Aliases for RHOV Gene

Aliases for RHOV Gene

  • Ras Homolog Family Member V 2 3 5
  • Rho-Related GTP-Binding Protein RhoV 3 4
  • Ras Homolog Gene Family, Member V 2 3
  • Wnt-1 Responsive Cdc42 Homolog 2 3 4
  • Rho GTPase-Like Protein ARHV 3 4
  • GTP-Binding Protein-Like 2 3 4
  • CDC42-Like GTPase 2 3 4
  • WRCH-2 3 4
  • WRCH2 3 4
  • ARHV 3 4
  • Wnt-1 Regulated Cdc42 Homolog 2 3
  • WRCH1-Related GTPase 3
  • CHP 3

External Ids for RHOV Gene

Previous HGNC Symbols for RHOV Gene

  • ARHV

Previous GeneCards Identifiers for RHOV Gene

  • GC15M038881
  • GC15M038952
  • GC15M041164
  • GC15M018012

Summaries for RHOV Gene

GeneCards Summary for RHOV Gene

RHOV (Ras Homolog Family Member V) is a Protein Coding gene. Diseases associated with RHOV include Ascaridiasis and Toxic Megacolon. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RHOU.

UniProtKB/Swiss-Prot Summary for RHOV Gene

  • Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

Additional gene information for RHOV Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOV Gene

Genomics for RHOV Gene

GeneHancer (GH) Regulatory Elements for RHOV Gene

Promoters and enhancers for RHOV Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J040869 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 506.7 +1.9 1850 5.3 CTCF SIN3A SP1 PHF8 EP300 ZIC2 POLR2A CLOCK ZNF423 GABPA RHOV ENSG00000274798 NDUFAF1 lnc-VPS18-3
GH15J040905 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -32.6 -32631 3.7 FOXK2 ZBTB40 ZNF217 CTCF NRF1 ZIC2 ZBTB10 ZNF423 GABPA TARDBP ENSG00000251161 LOC105370943 CHAC1 RHOV CHP1 EXD1 DLL4
GH15J040791 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.7 +79.5 79488 6 ZSCAN5C TCF12 NCOR1 JUND FOS KDM6A EP300 SKI TEAD1 NR2F2 ZFYVE19 RMDN3 CCDC32 C15orf62 SPINT1 GCHFR RAD51-AS1 RAD51 RHOV RPUSD2
GH15J040785 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.7 +86.2 86188 6.6 ZNF217 CTCF ZIC2 REST CUX1 HDAC2 CTBP1 OSR2 NR3C1 YY1 ZFYVE19 CCDC32 GCHFR RMDN3 SPINT1 RAD51 RAD51-AS1 RHOV VPS18 ENSG00000251161
GH15J040742 Enhancer 1.1 Ensembl ENCODE 10.8 +127.2 127159 10.3 CTCF NRF1 FOS ZNF10 ZIC2 ZNF423 REST MYC RAD21 CTBP1 CCDC32 RAD51 RMDN3 C15orf62 ZFYVE19 DNAJC17 RAD51-AS1 SPINT1 RHOV VPS18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOV on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RHOV

Top Transcription factor binding sites by QIAGEN in the RHOV gene promoter:
  • CREB
  • deltaCREB
  • E47
  • LUN-1
  • Nkx3-1 v1
  • Nkx6-1
  • Pax-5
  • RORalpha2
  • SRF
  • SRF (504 AA)

Genomic Locations for RHOV Gene

Genomic Locations for RHOV Gene
chr15:40,872,214-40,874,289
(GRCh38/hg38)
Size:
2,076 bases
Orientation:
Minus strand
chr15:41,164,412-41,166,487
(GRCh37/hg19)
Size:
2,076 bases
Orientation:
Minus strand

Genomic View for RHOV Gene

Genes around RHOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOV Gene

Proteins for RHOV Gene

  • Protein details for RHOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L33-RHOV_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoV
    Protein Accession:
    Q96L33
    Secondary Accessions:
    • Q2KHQ5
    • Q8TDW6

    Protein attributes for RHOV Gene

    Size:
    236 amino acids
    Molecular mass:
    26217 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PAK2.

neXtProt entry for RHOV Gene

Post-translational modifications for RHOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOV Gene

Domains & Families for RHOV Gene

Gene Families for RHOV Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RHOV Gene

Blocks:
  • Transforming protein P21 RAS signature
  • Ras small GTPase, Rho type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RHOV Gene

GenScript: Design optimal peptide antigens:
  • RHOV protein (Q05D03_HUMAN)
  • Wnt-1 responsive Cdc42 homolog 2 (RHOV_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96L33

UniProtKB/Swiss-Prot:

