Aliases for RHOV Gene

Aliases for RHOV Gene

  • Ras Homolog Family Member V 2 3 5
  • WRCH2 2 3 4
  • Rho-Related GTP-Binding Protein RhoV 3 4
  • Ras Homolog Gene Family, Member V 2 3
  • Wnt-1 Responsive Cdc42 Homolog 2 3 4
  • Rho GTPase-Like Protein ARHV 3 4
  • GTP-Binding Protein-Like 2 3 4
  • CDC42-Like GTPase 2 3 4
  • WRCH-2 3 4
  • ARHV 3 4
  • Wnt-1 Regulated Cdc42 Homolog 2 3
  • WRCH1-Related GTPase 3
  • RHOV 5
  • CHP 3
  • Chp 2

External Ids for RHOV Gene

Previous HGNC Symbols for RHOV Gene

  • ARHV

Previous GeneCards Identifiers for RHOV Gene

  • GC15M038881
  • GC15M038952
  • GC15M041164
  • GC15M018012

Summaries for RHOV Gene

GeneCards Summary for RHOV Gene

RHOV (Ras Homolog Family Member V) is a Protein Coding gene. Diseases associated with RHOV include Ascaridiasis and Deafness, Autosomal Recessive 104. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RHOU.

UniProtKB/Swiss-Prot Summary for RHOV Gene

  • Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOV Gene

Genomics for RHOV Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RHOV Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J040869 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 256.7 +1.8 1795 5.3 SP1 ZNF207 IKZF1 MYC ZNF600 ZNF592 POLR2A ZIC2 BCL11A REST RHOV ENSG00000274798 NDUFAF1 MN298678-025 SPINT1
GH15J040905 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -32.7 -32686 3.7 BCLAF1 ZNF654 IKZF1 MYC ZNF580 KLF9 POLR2A NFIC ZIC2 ZBTB10 ENSG00000251161 HSALNG0105310 HSALNG0105311 LOC105370943 CHAC1 RHOV CHP1 EXD1 DLL4 VPS18
GH15J040742 Promoter/Enhancer 1.3 Ensembl ENCODE 10.8 +128.3 128310 7.4 ZNF654 MYC NCOR1 IKZF1 ZNF600 ZNF592 ZNF10 NFIC ZIC2 YY1 HSALNG0105282 CCDC32 RAD51 C15orf62 ZFYVE19 DNAJC17 RAD51-AS1 SPINT1 RHOV VPS18
GH15J040785 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.7 +85.9 85933 6.2 IKZF1 ZNF600 ZIC2 CEBPB REST ETS1 CTCF SIN3A ZNF217 ELF1 ZFYVE19 CCDC32 GCHFR RMDN3 SPINT1 RAD51 RAD51-AS1 RHOV VPS18 ENSG00000251161
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOV on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RHOV

Top Transcription factor binding sites by QIAGEN in the RHOV gene promoter:
  • CREB
  • deltaCREB
  • E47
  • LUN-1
  • Nkx3-1 v1
  • Nkx6-1
  • Pax-5
  • RORalpha2
  • SRF
  • SRF (504 AA)

Genomic Locations for RHOV Gene

Latest Assembly
2,021 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
2,021 bases
Minus strand

(GRCh37/hg19 by Ensembl)
2,076 bases
Minus strand

Genomic View for RHOV Gene

Genes around RHOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOV Gene

Proteins for RHOV Gene

  • Protein details for RHOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related GTP-binding protein RhoV
    Protein Accession:
    Secondary Accessions:
    • Q2KHQ5
    • Q8TDW6

    Protein attributes for RHOV Gene

    236 amino acids
    Molecular mass:
    26217 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PAK2.

neXtProt entry for RHOV Gene

Post-translational modifications for RHOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOV Gene

Domains & Families for RHOV Gene

Gene Families for RHOV Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RHOV Gene

  • Transforming protein P21 RAS signature
  • Ras small GTPase, Rho type

Suggested Antigen Peptide Sequences for RHOV Gene

GenScript: Design optimal peptide antigens:
  • RHOV protein (Q05D03_HUMAN)
  • Wnt-1 responsive Cdc42 homolog 2 (RHOV_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rho family.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOV: view

Function for RHOV Gene

Molecular function for RHOV Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

Phenotypes From GWAS Catalog for RHOV Gene

Gene Ontology (GO) - Molecular Function for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA 21873635
GO:0005515 protein binding IPI 16752908
GO:0005525 GTP binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RHOV: view
genes like me logo Genes that share phenotypes with RHOV: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOV

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOV Gene

Localization for RHOV Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOV Gene

