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Aliases for RHOB Gene
Aliases for RHOB Gene
External Ids for RHOB Gene
- HGNC: 668
- Entrez Gene: 388
- Ensembl: ENSG00000143878
- OMIM: 165370
- UniProtKB: P62745
Previous HGNC Symbols for RHOB Gene
- ARH6
- ARHB
Previous GeneCards Identifiers for RHOB Gene
- GC02P020632
- GC02P020568
- GC02P020510
- GC02P020404
- GC02P020646
Summaries for RHOB Gene
GeneCards Summary for RHOB Gene
RHOB (Ras Homolog Family Member B) is a Protein Coding gene. Diseases associated with RHOB include Pancreatic Adenocarcinoma and Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are Guidance Cues and Growth Cone Motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RHOA.
UniProtKB/Swiss-Prot Summary for RHOB Gene
-
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Additional gene information for RHOB Gene
- HGNC(668)
- Entrez Gene(388)
- Ensembl(ENSG00000143878)
- OMIM(165370)
- UniProtKB(P62745)
- Open Targets Platform(ENSG00000143878)
- Search for RHOB at DataMed
- Search for RHOB at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOB Gene
Genomics for RHOB Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RHOB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RHOB on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RHOB
- Top Transcription factor binding sites by QIAGEN in the RHOB gene promoter:
-
- AP-1
- AP-2alpha
- AP-2alphaA
- AP-2beta
- ATF-2
- c-Jun
- CREB
- deltaCREB
- GR
- GR-alpha
Genomic Locations for RHOB Gene
Genomic Locations for RHOB Gene
- chr2:20,447,074-20,449,440
- (GRCh38/hg38)
- Size:
- 2,367 bases
- Orientation:
- Plus strand
- chr2:20,646,835-20,649,201
- (GRCh37/hg19)
- Size:
- 2,367 bases
- Orientation:
- Plus strand
Genomic View for RHOB Gene
Genes around RHOB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p24.1 by HGNC
- 2p24.1 by Entrez Gene
- 2p24.1 by Ensembl
RHOB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RHOB Gene
Proteins for RHOB Gene
-
Protein details for RHOB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62745-RHOB_HUMAN
- Recommended name:
- Rho-related GTP-binding protein RhoB
- Protein Accession:
- P62745
- B2R692
- P01121
- Q5U0H6
- Q7RTN5
- Q7RTR9
- Q9CUV7
Protein attributes for RHOB Gene
- Size:
- 196 amino acids
- Molecular mass:
- 22123 Da
- Quaternary structure:
-
- Binds ROCK1 and ROCK2 (By similarity). Also binds PKN1/PRK1 (PubMed:9478917). Interacts with ARGGEF3 (PubMed:12221096). Interacts with RTKN (By similarity). Interacts with AKAP13 (PubMed:11546812). Interacts with RIPOR1 (PubMed:27807006).
- Miscellaneous:
-
- RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.
Protein Expression for RHOB Gene
Post-translational modifications for RHOB Gene
- Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
- (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
-
Glycosylation at Tyr34
- NX_P62745 (NX_P62745-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RHOB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences RHOB Antibody
- G Biosciences Immunotag™ RHOB Antibody
- NSJ Bioreagents RHOB Antibody
-
Custom Antibody ServicesOriGene Antibodies for RHOB
- Novus Biologicals Antibodies for RHOB
-
Abcam antibodies for RHOB
- Invitrogen Antibodies for RHOB (AFLGC-RHOB)
- antibodies-online: Show 19 available RHOB Antibodies ranked by validation data
-
Biorbyt antibodies for RHOB
-
Santa Cruz Biotechnology (SCBT) Antibodies for RHOB
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RHOB
- Origene Custom Protein Services for RHOB
- ProSpec Recombinant Proteins for RHOB
- antibodies-online: Search results for available RHOB related products ranked by validation data
-
Abcam proteins for RHOB
Assay Products
- antibodies-online: Search results for available RHOB related products ranked by validation data
-
Abcam assays for RHOB
No data available for DME Specific Peptides for RHOB Gene
Domains & Families for RHOB Gene
Gene Families for RHOB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for RHOB Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RHOB Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92847, Homo sapiens ras homolog gene family, member B (ARHB), mRNA (B2R692_HUMAN)
- MSTP081 (Q7Z4F6_HUMAN)
- Rho cDNA clone 6 (RHOB_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62745- Family:
-
- Belongs to the small GTPase superfamily. Rho family.
