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Aliases for RHOXF1 Gene

Aliases for RHOXF1 Gene

  • Rhox Homeobox Family Member 1 2 3 3 5
  • Ovary-, Testis- And Epididymis-Expressed Gene Protein 3 4
  • Paired-Like Homeobox Protein PEPP-1 3 4
  • PEPP1 3 4
  • OTEX 3 4
  • Rhox Homeobox Family, Member 1 2
  • PEPP Subfamily Gene 1 3

External Ids for RHOXF1 Gene

Previous GeneCards Identifiers for RHOXF1 Gene

  • GC0XM119128
  • GC0XM119243
  • GC0XM108694

Summaries for RHOXF1 Gene

Entrez Gene Summary for RHOXF1 Gene

  • This gene is a member of the PEPP subfamily of paired-like homoebox genes. The gene may be regulated by androgens and epigenetic mechanisms. The encoded nuclear protein is likely a transcription factor that may play a role in human reproduction. [provided by RefSeq, Dec 2012]

GeneCards Summary for RHOXF1 Gene

RHOXF1 (Rhox Homeobox Family Member 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ESX1.

UniProtKB/Swiss-Prot for RHOXF1 Gene

  • Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.

Gene Wiki entry for RHOXF1 Gene

Additional gene information for RHOXF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOXF1 Gene

Genomics for RHOXF1 Gene

GeneHancer (GH) Regulatory Elements for RHOXF1 Gene

Promoters and enhancers for RHOXF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ120115 Promoter 0.5 EPDnew 650.7 +1.8 1803 0.1 RHOXF1 GC0XP120082 GC0XP120083 GC0XP120084 GC0XP120085 GC0XP120087 GC0XP120088 RHOXF1-AS1
GH0XJ119769 Enhancer 0.6 FANTOM5 26.9 +348.2 348208 0.4 ZNF316 NFATC3 NFYB SP2 ASH1L EMSY MAFK RHOXF1 RNF113A NDUFA1 AKAP14 UPF3B SOWAHD SNORA69 GC0XM119789 GC0XM119788
GH0XJ120309 Enhancer 1.2 Ensembl ENCODE 12.8 -192.5 -192491 2.4 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 ZNF416 TMEM255A NKAPP1 UPF3B EEF1A1P30 NKAP LINC01402 RHOXF2B CT47A6 CT47B1 CT47A1
GH0XJ120250 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.7 -133.5 -133492 2.4 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A ZNF48 YY1 POLR2B ZNF143 ZBTB33 RHOXF1-AS1 RHOXF1 ENSG00000232042 TMEM255A
GH0XJ119941 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 4.8 +174.6 174551 2.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 NKAP RHOXF1P3 CUL4B RHOXF1-AS1 NKRF RHOXF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOXF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RHOXF1 gene promoter:
  • SRF
  • SRF (504 AA)
  • HOXA3
  • FAC1
  • POU3F1

Genomic Locations for RHOXF1 Gene

Genomic Locations for RHOXF1 Gene
chrX:120,109,049-120,117,709
(GRCh38/hg38)
Size:
8,661 bases
Orientation:
Minus strand
chrX:119,243,011-119,249,847
(GRCh37/hg19)
Size:
6,837 bases
Orientation:
Minus strand

Genomic View for RHOXF1 Gene

Genes around RHOXF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOXF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOXF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOXF1 Gene

Proteins for RHOXF1 Gene

  • Protein details for RHOXF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHV9-RHXF1_HUMAN
    Recommended name:
    Rhox homeobox family member 1
    Protein Accession:
    Q8NHV9
    Secondary Accessions:
    • O95030
    • Q3SYE0

    Protein attributes for RHOXF1 Gene

    Size:
    184 amino acids
    Molecular mass:
    20542 Da
    Quaternary structure:
    • Does not interact with itself.
    SequenceCaution:
    • Sequence=AAC78617.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RHOXF1 Gene

Post-translational modifications for RHOXF1 Gene

No Post-translational modifications

Other Protein References for RHOXF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOXF1 Gene

Domains & Families for RHOXF1 Gene

Gene Families for RHOXF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for RHOXF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHV9

UniProtKB/Swiss-Prot:

RHXF1_HUMAN :
  • Mutagenesis of amino acids 147 to 164 and 155 to 164 lead to a major cytoplasmic localization, with only minor localization in the nucleus.
  • Belongs to the paired-like homeobox family. PEPP subfamily.
Domain:
  • Mutagenesis of amino acids 147 to 164 and 155 to 164 lead to a major cytoplasmic localization, with only minor localization in the nucleus.
Family:
  • Belongs to the paired-like homeobox family. PEPP subfamily.
genes like me logo Genes that share domains with RHOXF1: view

Function for RHOXF1 Gene

Molecular function for RHOXF1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.
UniProtKB/Swiss-Prot Induction:
By androgen.

