Aliases for RIC8A Gene

Aliases for RIC8A Gene

  • RIC8 Guanine Nucleotide Exchange Factor A 2 3 5
  • Synembryn-A 2 3 4
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog A (C. Elegans) 2
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog A 3
  • Protein Ric-8A 4
  • Synembryn 2
  • RIC8A 5
  • RIC8 3

External Ids for RIC8A Gene

Previous GeneCards Identifiers for RIC8A Gene

  • GC11P000200
  • GC11P000028

Summaries for RIC8A Gene

GeneCards Summary for RIC8A Gene

RIC8A (RIC8 Guanine Nucleotide Exchange Factor A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8B.

UniProtKB/Swiss-Prot Summary for RIC8A Gene

  • Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Gene Wiki entry for RIC8A Gene

Additional gene information for RIC8A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RIC8A Gene

Genomics for RIC8A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RIC8A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIC8A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RIC8A

Top Transcription factor binding sites by QIAGEN in the RIC8A gene promoter:
  • AREB6
  • E47
  • MRF-2
  • NF-1
  • NF-1/L
  • Nkx2-5
  • Pax-4a
  • RFX1
  • Roaz
  • Tal-1beta

Genomic Locations for RIC8A Gene

Genomic Locations for RIC8A Gene
chr11:207,511-215,175
(GRCh38/hg38)
Size:
7,665 bases
Orientation:
Plus strand
chr11:207,511-215,113
(GRCh37/hg19)
Size:
7,603 bases
Orientation:
Plus strand

Genomic View for RIC8A Gene

Genes around RIC8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIC8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIC8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC8A Gene

Proteins for RIC8A Gene

  • Protein details for RIC8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPQ8-RIC8A_HUMAN
    Recommended name:
    Synembryn-A
    Protein Accession:
    Q9NPQ8
    Secondary Accessions:
    • Q0P508
    • Q2T9J1
    • Q7Z352
    • Q96EZ1
    • Q96SZ2
    • Q9H064
    • Q9H5H3
    • Q9H9E7

    Protein attributes for RIC8A Gene

    Size:
    531 amino acids
    Molecular mass:
    59710 Da
    Quaternary structure:
    • Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).
    SequenceCaution:
    • Sequence=BAB14282.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14282.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB15653.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB55126.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC8A Gene

Post-translational modifications for RIC8A Gene

  • Ubiquitination at Lys353 and Lys409
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RIC8A Gene

Domains & Families for RIC8A Gene

Gene Families for RIC8A Gene

Protein Domains for RIC8A Gene

Suggested Antigen Peptide Sequences for RIC8A Gene

GenScript: Design optimal peptide antigens:
  • Protein Ric-8A (RIC8A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPQ8

UniProtKB/Swiss-Prot:

RIC8A_HUMAN :
  • Belongs to the synembryn family.
Family:
  • Belongs to the synembryn family.
genes like me logo Genes that share domains with RIC8A: view

Function for RIC8A Gene

Molecular function for RIC8A Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Phenotypes From GWAS Catalog for RIC8A Gene

Gene Ontology (GO) - Molecular Function for RIC8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IBA 21873635
GO:0005085 guanyl-nucleotide exchange factor activity IBA 21873635
GO:0005096 GTPase activator activity IBA 21873635
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RIC8A: view
genes like me logo Genes that share phenotypes with RIC8A: view

Animal Models for RIC8A Gene

MGI Knock Outs for RIC8A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIC8A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIC8A Gene

Localization for RIC8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC8A Gene

Cytoplasm. Cell membrane. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIC8A gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RIC8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,ISS --
GO:0005886 plasma membrane IBA,ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RIC8A: view

Pathways & Interactions for RIC8A Gene

PathCards logo

SuperPathways for RIC8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIC8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001944 vasculature development IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA --
GO:0007369 gastrulation IEA --
genes like me logo Genes that share ontologies with RIC8A: view

