This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and... See more...

Aliases for RHOC Gene

Aliases for RHOC Gene

  • Ras Homolog Family Member C 2 3 5
  • Rho-Related GTP-Binding Protein RhoC 3 4
  • Ras Homolog Gene Family, Member C 2 3
  • Rho CDNA Clone 9 3 4
  • ARH9 3 4
  • ARHC 3 4
  • H9 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Small GTP Binding Protein RhoC 3
  • RAS-Related Homolog 9 3
  • Oncogene RHO H9 3
  • RhoC GTPase 3
  • RHOH9 3
  • RHOC 5

External Ids for RHOC Gene

Previous HGNC Symbols for RHOC Gene

  • ARH9
  • ARHC

Previous GeneCards Identifiers for RHOC Gene

  • GC01M112544
  • GC01M112955
  • GC01M113243
  • GC01M111103

Summaries for RHOC Gene

Entrez Gene Summary for RHOC Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RHOC Gene

RHOC (Ras Homolog Family Member C) is a Protein Coding gene. Diseases associated with RHOC include Breast Disease and Inflammatory Breast Carcinoma. Among its related pathways are Guidance Cues and Growth Cone Motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot Summary for RHOC Gene

  • Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Gene Wiki entry for RHOC Gene

Additional gene information for RHOC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOC Gene

Genomics for RHOC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RHOC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RHOC

Top Transcription factor binding sites by QIAGEN in the RHOC gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • GR-alpha
  • p53

Genomic Locations for RHOC Gene

Genomic Locations for RHOC Gene
chr1:112,701,127-112,707,434
(GRCh38/hg38)
Size:
6,308 bases
Orientation:
Minus strand
chr1:113,243,728-113,250,056
(GRCh37/hg19)
Size:
6,329 bases
Orientation:
Minus strand

Genomic View for RHOC Gene

Genes around RHOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOC Gene

Proteins for RHOC Gene

  • Protein details for RHOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08134-RHOC_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoC
    Protein Accession:
    P08134
    Secondary Accessions:
    • B3KSW1
    • Q6ICN3

    Protein attributes for RHOC Gene

    Size:
    193 amino acids
    Molecular mass:
    22006 Da
    Quaternary structure:
    • Interacts with RTKN (By similarity). Interacts with AKAP13 (PubMed:11546812). Interacts with DIAPH1 (PubMed:15864301). Interacts with PKN2 (PubMed:20974804). Interacts with ROCK1 and ROCK2 (PubMed:8816443). Interacts with ARHGDIA (PubMed:20400958). Interacts with RIPOR1 (PubMed:27807006).

    Three dimensional structures from OCA and Proteopedia for RHOC Gene

neXtProt entry for RHOC Gene

Post-translational modifications for RHOC Gene

  • (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
  • Glycosylation at Tyr34
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RHOC Gene

Domains & Families for RHOC Gene

Gene Families for RHOC Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RHOC Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
  • Ras small GTPase, Rho type
ProtoNet:

Suggested Antigen Peptide Sequences for RHOC Gene

GenScript: Design optimal peptide antigens:
  • Rho cDNA clone 9 (RHOC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08134

UniProtKB/Swiss-Prot:

RHOC_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOC: view

Function for RHOC Gene

Molecular function for RHOC Gene

UniProtKB/Swiss-Prot Function:
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Phenotypes From GWAS Catalog for RHOC Gene

Gene Ontology (GO) - Molecular Function for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA 21873635
GO:0005515 protein binding IPI 20974804
GO:0005525 GTP binding IBA 21873635
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with RHOC: view
genes like me logo Genes that share phenotypes with RHOC: view

Animal Models for RHOC Gene

MGI Knock Outs for RHOC:

Animal Model Products

  • Taconic Biosciences Mouse Models for RHOC

CRISPR Products

miRNA for RHOC Gene

miRTarBase miRNAs that target RHOC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOC

Clone Products

  • Addgene plasmids for RHOC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOC Gene

Localization for RHOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOC Gene

Cell membrane. Lipid-anchor. Cytoplasmic side. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOC gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 3
nucleus 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0005938 cell cortex IBA 21873635
genes like me logo Genes that share ontologies with RHOC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOC Gene

Pathways & Interactions for RHOC Gene

PathCards logo

SuperPathways for RHOC Gene

SuperPathway Contained pathways
1 Semaphorin interactions
2 G-AlphaQ Signaling
.47
.47
.40
3 GPCR Pathway
.73
.62
.59
4 ERK Signaling
.61
.51
.49
5 Signaling by GPCR
genes like me logo Genes that share pathways with RHOC: view

Pathways by source for RHOC Gene

33 Qiagen pathways for RHOC Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C
1 Cell Signaling Technology pathway for RHOC Gene

