Aliases for RHOF Gene

Aliases for RHOF Gene

  • Ras Homolog Family Member F, Filopodia Associated 2 3 5
  • Rho In Filopodia 2 3 4
  • Ras Homolog Gene Family, Member F (In Filopodia) 2 3
  • Ras Homolog Family Member F (In Filopodia) 2 3
  • Rho-Related GTP-Binding Protein RhoF 3 4
  • Rho Family GTPase Rif 3 4
  • ARHF 3 4
  • RIF 3 4

External Ids for RHOF Gene

Previous HGNC Symbols for RHOF Gene

  • ARHF

Previous GeneCards Identifiers for RHOF Gene

  • GC12M120615
  • GC12M120678
  • GC12M120700
  • GC12M122215
  • GC12M119227

Summaries for RHOF Gene

GeneCards Summary for RHOF Gene

RHOF (Ras Homolog Family Member F, Filopodia Associated) is a Protein Coding gene. Diseases associated with RHOF include Charcot-Marie-Tooth Disease, Axonal, Type 2L and Malaria. Among its related pathways are Innate Immune System and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOD.

UniProtKB/Swiss-Prot Summary for RHOF Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.

Additional gene information for RHOF Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOF Gene

Genomics for RHOF Gene

GeneHancer (GH) Regulatory Elements for RHOF Gene

Promoters and enhancers for RHOF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RHOF gene promoter:
  • AREB6
  • HOXA5
  • Ik-3
  • Lmo2
  • MyoD
  • Olf-1
  • p53
  • USF-1
  • USF1

Genomic Locations for RHOF Gene

Genomic Locations for RHOF Gene
chr12:121,777,754-121,803,403
(GRCh38/hg38)
Size:
25,650 bases
Orientation:
Minus strand
chr12:122,215,660-122,241,309
(GRCh37/hg19)
Size:
25,650 bases
Orientation:
Minus strand

Genomic View for RHOF Gene

Genes around RHOF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOF Gene

Proteins for RHOF Gene

  • Protein details for RHOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH0-RHOF_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoF
    Protein Accession:
    Q9HBH0
    Secondary Accessions:
    • Q8WVB1
    • Q9NXH6

    Protein attributes for RHOF Gene

    Size:
    211 amino acids
    Molecular mass:
    23625 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RHOF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHOF Gene

Post-translational modifications for RHOF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOF Gene

No data available for DME Specific Peptides for RHOF Gene

Domains & Families for RHOF Gene

Gene Families for RHOF Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RHOF Gene

GenScript: Design optimal peptide antigens:
  • Rho in filopodia (RHOF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HBH0

UniProtKB/Swiss-Prot:

RHOF_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOF: view

Function for RHOF Gene

Molecular function for RHOF Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.

Phenotypes From GWAS Catalog for RHOF Gene

Gene Ontology (GO) - Molecular Function for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS,IEA 11084341
GO:0005525 GTP binding IEA,IBA 21873635
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with RHOF: view
genes like me logo Genes that share phenotypes with RHOF: view

Animal Models for RHOF Gene

MGI Knock Outs for RHOF:
  • Rhof Rhof<tm1.2Tac>

Animal Model Products

CRISPR Products

miRNA for RHOF Gene

miRTarBase miRNAs that target RHOF

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOF Gene

Localization for RHOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOF Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOF gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
extracellular 2
nucleus 2
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton NAS 11084341
GO:0005886 plasma membrane TAS,IBA --
genes like me logo Genes that share ontologies with RHOF: view

Pathways & Interactions for RHOF Gene

genes like me logo Genes that share pathways with RHOF: view

Pathways by source for RHOF Gene

Gene Ontology (GO) - Biological Process for RHOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA,IDA 11084341
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IBA 21873635
GO:0008360 regulation of cell shape IBA 21873635
GO:0016477 cell migration IBA 21873635
genes like me logo Genes that share ontologies with RHOF: view

No data available for SIGNOR curated interactions for RHOF Gene

Drugs & Compounds for RHOF Gene

(1) Drugs for RHOF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHOF: view

Transcripts for RHOF Gene

mRNA/cDNA for RHOF Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOF

Alternative Splicing Database (ASD) splice patterns (SP) for RHOF Gene

No ASD Table

Relevant External Links for RHOF Gene

GeneLoc Exon Structure for
RHOF
ECgene alternative splicing isoforms for
RHOF

Expression for RHOF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOF Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for RHOF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.1), Platelet (7.8), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOF Gene



Protein tissue co-expression partners for RHOF Gene

NURSA nuclear receptor signaling pathways regulating expression of RHOF Gene:

RHOF

SOURCE GeneReport for Unigene cluster for RHOF Gene:

Hs.644504

Evidence on tissue expression from TISSUES for RHOF Gene

  • Intestine(4.4)
  • Nervous system(3.7)
  • Lung(3.6)
  • Pancreas(2.7)
genes like me logo Genes that share expression patterns with RHOF: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOF Gene

Orthologs for RHOF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOF 33 32
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RHOF 33 32
  • 93.2 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOF 33
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOF 33 32
  • 90.94 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOF 33
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhof 32
  • 87.99 (n)
mouse
(Mus musculus)
Mammalia Rhof 17 33 32
  • 87.36 (n)
chicken
(Gallus gallus)
Aves RHOF 33 32
  • 69.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOF 33
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhof 32
  • 66.5 (n)
Str.8197 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.16583 32
zebrafish
(Danio rerio)
Actinopterygii rhof 33 32
  • 62.69 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10985 32
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 33
  • 48 (a)
OneToMany
Species where no ortholog for RHOF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOF Gene

ENSEMBL:
Gene Tree for RHOF (if available)
TreeFam:
Gene Tree for RHOF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOF: view image

Paralogs for RHOF Gene

(52) SIMAP similar genes for RHOF Gene using alignment to 5 proteins:

  • RHOF_HUMAN
  • F5GXB1_HUMAN
  • V9GY67_HUMAN
  • V9GYB3_HUMAN
  • V9GYQ1_HUMAN
genes like me logo Genes that share paralogs with RHOF: view

Variants for RHOF Gene

Sequence variations from dbSNP and Humsavar for RHOF Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000148507 -- 121,795,445(-) G/A upstream_transcript_variant
rs1000233999 -- 121,782,059(-) C/T intron_variant
rs1000284728 -- 121,781,892(-) T/C intron_variant
rs1000363191 -- 121,793,293(-) T/C intron_variant
rs1000372640 -- 121,791,770(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RHOF Gene

Variant ID Type Subtype PubMed ID
esv2670889 CNV deletion 23128226
esv2746493 CNV deletion 23290073
esv2746494 CNV deletion 23290073
esv2746495 CNV deletion 23290073
esv3549897 CNV deletion 23714750
esv3630958 CNV loss 21293372
esv3892268 CNV loss 25118596
nsv1160065 CNV deletion 26073780

Variation tolerance for RHOF Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOF Gene

Disorders for RHOF Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHOF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2l
  • cmt2l
malaria
  • malaria, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search RHOF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOF

genes like me logo Genes that share disorders with RHOF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOF Gene

Publications for RHOF Gene

  1. The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements. (PMID: 11084341) Ellis S … Mellor H (Current biology : CB 2000) 2 3 4 23 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  5. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. (PMID: 29656893) Gupta R … Choudhary C (Cell 2018) 3 56

Products for RHOF Gene

Sources for RHOF Gene