Aliases for RICTOR Gene
Aliases for RICTOR Gene
External Ids for RICTOR Gene
- HGNC: 28611
- Entrez Gene: 253260
- Ensembl: ENSG00000164327
- OMIM: 609022
- UniProtKB: Q6R327
Previous GeneCards Identifiers for RICTOR Gene
- GC05M038977
Summaries for RICTOR Gene
-
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
GeneCards Summary for RICTOR Gene
RICTOR (RPTOR Independent Companion Of MTOR Complex 2) is a Protein Coding gene. Diseases associated with RICTOR include Bardet-Biedl Syndrome. Among its related pathways are Gene Expression and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include binding and ribosome binding.
UniProtKB/Swiss-Prot for RICTOR Gene
-
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.
Additional gene information for RICTOR Gene
- Monarch Initiative
- Search for RICTOR at DataMed
- Search for RICTOR at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RICTOR Gene
Genomics for RICTOR Gene
GeneHancer (GH) Regulatory Elements for RICTOR Gene
Promoters and enhancers for RICTOR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around RICTOR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RICTOR gene promoter:
-
- FOXF2
- Meis-1b
- Meis-1a
- Meis-1
- AML1a
- HSF1short
- HSF1 (long)
- GATA-2
- C/EBPbeta
- Sox9
Regulatory Element Products
Genomic Locations for RICTOR Gene
Genomic Locations for RICTOR Gene
- chr5:38,937,919-39,074,419
- (GRCh38/hg38)
- Size:
- 136,501 bases
- Orientation:
- Minus strand
- chr5:38,938,021-39,074,510
- (GRCh37/hg19)
- Size:
- 136,490 bases
- Orientation:
- Minus strand
Genomic View for RICTOR Gene
Genes around RICTOR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.1 by Entrez Gene
- 5p13.1 by HGNC
- 5p13.1 by Ensembl
RICTOR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RICTOR Gene
Proteins for RICTOR Gene
-
Protein details for RICTOR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6R327-RICTR_HUMAN
- Recommended name:
- Rapamycin-insensitive companion of mTOR
- Protein Accession:
- Q6R327
- B2RNX0
- B7ZMF7
- Q68DT5
- Q86UB7
- Q8N3A0
- Q8NCM6
Protein attributes for RICTOR Gene
- Size:
- 1708 amino acids
- Molecular mass:
- 192218 Da
- Quaternary structure:
-
- Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex (PubMed:15268862, PubMed:17461779, PubMed:17599906). Interacts with CCDC28B (PubMed:23727834). Interacts with NBN (PubMed:23762398). Interacts with PRR5L (PubMed:17461779, PubMed:21964062).
- SequenceCaution:
-
- Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for RICTOR Gene
Post-translational modifications for RICTOR Gene
- Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RICTOR Gene
Antibody Products
- R&D Systems Antibodies for RICTOR (Rictor)
-
Custom Antibody ServicesOriGene Antibodies for RICTOR
- Novus Biologicals Antibodies for RICTOR
-
Abcam antibodies for RICTOR
- Invitrogen Antibodies for RICTOR
- antibodies-online: Search results for 194 available RICTOR Antibodies ranked by validation data
- Compare Top RICTOR Antibodies
-
Recommended
- 133 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 58 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 6 WB Antibodies (anti-rat)
- GeneTex RICTOR Antibody for RICTOR
-
Santa Cruz Biotechnology (SCBT) Antibodies for RICTOR
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RICTOR
- Origene Custom Protein Services for RICTOR
- Search GeneTex for Proteins for RICTOR
-
Abcam proteins for RICTOR
Assay Products
No data available for DME Specific Peptides for RICTOR Gene
Domains & Families for RICTOR Gene
Gene Families for RICTOR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RICTOR Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RICTOR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6R327- Family:
-
- Belongs to the RICTOR family.
Function for RICTOR Gene
Molecular function for RICTOR Gene
- UniProtKB/Swiss-Prot Function:
- Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.
