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Aliases for RHOC Gene

Aliases for RHOC Gene

  • Ras Homolog Family Member C 2 3 5
  • Ras Homolog Gene Family, Member C 2 3
  • Rho CDNA Clone 9 3 4
  • ARH9 3 4
  • ARHC 3 4
  • H9 3 4
  • Rho-Related GTP-Binding Protein RhoC 3
  • Small GTP Binding Protein RhoC 3
  • RAS-Related Homolog 9 3
  • Oncogene RHO H9 3
  • RhoC GTPase 3
  • RHOH9 3

External Ids for RHOC Gene

Previous HGNC Symbols for RHOC Gene

  • ARH9
  • ARHC

Previous GeneCards Identifiers for RHOC Gene

  • GC01M112544
  • GC01M112955
  • GC01M113243
  • GC01M111103

Summaries for RHOC Gene

Entrez Gene Summary for RHOC Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RHOC Gene

RHOC (Ras Homolog Family Member C) is a Protein Coding gene. Diseases associated with RHOC include Breast Disease and Breast Cancer. Among its related pathways are ERK Signaling and Signaling events mediated by PRL. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RHOC Gene

  • Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Gene Wiki entry for RHOC Gene

Additional gene information for RHOC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOC Gene

Genomics for RHOC Gene

GeneHancer (GH) Regulatory Elements for RHOC Gene

Promoters and enhancers for RHOC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J112696 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 656.5 +5.0 4981 11.2 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 MEF2D RHOC PIR32287 PIR38214 ST7L LOC100421402 LRIG2 DDX20 SLC16A1-AS1 CAPZA1 WNT2B
GH01J112617 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 +87.1 87121 6.2 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ST7L CAPZA1 LOC100421402 LRIG2 KCND3-AS1 DDX20 RPS15P1 LOC105378910 MOV10 ENSG00000225075
GH01J113040 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -334.9 -334906 4.1 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF766 ZNF143 DEK REST LRIG2 LOC100996251 SLC16A1 RHOC PPM1J RPS15P1 GC01P113034 PIRC4 SLC16A1-AS1
GH01J112816 Enhancer 1.4 Ensembl ENCODE dbSUPER 11 -112.3 -112335 6.8 HDGF PKNOX1 ATF1 ARNT FEZF1 ZNF2 TCF12 ZNF766 GLIS2 GATA2 GC01P112820 LRIG2 LOC100421402 ST7L PPM1J RHOC LOC100996251 ENSG00000225075 MOV10 KCND3
GH01J112807 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.4 -101.4 -101424 3.5 HDGF RB1 SIN3A ZNF2 RAD21 ARID2 EGR1 ZNF143 ATF7 DEK PPM1J RHOC LOC100421402 HP08777 GC01P112820 GC01M112752
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RHOC gene promoter:
  • c-Jun
  • ATF-2
  • p53
  • AP-1
  • GR-alpha

Genomic Locations for RHOC Gene

Genomic Locations for RHOC Gene
6,329 bases
Minus strand
6,329 bases
Minus strand

Genomic View for RHOC Gene

Genes around RHOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOC Gene

Proteins for RHOC Gene

  • Protein details for RHOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related GTP-binding protein RhoC
    Protein Accession:
    Secondary Accessions:
    • B3KSW1
    • Q6ICN3

    Protein attributes for RHOC Gene

    193 amino acids
    Molecular mass:
    22006 Da
    Quaternary structure:
    • Interacts with RTKN (By similarity). Interacts with AKAP13 (PubMed:11546812). Interacts with DIAPH1 (PubMed:15864301). Interacts with PKN2 (PubMed:20974804). Interacts with ROCK1 and ROCK2 (PubMed:8816443). Interacts with ARHGDIA (PubMed:20400958). Interacts with RIPOR1 (PubMed:27807006).

    Three dimensional structures from OCA and Proteopedia for RHOC Gene

neXtProt entry for RHOC Gene

Post-translational modifications for RHOC Gene

  • (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RHOC Gene

Domains & Families for RHOC Gene

Gene Families for RHOC Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RHOC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rho family.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOC: view

Function for RHOC Gene

Molecular function for RHOC Gene

UniProtKB/Swiss-Prot Function:
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Phenotypes From GWAS Catalog for RHOC Gene

Gene Ontology (GO) - Molecular Function for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0004871 obsolete signal transducer activity HMP --
GO:0005515 protein binding IPI 20974804
GO:0005525 GTP binding IEA --
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with RHOC: view
genes like me logo Genes that share phenotypes with RHOC: view

Animal Models for RHOC Gene

MGI Knock Outs for RHOC:

