Aliases for RHPN2 Gene
External Ids for RHPN2 Gene
Previous GeneCards Identifiers for RHPN2 Gene
This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009]
GeneCards Summary for RHPN2 Gene
RHPN2 (Rhophilin Rho GTPase Binding Protein 2) is a Protein Coding gene. Diseases associated with RHPN2 include Hereditary Mixed Polyposis Syndrome. Among its related pathways are Signaling by GPCR and RHO GTPases Activate Rhotekin and Rhophilins. An important paralog of this gene is RHPN1.
UniProtKB/Swiss-Prot Summary for RHPN2 Gene
Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.