RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008] See more...

Aliases for RICTOR Gene

Aliases for RICTOR Gene

  • RPTOR Independent Companion Of MTOR Complex 2 2 3 5
  • Rapamycin-Insensitive Companion Of MTOR 2 3 4
  • AVO3 Homolog 3 4
  • Pianissimo 2 3
  • KIAA1999 2 4
  • HAVO3 3 4
  • AVO3 2 3
  • PIA 2 3
  • RPTOR Independent Companion Of MTOR, Complex 2 2
  • TORC2-Specific Protein AVO3 3
  • MGC39830 2
  • RICTOR 5

External Ids for RICTOR Gene

Previous GeneCards Identifiers for RICTOR Gene

  • GC05M038977

Summaries for RICTOR Gene

Entrez Gene Summary for RICTOR Gene

  • RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

CIViC Summary for RICTOR Gene

GeneCards Summary for RICTOR Gene

RICTOR (RPTOR Independent Companion Of MTOR Complex 2) is a Protein Coding gene. Diseases associated with RICTOR include Arachnoiditis and Spinal Cord Lipoma. Among its related pathways are RET signaling and CD28 co-stimulation. Gene Ontology (GO) annotations related to this gene include binding and ribosome binding.

UniProtKB/Swiss-Prot Summary for RICTOR Gene

  • Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

Gene Wiki entry for RICTOR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RICTOR Gene

Genomics for RICTOR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RICTOR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J039072 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 639.7 -0.4 -351 6.3 BRCA1 HNRNPL GATAD2A CTCF PRDM10 ZNF629 TFE3 LEF1 IKZF1 ZNF692 RICTOR lnc-OSMR-2 FYB1 OSMR RF00017-4589
GH05J039207 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.1 -139.5 -139472 13.1 CTCF ZNF512 JUND ZNF143 ZIC2 PKNOX1 REST RAD21 ZNF24 TRIM22 FYB1 RICTOR OSMR HSALNG0041310 FJ601672-001
GH05J038258 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 15.8 +815.5 815521 2.2 PRDM10 ZNF692 PRDM1 ZIC2 PATZ1 CTCF ZNF501 EZH2 ZNF600 ZNF341 EGFLAM lnc-LIFR-9 WDR70 RICTOR EGFLAM-AS4 LIFR
GH05J039185 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.8 -121.1 -121094 20.7 GATAD2A ZNF512 LEF1 IKZF1 ETV6 JUND DDX20 MTA2 PKNOX1 RXRB FYB1 FJ601672-001 RICTOR C9 DAB2 HSALNG0041309 HSALNG0041310
GH05J038806 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.9 +266.1 266128 5.4 CTCF PRDM10 ZNF629 LEF1 IKZF1 ETV6 JUND DDX20 PKNOX1 PATZ1 RICTOR ENSG00000248234 EGFLAM-AS1 EGFLAM-AS2 EGFLAM LINC02110 LOC105374733 LOC112267930 LOC107986414 LINC01265
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RICTOR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RICTOR

Top Transcription factor binding sites by QIAGEN in the RICTOR gene promoter:
  • AML1a
  • C/EBPbeta
  • FOXF2
  • GATA-2
  • HSF1 (long)
  • HSF1short
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Sox9

Genomic Locations for RICTOR Gene

Genomic Locations for RICTOR Gene
chr5:38,937,920-39,074,421
(GRCh38/hg38)
Size:
136,502 bases
Orientation:
Minus strand
chr5:38,938,021-39,074,510
(GRCh37/hg19)
Size:
136,490 bases
Orientation:
Minus strand

Genomic View for RICTOR Gene

Genes around RICTOR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RICTOR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RICTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RICTOR Gene

Proteins for RICTOR Gene

  • Protein details for RICTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6R327-RICTR_HUMAN
    Recommended name:
    Rapamycin-insensitive companion of mTOR
    Protein Accession:
    Q6R327
    Secondary Accessions:
    • B2RNX0
    • B7ZMF7
    • Q68DT5
    • Q86UB7
    • Q8N3A0
    • Q8NCM6

    Protein attributes for RICTOR Gene

    Size:
    1708 amino acids
    Molecular mass:
    192218 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex (PubMed:15268862, PubMed:17461779, PubMed:17599906). Interacts with CCDC28B (PubMed:23727834). Interacts with NBN (PubMed:23762398). Interacts with PRR5L (PubMed:17461779, PubMed:21964062). Interacts with SIK3 (PubMed:30232230).
    • (Microbial infection) Interacts with vaccinia virus protein F17; this interaction dysregulates mTOR.
    SequenceCaution:
    • Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for RICTOR Gene

