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This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and... See more...
Aliases for RHOC Gene
Aliases for RHOC Gene
External Ids for RHOC Gene
- HGNC: 669
- Entrez Gene: 389
- Ensembl: ENSG00000155366
- OMIM: 165380
- UniProtKB: P08134
Previous HGNC Symbols for RHOC Gene
- ARH9
- ARHC
Previous GeneCards Identifiers for RHOC Gene
- GC01M112544
- GC01M112955
- GC01M113243
- GC01M111103
Summaries for RHOC Gene
-
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for RHOC Gene
RHOC (Ras Homolog Family Member C) is a Protein Coding gene. Diseases associated with RHOC include Breast Disease and Inflammatory Breast Carcinoma. Among its related pathways are Guidance Cues and Growth Cone Motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is RHOA.
UniProtKB/Swiss-Prot Summary for RHOC Gene
-
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
Additional gene information for RHOC Gene
- HGNC(669)
- Entrez Gene(389)
- Ensembl(ENSG00000155366)
- OMIM(165380)
- UniProtKB(P08134)
- Open Targets Platform(ENSG00000155366)
- Search for RHOC at DataMed
- Search for RHOC at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOC Gene
Genomics for RHOC Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RHOC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RHOC on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RHOC
- Top Transcription factor binding sites by QIAGEN in the RHOC gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- GR-alpha
- p53
Genomic Locations for RHOC Gene
Genomic Locations for RHOC Gene
- chr1:112,701,127-112,707,434
- (GRCh38/hg38)
- Size:
- 6,308 bases
- Orientation:
- Minus strand
- chr1:113,243,728-113,250,056
- (GRCh37/hg19)
- Size:
- 6,329 bases
- Orientation:
- Minus strand
Genomic View for RHOC Gene
Genes around RHOC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
RHOC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RHOC Gene
Proteins for RHOC Gene
-
Protein details for RHOC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08134-RHOC_HUMAN
- Recommended name:
- Rho-related GTP-binding protein RhoC
- Protein Accession:
- P08134
- B3KSW1
- Q6ICN3
Protein attributes for RHOC Gene
- Size:
- 193 amino acids
- Molecular mass:
- 22006 Da
- Quaternary structure:
-
- Interacts with RTKN (By similarity). Interacts with AKAP13 (PubMed:11546812). Interacts with DIAPH1 (PubMed:15864301). Interacts with PKN2 (PubMed:20974804). Interacts with ROCK1 and ROCK2 (PubMed:8816443). Interacts with ARHGDIA (PubMed:20400958). Interacts with RIPOR1 (PubMed:27807006).
Protein Expression for RHOC Gene
Post-translational modifications for RHOC Gene
- (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
-
Glycosylation at Tyr34
- NX_P08134 (NX_P08134-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RHOC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RHOC Antibody
- Novus Biologicals Antibodies for RHOC
-
Abcam antibodies for RHOC
- Invitrogen Antibodies for RHOC (AFLGC-RHOC)
-
Boster Bio Antibodies for RHOC
-
Santa Cruz Biotechnology (SCBT) Antibodies for RHOC
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RHOC
- Origene Custom Protein Services for RHOC
- ProSpec Recombinant Proteins for RHOC
-
Signalway Proteins for RHOC
-
Abcam proteins for RHOC
Assay Products
- antibodies-online: Show 11 available RHOC Elisa Kits ranked by validation data
- Compare Top RHOC Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for RHOC
-
Abcam assays for RHOC
No data available for DME Specific Peptides for RHOC Gene
Domains & Families for RHOC Gene
Gene Families for RHOC Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for RHOC Gene
- InterPro:
- Blocks:
-
- Transforming protein P21 RAS signature
- Ras small GTPase, Rho type
- ProtoNet:
Suggested Antigen Peptide Sequences for RHOC Gene
- GenScript: Design optimal peptide antigens:
-
- Rho cDNA clone 9 (RHOC_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08134- Family:
-
- Belongs to the small GTPase superfamily. Rho family.