RHOV_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOV: view

Function for RHOV Gene

Molecular function for RHOV Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

Phenotypes From GWAS Catalog for RHOV Gene

Gene Ontology (GO) - Molecular Function for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA 21873635
GO:0005515 protein binding IPI 16752908
GO:0005525 GTP binding IBA 21873635
GO:0019901 protein kinase binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RHOV: view
genes like me logo Genes that share phenotypes with RHOV: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOV

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOV Gene

Localization for RHOV Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOV Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250 UniProtKB:Q9Z1Y0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOV gene
Compartment Confidence
cytosol 5
plasma membrane 4
endosome 4
cytoskeleton 3
nucleus 3
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA,TAS --
genes like me logo Genes that share ontologies with RHOV: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOV Gene

Pathways & Interactions for RHOV Gene

genes like me logo Genes that share pathways with RHOV: view

Pathways by source for RHOV Gene

Gene Ontology (GO) - Biological Process for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IBA 21873635
GO:0007015 actin filament organization IBA 21873635
GO:0007163 establishment or maintenance of cell polarity IBA 21873635
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IBA 21873635
genes like me logo Genes that share ontologies with RHOV: view

No data available for SIGNOR curated interactions for RHOV Gene

Drugs & Compounds for RHOV Gene

(1) Drugs for RHOV Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with RHOV: view

Transcripts for RHOV Gene

mRNA/cDNA for RHOV Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOV

Alternative Splicing Database (ASD) splice patterns (SP) for RHOV Gene

No ASD Table

Relevant External Links for RHOV Gene

GeneLoc Exon Structure for
RHOV

Expression for RHOV Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHOV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOV Gene

This gene is overexpressed in Esophagus - Mucosa (x14.4), Skin - Sun Exposed (Lower leg) (x9.2), Skin - Not Sun Exposed (Suprapubic) (x9.0), and Vagina (x5.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RHOV

SOURCE GeneReport for Unigene cluster for RHOV Gene:

Hs.447901

mRNA Expression by UniProt/SwissProt for RHOV Gene:

Q96L33-RHOV_HUMAN
Tissue specificity: Highly expressed in pancreas, placenta, and fetal brain.
genes like me logo Genes that share expression patterns with RHOV: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOV Gene

Orthologs for RHOV Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOV 31 30
  • 99.44 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOV 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOV 31 30
  • 93.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RHOV 31 30
  • 92.23 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhov 30
  • 90.54 (n)
mouse
(Mus musculus)
Mammalia Rhov 17 31 30
  • 89.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RHOV 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOV 31 30
  • 78.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOV 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhov 30
  • 72.3 (n)
Str.15841 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.2434 30
zebrafish
(Danio rerio)
Actinopterygii rhov 31 30
  • 63.61 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34104 31
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea chw-1 31
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9013 31
  • 50 (a)
OneToMany
Species where no ortholog for RHOV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOV Gene

ENSEMBL:
Gene Tree for RHOV (if available)
TreeFam:
Gene Tree for RHOV (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOV: view image

Paralogs for RHOV Gene

(39) SIMAP similar genes for RHOV Gene using alignment to 2 proteins:

  • RHOV_HUMAN
  • Q05D03_HUMAN
genes like me logo Genes that share paralogs with RHOV: view

Variants for RHOV Gene

Additional dbSNP identifiers (rs#s) for RHOV Gene

Structural Variations from Database of Genomic Variants (DGV) for RHOV Gene

Variant ID Type Subtype PubMed ID
nsv1054764 CNV gain 25217958
nsv569228 CNV loss 21841781

Variation tolerance for RHOV Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOV

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RHOV Gene

Disorders for RHOV Gene

MalaCards: The human disease database

(3) MalaCards diseases for RHOV Gene - From: DISEASES

Disorder Aliases PubMed IDs
ascaridiasis
  • ascariasis
toxic megacolon
  • megacolon, toxic
cardiomyopathy, familial hypertrophic, 1
  • fhc
- elite association - COSMIC cancer census association via MalaCards
Search RHOV in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOV

genes like me logo Genes that share disorders with RHOV: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOV Gene

Publications for RHOV Gene

  1. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. (PMID: 11956592) Katoh M (International journal of oncology 2002) 3 4 23 54
  2. The Rho GTPase family: a Racs to Wrchs story. (PMID: 11839775) Wherlock M … Mellor H (Journal of cell science 2002) 2 3 4 54
  3. [Mutations in the Effector Domain of RhoV GTPase Impair Its Binding to Pak1 Protein Kinase]. (PMID: 30113035) Korobko IV … Shepelev MV (Molekuliarnaia biologiia 2018) 3 54
  4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 54
  5. Atypical RhoV and RhoU GTPases control development of the neural crest. (PMID: 26555387) Faure S … Fort P (Small GTPases 2015) 3 54

Products for RHOV Gene

Sources for RHOV Gene