Aliases for RHOD Gene
External Ids for RHOD Gene
Previous HGNC Symbols for RHOD Gene
Previous GeneCards Identifiers for RHOD Gene
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for RHOD Gene
RHOD (Ras Homolog Family Member D) is a Protein Coding gene. Diseases associated with RHOD include Clostridium Difficile Colitis and Wiskott-Aldrich Syndrome. Among its related pathways are p75 NTR receptor-mediated signalling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOF.
UniProtKB/Swiss-Prot Summary for RHOD Gene
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.