This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine... See more...

Aliases for RHOG Gene

Aliases for RHOG Gene

  • Ras Homolog Family Member G 2 3 5
  • Ras Homolog Gene Family, Member G (Rho G) 2 3
  • Rho-Related GTP-Binding Protein RhoG 3 4
  • ARHG 3 4
  • MGC125835 2
  • MGC125836 2
  • RHOG 5

External Ids for RHOG Gene

Previous HGNC Symbols for RHOG Gene

  • ARHG

Previous GeneCards Identifiers for RHOG Gene

  • GC11M003813
  • GC11M003804
  • GC11M003581

Summaries for RHOG Gene

Entrez Gene Summary for RHOG Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

GeneCards Summary for RHOG Gene

RHOG (Ras Homolog Family Member G) is a Protein Coding gene. Diseases associated with RHOG include Progressive Familial Heart Block, Type Ii and Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are p75 NTR receptor-mediated signalling and NGF Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot Summary for RHOG Gene

  • Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

Tocris Summary for RHOG Gene

  • Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.

Gene Wiki entry for RHOG Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOG Gene

Genomics for RHOG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RHOG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RHOG

Top Transcription factor binding sites by QIAGEN in the RHOG gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXJ2
  • FOXJ2 (long isoform)
  • MAZR
  • MRF-2
  • NF-kappaB1
  • SRF
  • SRF (504 AA)

Genomic Locations for RHOG Gene

Latest Assembly
chr11:3,826,978-3,840,959
(GRCh38/hg38)
Size:
13,982 bases
Orientation:
Minus strand

Previous Assembly
chr11:3,848,208-3,862,189
(GRCh37/hg19 by Entrez Gene)
Size:
13,982 bases
Orientation:
Minus strand

chr11:3,848,208-3,862,213
(GRCh37/hg19 by Ensembl)
Size:
14,006 bases
Orientation:
Minus strand

Genomic View for RHOG Gene

Genes around RHOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOG Gene

Proteins for RHOG Gene

  • Protein details for RHOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84095-RHOG_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoG
    Protein Accession:
    P84095
    Secondary Accessions:
    • P35238
    • Q8NI04

    Protein attributes for RHOG Gene

    Size:
    191 amino acids
    Molecular mass:
    21309 Da
    Quaternary structure:
    • Interacts with ARHGEF26. Interacts with ARHGEF16.

    Three dimensional structures from OCA and Proteopedia for RHOG Gene

neXtProt entry for RHOG Gene

Post-translational modifications for RHOG Gene

  • (Microbial infection) Glucosylated at Thr-35 by C.difficile toxin TcdB.
  • (Microbial infection) Glycosylated (O-GlcNAcylated) at Thr-35 by C.novyi toxin TcdA (PubMed:8810274). O-GlcNAcylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption (PubMed:8810274).
  • Glycosylation at Thr35
  • Ubiquitination at Lys130, Lys147, and Lys183
  • Modification sites at PhosphoSitePlus

Other Protein References for RHOG Gene

Antibodies for research

  • Abcam antibodies for RHOG
  • Boster Bio Antibodies for RHOG

No data available for DME Specific Peptides for RHOG Gene

Domains & Families for RHOG Gene

Gene Families for RHOG Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RHOG Gene

Suggested Antigen Peptide Sequences for RHOG Gene

GenScript: Design optimal peptide antigens:
  • Ras homolog gene family, member G (Rho G), isoform CRA_a (Q6ICQ8_HUMAN)
  • Rho-related GTP-binding protein RhoG (RHOG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P84095

UniProtKB/Swiss-Prot:

RHOG_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOG: view

Function for RHOG Gene

Molecular function for RHOG Gene

UniProtKB/Swiss-Prot Function:
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.

Phenotypes From GWAS Catalog for RHOG Gene

Gene Ontology (GO) - Molecular Function for RHOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IDA 12376551
GO:0005515 protein binding IPI 12879077
GO:0005525 GTP binding IBA 21873635
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with RHOG: view
genes like me logo Genes that share phenotypes with RHOG: view

Animal Models for RHOG Gene

MGI Knock Outs for RHOG:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOG Gene

Localization for RHOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOG Gene

Cell membrane. Lipid-anchor. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOG gene
Compartment Confidence
cytosol 5
plasma membrane 4
extracellular 4
cytoskeleton 4
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for RHOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with RHOG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOG Gene

Pathways & Interactions for RHOG Gene

PathCards logo

SuperPathways for RHOG Gene

SuperPathway Contained pathways
1 G-AlphaQ Signaling
.47
.47
.40
2 GPCR Pathway
.73
.62
.59
3 ERK Signaling
.61
.51
.49
4 Signaling by GPCR
5 Innate Immune System
genes like me logo Genes that share pathways with RHOG: view

Pathways by source for RHOG Gene

35 Qiagen pathways for RHOG Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C

Gene Ontology (GO) - Biological Process for RHOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA 21873635
GO:0007163 establishment or maintenance of cell polarity IBA 21873635
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IDA 12376551
GO:0008045 motor neuron axon guidance IBA 21873635
genes like me logo Genes that share ontologies with RHOG: view