Gene Ontology (GO) - Molecular Function for RHOXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003677 DNA binding NAS 11980563
GO:0003700 DNA binding transcription factor activity NAS 12490318
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with RHOXF1: view
genes like me logo Genes that share phenotypes with RHOXF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOXF1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RHOXF1 Gene

Localization for RHOXF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOXF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOXF1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RHOXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11980563
genes like me logo Genes that share ontologies with RHOXF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOXF1 Gene

Pathways & Interactions for RHOXF1 Gene

SuperPathways for RHOXF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RHOXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 11980563
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development NAS 11980563
GO:0007276 gamete generation NAS 11980563
genes like me logo Genes that share ontologies with RHOXF1: view

No data available for Pathways by source and SIGNOR curated interactions for RHOXF1 Gene

Drugs & Compounds for RHOXF1 Gene

No Compound Related Data Available

Transcripts for RHOXF1 Gene

mRNA/cDNA for RHOXF1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOXF1 Gene

Rhox homeobox family, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOXF1

Alternative Splicing Database (ASD) splice patterns (SP) for RHOXF1 Gene

No ASD Table

Relevant External Links for RHOXF1 Gene

GeneLoc Exon Structure for
RHOXF1
ECgene alternative splicing isoforms for
RHOXF1

Expression for RHOXF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOXF1 Gene

mRNA differential expression in normal tissues according to GTEx for RHOXF1 Gene

This gene is overexpressed in Testis (x9.8), Brain - Cerebellar Hemisphere (x5.6), and Brain - Cerebellum (x4.6).

Protein differential expression in normal tissues from HIPED for RHOXF1 Gene

This gene is overexpressed in Plasma (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RHOXF1 Gene



Protein tissue co-expression partners for RHOXF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHOXF1 Gene:

RHOXF1

SOURCE GeneReport for Unigene cluster for RHOXF1 Gene:

Hs.644617

mRNA Expression by UniProt/SwissProt for RHOXF1 Gene:

Q8NHV9-RHXF1_HUMAN
Tissue specificity: Ovary, testis and epididymis. Also detected in the prostate and the mammary gland. Expressed in many tumor cell lines derived from acute lymphocytic leukemia, prostate, endometrial adenocarcinoma, melanoma, bladder carcinoma, colon carcinoma, erythroleukemia and breast carcinoma. Not expressed in placenta. In testis, mainly expressed in germ cells, but also detected in somatic cells such as Sertoli cells, Leydig cells and peritubular cells (PubMed:28171660).
genes like me logo Genes that share expression patterns with RHOXF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOXF1 Gene

Orthologs for RHOXF1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RHOXF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOXF1 33
  • 98 (n)
dog
(Canis familiaris)
Mammalia LOC481034 33
  • 63.33 (n)
RHOXF1 34
  • 36 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhox13 34
  • 19 (a)
OneToOne
Species where no ortholog for RHOXF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RHOXF1 Gene

ENSEMBL:
Gene Tree for RHOXF1 (if available)
TreeFam:
Gene Tree for RHOXF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOXF1: view image

Paralogs for RHOXF1 Gene

Paralogs for RHOXF1 Gene

(2) SIMAP similar genes for RHOXF1 Gene using alignment to 1 proteins:

  • RHXF1_HUMAN
genes like me logo Genes that share paralogs with RHOXF1: view

Variants for RHOXF1 Gene

Sequence variations from dbSNP and Humsavar for RHOXF1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001155981 -- 120,111,814(-) T/C intron_variant
rs1001599870 -- 120,116,858(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002051265 -- 120,119,349(-) A/G upstream_transcript_variant
rs1002114263 -- 120,117,228(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002221084 -- 120,110,309(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RHOXF1 Gene

Variant ID Type Subtype PubMed ID
esv1505897 CNV insertion 17803354
esv2758888 CNV gain 17122850
nsv1117914 CNV tandem duplication 24896259
nsv476477 CNV novel sequence insertion 20440878
nsv526653 CNV gain 19592680
nsv7457 OTHER inversion 18451855

Variation tolerance for RHOXF1 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOXF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOXF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOXF1 Gene

Disorders for RHOXF1 Gene

Additional Disease Information for RHOXF1

No disorders were found for RHOXF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOXF1 Gene

Publications for RHOXF1 Gene

  1. OTEX, an androgen-regulated human member of the paired-like class of homeobox genes. (PMID: 11980563) Geserick C … Haendler B (The Biochemical journal 2002) 2 3 4 22 58
  2. Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. (PMID: 12490318) Wayne CM … Wilkinson MF (Gene 2002) 2 3 4 58
  3. The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men. (PMID: 28171660) Borgmann J … Gromoll J (Human molecular genetics 2016) 3 4 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RHOXF1 Gene

Sources for RHOXF1 Gene

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