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RHOF (Ras Homolog Family Member F, Filopodia Associated) is a Protein Coding gene. Diseases associated with RHOF include Charcot-Marie-Tooth Disease, Axonal, Type 2L and Malaria. Among its related pathways are Innate Immune System and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOD.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003924 | GTPase activity | NAS,IEA | 11084341 |
GO:0005525 | GTP binding | IEA,IBA | 21873635 |
GO:0019901 | protein kinase binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IEA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0005856 | cytoskeleton | NAS | 11084341 |
GO:0005886 | plasma membrane | TAS,IBA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
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2 | p75 NTR receptor-mediated signalling |
.36
|
|
3 | Signaling by GPCR | ||
4 | Signaling by Rho GTPases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007015 | actin filament organization | IBA,IDA | 11084341 |
GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
GO:0007266 | Rho protein signal transduction | IBA | 21873635 |
GO:0008360 | regulation of cell shape | IBA | 21873635 |
GO:0016477 | cell migration | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine triphosphate | Experimental | Pharma | 0 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | RHOF 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | RHOF 33 32 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | RHOF 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | RHOF 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | RHOF 33 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Rhof 32 |
|
||
mouse (Mus musculus) |
Mammalia | Rhof 17 33 32 |
|
||
chicken (Gallus gallus) |
Aves | RHOF 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | RHOF 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rhof 32 |
|
||
Str.8197 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16583 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | rhof 33 32 |
|
OneToOne | |
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10985 32 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RHO1 33 |
|
OneToMany |
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000148507 | -- | 121,795,445(-) | G/A | upstream_transcript_variant | |
rs1000233999 | -- | 121,782,059(-) | C/T | intron_variant | |
rs1000284728 | -- | 121,781,892(-) | T/C | intron_variant | |
rs1000363191 | -- | 121,793,293(-) | T/C | intron_variant | |
rs1000372640 | -- | 121,791,770(-) | G/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2670889 | CNV | deletion | 23128226 |
esv2746493 | CNV | deletion | 23290073 |
esv2746494 | CNV | deletion | 23290073 |
esv2746495 | CNV | deletion | 23290073 |
esv3549897 | CNV | deletion | 23714750 |
esv3630958 | CNV | loss | 21293372 |
esv3892268 | CNV | loss | 25118596 |
nsv1160065 | CNV | deletion | 26073780 |
Disorder | Aliases | PubMed IDs |
---|---|---|
charcot-marie-tooth disease, axonal, type 2l |
|
|
malaria |
|