hatching | IEA,ISS | -- |
| GO:0010468 | regulation of gene expression | IEA | -- |
Drugs & Compounds for RICTOR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| OSI-027 | Investigational | Pharma | inhibitor | MTORC1/ mTORC2 inhibitor, Kinase Inhibitors | 0 | |
| GDC-0349 | Investigational | Pharma | MTOR inhibitor | 0 | ||
| AZD2014 | Pharma | Novel mTOR inhibitor | 0 | |||
| GDC-0980 (RG7422) | Pharma | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 0 | |||
| INK 128 (MLN0128) | Pharma | MTOR(TORC-1/-2) inhibitor,potent and selective | 0 |
(12) ApexBio Compounds for RICTOR Gene
| Compound | Action | Cas Number |
|---|---|---|
| AZD2014 | Novel mTOR inhibitor | 1009298-59-2 |
| GDC-0349 | MTOR inhibitor | 1207360-89-1 |
| GDC-0980 (RG7422) | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 1032754-93-0 |
| INK 128 (MLN0128) | MTOR(TORC-1/-2) inhibitor,potent and selective | 1224844-38-5 |
| KU-0063794 | MTORC1 and mTORC2 inhibitor | 938440-64-3 |
| OSI-027 | MTORC1/ mTORC2 inhibitor | 936890-98-1 |
| Ridaforolimus (Deforolimus, MK-8669) | MTOR inhibitor | 572924-54-0 |
| WAY-600 | MTOR inhibitor | 1062159-35-6 |
| WYE-125132 (WYE-132) | ATP-competitive mTOR inhibitor, highly potent | 1144068-46-1 |
| WYE-354 | MTOR inhibitor,potent,ATP-competitive and cell-permeable | 1062169-56-5 |
| WYE-687 | MTOR inhibitor,ATP-competitive and selective | 1062161-90-3 |
| XL388 | MTOR inhibitor,highly potent and selective | 1251156-08-7 |
Transcripts for RICTOR Gene
mRNA/cDNA for RICTOR Gene
- 3 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000296782 7505 nts (view in UCSC)
- ENST00000357387 9533 nts (view in UCSC)
- ENST00000503698 780 nts (view in UCSC)
- ENST00000505927 570 nts (view in UCSC)
- ENST00000509567 638 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RICTOR - Starting at $85 >
- * RICTOR CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RICTOR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RICTOR
-
Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RICTOR
- Browse OriGene Inhibitory RNA Products For RICTOR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RICTOR
Clone products for research
- Applied Biological Materials (abm): Clones for RICTOR - Starting at $45 >
- * RICTOR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RICTOR
- Addgene plasmids for RICTOR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RICTOR
Relevant External Links for RICTOR Gene
- GeneLoc Exon Structure for
- RICTOR
Expression for RICTOR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
This gene is overexpressed in Tlymphocyte (42.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RICTOR Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RICTOR
SOURCE GeneReport for Unigene cluster for RICTOR Gene:
Hs.407926Evidence on tissue expression from TISSUES for RICTOR Gene
- Nervous system(4.7)
- Liver(4.5)
- Muscle(2.8)
- Kidney(2.6)
- Heart(2.6)
- Spleen(2.5)
- Intestine(2.5)
- Blood(2.5)
- Skin(2.4)
- Lung(2.4)
- Bone marrow(2.4)
- Lymph node(2.3)
- Pancreas(2.3)
- Thyroid gland(2.1)
Primer products for research
-
OriGene qPCR primer pairs for RICTOR
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RICTOR Gene
Orthologs for RICTOR Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RICTOR 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RICTOR 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RICTOR 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rictor 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RICTOR 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rictor 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RICTOR 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RICTOR 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RICTOR 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rictor 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | RICTOR (3 of 3) 30 |
|
OneToMany | |
| rictora 30 |
|
OneToMany | |||
| rictorb 29 30 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | rictor 30 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | rict-1 30 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TSC11 30 32 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2872 30 |
|
OneToOne |
- Species where no ortholog for RICTOR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RICTOR Gene
- ENSEMBL:
