Aliases for RHOBTB3 Gene
External Ids for RHOBTB3 Gene
Previous GeneCards Identifiers for RHOBTB3 Gene
RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM, Apr 2004]
GeneCards Summary for RHOBTB3 Gene
RHOBTB3 (Rho Related BTB Domain Containing 3) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include GTP binding and Rab GTPase binding. An important paralog of this gene is RAC1.
UniProtKB/Swiss-Prot Summary for RHOBTB3 Gene
Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.