Function for RHOC Gene
Molecular function for RHOC Gene
- UniProtKB/Swiss-Prot Function:
- Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
Phenotypes From GWAS Catalog for RHOC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 20974804 |
| GO:0005525 | GTP binding | IBA | 21873635 |
| GO:0019901 | protein kinase binding | IBA | 21873635 |
Phenotypes for RHOC Gene
- MGI mutant phenotypes for RHOC:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RHOC:
Animal Models for RHOC Gene
- MGI Knock Outs for RHOC:
-
- Rhoc Rhoc<tm1Mak>
Animal Model Products
-
Taconic Biosciences Mouse Models for RHOC
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RHOC - Select products 50% OFF >
- * RHOC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RHOC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RHOC
-
Santa Cruz Biotechnology (SCBT) CRISPR for RHOC
miRNA for RHOC Gene
- miRTarBase miRNAs that target RHOC
-
- hsa-miR-138-5p (MIRT000495)
- hsa-miR-372-3p (MIRT005932)
- hsa-miR-302b-3p (MIRT005933)
- rno-miR-10b-5p (MIRT006044)
- hsa-miR-124-3p (MIRT022794)
- hsa-miR-1-3p (MIRT023854)
- hsa-miR-455-3p (MIRT037911)
- hsa-miR-493-3p (MIRT052962)
- rno-miR-138-5p (MIRT438892)
- hsa-miR-7152-5p (MIRT554727)
- hsa-miR-3074-5p (MIRT554728)
- hsa-miR-6818-5p (MIRT554729)
- hsa-miR-6808-3p (MIRT554730)
- hsa-miR-568 (MIRT554731)
- hsa-miR-6807-5p (MIRT554732)
- hsa-miR-6867-5p (MIRT554733)
- hsa-miR-7973 (MIRT554734)
- hsa-miR-3650 (MIRT554735)
- hsa-miR-6131 (MIRT554736)
- hsa-miR-133a-5p (MIRT554737)
- hsa-miR-591 (MIRT554738)
- hsa-miR-3124-3p (MIRT554739)
- hsa-miR-7978 (MIRT554740)
- hsa-miR-4677-3p (MIRT554741)
- hsa-miR-1914-5p (MIRT554742)
- hsa-miR-512-3p (MIRT554743)
- hsa-miR-4796-3p (MIRT554744)
- hsa-miR-548ah-5p (MIRT554745)
- hsa-miR-3609 (MIRT554746)
- hsa-miR-340-5p (MIRT554747)
- hsa-miR-5590-3p (MIRT554748)
- hsa-miR-142-5p (MIRT554749)
- hsa-miR-526b-3p (MIRT554750)
- hsa-miR-20a-5p (MIRT554751)
- hsa-miR-93-5p (MIRT554752)
- hsa-miR-519d-3p (MIRT554753)
- hsa-miR-20b-5p (MIRT554754)
- hsa-miR-17-5p (MIRT554755)
- hsa-miR-106b-5p (MIRT554756)
- hsa-miR-106a-5p (MIRT554757)
- hsa-miR-520e (MIRT554758)
- hsa-miR-302a-3p (MIRT554759)
- hsa-miR-302c-3p (MIRT554760)
- hsa-miR-520d-3p (MIRT554761)
- hsa-miR-520c-3p (MIRT554762)
- hsa-miR-520b (MIRT554763)
- hsa-miR-520a-3p (MIRT554764)
- hsa-miR-373-3p (MIRT554765)
- hsa-miR-302e (MIRT554766)
- hsa-miR-302d-3p (MIRT554767)
- hsa-miR-493-5p (MIRT732963)
- hsa-miR-2110 (MIRT738913)
- hsa-miR-3121-5p (MIRT739975)
- hsa-miR-3150a-3p (MIRT740284)
- hsa-miR-3974 (MIRT743205)
- hsa-miR-4260 (MIRT743468)
- hsa-miR-4271 (MIRT743636)
- hsa-miR-450a-2-3p (MIRT745590)
- hsa-miR-4725-3p (MIRT747717)
- hsa-miR-4747-5p (MIRT748271)
- hsa-miR-501-5p (MIRT749530)
- hsa-miR-5196-5p (MIRT750055)
- hsa-miR-5572 (MIRT750913)
- hsa-miR-6763-5p (MIRT755026)
- hsa-miR-6780b-5p (MIRT755648)
- hsa-miR-6810-5p (MIRT756669)
- hsa-miR-6857-5p (MIRT757770)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RHOC
- Browse OriGene Inhibitory RNA Products For RHOC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOC
Clone Products
- Applied Biological Materials (abm): Clones for RHOC - Select products 50% OFF >
- * RHOC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201861
- MR201861
- MR201861L3
- MR201861L4
- MR228409
- RC200332
- RC200332L3
- RC200332L4
- RC208751
- RC208751L1
- RC208751L2
- RC208751L3
- RC208751L4
- RC217556
- RC217556L1
- RC217556L2
- RC217556L3
- RC217556L4
- RG200332
- RG208751
- RG217556
- RR211005
- RR211005L3
- RR211005L4
- MR201861L3V
- MR201861L4V
- RC200332L3V
- RC200332L4V
- RC208751L1V
- RC208751L2V
- RC208751L3V
- RC208751L4V
- RC217556L1V
- RC217556L2V
- RC217556L3V
- RC217556L4V
- RR211005L3V
- RR211005L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RHOC
- Addgene plasmids for RHOC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RHOC
Cell Line Products
-
Horizon Cell Lines for RHOC
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOC Gene
Localization for RHOC Gene
Subcellular locations from UniProtKB/Swiss-Prot for RHOC Gene
- Cell membrane. Lipid-anchor. Cytoplasmic side. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005938 | cell cortex | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOC Gene
Pathways & Interactions for RHOC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Semaphorin interactions | ||
| 2 | G-AlphaQ Signaling |
G-AlphaI Signaling
.47
G-AlphaQ Signaling
.47
|
Thrombin Signaling
.40
|
| 3 | GPCR Pathway |
Ras Pathway
.73
GPCR Pathway
.62
|
Pancreatic Adenocarcinoma
.59
|
| 4 | ERK Signaling |
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
|
ILK Signaling
.49
|
| 5 | Signaling by GPCR | ||
Pathways by source for RHOC Gene
2 BioSystems pathways for RHOC Gene
17 Reactome pathways for RHOC Gene
1 R&D Systems pathway for RHOC Gene
33 Qiagen pathways for RHOC Gene
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Activation of PKC through GPCR
- Antioxidant Action of Vitamin-C
1 Cell Signaling Technology pathway for RHOC Gene
Interacting Proteins for RHOC Gene
Selected Interacting proteins:
P08134-RHOC_HUMAN
ENSP00000285735
for RHOC Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RHOC
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000281 | mitotic cytokinesis | IDA | 16236794 |
| GO:0007015 | actin filament organization | IBA | 21873635 |
| GO:0007163 | establishment or maintenance of cell polarity | IBA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
Transcripts for RHOC Gene
mRNA/cDNA for RHOC Gene
- 3 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000285735 2199 nts (view in UCSC)
- ENST00000339083 1117 nts (view in UCSC)
- ENST00000369632 1026 nts (view in UCSC)
- ENST00000369633 1295 nts (view in UCSC)
- ENST00000369636 786 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RHOC - Select products 50% OFF >
- * RHOC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RHOC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RHOC
-
Santa Cruz Biotechnology (SCBT) CRISPR for RHOC
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RHOC
- Browse OriGene Inhibitory RNA Products For RHOC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOC
Clone Products
- Applied Biological Materials (abm): Clones for RHOC - Select products 50% OFF >
- * RHOC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201861
- MR201861
- MR201861L3
- MR201861L4
- MR228409
- RC200332
- RC200332L3
- RC200332L4
- RC208751
- RC208751L1
- RC208751L2
- RC208751L3
- RC208751L4
- RC217556
- RC217556L1
- RC217556L2
- RC217556L3
- RC217556L4
- RG200332
- RG208751
- RG217556
- RR211005
- RR211005L3
- RR211005L4
- MR201861L3V
- MR201861L4V
- RC200332L3V
- RC200332L4V
- RC208751L1V
- RC208751L2V
- RC208751L3V
- RC208751L4V
- RC217556L1V
- RC217556L2V
- RC217556L3V
- RC217556L4V
- RR211005L3V
- RR211005L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RHOC
- Addgene plasmids for RHOC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RHOC
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | · | 11f | · | 11g | · | 11h |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - |
Relevant External Links for RHOC Gene
- GeneLoc Exon Structure for
- RHOC
Expression for RHOC Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Liver (Hepatobiliary System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Brain (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOC Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RHOC
SOURCE GeneReport for Unigene cluster for RHOC Gene:
Hs.502659Evidence on tissue expression from TISSUES for RHOC Gene
- Nervous system(4.9)
- Skin(4.9)
- Eye(4.6)
- Intestine(3.8)
- Lung(3.7)
- Heart(3.6)
- Kidney(3.6)
- Muscle(3.5)
- Liver(3.3)
- Spleen(3)
- Lymph node(2.9)
- Stomach(2.9)
- Blood(2.8)
- Adrenal gland(2.7)
- Thyroid gland(2.7)
- Pancreas(2.6)
- Gall bladder(2.4)
- Bone marrow(2.2)
- Bone(2)
Primer Products
-
OriGene qPCR primer pairs for RHOC
-
OriGene qPCR primer pairs and template standards for RHOC
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOC Gene
Orthologs for RHOC Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RHOC 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RHOC 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RHOC 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RHOC 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rhoc 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rhoc 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RHOC 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RHOC 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rhoc 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rhoae 31 |
|
OneToMany | |
| rhoad 30 31 |
|
OneToMany | |||
| zgc64015 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1986 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005160 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rho1 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rho-1 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RHO1 31 |
|
OneToMany | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABR182W 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11308 31 |
|
OneToMany |
- Species where no ortholog for RHOC was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RHOC Gene
- ENSEMBL:
- Gene Tree for RHOC (if available)
- TreeFam:
- Gene Tree for RHOC (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RHOC: view image
Paralogs for RHOC Gene
Paralogs for RHOC Gene
(84) SIMAP similar genes for RHOC Gene using alignment to 8 proteins:
- RHOC_HUMAN
- E9PLA2_HUMAN
- E9PN11_HUMAN
- E9PQH6_HUMAN
- Q5JR05_HUMAN
- Q5JR06_HUMAN
- Q5JR07_HUMAN
- Q5JR08_HUMAN
- RHOA
- RHOB
- ARHA
- RHOF
- ARHE
- RHOQ
- RND3
- RHOD
- RAC3
- CDC42
- RHOU
- RND2
- RHOJ
- RHOG
- ARHG
- RAC2
- RHOV
- RAC1
- RHOH
- RND1
- ARHH
- RIT2
- RAB4B
- RAB2B
- RAB8B
- RAB35
- RAB43
- RAB31
- RAB21
- RAB19
- RAB30
- LOC51277
- RAB28
- RAB13
- RAP1B
- RAB15
- DKFZp686J07132
- c-bas/has
- RHOBTB1
- RAB8A
- RAB3A
- RAB5B
- RAB37
- RAB7A
- RHOBTB2
- RAB5C
- HRAS
- RALB
- RALA
- RAB10
- RAB6A
- RAB1A
- RAB3D
- RAB2A
- RAB1C
- RAB12
- KRAS
- DKFZp313C1541
- DIRAS1
- RAB34
- RAP1A
- RAB26
- RAB6B
- RAB1B
- TC4
- RHOT2
- RAB39B
- RANP1
- RAP2A
- RAB11A
- RAB11B
- RAN
- RAB44
- RAB40C
- RAB36
- RAB23
- RAP2C
- RAP2B
- DKFZp547A0616
- NRAS
- RAB6C
- RAB27A
- RAB18
- IFT27
Variants for RHOC Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RHOC Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11538959 | - | p.Asp120His |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2414426 | CNV | deletion | 18987734 |
| esv27061 | CNV | gain+loss | 19812545 |
| esv2716318 | CNV | deletion | 23290073 |
| esv2716329 | CNV | deletion | 23290073 |
| esv27598 | CNV | loss | 19812545 |
| nsv547566 | CNV | gain | 21841781 |
| nsv998794 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.26;
25.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RHOC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RHOC
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOC Gene
Disorders for RHOC Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast disease |
|
|
| inflammatory breast carcinoma |
|
|
| choriocarcinoma of ovary |
|
|
| epilepsy, idiopathic generalized 7 |
|
|
| tongue squamous cell carcinoma |
|
|
Search RHOC in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RHOC
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RHOC Gene
Publications for RHOC Gene
- The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. (PMID: 8816443) Leung T … Lim L (Molecular and cellular biology 1996) 3 4 23
- Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P … Tavitian A (Nucleic acids research 1988) 2 3 4
- RHO binding to FAM65A regulates Golgi reorientation during cell migration. (PMID: 27807006) Mardakheh FK … Marshall CJ (Journal of cell science 2016) 3 4
- The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. (PMID: 20974804) Wallace SW … Hall A (Molecular and cellular biology 2011) 3 4
- Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. (PMID: 20101212) Kitzing TM … Grosse R (Oncogene 2010) 3 23
ExternalLinks
Products for RHOC Gene
- Custom Antibody ServicesOriGene Antibodies for RHOC
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RHOC
- Origene Custom Protein Services for RHOC
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RHOC
- Browse OriGene Inhibitory RNA Products For RHOC
- OriGene qPCR primer pairs for RHOC
- OriGene qPCR primer pairs and template standards for RHOC
- OriGene CRISPR knockouts for RHOC
- MG201861
- MR201861
- MR201861L3
- MR201861L4
- MR228409
- RC200332
- RC200332L3
- RC200332L4
- RC208751
- RC208751L1
- RC208751L2
- RC208751L3
- RC208751L4
- RC217556
- RC217556L1
- RC217556L2
- RC217556L3
- RC217556L4
- RG200332
- RG208751
- RG217556
- RR211005
- RR211005L3
- RR211005L4
- MR201861L3V
- MR201861L4V
- RC200332L3V
- RC200332L4V
- RC208751L1V
- RC208751L2V
- RC208751L3V
- RC208751L4V
- RC217556L1V
- RC217556L2V
- RC217556L3V
- RC217556L4V
- RR211005L3V
- RR211005L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RHOC
- Sino Biological Human cDNA Clone for RHOC
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RHOC
- Novus Biologicals proteins and lysates for RHOC
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RHOC
- Abcam proteins for RHOC
- Abcam assays for RHOC
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for RHOC
- Taconic Biosciences Mouse Models for RHOC
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RHOC (AFLGC-RHOC)
- VectorBuilder Custom and pre-made DNA vectors for RHOC (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RHOC (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RHOC (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RHOC CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RHOC
- Addgene plasmids for RHOC
- antibodies-online: Show 20 available RHOC Antibodies ranked by validation data
- Compare Top RHOC Antibodies
- antibodies-online: Show 11 available RHOC Elisa Kits ranked by validation data
- Compare Top RHOC Elisa Kits
- Quality Products:
- antibodies-online: Show 18 available RHOC Proteins ranked by validation data
- Compare Top RHOC Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for RHOC
- Search Santa Cruz Biotechnology (SCBT) for RHOC siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RHOC
- Horizon Cell Lines for RHOC
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RHOC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RHOC
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RHOC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOC
- Boster Bio Antibodies for RHOC
- Browse Boster Bio ELISA Kits
Sources for RHOC Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB