Aliases for RIC1 Gene
External Ids for RIC1 Gene
Previous HGNC Symbols for RIC1 Gene
Previous GeneCards Identifiers for RIC1 Gene
GeneCards Summary for RIC1 Gene
RIC1 (RIC1 Homolog, RAB6A GEF Complex Partner 1) is a Protein Coding gene. Diseases associated with RIC1 include Catifa Syndrome and Hodgkin's Lymphoma, Nodular Sclerosis. Among its related pathways are Retrograde transport at the Trans-Golgi-Network and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include Rab GTPase binding and Rab guanyl-nucleotide exchange factor activity.
UniProtKB/Swiss-Prot Summary for RIC1 Gene
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796).