Phenotypes From GWAS Catalog for RICTOR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005488 | binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 15467718 |
| GO:0008047 | enzyme activator activity | IBA | -- |
| GO:0019901 | protein kinase binding | IPI | 21177249 |
| GO:0043022 | ribosome binding | IEA | -- |
Phenotypes for RICTOR Gene
- MGI mutant phenotypes for RICTOR:
-
inferred from 8 alleles
- cardiovascular system phenotype
- homeostasis/metabolism phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for RICTOR:
-
- Decreased shRNA abundance (Z-score < -2)
- Decreased NANOG protein expression
- Decreased OCT4 protein expression
- Decreased POU5F1-GFP protein expression
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell migration
- Decreased cell migration
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
Animal Models for RICTOR Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RICTOR
-
CRISPR Products
-
OriGene CRISPR knockouts for RICTOR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RICTOR
- genomics-online: gRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
- Applied Biological Materials CRISPR for RICTOR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
- GenScript: Design CRISPR guide RNA sequences for RICTOR
miRNA for RICTOR Gene
- miRTarBase miRNAs that target RICTOR
-
- hsa-mir-218-5p (MIRT006105)
- hsa-mir-335-5p (MIRT018260)
- hsa-mir-155-5p (MIRT020841)
- hsa-mir-31-3p (MIRT038935)
- hsa-mir-18a-5p (MIRT050668)
- hsa-mir-34a-5p (MIRT054810)
- hsa-mir-6747-5p (MIRT166223)
- hsa-mir-3124-3p (MIRT391490)
- hsa-let-7c-5p (MIRT437348)
- hsa-mir-16-5p (MIRT437349)
- hsa-mir-142-3p (MIRT439769)
- hsa-mir-4665-5p (MIRT469189)
- hsa-mir-1275 (MIRT469190)
- hsa-mir-4472 (MIRT469191)
- hsa-mir-4447 (MIRT469192)
- hsa-mir-6769b-5p (MIRT469193)
- hsa-mir-6769a-5p (MIRT469194)
- hsa-mir-92a-2-5p (MIRT469195)
- hsa-mir-654-5p (MIRT469196)
- hsa-mir-541-3p (MIRT469197)
- hsa-mir-7110-5p (MIRT469198)
- hsa-mir-6842-5p (MIRT469199)
- hsa-mir-6752-5p (MIRT469200)
- hsa-mir-5010-5p (MIRT469201)
- hsa-mir-4525 (MIRT469202)
- hsa-mir-7111-5p (MIRT469203)
- hsa-mir-6870-5p (MIRT469204)
- hsa-mir-4723-5p (MIRT469205)
- hsa-mir-5698 (MIRT469206)
- hsa-mir-6825-5p (MIRT469207)
- hsa-mir-625-5p (MIRT469208)
- hsa-mir-6883-5p (MIRT469209)
- hsa-mir-6785-5p (MIRT469210)
- hsa-mir-4728-5p (MIRT469211)
- hsa-mir-149-3p (MIRT469212)
- hsa-mir-8069 (MIRT469213)
- hsa-mir-8062 (MIRT469214)
- hsa-mir-8079 (MIRT469215)
- hsa-mir-1245a (MIRT469216)
- hsa-mir-6841-5p (MIRT469217)
- hsa-mir-6732-5p (MIRT469218)
- hsa-mir-384 (MIRT654255)
- hsa-mir-3685 (MIRT654256)
- hsa-mir-6509-5p (MIRT654257)
- hsa-mir-202-5p (MIRT654258)
- hsa-mir-337-3p (MIRT654259)
- hsa-mir-3160-5p (MIRT654260)
- hsa-mir-3927-5p (MIRT654261)
- hsa-mir-500b-5p (MIRT654262)
- hsa-mir-362-5p (MIRT654263)
- hsa-mir-128-3p (MIRT733520)
- hsa-mir-153-5p (MIRT735419)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RICTOR
- Browse OriGene Inhibitory RNA Products For RICTOR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RICTOR
- genomics-online: shRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RICTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RICTOR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RICTOR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RICTOR
- Applied Biological Materials Clones for RICTOR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RICTOR
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RICTOR Gene
Localization for RICTOR Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0031932 | TORC2 complex | IDA,IEA | 15268862 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RICTOR Gene
Pathways & Interactions for RICTOR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | PI3K/AKT activation |
.89
|
|
| 3 | CD28 co-stimulation | ||
| 4 | mTOR signaling pathway (KEGG) | ||
| 5 | Constitutive Signaling by AKT1 E17K in Cancer | ||
Pathways by source for RICTOR Gene
1 GeneTex pathway for RICTOR Gene
10 BioSystems pathways for RICTOR Gene
35 Reactome pathways for RICTOR Gene
1 KEGG pathway for RICTOR Gene
2 R&D Systems pathways for RICTOR Gene
1 Qiagen pathway for RICTOR Gene
1 Cell Signaling Technology pathway for RICTOR Gene
Interacting Proteins for RICTOR Gene
Selected Interacting proteins:
Q6R327-RICTR_HUMAN
ENSP00000349959