Animal Model Products

  • Taconic Biosciences Mouse Models for RHOC

miRNA for RHOC Gene

miRTarBase miRNAs that target RHOC

Clone Products

  • Addgene plasmids for RHOC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOC Gene

Localization for RHOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOC Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOC gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
nucleus 4
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOC Gene

Pathways & Interactions for RHOC Gene

genes like me logo Genes that share pathways with RHOC: view

SIGNOR curated interactions for RHOC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IDA 16236794
GO:0007015 actin filament organization IBA --
GO:0007163 establishment or maintenance of cell polarity IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RHOC: view

Drugs & Compounds for RHOC Gene

(3) Additional Compounds for RHOC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHOC: view

Transcripts for RHOC Gene

mRNA/cDNA for RHOC Gene

Unigene Clusters for RHOC Gene

Ras homolog family member C:
Representative Sequences:

Clone Products

  • Addgene plasmids for RHOC

Alternative Splicing Database (ASD) splice patterns (SP) for RHOC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - -
SP11: - - - -

Relevant External Links for RHOC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RHOC Gene

This gene is overexpressed in Brain (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOC Gene

Protein tissue co-expression partners for RHOC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHOC Gene:


SOURCE GeneReport for Unigene cluster for RHOC Gene:


Evidence on tissue expression from TISSUES for RHOC Gene

  • Nervous system(4.9)
  • Skin(4.8)
  • Eye(4.4)
  • Lung(3.6)
  • Intestine(3.1)
  • Heart(3)
  • Kidney(2.9)
  • Liver(2.7)
  • Muscle(2.6)
  • Lymph node(2.3)
  • Gall bladder(2)
  • Spleen(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RHOC: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOC Gene

Orthologs for RHOC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHOC 34 33
  • 99.48 (n)
(Monodelphis domestica)
Mammalia RHOC 34
  • 99 (a)
(Bos Taurus)
Mammalia RHOC 34 33
  • 93.44 (n)
(Canis familiaris)
Mammalia RHOC 34 33
  • 93.09 (n)
(Rattus norvegicus)
Mammalia Rhoc 33
  • 92.57 (n)
(Mus musculus)
Mammalia Rhoc 16 34 33
  • 92.06 (n)
(Gallus gallus)
Aves RHOC 34 33
  • 85.15 (n)
(Anolis carolinensis)
Reptilia RHOC 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhoc 33
  • 77.2 (n)
(Danio rerio)
Actinopterygii rhoae 34
  • 93 (a)
rhoad 34 33
  • 77.2 (n)
zgc64015 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1986 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005160 33
  • 72.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rho1 34 33
  • 72.16 (n)
(Caenorhabditis elegans)
Secernentea rho-1 34 33
  • 70.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 34
  • 65 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR182W 33
  • 62.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11308 34
  • 82 (a)
Species where no ortholog for RHOC was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOC Gene

Gene Tree for RHOC (if available)
Gene Tree for RHOC (if available)
Evolutionary constrained regions (ECRs) for RHOC: view image

Paralogs for RHOC Gene

Paralogs for RHOC Gene

genes like me logo Genes that share paralogs with RHOC: view

Variants for RHOC Gene

Sequence variations from dbSNP and Humsavar for RHOC Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000114216 -- 112,701,137(-) C/T 3_prime_UTR_variant
rs1000726231 -- 112,702,707(-) C/T intron_variant
rs1000856088 -- 112,708,992(-) T/C upstream_transcript_variant
rs1001048596 -- 112,705,054(-) T/G intron_variant
rs1001391725 -- 112,705,417(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RHOC Gene

Variant ID Type Subtype PubMed ID
esv2414426 CNV deletion 18987734
esv27061 CNV gain+loss 19812545
esv2716318 CNV deletion 23290073
esv2716329 CNV deletion 23290073
esv27598 CNV loss 19812545
nsv547566 CNV gain 21841781
nsv998794 CNV gain 25217958

Variation tolerance for RHOC Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOC Gene

Disorders for RHOC Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHOC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast disease
  • abnormality of the breast
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search RHOC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOC

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RHOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOC Gene

Publications for RHOC Gene

  1. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. (PMID: 8816443) Leung T … Lim L (Molecular and cellular biology 1996) 3 4 22 58
  2. Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P … Tavitian A (Nucleic acids research 1988) 2 3 4 58
  3. RHO binding to FAM65A regulates Golgi reorientation during cell migration. (PMID: 27807006) Mardakheh FK … Marshall CJ (Journal of cell science 2016) 3 4 58
  4. The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. (PMID: 20974804) Wallace SW … Hall A (Molecular and cellular biology 2011) 3 4 58
  5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 44 58

Products for RHOC Gene

Sources for RHOC Gene

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