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RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
RICTOR (RPTOR Independent Companion Of MTOR Complex 2) is a Protein Coding gene. Diseases associated with RICTOR include Arachnoiditis and Spinal Cord Lipoma. Among its related pathways are RET signaling and CD28 co-stimulation. Gene Ontology (GO) annotations related to this gene include binding and ribosome binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 15467718 |
GO:0008047 | enzyme activator activity | IBA | 21873635 |
GO:0019901 | protein kinase binding | IPI | 21177249 |
GO:0043022 | ribosome binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0031932 | TORC2 complex | IEA,IDA | 15268862 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | GAB1 signalosome |
.89
|
|
3 | CD28 co-stimulation | ||
4 | mTOR signaling pathway (KEGG) |
.38
|
|
5 | Constitutive Signaling by AKT1 E17K in Cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001932 | regulation of protein phosphorylation | IEA | -- |
GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0009792 | embryo development ending in birth or egg hatching | IEA,ISS | -- |
GO:0010468 | regulation of gene expression | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
OSI-027 | Investigational | Pharma | inhibitor | MTORC1/ mTORC2 inhibitor, Kinase Inhibitors | 0 | |
GDC-0349 | Investigational | Pharma | MTOR inhibitor | 0 | ||
AZD2014 | Pharma | Novel mTOR inhibitor | 0 | |||
GDC-0980 (RG7422) | Pharma | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 0 | |||
INK 128 (MLN0128) | Pharma | MTOR(TORC-1/-2) inhibitor,potent and selective | 0 |
Compound | Action | Cas Number |
---|---|---|
AZD2014 | Novel mTOR inhibitor | 1009298-59-2 |
GDC-0349 | MTOR inhibitor | 1207360-89-1 |
GDC-0980 (RG7422) | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 1032754-93-0 |
INK 128 (MLN0128) | MTOR(TORC-1/-2) inhibitor,potent and selective | 1224844-38-5 |
KU-0063794 | MTORC1 and mTORC2 inhibitor | 938440-64-3 |
OSI-027 | MTORC1/ mTORC2 inhibitor | 936890-98-1 |
Ridaforolimus (Deforolimus, MK-8669) | MTOR inhibitor | 572924-54-0 |
WAY-600 | MTOR inhibitor | 1062159-35-6 |
WYE-125132 (WYE-132) | ATP-competitive mTOR inhibitor, highly potent | 1144068-46-1 |
WYE-354 | MTOR inhibitor,potent,ATP-competitive and cell-permeable | 1062169-56-5 |
WYE-687 | MTOR inhibitor,ATP-competitive and selective | 1062161-90-3 |
XL388 | MTOR inhibitor,highly potent and selective | 1251156-08-7 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RICTOR 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RICTOR 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RICTOR 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rictor 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RICTOR 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rictor 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RICTOR 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RICTOR 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RICTOR 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rictor 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | RICTOR (3 of 3) 31 |
|
OneToMany | |
rictora 31 |
|
OneToMany | |||
rictorb 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | rictor 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | rict-1 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TSC11 31 33 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2872 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713422 | Benign: not provided | 38,958,763(-) | A/G | SYNONYMOUS_VARIANT | |
782097 | Benign: not provided | 38,957,718(-) | A/T | SYNONYMOUS_VARIANT | |
rs1554059320 | Likely Pathogenic: Inborn genetic diseases | 38,946,520(-) | GT/G | FRAMESHIFT_VARIANT | |
rs2043112 | - | p.Ser837Phe |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5636n100 | CNV | loss | 25217958 |
dgv9730n54 | CNV | gain | 21841781 |
esv1576101 | CNV | insertion | 17803354 |
esv24079 | CNV | loss | 19812545 |
esv2730111 | CNV | deletion | 23290073 |
esv3418125 | CNV | insertion | 20981092 |
esv3604775 | CNV | gain | 21293372 |
esv3604776 | CNV | loss | 21293372 |
esv3604777 | CNV | gain | 21293372 |
nsv4802 | CNV | insertion | 18451855 |
nsv4803 | CNV | deletion | 18451855 |
nsv519072 | CNV | loss | 19592680 |
nsv528773 | CNV | loss | 19592680 |
nsv529023 | CNV | loss | 19592680 |
nsv597860 | CNV | gain | 21841781 |
nsv597861 | CNV | gain | 21841781 |
nsv597862 | CNV | gain+loss | 21841781 |
nsv597863 | CNV | gain | 21841781 |
nsv597867 | CNV | gain | 21841781 |
nsv597868 | CNV | loss | 21841781 |
nsv597869 | CNV | gain | 21841781 |
nsv597870 | CNV | loss | 21841781 |
nsv818346 | CNV | loss | 17921354 |
nsv820160 | CNV | loss | 19587683 |
nsv950671 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
arachnoiditis |
|
|
spinal cord lipoma |
|
|
brain stem ependymoma |
|
|
tuberous sclerosis 1 |
|
|
tuberous sclerosis |
|
|