SIGNOR curated interactions for RHOC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IDA 16236794
GO:0007015 actin filament organization IBA 21873635
GO:0007163 establishment or maintenance of cell polarity IBA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RHOC: view

Drugs & Compounds for RHOC Gene

(3) Additional Compounds for RHOC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHOC: view

Transcripts for RHOC Gene

mRNA/cDNA for RHOC Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOC

Clone Products

  • Addgene plasmids for RHOC

Alternative Splicing Database (ASD) splice patterns (SP) for RHOC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - -
SP11: - - - -

Relevant External Links for RHOC Gene

GeneLoc Exon Structure for
RHOC

Expression for RHOC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RHOC Gene

This gene is overexpressed in Brain (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOC Gene



Protein tissue co-expression partners for RHOC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RHOC

SOURCE GeneReport for Unigene cluster for RHOC Gene:

Hs.502659

Evidence on tissue expression from TISSUES for RHOC Gene

  • Nervous system(4.9)
  • Skin(4.9)
  • Eye(4.6)
  • Intestine(3.8)
  • Lung(3.7)
  • Heart(3.6)
  • Kidney(3.6)
  • Muscle(3.5)
  • Liver(3.3)
  • Spleen(3)
  • Lymph node(2.9)
  • Stomach(2.9)
  • Blood(2.8)
  • Adrenal gland(2.7)
  • Thyroid gland(2.7)
  • Pancreas(2.6)
  • Gall bladder(2.4)
  • Bone marrow(2.2)
  • Bone(2)
genes like me logo Genes that share expression patterns with RHOC: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOC Gene

Orthologs for RHOC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RHOC 30 31
  • 99.48 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RHOC 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RHOC 30 31
  • 93.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RHOC 30 31
  • 93.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rhoc 30
  • 92.57 (n)
Mouse
(Mus musculus)
Mammalia Rhoc 30 17 31
  • 92.06 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RHOC 30 31
  • 85.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RHOC 31
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rhoc 30
  • 77.2 (n)
Zebrafish
(Danio rerio)
Actinopterygii rhoae 31
  • 93 (a)
OneToMany
rhoad 30 31
  • 77.2 (n)
OneToMany
zgc64015 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1986 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005160 30
  • 72.87 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Rho1 30 31
  • 72.16 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rho-1 30 31
  • 70.49 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 31
  • 65 (a)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABR182W 30
  • 62.81 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11308 31
  • 82 (a)
OneToMany
Species where no ortholog for RHOC was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RHOC Gene

ENSEMBL:
Gene Tree for RHOC (if available)
TreeFam:
Gene Tree for RHOC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOC: view image

Paralogs for RHOC Gene

genes like me logo Genes that share paralogs with RHOC: view

Variants for RHOC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RHOC Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11538959 - p.Asp120His

Additional dbSNP identifiers (rs#s) for RHOC Gene

Structural Variations from Database of Genomic Variants (DGV) for RHOC Gene

Variant ID Type Subtype PubMed ID
esv2414426 CNV deletion 18987734
esv27061 CNV gain+loss 19812545
esv2716318 CNV deletion 23290073
esv2716329 CNV deletion 23290073
esv27598 CNV loss 19812545
nsv547566 CNV gain 21841781
nsv998794 CNV gain 25217958

Variation tolerance for RHOC Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOC Gene

Disorders for RHOC Gene

MalaCards: The human disease database

(10) MalaCards diseases for RHOC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast disease
  • breast diseases
inflammatory breast carcinoma
  • inflammatory carcinoma of breast
choriocarcinoma of ovary
  • ovarian choriocarcinoma
epilepsy, idiopathic generalized 7
  • epilepsy, idiopathic generalized, susceptibility to, 7
tongue squamous cell carcinoma
  • squamous cell carcinoma of tongue
- elite association - COSMIC cancer census association via MalaCards
Search RHOC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RHOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOC Gene

Publications for RHOC Gene

  1. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. (PMID: 8816443) Leung T … Lim L (Molecular and cellular biology 1996) 3 4 23
  2. Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P … Tavitian A (Nucleic acids research 1988) 2 3 4
  3. RHO binding to FAM65A regulates Golgi reorientation during cell migration. (PMID: 27807006) Mardakheh FK … Marshall CJ (Journal of cell science 2016) 3 4
  4. The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. (PMID: 20974804) Wallace SW … Hall A (Molecular and cellular biology 2011) 3 4
  5. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. (PMID: 20101212) Kitzing TM … Grosse R (Oncogene 2010) 3 23

Products for RHOC Gene

  • Signalway ELISA kits for RHOC
  • Signalway Proteins for RHOC

Sources for RHOC Gene