Aliases for RIC8B Gene

Aliases for RIC8B Gene

  • RIC8 Guanine Nucleotide Exchange Factor B 2 3 5
  • Brain Synembryn 3 4
  • Synembryn-B 3 4
  • HSyn 3 4
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog B (C. Elegans) 2
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog B 3
  • Brain Synembrin 3
  • Protein Ric-8B 4
  • RIC8 3

External Ids for RIC8B Gene

Previous GeneCards Identifiers for RIC8B Gene

  • GC12P105671
  • GC12P107168
  • GC12P104228

Summaries for RIC8B Gene

GeneCards Summary for RIC8B Gene

RIC8B (RIC8 Guanine Nucleotide Exchange Factor B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8A.

UniProtKB/Swiss-Prot Summary for RIC8B Gene

  • Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

Additional gene information for RIC8B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RIC8B Gene

Genomics for RIC8B Gene

GeneHancer (GH) Regulatory Elements for RIC8B Gene

Promoters and enhancers for RIC8B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIC8B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RIC8B

Top Transcription factor binding sites by QIAGEN in the RIC8B gene promoter:
  • C/EBPalpha
  • HNF-3beta
  • HSF1 (long)
  • Lmo2
  • MAZR
  • NF-1
  • NF-1/L
  • Pbx1a
  • POU2F1
  • POU2F1a

Genomic Locations for RIC8B Gene

Genomic Locations for RIC8B Gene
chr12:106,774,285-106,889,316
(GRCh38/hg38)
Size:
115,032 bases
Orientation:
Plus strand
chr12:107,168,373-107,283,094
(GRCh37/hg19)
Size:
114,722 bases
Orientation:
Plus strand

Genomic View for RIC8B Gene

Genes around RIC8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIC8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIC8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC8B Gene

Proteins for RIC8B Gene

  • Protein details for RIC8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVN3-RIC8B_HUMAN
    Recommended name:
    Synembryn-B
    Protein Accession:
    Q9NVN3
    Secondary Accessions:
    • A2RTZ0
    • Q4G103
    • Q6ZRN4
    • Q86WD3

    Protein attributes for RIC8B Gene

    Size:
    520 amino acids
    Molecular mass:
    58825 Da
    Quaternary structure:
    • Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
    Miscellaneous:
    • [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=AAO65923.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC8B Gene

Post-translational modifications for RIC8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIC8B Gene

Domains & Families for RIC8B Gene

Gene Families for RIC8B Gene

Protein Domains for RIC8B Gene

Suggested Antigen Peptide Sequences for RIC8B Gene

GenScript: Design optimal peptide antigens:
  • Protein Ric-8B (RIC8B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NVN3

UniProtKB/Swiss-Prot:

RIC8B_HUMAN :
  • Belongs to the synembryn family.
Family:
  • Belongs to the synembryn family.
genes like me logo Genes that share domains with RIC8B: view

Function for RIC8B Gene

Molecular function for RIC8B Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

Phenotypes From GWAS Catalog for RIC8B Gene

Gene Ontology (GO) - Molecular Function for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IDA 12652642
GO:0005085 guanyl-nucleotide exchange factor activity IBA 21873635
GO:0005096 GTPase activator activity IBA 21873635
genes like me logo Genes that share ontologies with RIC8B: view
genes like me logo Genes that share phenotypes with RIC8B: view

Animal Models for RIC8B Gene

MGI Knock Outs for RIC8B:
  • Ric8b Ric8b<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIC8B Gene

Localization for RIC8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC8B Gene

Cytoplasm, cell cortex. Note=Localizes to the cell cortex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIC8B gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 3
nucleus 3
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA 12652642
GO:0005886 plasma membrane IDA 12652642
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with RIC8B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RIC8B Gene

Pathways & Interactions for RIC8B Gene

PathCards logo

SuperPathways for RIC8B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0008277 regulation of G protein-coupled receptor signaling pathway IDA 12652642
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RIC8B: view

No data available for Pathways by source and SIGNOR curated interactions for RIC8B Gene

Drugs & Compounds for RIC8B Gene

(4) Drugs for RIC8B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIC8B: view

Transcripts for RIC8B Gene

mRNA/cDNA for RIC8B Gene

10 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIC8B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - -
SP5: - - - - - - -
SP6: -
SP7:
SP8: - - - - - - - - - - - - - - - - - - - -
SP9: - - -

ExUns: 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RIC8B Gene

GeneLoc Exon Structure for
RIC8B

Expression for RIC8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RIC8B Gene

Protein differential expression in normal tissues from HIPED for RIC8B Gene

This gene is overexpressed in Cerebrospinal fluid (57.4) and Bone (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RIC8B Gene



Protein tissue co-expression partners for RIC8B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RIC8B

SOURCE GeneReport for Unigene cluster for RIC8B Gene:

Hs.131306

Evidence on tissue expression from TISSUES for RIC8B Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with RIC8B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIC8B Gene

Orthologs for RIC8B Gene

This gene was present in the common ancestor of animals.

Orthologs for RIC8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIC8B 31 30
  • 99.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RIC8B 31 30
  • 96.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RIC8B 31 30
  • 96.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ric8b 17 31 30
  • 94.23 (n)
rat
(Rattus norvegicus)
Mammalia Ric8b 30
  • 92.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RIC8B 31
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RIC8B 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIC8B 31 30
  • 74.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIC8B 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ric8b 30
  • 68.63 (n)
zebrafish
(Danio rerio)
Actinopterygii ric8b 31 30
  • 57.01 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ric8a 31
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ric-8 31
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2446 31
  • 28 (a)
OneToMany
Species where no ortholog for RIC8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIC8B Gene

ENSEMBL:
Gene Tree for RIC8B (if available)
TreeFam:
Gene Tree for RIC8B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RIC8B: view image

Paralogs for RIC8B Gene

Paralogs for RIC8B Gene

(1) SIMAP similar genes for RIC8B Gene using alignment to 7 proteins:

  • RIC8B_HUMAN
  • B7WPL0_HUMAN
  • F8VR30_HUMAN
  • F8VSN5_HUMAN
  • F8VY51_HUMAN
  • H0YHS3_HUMAN
  • J3QRA4_HUMAN
genes like me logo Genes that share paralogs with RIC8B: view

Variants for RIC8B Gene

Additional dbSNP identifiers (rs#s) for RIC8B Gene

Structural Variations from Database of Genomic Variants (DGV) for RIC8B Gene

Variant ID Type Subtype PubMed ID
nsv560090 CNV gain 21841781
nsv9005 CNV gain 18304495

Variation tolerance for RIC8B Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIC8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIC8B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RIC8B Gene

Disorders for RIC8B Gene

Additional Disease Information for RIC8B

No disorders were found for RIC8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC8B Gene

Publications for RIC8B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. (PMID: 12652642) Klattenhoff C … Olate J (Journal of cellular physiology 2003) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54

Products for RIC8B Gene

Sources for RIC8B Gene