- Gene Tree for RICTOR (if available)
- TreeFam:
- Gene Tree for RICTOR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RICTOR: view image
- Alliance of Genome Resources:
- Additional Orthologs for RICTOR
Paralogs for RICTOR Gene
No data available for Paralogs for RICTOR Gene
Variants for RICTOR Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RICTOR Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 929749 | Likely Pathogenic: Premature ovarian failure | 38,964,867(-) |
T/C NM_152756.5(RICTOR):c.1325A>G (p.His442Arg) |
MISSENSE | |
| rs149642899 | Benign: not provided | 38,958,763(-) |
A/G NM_152756.5(RICTOR):c.2247T>C (p.Asn749=) |
SYNONYMOUS | |
| rs1554059320 | Likely Pathogenic: Inborn genetic diseases | 38,946,520(-) |
GT/G NM_152756.5(RICTOR):c.4346del (p.Asn1449fs) |
FRAMESHIFT | |
| rs41271103 | Benign: not provided | 38,957,718(-) |
A/T NM_152756.5(RICTOR):c.2433T>A (p.Ile811=) |
SYNONYMOUS | |
| rs2043112 | -- |
p.Ser837Phe |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5636n100 | CNV | loss | 25217958 |
| dgv9730n54 | CNV | gain | 21841781 |
| esv1576101 | CNV | insertion | 17803354 |
| esv24079 | CNV | loss | 19812545 |
| esv2730111 | CNV | deletion | 23290073 |
| esv3418125 | CNV | insertion | 20981092 |
| esv3604775 | CNV | gain | 21293372 |
| esv3604776 | CNV | loss | 21293372 |
| esv3604777 | CNV | gain | 21293372 |
| nsv4802 | CNV | insertion | 18451855 |
| nsv4803 | CNV | deletion | 18451855 |
| nsv519072 | CNV | loss | 19592680 |
| nsv528773 | CNV | loss | 19592680 |
| nsv529023 | CNV | loss | 19592680 |
| nsv597860 | CNV | gain | 21841781 |
| nsv597861 | CNV | gain | 21841781 |
| nsv597862 | CNV | gain+loss | 21841781 |
| nsv597863 | CNV | gain | 21841781 |
| nsv597867 | CNV | gain | 21841781 |
| nsv597868 | CNV | loss | 21841781 |
| nsv597869 | CNV | gain | 21841781 |
| nsv597870 | CNV | loss | 21841781 |
| nsv818346 | CNV | loss | 17921354 |
| nsv820160 | CNV | loss | 19587683 |
| nsv950671 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
1.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.84;
93.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RICTOR Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RICTOR Gene
Disorders for RICTOR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| premature menopause |
|
|
| tuberous sclerosis |
|
|
| tuberous sclerosis 1 |
|
|
| subependymal glioma |
|
|
| kidney angiomyolipoma |
|
|
Search RICTOR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RICTOR
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RICTOR Gene
Publications for RICTOR Gene
- mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. (PMID: 19995915) Julien LA … Roux PP (Molecular and cellular biology 2010) 3 4 22
- Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PMID: 15718470) Sarbassov DD … Sabatini DM (Science (New York, N.Y.) 2005) 3 4 22
- Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. (PMID: 15268862) Sarbassov DD … Sabatini DM (Current biology : CB 2004) 2 3 4
- The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling. (PMID: 30232230) Csukasi F … Krakow D (Science translational medicine 2018) 3 4
- Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PMID: 23762398) Wang JQ … Wu KJ (PloS one 2013) 3 4
ExternalLinks
Products for RICTOR Gene
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- antibodies-online: Show 65 available RICTOR Antibodies ranked by validation data
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- 1 IP Antibody (anti-mouse)
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- antibodies-online: Search results for available RICTOR related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for RICTOR
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- Custom Antibody ServicesProSci Antibodies for RICTOR
- RPTOR independent companion of MTOR, complex 2 [22-021]
- RPTOR independent companion of MTOR, complex 2 [46-299]
- RPTOR independent companion of MTOR, complex 2 [70-186]
- Rapamycin-insensitive companion of mTOR [62-768]
- Rapamycin-insensitive companion of mTOR [62-769]
- Rapamycin-insensitive companion of mTOR [62-770]
- Rapamycin-insensitive companion of mTOR [62-771]
- Search for RICTOR Proteins at ProSci
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Sources for RICTOR Gene
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