for RICTOR Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RICTOR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009792 | embryo development ending in birth or egg hatching | ISS,IEA | -- |
| GO:0010468 | regulation of gene expression | IEA | -- |
| GO:0018105 | peptidyl-serine phosphorylation | IGI | 21177249 |
Drugs & Compounds for RICTOR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| OSI-027 | Investigational | Pharma | inhibitor | MTORC1/ mTORC2 inhibitor, Kinase Inhibitors | 0 | |
| GDC-0349 | Investigational | Pharma | MTOR inhibitor | 0 | ||
| AZD2014 | Pharma | Novel mTOR inhibitor | 0 | |||
| GDC-0980 (RG7422) | Pharma | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 0 | |||
| INK 128 (MLN0128) | Pharma | MTOR(TORC-1/-2) inhibitor,potent and selective | 0 |
Drug Products
Transcripts for RICTOR Gene
mRNA/cDNA for RICTOR Gene
- (11) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000357387 9543 bps (uc003jlp.4)
- ENST00000511516 7312 bps (uc063ddm.1)
- ENST00000296782 7505 bps (uc003jlo.4)
- ENST00000505927 570 bps (uc063ddn.1)
- ENST00000503698 780 bps (uc063ddo.1)
Unigene Clusters for RICTOR Gene
- RPTOR independent companion of MTOR, complex 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RICTOR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RICTOR
- genomics-online: gRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
- Applied Biological Materials CRISPR for RICTOR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
- GenScript: Design CRISPR guide RNA sequences for RICTOR
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RICTOR
- Browse OriGene Inhibitory RNA Products For RICTOR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RICTOR
- genomics-online: shRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RICTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RICTOR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RICTOR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RICTOR
- Applied Biological Materials Clones for RICTOR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RICTOR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
This gene is overexpressed in Tlymphocyte (42.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RICTOR Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RICTOR Gene:
RICTORSOURCE GeneReport for Unigene cluster for RICTOR Gene:
Hs.407926Evidence on tissue expression from TISSUES for RICTOR Gene
- Nervous system(4.6)
- Liver(4.3)
- Muscle(2.4)
- Heart(2.1)
- Kidney(2.1)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for RICTOR
- genomics-online: primer clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RICTOR Gene
Orthologs for RICTOR Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RICTOR 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RICTOR 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RICTOR 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Rictor 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RICTOR 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rictor 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RICTOR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RICTOR 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RICTOR 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rictor 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | RICTOR (3 of 3) 34 |
|
OneToMany | |
| rictora 34 |
|
OneToMany | |||
| rictorb 34 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | rictor 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | rict-1 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TSC11 36 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2872 34 |
|
OneToOne |
- Species where no ortholog for RICTOR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RICTOR Gene
- ENSEMBL:
- Gene Tree for RICTOR (if available)
- TreeFam:
- Gene Tree for RICTOR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RICTOR: view image
Paralogs for RICTOR Gene
No data available for Paralogs for RICTOR Gene
Variants for RICTOR Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034056 | -- | 38,955,318(-) | A/G | intron_variant | |
| rs1000086489 | -- | 39,000,942(-) | A/T | intron_variant | |
| rs1000097359 | -- | 39,007,619(-) | C/A | intron_variant | |
| rs1000140204 | -- | 39,053,123(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000169585 | -- | 39,040,373(-) | C/G/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5636n100 | CNV | loss | 25217958 |
