Aliases for RHOJ Gene
External Ids for RHOJ Gene
Previous HGNC Symbols for RHOJ Gene
Previous GeneCards Identifiers for RHOJ Gene
This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]
GeneCards Summary for RHOJ Gene
RHOJ (Ras Homolog Family Member J) is a Protein Coding gene. Diseases associated with RHOJ include Ascaridiasis and Deafness, Autosomal Recessive 104. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOQ.
UniProtKB/Swiss-Prot Summary for RHOJ Gene
Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707).