Cell membrane. Lipid-anchor. Cytoplasmic side. Endosome membrane. Lipid-anchor. Cytoplasmic side. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250 UniProtKB:Q9Z1Y0}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOV gene
Compartment Confidence
cytosol 5
plasma membrane 4
endosome 4
cytoskeleton 3
nucleus 3
extracellular 2
lysosome 2
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RHOV: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOV Gene

Pathways & Interactions for RHOV Gene

genes like me logo Genes that share pathways with RHOV: view

Pathways by source for RHOV Gene

Gene Ontology (GO) - Biological Process for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IBA 21873635
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0016477 cell migration IBA 21873635
GO:0030031 cell projection assembly IBA 21873635
GO:0032488 Cdc42 protein signal transduction IBA 21873635
genes like me logo Genes that share ontologies with RHOV: view

No data available for SIGNOR curated interactions for RHOV Gene

Drugs & Compounds for RHOV Gene

(1) Drugs for RHOV Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with RHOV: view

Transcripts for RHOV Gene

mRNA/cDNA for RHOV Gene

6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOV

Alternative Splicing Database (ASD) splice patterns (SP) for RHOV Gene

No ASD Table

Relevant External Links for RHOV Gene

GeneLoc Exon Structure for

Expression for RHOV Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHOV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOV Gene

This gene is overexpressed in Esophagus - Mucosa (x14.4), Skin - Sun Exposed (Lower leg) (x9.2), Skin - Not Sun Exposed (Suprapubic) (x9.0), and Vagina (x5.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RHOV

SOURCE GeneReport for Unigene cluster for RHOV Gene:


mRNA Expression by UniProt/SwissProt for RHOV Gene:

Tissue specificity: Highly expressed in pancreas, placenta, and fetal brain.

Evidence on tissue expression from TISSUES for RHOV Gene

  • Skin(2.7)
  • Nervous system(2.4)
  • Intestine(2.2)
  • Blood(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RHOV: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOV Gene

Orthologs for RHOV Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOV Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHOV 29 30
  • 99.44 (n)
(Monodelphis domestica)
Mammalia RHOV 30
  • 94 (a)
(Canis familiaris)
Mammalia RHOV 29 30
  • 93.22 (n)
(Bos Taurus)
Mammalia RHOV 29 30
  • 92.23 (n)
(Rattus norvegicus)
Mammalia Rhov 29
  • 90.54 (n)
(Mus musculus)
Mammalia Rhov 29 16 30
  • 89.55 (n)
(Ornithorhynchus anatinus)
Mammalia RHOV 30
  • 80 (a)
(Gallus gallus)
Aves RHOV 29 30
  • 78.1 (n)
(Anolis carolinensis)
Reptilia RHOV 30
  • 81 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rhov 29
  • 72.3 (n)
Str.15841 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.2434 29
(Danio rerio)
Actinopterygii rhov 29 30
  • 63.61 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG34104 30
  • 17 (a)
(Caenorhabditis elegans)
Secernentea chw-1 30
  • 47 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9013 30
  • 50 (a)
Species where no ortholog for RHOV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RHOV Gene

Gene Tree for RHOV (if available)
Gene Tree for RHOV (if available)
Evolutionary constrained regions (ECRs) for RHOV: view image
Alliance of Genome Resources:
Additional Orthologs for RHOV

Paralogs for RHOV Gene

(39) SIMAP similar genes for RHOV Gene using alignment to 2 proteins:

  • Q05D03_HUMAN
genes like me logo Genes that share paralogs with RHOV: view

Variants for RHOV Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RHOV Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RHOV Gene

Variant ID Type Subtype PubMed ID
nsv1054764 CNV gain 25217958
nsv569228 CNV loss 21841781

Variation tolerance for RHOV Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RHOV Gene

Disorders for RHOV Gene

MalaCards: The human disease database

(4) MalaCards diseases for RHOV Gene - From: COP

Disorder Aliases PubMed IDs
  • ascariasis
deafness, autosomal recessive 104
  • dfnb104
toxic megacolon
  • megacolon, toxic
cardiomyopathy, familial hypertrophic, 1
  • cmh1
- elite association - COSMIC cancer census association via MalaCards
Search RHOV in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOV

genes like me logo Genes that share disorders with RHOV: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOV Gene

Publications for RHOV Gene

  1. The Rho GTPase family: a Racs to Wrchs story. (PMID: 11839775) Wherlock M … Mellor H (Journal of cell science 2002) 2 3 4
  2. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. (PMID: 11956592) Katoh M (International journal of oncology 2002) 3 4 22
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. [Mutations in the Effector Domain of RhoV GTPase Impair Its Binding to Pak1 Protein Kinase]. (PMID: 30113035) Korobko IV … Shepelev MV (Molekuliarnaia biologiia 2018) 3
  5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. (PMID: 26760575) Uren PJ … Penalva LO (RNA biology 2016) 3

Products for RHOV Gene

Sources for RHOV Gene