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Aliases for RHOG Gene

Aliases for RHOG Gene

  • Ras Homolog Family Member G 2 3 5
  • Ras Homolog Gene Family, Member G (Rho G) 2 3
  • Rho-Related GTP-Binding Protein RhoG 3 4
  • ARHG 3 4

External Ids for RHOG Gene

Previous HGNC Symbols for RHOG Gene

  • ARHG

Previous GeneCards Identifiers for RHOG Gene

  • GC11M003813
  • GC11M003804
  • GC11M003581

Summaries for RHOG Gene

Entrez Gene Summary for RHOG Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

GeneCards Summary for RHOG Gene

RHOG (Ras Homolog Family Member G) is a Protein Coding gene. Diseases associated with RHOG include Tangier Disease and Oral Hairy Leukoplakia. Among its related pathways are Semaphorin Signaling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RHOG Gene

  • Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

Tocris Summary for RHOG Gene

  • Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.

Gene Wiki entry for RHOG Gene

Additional gene information for RHOG Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOG Gene

Genomics for RHOG Gene

GeneHancer (GH) Regulatory Elements for RHOG Gene

Promoters and enhancers for RHOG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RHOG gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXJ2
  • FOXJ2 (long isoform)
  • MAZR
  • MRF-2
  • NF-kappaB1
  • SRF
  • SRF (504 AA)

Genomic Locations for RHOG Gene

Genomic Locations for RHOG Gene
chr11:3,826,978-3,840,983
(GRCh38/hg38)
Size:
14,006 bases
Orientation:
Minus strand
chr11:3,848,208-3,862,213
(GRCh37/hg19)
Size:
14,006 bases
Orientation:
Minus strand

Genomic View for RHOG Gene

Genes around RHOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOG Gene

Proteins for RHOG Gene

  • Protein details for RHOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84095-RHOG_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoG
    Protein Accession:
    P84095
    Secondary Accessions:
    • P35238
    • Q8NI04

    Protein attributes for RHOG Gene

    Size:
    191 amino acids
    Molecular mass:
    21309 Da
    Quaternary structure:
    • Interacts with ARHGEF26. Interacts with ARHGEF16.

neXtProt entry for RHOG Gene

Post-translational modifications for RHOG Gene

  • Ubiquitination at isoforms=130 and posLast=147147
  • Modification sites at PhosphoSitePlus

Other Protein References for RHOG Gene

No data available for DME Specific Peptides for RHOG Gene

Domains & Families for RHOG Gene

Gene Families for RHOG Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RHOG Gene

Suggested Antigen Peptide Sequences for RHOG Gene

GenScript: Design optimal peptide antigens:
  • Ras homolog gene family, member G (Rho G), isoform CRA_a (Q6ICQ8_HUMAN)
  • Rho-related GTP-binding protein RhoG (RHOG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P84095

UniProtKB/Swiss-Prot:

RHOG_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOG: view

Function for RHOG Gene

Molecular function for RHOG Gene

UniProtKB/Swiss-Prot Function:
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

Phenotypes From GWAS Catalog for RHOG Gene

Gene Ontology (GO) - Molecular Function for RHOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 12376551
GO:0005515 protein binding IPI 12879077
GO:0005525 GTP binding IBA 21873635
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with RHOG: view
genes like me logo Genes that share phenotypes with RHOG: view

Animal Models for RHOG Gene

MGI Knock Outs for RHOG:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for RHOG - Now 50% OFF >
  • * RHOG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * RHOG tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOG Gene

Localization for RHOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOG Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOG gene
Compartment Confidence
cytosol 5
plasma membrane 4
endoplasmic reticulum 4
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RHOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA,TAS --
genes like me logo Genes that share ontologies with RHOG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOG Gene

Pathways & Interactions for RHOG Gene

genes like me logo Genes that share pathways with RHOG: view

Gene Ontology (GO) - Biological Process for RHOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA 21873635
GO:0007163 establishment or maintenance of cell polarity IBA 21873635
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IDA 12376551
GO:0008284 positive regulation of cell proliferation TAS 1620121
genes like me logo Genes that share ontologies with RHOG: view

No data available for SIGNOR curated interactions for RHOG Gene

Drugs & Compounds for RHOG Gene

(3) Drugs for RHOG Gene - From: ApexBio and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
EHop-016 Pharma Rac1/Rac3 GTPase inhibitor,potent and specific 0
NSC 23766 Pharma Selective inhibitor of Rac1-GEF interaction., Selective inhibitor of Rac1-GEF interaction; antioncogenic 0
QS 11 Pharma Wnt synergistic agonist, ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling 0

(5) Additional Compounds for RHOG Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Rac1 Inhibitor F56, control peptide
1315378-77-8
Rac1 Inhibitor W56
1095179-01-3
SecinH3
853625-60-2

(5) Tocris Compounds for RHOG Gene

Compound Action Cas Number
NSC 23766 Selective inhibitor of Rac1-GEF interaction; antioncogenic 1177865-17-6
QS 11 ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling 944328-88-5
Rac1 Inhibitor F56, control peptide Control peptide version of Rac1 Inhibitor W56 (Cat. No. 2221) 1315378-77-8
Rac1 Inhibitor W56 Selective inhibitor of Rac1-GEF interaction 1095179-01-3
SecinH3 Sec7-specific GEF inhibitor (cytohesins) 853625-60-2

(1) ApexBio Compounds for RHOG Gene

Compound Action Cas Number
EHop-016 Rac1/Rac3 GTPase inhibitor,potent and specific 1380432-32-5
genes like me logo Genes that share compounds with RHOG: view

Drug Products

Transcripts for RHOG Gene

mRNA/cDNA for RHOG Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(289) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for RHOG Gene

Ras homolog family member G:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for RHOG - Now 50% OFF >
  • * RHOG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * RHOG tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for RHOG Gene

No ASD Table

Relevant External Links for RHOG Gene

GeneLoc Exon Structure for
RHOG
ECgene alternative splicing isoforms for
RHOG

Expression for RHOG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOG Gene

This gene is overexpressed in Whole Blood (x24.6).

Protein differential expression in normal tissues from HIPED for RHOG Gene

This gene is overexpressed in Neutrophil (10.5), Tlymphocyte (8.7), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOG Gene



Protein tissue co-expression partners for RHOG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHOG Gene:

RHOG

SOURCE GeneReport for Unigene cluster for RHOG Gene:

Hs.501728

Evidence on tissue expression from TISSUES for RHOG Gene

  • Nervous system(4.6)
  • Blood(3.3)
  • Skin(2.7)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with RHOG: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOG Gene

Orthologs for RHOG Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOG 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOG 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOG 35 34
  • 93.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RHOG 35 34
  • 93.02 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhog 34
  • 91.8 (n)
mouse
(Mus musculus)
Mammalia Rhog 17 35 34
  • 90.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RHOG 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOG 35
  • 81 (a)
OneToOne
LOC100859599 34
  • 80.45 (n)
lizard
(Anolis carolinensis)
Reptilia RHOG 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489878 34
  • 75.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68933 34
zebrafish
(Danio rerio)
Actinopterygii rhoga 35
  • 73 (a)
OneToMany
rhogb 35 34
  • 72.6 (n)
OneToMany
wufk30f01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5267 34
fruit fly
(Drosophila melanogaster)
Insecta Rac1 35
  • 68 (a)
ManyToMany
Rac2 35
  • 67 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ced-10 35
  • 67 (a)
ManyToMany
Species where no ortholog for RHOG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOG Gene

ENSEMBL:
Gene Tree for RHOG (if available)
TreeFam:
Gene Tree for RHOG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOG: view image

Paralogs for RHOG Gene

Pseudogenes.org Pseudogenes for RHOG Gene

genes like me logo Genes that share paralogs with RHOG: view

Variants for RHOG Gene

Sequence variations from dbSNP and Humsavar for RHOG Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000052163 -- 3,827,227(-) A/G/T 3_prime_UTR_variant
rs1000080275 -- 3,831,892(-) C/A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000246406 -- 3,836,549(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000394994 -- 3,842,112(-) C/T upstream_transcript_variant
rs1000660146 -- 3,831,291(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RHOG Gene

Variant ID Type Subtype PubMed ID
nsv1070933 CNV deletion 25765185

Variation tolerance for RHOG Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOG
Human Gene Mutation Database (HGMD)
RHOG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOG Gene

Disorders for RHOG Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHOG Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
tangier disease
  • tgd
oral hairy leukoplakia
  • hairy leukoplakia
- elite association - COSMIC cancer census association via MalaCards
Search RHOG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RHOG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOG Gene

Publications for RHOG Gene

  1. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 45 58
  2. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. (PMID: 20679435) Hiramoto-Yamaki N … Katoh H (The Journal of cell biology 2010) 3 4 58
  3. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I … Robledo M (PLoS genetics 2009) 3 45 58
  4. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. (PMID: 17875742) van Buul JD … Burridge K (The Journal of cell biology 2007) 3 4 58
  5. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. (PMID: 15199069) Skowronek KR … Nassar N (The Journal of biological chemistry 2004) 3 23 58

Products for RHOG Gene

Sources for RHOG Gene

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