No data available for SIGNOR curated interactions for RHOG Gene

Drugs & Compounds for RHOG Gene

(2) Drugs for RHOG Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NSC 23766 Pharma Selective inhibitor of Rac1-GEF interaction., Selective inhibitor of Rac1-GEF interaction; antioncogenic 0
QS 11 Pharma Wnt synergistic agonist, ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling 0

(5) Additional Compounds for RHOG Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Rac1 Inhibitor F56, control peptide
1315378-77-8
Rac1 Inhibitor W56
1095179-01-3
SecinH3
853625-60-2

(5) Tocris Compounds for RHOG Gene

Compound Action Cas Number
NSC 23766 Selective inhibitor of Rac1-GEF interaction; antioncogenic 1177865-17-6
QS 11 ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling 944328-88-5
Rac1 Inhibitor F56, control peptide Control peptide version of Rac1 Inhibitor W56 (Cat. No. 2221) 1315378-77-8
Rac1 Inhibitor W56 Selective inhibitor of Rac1-GEF interaction 1095179-01-3
SecinH3 Sec7-specific GEF inhibitor (cytohesins) 853625-60-2
genes like me logo Genes that share compounds with RHOG: view

Transcripts for RHOG Gene

mRNA/cDNA for RHOG Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOG

Alternative Splicing Database (ASD) splice patterns (SP) for RHOG Gene

No ASD Table

Relevant External Links for RHOG Gene

GeneLoc Exon Structure for
RHOG

Expression for RHOG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHOG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOG Gene

This gene is overexpressed in Whole Blood (x24.6).

Protein differential expression in normal tissues from HIPED for RHOG Gene

This gene is overexpressed in Neutrophil (10.5), Tlymphocyte (8.7), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOG Gene



Protein tissue co-expression partners for RHOG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RHOG

SOURCE GeneReport for Unigene cluster for RHOG Gene:

Hs.501728

Evidence on tissue expression from TISSUES for RHOG Gene

  • Nervous system(4.7)
  • Blood(3.6)
  • Skin(3.3)
  • Bone marrow(2.8)
  • Intestine(2.8)
  • Muscle(2.7)
  • Spleen(2.7)
  • Lymph node(2.7)
  • Liver(2.6)
  • Heart(2.5)
  • Lung(2.4)
  • Kidney(2.4)
  • Adrenal gland(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RHOG: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOG Gene

Orthologs for RHOG Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RHOG 30
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RHOG 30
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RHOG 29 30
  • 93.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RHOG 29 30
  • 93.02 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rhog 29
  • 91.8 (n)
Mouse
(Mus musculus)
Mammalia Rhog 29 16 30
  • 90.92 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RHOG 30
  • 89 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RHOG 30
  • 81 (a)
OneToOne
LOC100859599 29
  • 80.45 (n)
Lizard
(Anolis carolinensis)
Reptilia RHOG 30
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100489878 29
  • 75.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68933 29
Zebrafish
(Danio rerio)
Actinopterygii rhoga 30
  • 73 (a)
OneToMany
rhogb 29 30
  • 72.6 (n)
OneToMany
wufk30f01 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5267 29
Fruit Fly
(Drosophila melanogaster)
Insecta Rac1 30
  • 68 (a)
ManyToMany
Rac2 30
  • 67 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ced-10 30
  • 67 (a)
ManyToMany
Species where no ortholog for RHOG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RHOG Gene

ENSEMBL:
Gene Tree for RHOG (if available)
TreeFam:
Gene Tree for RHOG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOG: view image
Alliance of Genome Resources:
Additional Orthologs for RHOG

Paralogs for RHOG Gene

Pseudogenes.org Pseudogenes for RHOG Gene

genes like me logo Genes that share paralogs with RHOG: view

Variants for RHOG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RHOG Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
985151 Uncertain Significance: Inborn genetic diseases 3,828,104(-) C/T
NM_001665.4(RHOG):c.35G>A (p.Gly12Glu)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RHOG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RHOG Gene

Variant ID Type Subtype PubMed ID
nsv1070933 CNV deletion 25765185

Variation tolerance for RHOG Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOG Gene

Human Gene Mutation Database (HGMD)
RHOG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOG
Leiden Open Variation Database (LOVD)
RHOG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOG Gene

Disorders for RHOG Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHOG Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search RHOG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOG

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RHOG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOG Gene

Publications for RHOG Gene

  1. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. (PMID: 20679435) Hiramoto-Yamaki N … Katoh H (The Journal of cell biology 2010) 3 4
  2. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 40
  3. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I … Robledo M (PLoS genetics 2009) 3 40
  4. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. (PMID: 17875742) van Buul JD … Burridge K (The Journal of cell biology 2007) 3 4
  5. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. (PMID: 15199069) Skowronek KR … Nassar N (The Journal of biological chemistry 2004) 3 22

Products for RHOG Gene

Sources for RHOG Gene