Aliases for RHOG Gene
External Ids for RHOG Gene
Previous HGNC Symbols for RHOG Gene
Previous GeneCards Identifiers for RHOG Gene
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]
GeneCards Summary for RHOG Gene
RHOG (Ras Homolog Family Member G) is a Protein Coding gene. Diseases associated with RHOG include Progressive Familial Heart Block, Type Ii and Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are p75 NTR receptor-mediated signalling and NGF Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC2.
UniProtKB/Swiss-Prot Summary for RHOG Gene
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.