| dgv9730n54 | CNV | gain | 21841781 |
| esv1576101 | CNV | insertion | 17803354 |
| esv24079 | CNV | loss | 19812545 |
| esv2730111 | CNV | deletion | 23290073 |
| esv3418125 | CNV | insertion | 20981092 |
| esv3604775 | CNV | gain | 21293372 |
| esv3604776 | CNV | loss | 21293372 |
| esv3604777 | CNV | gain | 21293372 |
| nsv4802 | CNV | insertion | 18451855 |
| nsv4803 | CNV | deletion | 18451855 |
| nsv519072 | CNV | loss | 19592680 |
| nsv528773 | CNV | loss | 19592680 |
| nsv529023 | CNV | loss | 19592680 |
| nsv597860 | CNV | gain | 21841781 |
| nsv597861 | CNV | gain | 21841781 |
| nsv597862 | CNV | gain+loss | 21841781 |
| nsv597863 | CNV | gain | 21841781 |
| nsv597867 | CNV | gain | 21841781 |
| nsv597868 | CNV | loss | 21841781 |
| nsv597869 | CNV | gain | 21841781 |
| nsv597870 | CNV | loss | 21841781 |
| nsv818346 | CNV | loss | 17921354 |
| nsv820160 | CNV | loss | 19587683 |
| nsv950671 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
1.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.84;
93.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RICTOR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RICTOR Gene
Disorders for RICTOR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bardet-biedl syndrome |
|
|
Search RICTOR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RICTOR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RICTOR Gene
Publications for RICTOR Gene
- mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. (PMID: 19995915) Julien LA … Roux PP (Molecular and cellular biology 2010) 3 4 22 58
- Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PMID: 15718470) Sarbassov DD … Sabatini DM (Science (New York, N.Y.) 2005) 3 4 22 58
- Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PMID: 23762398) Wang JQ … Wu KJ (PloS one 2013) 3 4 58
- Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. (PMID: 21964062) Holmes B … Gera J (Cellular signalling 2012) 3 4 58
- MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
Products for RICTOR Gene
- R&D Systems Antibodies for RICTOR (Rictor)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for RICTOR
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RICTOR
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for RICTOR
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- Browse OriGene miRNA Products For RICTOR
- GenScript: Next-day shipping of latest version cDNA ORF clones for RICTOR in any vector
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- GenScript: Design CRISPR guide RNA sequences for RICTOR
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- Browse Sino Biological cDNA Clones
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for RICTOR
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- VectorBuilder custom plasmid, inducible vectors for RICTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RICTOR
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RICTOR
- antibodies-online: Search results for 194 available RICTOR Antibodies ranked by validation data
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- Recommended
- 133 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 58 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 6 WB Antibodies (anti-rat)
- antibodies-online: Search results for 5 available RICTOR Elisa Kits ranked by validation data
- Compare Top RICTOR Elisa Kits
- Recommended
- antibodies-online: Search results for available RICTOR related products ranked by validation data
- GeneTex RICTOR Antibody for RICTOR
- Search GeneTex for Proteins for RICTOR
- Santa Cruz Biotechnology (SCBT) Antibodies for RICTOR
- Search Santa Cruz Biotechnology (SCBT) for RICTOR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
- Horizon Cell Lines for RICTOR
- genomics-online: cdna clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
- orf clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
- genomics-online: gRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
- genomics-online: primer clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
- genomics-online: shRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RICTOR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RICTOR
- GeneCopoeia miRNA 3'UTR Target clone products for RICTOR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RICTOR
Sources for RICTOR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt