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Aliases for RHOJ Gene

Aliases for RHOJ Gene

  • Ras Homolog Family Member J 2 3 5
  • Ras-Like Protein Family Member 7B 3 4
  • Ras Homolog Gene Family, Member J 2 3
  • Tc10-Like GTP-Binding Protein 3 4
  • RAS-Like, Family 7, Member B 2 3
  • RASL7B 3 4
  • ARHJ 3 4
  • TCL 3 4
  • Rho-Related GTP-Binding Protein RhoJ 3
  • TC10-Like Rho GTPase 3
  • TC10B 3
  • RHOI 4

External Ids for RHOJ Gene

Previous HGNC Symbols for RHOJ Gene

  • RASL7B
  • ARHJ

Previous GeneCards Identifiers for RHOJ Gene

  • GC14P061662
  • GC14P062740
  • GC14P063671
  • GC14P043837

Summaries for RHOJ Gene

Entrez Gene Summary for RHOJ Gene

  • This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]

GeneCards Summary for RHOJ Gene

RHOJ (Ras Homolog Family Member J) is a Protein Coding gene. Diseases associated with RHOJ include Parasitic Ichthyosporea Infectious Disease and Rhinosporidiosis. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOQ.

UniProtKB/Swiss-Prot for RHOJ Gene

  • GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).

Gene Wiki entry for RHOJ Gene

Additional gene information for RHOJ Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOJ Gene

Genomics for RHOJ Gene

GeneHancer (GH) Regulatory Elements for RHOJ Gene

Promoters and enhancers for RHOJ Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J063203 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 673.2 +1.0 958 4 ELF3 FOXA2 ARID4B MZF1 RAD21 YY1 ATF7 FOS ZBTB11 ZHX2 RHOJ KCNH5 GPHB5 LOC105370531 GC14M063214
GH14J063174 Enhancer 1 Ensembl ENCODE dbSUPER 9.5 -29.1 -29089 1.4 CTCF ZNF654 JUN RAD21 JUND GLIS1 SMC3 CREB1 RHOJ LOC105370530 LOC105370531 PARP1P2
GH14J063181 Enhancer 0.4 dbSUPER 22.9 -21.1 -21066 2.2 JUN NR2F2 RHOJ LOC105370530 LOC105370531
GH14J063178 Enhancer 0.6 ENCODE dbSUPER 11.8 -24.7 -24717 2.2 GATA3 JUN LOC105370530 RHOJ LOC105370531
GH14J063214 Enhancer 0.5 ENCODE dbSUPER 14.1 +10.4 10384 0.9 JUN RHOJ GC14M063214 LOC105370531
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOJ on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RHOJ gene promoter:
  • STAT3
  • PPAR-gamma2
  • PPAR-gamma1
  • POU2F1b
  • POU2F1
  • POU2F1a
  • POU2F1c
  • POU6F1 (c2)

Genomic Locations for RHOJ Gene

Genomic Locations for RHOJ Gene
89,399 bases
Plus strand
89,106 bases
Plus strand

Genomic View for RHOJ Gene

Genes around RHOJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOJ Gene

Proteins for RHOJ Gene

  • Protein details for RHOJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related GTP-binding protein RhoJ
    Protein Accession:
    Secondary Accessions:
    • Q96KC1

    Protein attributes for RHOJ Gene

    214 amino acids
    Molecular mass:
    23821 Da
    Quaternary structure:
    • Interacts with the CRIB domains of proteins such as Pak1 and Was/Wasp.
    • Sequence=BAB55013.1; Type=Frameshift; Positions=143; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOJ Gene


neXtProt entry for RHOJ Gene

Post-translational modifications for RHOJ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOJ Gene

No data available for DME Specific Peptides for RHOJ Gene

Domains & Families for RHOJ Gene

Gene Families for RHOJ Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RHOJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rho family.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOJ: view

Function for RHOJ Gene

Molecular function for RHOJ Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).

Gene Ontology (GO) - Molecular Function for RHOJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS,IEA 10967094
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with RHOJ: view
genes like me logo Genes that share phenotypes with RHOJ: view

Animal Models for RHOJ Gene

MGI Knock Outs for RHOJ:
  • Rhoj Rhoj<tm1a(KOMP)Wtsi>
  • Rhoj Rhoj<tm1.2Auem>

Animal Model Products

CRISPR Products

miRNA for RHOJ Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOJ

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOJ Gene

Localization for RHOJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOJ Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOJ gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 1
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RHOJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IBA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOJ: view

Pathways & Interactions for RHOJ Gene

genes like me logo Genes that share pathways with RHOJ: view

Gene Ontology (GO) - Biological Process for RHOJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IBA --
GO:0007015 actin filament organization IBA --
GO:0007163 establishment or maintenance of cell polarity IBA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IEA --
genes like me logo Genes that share ontologies with RHOJ: view

No data available for SIGNOR curated interactions for RHOJ Gene

Drugs & Compounds for RHOJ Gene

(1) Drugs for RHOJ Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHOJ: view

Transcripts for RHOJ Gene

mRNA/cDNA for RHOJ Gene

Unigene Clusters for RHOJ Gene

Ras homolog family member J:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOJ

Alternative Splicing Database (ASD) splice patterns (SP) for RHOJ Gene

No ASD Table

Relevant External Links for RHOJ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOJ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOJ Gene

Protein differential expression in normal tissues from HIPED for RHOJ Gene

This gene is overexpressed in Breast (61.6) and Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RHOJ Gene

Protein tissue co-expression partners for RHOJ Gene

NURSA nuclear receptor signaling pathways regulating expression of RHOJ Gene:


SOURCE GeneReport for Unigene cluster for RHOJ Gene:


Evidence on tissue expression from TISSUES for RHOJ Gene

  • Intestine(4.2)
  • Nervous system(3.3)
  • Blood(2.3)
  • Kidney(2.2)
  • Eye(2)
  • Heart(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with RHOJ: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOJ Gene

Orthologs for RHOJ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOJ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHOJ 34 33
  • 99.84 (n)
(Canis familiaris)
Mammalia RHOJ 34 33
  • 93.15 (n)
(Bos Taurus)
Mammalia RHOJ 34 33
  • 92.83 (n)
(Monodelphis domestica)
Mammalia RHOJ 34
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
-- 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Rhoj 33
  • 88.31 (n)
(Mus musculus)
Mammalia Rhoj 16 34 33
  • 87.85 (n)
(Gallus gallus)
Aves RHOJ 34 33
  • 82.94 (n)
(Anolis carolinensis)
Reptilia RHOJ 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhoj 33
  • 76.95 (n)
Str.13316 33
(Danio rerio)
Actinopterygii rhoj 34 33
  • 74.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoL 34
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC42 34
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10939 34
  • 52 (a)
CSA.6319 34
  • 50 (a)
Species where no ortholog for RHOJ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOJ Gene

Gene Tree for RHOJ (if available)
Gene Tree for RHOJ (if available)
Evolutionary constrained regions (ECRs) for RHOJ: view image

Paralogs for RHOJ Gene

Paralogs for RHOJ Gene

(42) SIMAP similar genes for RHOJ Gene using alignment to 3 proteins:

  • G3V476_HUMAN
  • G3V4H1_HUMAN
genes like me logo Genes that share paralogs with RHOJ: view

Variants for RHOJ Gene

Sequence variations from dbSNP and Humsavar for RHOJ Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000060517 -- 63,279,663(+) C/T intron_variant
rs1000060772 -- 63,225,068(+) C/G intron_variant
rs1000107560 -- 63,254,078(+) C/G intron_variant
rs1000114346 -- 63,210,439(+) C/A intron_variant
rs1000130187 -- 63,275,881(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RHOJ Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV gain 19592680
dgv398e199 CNV deletion 23128226
dgv87e55 CNV gain 17911159
esv2658318 CNV deletion 23128226
esv2748771 CNV deletion 23290073
esv28040 CNV loss 19812545
esv3551642 CNV deletion 23714750
esv3567910 CNV gain 25503493
esv3634722 CNV loss 21293372
esv6302 CNV gain 19470904
nsv1051684 CNV gain 25217958
nsv1153869 CNV deletion 26484159
nsv516899 CNV loss 19592680
nsv521404 CNV loss 19592680
nsv564893 CNV gain 21841781
nsv564894 CNV loss 21841781
nsv564895 CNV loss 21841781
nsv564896 CNV loss 21841781
nsv826963 CNV loss 20364138
nsv832815 CNV gain 17160897
nsv952850 CNV deletion 24416366
nsv957488 CNV deletion 24416366

Variation tolerance for RHOJ Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOJ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOJ Gene

Disorders for RHOJ Gene

MalaCards: The human disease database

(5) MalaCards diseases for RHOJ Gene - From: DISEASES

Disorder Aliases PubMed IDs
parasitic ichthyosporea infectious disease
  • infection by rhinosporidium seeberi
suppurative thyroiditis
  • acute suppurative thyroiditis
pediatric lymphoma
  • childhood lymphoma
lung lymphoma
  • lymphoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search RHOJ in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOJ

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RHOJ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOJ Gene

Publications for RHOJ Gene

  1. Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. (PMID: 10967094) Vignal E … Fort P (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RHOJ Gene

Sources for RHOJ Gene

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