Aliases for RICTOR Gene
External Ids for RICTOR Gene
Previous GeneCards Identifiers for RICTOR Gene
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
GeneCards Summary for RICTOR Gene
RICTOR (RPTOR Independent Companion Of MTOR Complex 2) is a Protein Coding gene. Diseases associated with RICTOR include Bardet-Biedl Syndrome. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and RET signaling. Gene Ontology (GO) annotations related to this gene include binding and ribosome binding.
UniProtKB/Swiss-Prot for RICTOR Gene
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.