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Aliases for RHOT2 Gene

Aliases for RHOT2 Gene

  • Ras Homolog Family Member T2 2 3 5
  • Ras Homolog Gene Family, Member T2 2 3
  • Mitochondrial Rho (MIRO) GTPase 2 2 3
  • C16orf39 3 4
  • MIRO-2 3 4
  • ARHT2 3 4
  • Chromosome 16 Open Reading Frame 39 2
  • Ras Homolog Gene Family Member T2 4
  • Mitochondrial Rho GTPase 2 3
  • EC 3.6.5.- 4
  • HMiro-2 4
  • MIRO2 3
  • RASL 3

External Ids for RHOT2 Gene

Previous HGNC Symbols for RHOT2 Gene

  • C16orf39
  • ARHT2

Previous GeneCards Identifiers for RHOT2 Gene

  • GC16P000660
  • GC16P000661
  • GC16P000719
  • GC16P000649
  • GC16P000720
  • GC16P000722
  • GC16P000723
  • GC16P000727
  • GC16P000792
  • GC16P000826
  • GC16P000847
  • GC16P000809
  • GC16P000834
  • GC16P000868
  • GC16P000891
  • GC16P000910
  • GC16P000930
  • GC16P000949
  • GC16P000970

Summaries for RHOT2 Gene

Entrez Gene Summary for RHOT2 Gene

  • This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]

GeneCards Summary for RHOT2 Gene

RHOT2 (Ras Homolog Family Member T2) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RHOT1.

UniProtKB/Swiss-Prot for RHOT2 Gene

  • Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).

Gene Wiki entry for RHOT2 Gene

Additional gene information for RHOT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOT2 Gene

Genomics for RHOT2 Gene

GeneHancer (GH) Regulatory Elements for RHOT2 Gene

Promoters and enhancers for RHOT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000666 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 660.9 +0.2 194 3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 POLR2B RHOT2 METTL26 WDR90 WFIKKN1 RHBDL1 CRAMP1 UNKL UBE2I ENSG00000262528 CHTF18
GH16J001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 126.2 +642.7 642671 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 ENSG00000261505 TELO2 ENSG00000260051 E4F1 TSC2 IFT140
GH16J001271 Enhancer 1 ENCODE 120.5 +603.7 603743 1.6 PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF416 KLF13 SP3 CRAMP1 WDR90 TELO2 IFT140 TSC2 ENSG00000261505 E4F1 WDR24 ENSG00000260051 RHOT2
GH16J000396 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 48.2 -268.2 -268200 7.7 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 NME4 DECR2 WDR90 ENSG00000261505 WASH4P RHOT2 UBE2I WDR24 JMJD8 LUC7L
GH16J000586 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 43.3 -77.0 -76951 8.4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 RAB40C GC16M000587 WDR90 ENSG00000261505 ENSG00000260051 WASH4P RHOT2 WFIKKN1 JMJD8 WDR24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RHOT2 gene promoter:
  • p53
  • Sp1
  • C/EBPbeta
  • deltaCREB
  • CREB

Genomic Locations for RHOT2 Gene

Genomic Locations for RHOT2 Gene
chr16:668,083-674,174
(GRCh38/hg38)
Size:
6,092 bases
Orientation:
Plus strand
chr16:718,086-724,174
(GRCh37/hg19)
Size:
6,089 bases
Orientation:
Plus strand

Genomic View for RHOT2 Gene

Genes around RHOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOT2 Gene

Proteins for RHOT2 Gene

  • Protein details for RHOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXI1-MIRO2_HUMAN
    Recommended name:
    Mitochondrial Rho GTPase 2
    Protein Accession:
    Q8IXI1
    Secondary Accessions:
    • A2IDC2
    • Q8NF53
    • Q96C13
    • Q96S17
    • Q9BT60
    • Q9H7M8

    Protein attributes for RHOT2 Gene

    Size:
    618 amino acids
    Molecular mass:
    68118 Da
    Quaternary structure:
    • Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (PubMed:16630562). Interacts with ARMCX3 (By similarity). Found in a complex with KIF5B, OGT, RHOT1 and TRAK1 (PubMed:24995978).
    SequenceCaution:
    • Sequence=AAK61240.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB15740.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03407.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RHOT2 Gene

    Alternative splice isoforms for RHOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHOT2 Gene

Post-translational modifications for RHOT2 Gene

  • Ubiquitination at posLast=429429, Lys420, Lys230, Lys179, and Lys119
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RHOT2 Gene

Domains & Families for RHOT2 Gene

Gene Families for RHOT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for RHOT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXI1

UniProtKB/Swiss-Prot:

MIRO2_HUMAN :
  • Belongs to the mitochondrial Rho GTPase family.
Family:
  • Belongs to the mitochondrial Rho GTPase family.
genes like me logo Genes that share domains with RHOT2: view

Function for RHOT2 Gene

Molecular function for RHOT2 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).

Enzyme Numbers (IUBMB) for RHOT2 Gene

Phenotypes From GWAS Catalog for RHOT2 Gene

Gene Ontology (GO) - Molecular Function for RHOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16630562
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RHOT2: view
genes like me logo Genes that share phenotypes with RHOT2: view

Animal Models for RHOT2 Gene

MGI Knock Outs for RHOT2:
  • Rhot2 Rhot2<tm1(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for RHOT2 Gene

miRTarBase miRNAs that target RHOT2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOT2

Clone Products

  • Addgene plasmids for RHOT2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOT2 Gene

Localization for RHOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOT2 Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOT2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
cytosol 5
peroxisome 2
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RHOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 COLOCALIZES_WITH mitochondrion IEA,IBA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane HDA,IEA 19946888
genes like me logo Genes that share ontologies with RHOT2: view

Pathways & Interactions for RHOT2 Gene

genes like me logo Genes that share pathways with RHOT2: view

Pathways by source for RHOT2 Gene

1 KEGG pathway for RHOT2 Gene
1 Cell Signaling Technology pathway for RHOT2 Gene

Gene Ontology (GO) - Biological Process for RHOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IEA,IBA --
GO:0007266 Rho protein signal transduction IBA --
GO:0010821 regulation of mitochondrion organization IBA --
GO:0019725 cellular homeostasis IMP 12482879
GO:0047497 mitochondrion transport along microtubule IMP 16630562
genes like me logo Genes that share ontologies with RHOT2: view

No data available for SIGNOR curated interactions for RHOT2 Gene

Drugs & Compounds for RHOT2 Gene

No Compound Related Data Available

Transcripts for RHOT2 Gene

Unigene Clusters for RHOT2 Gene

Ras homolog family member T2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOT2

Clone Products

  • Addgene plasmids for RHOT2

Alternative Splicing Database (ASD) splice patterns (SP) for RHOT2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - -
SP10: - - - - -
SP11: - - - - - -
SP12: - - - - -
SP13: - - - - - -
SP14: - - - - - - - - - - - - - - - - -
SP15: - -
SP16: - - -
SP17: - -
SP18: -
SP19: - - - - - -
SP20: - - - - -
SP21: - -
SP22: - - -
SP23: - -
SP24:
SP25:
SP26: - -
SP27: - - -
SP28:
SP29:
SP30: -
SP31:
SP32: - - -
SP33:

ExUns: 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c · 24d · 24e
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: -
SP24:
SP25:
SP26:
SP27:
SP28: -
SP29: -
SP30:
SP31:
SP32:
SP33: -

Relevant External Links for RHOT2 Gene

GeneLoc Exon Structure for
RHOT2
ECgene alternative splicing isoforms for
RHOT2

Expression for RHOT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOT2 Gene

Protein differential expression in normal tissues from HIPED for RHOT2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1) and Retina (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOT2 Gene



Protein tissue co-expression partners for RHOT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHOT2 Gene:

RHOT2

SOURCE GeneReport for Unigene cluster for RHOT2 Gene:

Hs.513242

mRNA Expression by UniProt/SwissProt for RHOT2 Gene:

Q8IXI1-MIRO2_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for RHOT2 Gene

  • Skin(4.3)
  • Spleen(4.3)
  • Nervous system(4)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with RHOT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOT2 Gene

Orthologs for RHOT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOT2 34 33
  • 98.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RHOT2 34 33
  • 85.09 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RHOT2 34 33
  • 83.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rhot2 16 34 33
  • 81.82 (n)
Gm20683 34
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rhot2 33
  • 81.61 (n)
oppossum
(Monodelphis domestica)
Mammalia RHOT2 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOT2 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOT2 34 33
  • 74.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOT2 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhot2 33
  • 69.66 (n)
Str.15678 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15769 33
zebrafish
(Danio rerio)
Actinopterygii rhot2 34 33
  • 66.4 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Miro 34
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea miro-1 34
  • 43 (a)
ManyToMany
miro-2 34
  • 40 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR402W 33
  • 45.1 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GEM1 34 33
  • 43.05 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A03465g 33
  • 41.88 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MIRO1 33
  • 45.83 (n)
rice
(Oryza sativa)
Liliopsida Os03g0810600 33
  • 49.2 (n)
Os.15115 33
bread mold
(Neurospora crassa)
Ascomycetes NCU03966 33
  • 49.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC320.04c 33
  • 43.46 (n)
Species where no ortholog for RHOT2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOT2 Gene

ENSEMBL:
Gene Tree for RHOT2 (if available)
TreeFam:
Gene Tree for RHOT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOT2: view image

Paralogs for RHOT2 Gene

Paralogs for RHOT2 Gene

(2) SIMAP similar genes for RHOT2 Gene using alignment to 8 proteins:

  • MIRO2_HUMAN
  • H3BMP9_HUMAN
  • H3BP40_HUMAN
  • H3BST5_HUMAN
  • H3BU27_HUMAN
  • H3BUX4_HUMAN
  • H3BVI5_HUMAN
  • I3L2C6_HUMAN
genes like me logo Genes that share paralogs with RHOT2: view

Variants for RHOT2 Gene

Sequence variations from dbSNP and Humsavar for RHOT2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000432796 -- 669,065(+) G/C intron_variant
rs1000866824 -- 669,130(+) CAC/CACAC intron_variant
rs1000888363 -- 668,923(+) T/C intron_variant
rs1001681087 -- 668,443(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001778598 -- 670,189(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RHOT2 Gene

Variant ID Type Subtype PubMed ID
dgv334n27 CNV loss 19166990
dgv4824n54 CNV loss 21841781
dgv4825n54 CNV loss 21841781
dgv4826n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457310 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv482180 CNV gain 20164927
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571016 CNV loss 21841781
nsv827480 CNV gain 20364138
nsv827481 CNV gain 20364138
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for RHOT2 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.62; 94.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOT2 Gene

Disorders for RHOT2 Gene

Additional Disease Information for RHOT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RHOT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOT2 Gene

Publications for RHOT2 Gene

  1. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PMID: 12482879) Fransson A … Aspenström P (The Journal of biological chemistry 2003) 2 3 4 58
  2. Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. (PMID: 24995978) Pekkurnaz G … Schwarz TL (Cell 2014) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. (PMID: 19528298) Li Y … Rempe DA (The Journal of cell biology 2009) 3 4 58
  5. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S … Aspenström P (Biochemical and biophysical research communications 2006) 3 4 58

Products for RHOT2 Gene

Sources for RHOT2 Gene