Aliases for RHPN2 Gene
External Ids for RHPN2 Gene
Previous GeneCards Identifiers for RHPN2 Gene
This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009]
GeneCards Summary for RHPN2 Gene
RHPN2 (Rhophilin Rho GTPase Binding Protein 2) is a Protein Coding gene. Diseases associated with RHPN2 include Hereditary Mixed Polyposis Syndrome. Among its related pathways are Signaling by GPCR and Actin Nucleation by ARP-WASP Complex. An important paralog of this gene is RHPN1.
UniProtKB/Swiss-Prot Summary for RHPN2 Gene
Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.