    Alternative splice isoforms for RICTOR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RICTOR Gene

Post-translational modifications for RICTOR Gene

  • Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
  • Ubiquitination at Lys1391
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for RICTOR

No data available for DME Specific Peptides for RICTOR Gene

Domains & Families for RICTOR Gene

Gene Families for RICTOR Gene

Protein Domains for RICTOR Gene

Suggested Antigen Peptide Sequences for RICTOR Gene

GenScript: Design optimal peptide antigens:
  • RICTOR protein (Q8N6M7_HUMAN)
  • AVO3 homolog (RICTR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6R327

UniProtKB/Swiss-Prot:

RICTR_HUMAN :
  • Belongs to the RICTOR family.
Family:
  • Belongs to the RICTOR family.
genes like me logo Genes that share domains with RICTOR: view

Function for RICTOR Gene

Molecular function for RICTOR Gene

UniProtKB/Swiss-Prot Function:
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

Phenotypes From GWAS Catalog for RICTOR Gene

Gene Ontology (GO) - Molecular Function for RICTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15467718
GO:0008047 enzyme activator activity IBA 21873635
GO:0019901 protein kinase binding IPI 21177249
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with RICTOR: view
genes like me logo Genes that share phenotypes with RICTOR: view

Animal Models for RICTOR Gene

MGI Knock Outs for RICTOR:

Animal Model Products

CRISPR Products

miRNA for RICTOR Gene

miRTarBase miRNAs that target RICTOR

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RICTOR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RICTOR Gene

Localization for RICTOR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RICTOR gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
cytoskeleton 3
mitochondrion 3
extracellular 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RICTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031932 TORC2 complex IEA,IDA 15268862
genes like me logo Genes that share ontologies with RICTOR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RICTOR Gene

Pathways & Interactions for RICTOR Gene

genes like me logo Genes that share pathways with RICTOR: view

Pathways by source for RICTOR Gene

1 Qiagen pathway for RICTOR Gene
  • mTOR Pathway
1 Cell Signaling Technology pathway for RICTOR Gene
1 GeneTex pathway for RICTOR Gene

SIGNOR curated interactions for RICTOR Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RICTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0007275 multicellular organism development IEA --
GO:0009792 embryo development ending in birth or egg hatching IEA,ISS --
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with RICTOR: view

Drugs & Compounds for RICTOR Gene

(18) Drugs for RICTOR Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
OSI-027 Investigational Pharma inhibitor MTORC1/ mTORC2 inhibitor, Kinase Inhibitors 0
GDC-0349 Investigational Pharma MTOR inhibitor 0
AZD2014 Pharma Novel mTOR inhibitor 0
GDC-0980 (RG7422) Pharma Class I PI3K inhibitor for PI3Kα/β/δ/γ 0
INK 128 (MLN0128) Pharma MTOR(TORC-1/-2) inhibitor,potent and selective 0

(12) ApexBio Compounds for RICTOR Gene

Compound Action Cas Number
AZD2014 Novel mTOR inhibitor 1009298-59-2
GDC-0349 MTOR inhibitor 1207360-89-1
GDC-0980 (RG7422) Class I PI3K inhibitor for PI3Kα/β/δ/γ 1032754-93-0
INK 128 (MLN0128) MTOR(TORC-1/-2) inhibitor,potent and selective 1224844-38-5
KU-0063794 MTORC1 and mTORC2 inhibitor 938440-64-3
OSI-027 MTORC1/ mTORC2 inhibitor 936890-98-1
Ridaforolimus (Deforolimus, MK-8669) MTOR inhibitor 572924-54-0
WAY-600 MTOR inhibitor 1062159-35-6
WYE-125132 (WYE-132) ATP-competitive mTOR inhibitor, highly potent 1144068-46-1
WYE-354 MTOR inhibitor,potent,ATP-competitive and cell-permeable 1062169-56-5
WYE-687 MTOR inhibitor,ATP-competitive and selective 1062161-90-3
XL388 MTOR inhibitor,highly potent and selective 1251156-08-7
genes like me logo Genes that share compounds with RICTOR: view

Drug Products

Transcripts for RICTOR Gene

mRNA/cDNA for RICTOR Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RICTOR

Alternative Splicing Database (ASD) splice patterns (SP) for RICTOR Gene

No ASD Table

Relevant External Links for RICTOR Gene

GeneLoc Exon Structure for
RICTOR

Expression for RICTOR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RICTOR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RICTOR Gene

This gene is overexpressed in Tlymphocyte (42.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RICTOR Gene



Protein tissue co-expression partners for RICTOR Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RICTOR

SOURCE GeneReport for Unigene cluster for RICTOR Gene:

Hs.407926

Evidence on tissue expression from TISSUES for RICTOR Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Muscle(3)
  • Skin(2.9)
  • Heart(2.9)
  • Kidney(2.9)
  • Blood(2.8)
  • Intestine(2.7)
  • Spleen(2.7)
  • Eye(2.6)
  • Lung(2.6)
  • Bone marrow(2.5)
  • Lymph node(2.5)
  • Bone(2.5)
  • Pancreas(2.4)
  • Thyroid gland(2.2)
  • Stomach(2.1)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with RICTOR: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RICTOR Gene

Orthologs for RICTOR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RICTOR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RICTOR 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RICTOR 30 31
  • 94.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RICTOR 30 31
  • 94.16 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rictor 30
  • 89.08 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RICTOR 31
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Rictor 30 17 31
  • 88.46 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RICTOR 31
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RICTOR 30 31
  • 80.38 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RICTOR 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rictor 30
  • 74.93 (n)
Zebrafish
(Danio rerio)
Actinopterygii RICTOR (3 of 3) 31
  • 81 (a)
OneToMany
rictora 31
  • 73 (a)
OneToMany
rictorb 30 31
  • 68.63 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta rictor 31
  • 21 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea rict-1 31
  • 17 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSC11 31 33
  • 18 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2872 31
  • 39 (a)
OneToOne
Species where no ortholog for RICTOR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RICTOR Gene

ENSEMBL:
Gene Tree for RICTOR (if available)
TreeFam:
Gene Tree for RICTOR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RICTOR: view image

Paralogs for RICTOR Gene

No data available for Paralogs for RICTOR Gene

Variants for RICTOR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RICTOR Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
713422 Benign: not provided 38,958,763(-) A/G SYNONYMOUS_VARIANT
782097 Benign: not provided 38,957,718(-) A/T SYNONYMOUS_VARIANT
rs1554059320 Likely Pathogenic: Inborn genetic diseases 38,946,520(-) GT/G FRAMESHIFT_VARIANT
rs2043112 - p.Ser837Phe

Additional dbSNP identifiers (rs#s) for RICTOR Gene

Structural Variations from Database of Genomic Variants (DGV) for RICTOR Gene

Variant ID Type Subtype PubMed ID
dgv5636n100 CNV loss 25217958
dgv9730n54 CNV gain 21841781
esv1576101 CNV insertion 17803354
esv24079 CNV loss 19812545
esv2730111 CNV deletion 23290073
esv3418125 CNV insertion 20981092
esv3604775 CNV gain 21293372
esv3604776 CNV loss 21293372
esv3604777 CNV gain 21293372
nsv4802 CNV insertion 18451855
nsv4803 CNV deletion 18451855
nsv519072 CNV loss 19592680
nsv528773 CNV loss 19592680
nsv529023 CNV loss 19592680
nsv597860 CNV gain 21841781
nsv597861 CNV gain 21841781
nsv597862 CNV gain+loss 21841781
nsv597863 CNV gain 21841781
nsv597867 CNV gain 21841781
nsv597868 CNV loss 21841781
nsv597869 CNV gain 21841781
nsv597870 CNV loss 21841781
nsv818346 CNV loss 17921354
nsv820160 CNV loss 19587683
nsv950671 CNV duplication 24416366

Variation tolerance for RICTOR Gene

Residual Variation Intolerance Score: 1.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.84; 93.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RICTOR Gene

Human Gene Mutation Database (HGMD)
RICTOR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RICTOR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RICTOR Gene

Disorders for RICTOR Gene

MalaCards: The human disease database

(21) MalaCards diseases for RICTOR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
arachnoiditis
  • spinal arachnoiditis
spinal cord lipoma
  • lipoma of spinal cord
brain stem ependymoma
  • ependymoma of the brainstem
tuberous sclerosis 1
  • ts
tuberous sclerosis
  • tuberous sclerosis 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RICTOR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RICTOR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RICTOR Gene

Publications for RICTOR Gene

  1. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. (PMID: 19995915) Julien LA … Roux PP (Molecular and cellular biology 2010) 3 4 23
  2. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PMID: 15718470) Sarbassov DD … Sabatini DM (Science (New York, N.Y.) 2005) 3 4 23
  3. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. (PMID: 15268862) Sarbassov DD … Sabatini DM (Current biology : CB 2004) 2 3 4
  4. The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling. (PMID: 30232230) Csukasi F … Krakow D (Science translational medicine 2018) 3 4
  5. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PMID: 23762398) Wang JQ … Wu KJ (PloS one 2013) 3 4

Products for RICTOR Gene

  • Signalway Proteins for RICTOR

Sources for RICTOR Gene