No data available for Pathways by source and SIGNOR curated interactions for RIC8A Gene

Drugs & Compounds for RIC8A Gene

(3) Drugs for RIC8A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIC8A: view

Transcripts for RIC8A Gene

mRNA/cDNA for RIC8A Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIC8A

Alternative Splicing Database (ASD) splice patterns (SP) for RIC8A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - - - - - - - -
SP6:
SP7: - -
SP8: - - -
SP9: - - - - -
SP10: - - - -
SP11: - -
SP12:

ExUns: 12d · 12e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RIC8A Gene

GeneLoc Exon Structure for
RIC8A

Expression for RIC8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RIC8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RIC8A Gene

This gene is overexpressed in Bone (43.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RIC8A Gene



Protein tissue co-expression partners for RIC8A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RIC8A

SOURCE GeneReport for Unigene cluster for RIC8A Gene:

Hs.592292

Evidence on tissue expression from TISSUES for RIC8A Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(4.1)
  • Kidney(3.4)
  • Lung(3.2)
  • Intestine(2.8)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RIC8A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIC8A Gene

Orthologs for RIC8A Gene

This gene was present in the common ancestor of animals.

Orthologs for RIC8A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RIC8A 30 31
  • 99.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RIC8A 30 31
  • 87.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RIC8A 30 31
  • 87.65 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ric8 30 31
  • 85.47 (n)
OneToOne
Ric8a 17
Rat
(Rattus norvegicus)
Mammalia Ric8a 30
  • 85.09 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RIC8A 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RIC8A 30 31
  • 70.98 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RIC8A 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ric8a 30
  • 62.94 (n)
MGC76200 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.22237 30
Zebrafish
(Danio rerio)
Actinopterygii ric8a 30 31
  • 61.64 (n)
OneToOne
Dr.11062 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010793 30
  • 50.91 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta ric8a 30 31
  • 49.35 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ric-8 31
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2446 31
  • 30 (a)
OneToMany
Species where no ortholog for RIC8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RIC8A Gene

ENSEMBL:
Gene Tree for RIC8A (if available)
TreeFam:
Gene Tree for RIC8A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RIC8A: view image

Paralogs for RIC8A Gene

Paralogs for RIC8A Gene

(1) SIMAP similar genes for RIC8A Gene using alignment to 8 proteins:

  • RIC8A_HUMAN
  • E9PI04_HUMAN
  • E9PLE5_HUMAN
  • E9PMP0_HUMAN
  • E9PSI0_HUMAN
  • H0YC88_HUMAN
  • H0YE35_HUMAN
  • H0YEN0_HUMAN
genes like me logo Genes that share paralogs with RIC8A: view

Variants for RIC8A Gene

Additional dbSNP identifiers (rs#s) for RIC8A Gene

Structural Variations from Database of Genomic Variants (DGV) for RIC8A Gene

Variant ID Type Subtype PubMed ID
dgv1010n100 CNV gain 25217958
dgv1011n100 CNV gain 25217958
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
esv22231 CNV gain 19812545
esv3625060 CNV gain 21293372
esv3625061 CNV gain 21293372
nsv1052484 CNV gain 25217958
nsv467630 CNV gain 19166990
nsv467631 CNV gain 19166990
nsv522596 CNV gain 19592680
nsv552762 CNV gain 21841781
nsv552765 CNV gain 21841781

Variation tolerance for RIC8A Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.55; 95.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIC8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIC8A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RIC8A Gene

Disorders for RIC8A Gene

No disorders were found for RIC8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC8A Gene

Publications for RIC8A Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells. (PMID: 16629901) Nishimura A … Itoh H (Genes to cells : devoted to molecular & cellular mechanisms 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. (PMID: 10985349) Miller KG … Rand JB (Neuron 2000) 2 3

Products for RIC8A Gene

  • Signalway Proteins for RIC8A

Sources for RIC8A Gene