Aliases for RHOB Gene
External Ids for RHOB Gene
Previous HGNC Symbols for RHOB Gene
Previous GeneCards Identifiers for RHOB Gene
GeneCards Summary for RHOB Gene
RHOB (Ras Homolog Family Member B) is a Protein Coding gene. Diseases associated with RHOB include Lung Cancer and Clostridium Difficile Colitis. Among its related pathways are Androgen receptor signaling pathway and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RHOA.
UniProtKB/Swiss-Prot Summary for RHOB Gene
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.