Function for RHOB Gene
Molecular function for RHOB Gene
- UniProtKB/Swiss-Prot Function:
- Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR).
Phenotypes From GWAS Catalog for RHOB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | IBA,TAS | 3888408 |
| GO:0005515 | protein binding | IPI | 19637314 |
| GO:0005525 | GTP binding | IBA,TAS | 1400319 |
| GO:0019003 | GDP binding | IEA | -- |
Phenotypes for RHOB Gene
- MGI mutant phenotypes for RHOB:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RHOB:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Decreased viability
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased cell migration
- Increased shRNA abundance
- Decreased shRNA abundance (Z-score < -2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased HPV16-GFP infection
- Negative genetic interaction between PTEN-/- and PTEN+/+
Animal Models for RHOB Gene
- MGI Knock Outs for RHOB:
-
- Rhob Rhob<tm1Gcp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RHOB - Select products 50% OFF >
- * RHOB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RHOB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RHOB
-
Santa Cruz Biotechnology (SCBT) CRISPR for RHOB
miRNA for RHOB Gene
- miRTarBase miRNAs that target RHOB
-
- hsa-miR-223-3p (MIRT001109)
- hsa-let-7b-5p (MIRT001599)
- hsa-miR-21-5p (MIRT003317)
- hsa-miR-335-5p (MIRT016875)
- hsa-miR-30a-5p (MIRT028477)
- hsa-miR-421 (MIRT039419)
- hsa-let-7c-5p (MIRT439149)
- hsa-miR-218-5p (MIRT439771)
- hsa-miR-4446-5p (MIRT469236)
- hsa-miR-5006-3p (MIRT469237)
- hsa-miR-4755-5p (MIRT469238)
- hsa-miR-2053 (MIRT469239)
- hsa-miR-642a-5p (MIRT469240)
- hsa-miR-6801-5p (MIRT469241)
- hsa-miR-6086 (MIRT469242)
- hsa-miR-377-5p (MIRT469243)
- hsa-miR-655-5p (MIRT469244)
- hsa-miR-627-3p (MIRT469245)
- hsa-miR-6845-3p (MIRT469246)
- hsa-miR-2276-5p (MIRT469247)
- hsa-miR-6892-3p (MIRT469248)
- hsa-miR-153-5p (MIRT469249)
- hsa-miR-1250-3p (MIRT469250)
- hsa-miR-6513-3p (MIRT469251)
- hsa-miR-2115-3p (MIRT469252)
- hsa-miR-6882-5p (MIRT469253)
- hsa-miR-595 (MIRT469254)
- hsa-miR-548t-5p (MIRT469255)
- hsa-miR-548az-5p (MIRT469256)
- hsa-miR-548n (MIRT469257)
- hsa-miR-548x-3p (MIRT469258)
- hsa-miR-548j-3p (MIRT469259)
- hsa-miR-548aq-3p (MIRT469260)
- hsa-miR-548am-3p (MIRT469261)
- hsa-miR-548aj-3p (MIRT469262)
- hsa-miR-548ah-3p (MIRT469263)
- hsa-miR-548ae-3p (MIRT469264)
- hsa-miR-548z (MIRT469265)
- hsa-miR-548h-3p (MIRT469266)
- hsa-miR-548d-3p (MIRT469267)
- hsa-miR-548bb-3p (MIRT469268)
- hsa-miR-548ac (MIRT469269)
- hsa-miR-527 (MIRT469270)
- hsa-miR-518a-5p (MIRT469271)
- hsa-miR-7849-3p (MIRT469272)
- hsa-miR-494-3p (MIRT469273)
- hsa-miR-6507-5p (MIRT469274)
- hsa-miR-7-2-3p (MIRT469275)
- hsa-miR-7-1-3p (MIRT469276)
- hsa-miR-186-5p (MIRT469277)
- hsa-miR-19b-3p (MIRT469278)
- hsa-miR-19a-3p (MIRT469279)
- hsa-miR-3614-3p (MIRT554768)
- hsa-miR-590-3p (MIRT554769)
- hsa-miR-6083 (MIRT566010)
- hsa-miR-3163 (MIRT566011)
- hsa-miR-4282 (MIRT566012)
- hsa-miR-6749-3p (MIRT614494)
- hsa-miR-4469 (MIRT614495)
- hsa-miR-5193 (MIRT614496)
- hsa-miR-4667-3p (MIRT614497)
- hsa-miR-1470 (MIRT614498)
- hsa-miR-5196-3p (MIRT614499)
- hsa-miR-3180-3p (MIRT740784)
- hsa-miR-3180 (MIRT740824)
- hsa-miR-3196 (MIRT741082)
- hsa-miR-3675-5p (MIRT742139)
- hsa-miR-4649-5p (MIRT746500)
- hsa-miR-6729-5p (MIRT753963)
- hsa-miR-6816-5p (MIRT756810)
- hsa-miR-1908-5p (MIRT763238)
- hsa-miR-342-5p (MIRT765753)
- hsa-miR-4651 (MIRT770737)
- hsa-miR-4664-5p (MIRT770817)
- hsa-miR-4787-5p (MIRT772344)
- hsa-miR-489-5p (MIRT772690)
- hsa-miR-5089-3p (MIRT773232)
- hsa-miR-6087 (MIRT775695)
- hsa-miR-608 (MIRT775763)
- hsa-miR-663a (MIRT777499)
- hsa-miR-6737-5p (MIRT778097)
- hsa-miR-6742-5p (MIRT778168)
- hsa-miR-6747-5p (MIRT778319)
- hsa-miR-6752-5p (MIRT778360)
- hsa-miR-6756-5p (MIRT778405)
- hsa-miR-6766-5p (MIRT778560)
- hsa-miR-6787-5p (MIRT779220)
- hsa-miR-6812-5p (MIRT779777)
- hsa-miR-6819-5p (MIRT779856)
- hsa-miR-6842-5p (MIRT780210)
- hsa-miR-7110-5p (MIRT781436)
- hsa-miR-92a-2-5p (MIRT782664)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RHOB
- Browse OriGene Inhibitory RNA Products For RHOB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOB
Clone Products
- Applied Biological Materials (abm): Clones for RHOB - Select products 50% OFF >
- * RHOB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RHOB
- Addgene plasmids for RHOB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RHOB
Cell Line Products
-
Horizon Cell Lines for RHOB
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOB Gene
Localization for RHOB Gene
Subcellular locations from UniProtKB/Swiss-Prot for RHOB Gene
- Late endosome membrane. Lipid-anchor. Cell membrane. Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | IEA | -- |
| GO:0005770 | late endosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOB Gene
Pathways & Interactions for RHOB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Semaphorin interactions | ||
| 2 | G-AlphaQ Signaling |
G-AlphaI Signaling
.47
G-AlphaQ Signaling
.47
|
Thrombin Signaling
.40
|
| 3 | GPCR Pathway |
Ras Pathway
.73
GPCR Pathway
.62
|
Pancreatic Adenocarcinoma
.59
|
| 4 | ERK Signaling |
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
|
ILK Signaling
.49
|
| 5 | Signaling by GPCR | ||
Pathways by source for RHOB Gene
4 BioSystems pathways for RHOB Gene
20 Reactome pathways for RHOB Gene
1 KEGG pathway for RHOB Gene
1 GeneGo (Thomson Reuters) pathway for RHOB Gene
- G-protein signaling_RhoB regulation pathway
1 R&D Systems pathway for RHOB Gene
33 Qiagen pathways for RHOB Gene
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Activation of PKC through GPCR
- Antioxidant Action of Vitamin-C
1 Cell Signaling Technology pathway for RHOB Gene
Interacting Proteins for RHOB Gene
Selected Interacting proteins:
P62745-RHOB_HUMAN
ENSP00000272233
for RHOB Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RHOB
SIGNOR curated interactions for RHOB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000281 | mitotic cytokinesis | IMP | 16236794 |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0006886 | intracellular protein transport | IEA | -- |
| GO:0006915 | apoptotic process | TAS | 19637314 |
| GO:0007015 | actin filament organization | IBA | 21873635 |
Drugs & Compounds for RHOB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| botulinum toxin type a | Approved, Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for RHOB Gene
mRNA/cDNA for RHOB Gene
- 1 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000272233 2367 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RHOB - Select products 50% OFF >
- * RHOB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RHOB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RHOB
-
Santa Cruz Biotechnology (SCBT) CRISPR for RHOB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RHOB
- Browse OriGene Inhibitory RNA Products For RHOB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOB
Clone Products
- Applied Biological Materials (abm): Clones for RHOB - Select products 50% OFF >
- * RHOB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RHOB
- Addgene plasmids for RHOB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RHOB
Relevant External Links for RHOB Gene
- GeneLoc Exon Structure for
- RHOB
Expression for RHOB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Gonad
- Primordial Germ Cell Precursors Epiblast
- Primordial Germ Cells Allantois
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for RHOB Gene
This gene is overexpressed in Artery - Tibial (x4.6).
This gene is overexpressed in Frontal cortex (21.9), Brain (19.9), and Fetal Brain (10.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOB Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RHOB
SOURCE GeneReport for Unigene cluster for RHOB Gene:
Hs.502876Evidence on tissue expression from TISSUES for RHOB Gene
- Nervous system(5)
- Kidney(4.8)
- Intestine(3.9)
- Lung(3.9)
- Liver(3.8)
- Muscle(3.6)
- Pancreas(3.6)
- Heart(3.6)
- Blood(3.3)
- Skin(3.2)
- Adrenal gland(3.1)
- Stomach(3)
- Eye(3)
- Spleen(2.9)
- Lymph node(2.7)
- Bone marrow(2.6)
- Thyroid gland(2.6)
- Gall bladder(2)
Primer Products
-
OriGene qPCR primer pairs for RHOB
-
OriGene qPCR primer pairs and template standards for RHOB
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOB Gene
Orthologs for RHOB Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RHOB 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RHOB 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RHOB 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rhob 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rhob 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RHOB 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | CRHOB 31 |
|
OneToOne | |
| RHOB 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | RHOB 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rhob 30 |
|
||
| Str.7519 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | rhoac 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rho1 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rho-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RHO1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11308 31 |
|
OneToMany |
- Species where no ortholog for RHOB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RHOB Gene
- ENSEMBL:
- Gene Tree for RHOB (if available)
- TreeFam:
- Gene Tree for RHOB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RHOB: view image
Paralogs for RHOB Gene
Paralogs for RHOB Gene
(54) SIMAP similar genes for RHOB Gene using alignment to 1 proteins:
- RHOB_HUMAN
- RHOA
- RHOC
- ARHA
- ARHE
- RHOD
- RND3
- RHOF
- CDC42
- RND2
- RHOG
- ARHG
- RHOU
- RAC3
- RHOV
- RHOJ
- RHOQ
- RAC2
- RAC1
- RND1
- RHOH
- ARHH
- RAB21
- RAB33B
- RHOBTB2
- RAB35
- RAB11B
- RAB11A
- RAB10
- RAB37
- RAB2B
- RAB2A
- RAB15
- DKFZp313C1541
- RAB13
- RAP1B
- RHOBTB1
- RAB8B
- RAB8A
- RAB19
- KRAS
- HRAS
- RAB30
- RAP2B
- RAP2A
- RALA
- RAB26
- RAB1C
- RAB1B
- RAB1A
- RAB18
- DKFZp547A0616
- RAP1A
- RALB
- RAP2C
Variants for RHOB Gene
Residual Variation Intolerance Score:
35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RHOB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RHOB Gene
Disorders for RHOB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatic adenocarcinoma |
|
|
| cardiomyopathy, familial hypertrophic, 1 |
|
|
| breast cancer |
|
|
| hypercholesterolemia, familial, 4 |
|
|
| lung cancer |
|
Search RHOB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RHOB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RHOB Gene
Publications for RHOB Gene
- RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. (PMID: 16278215) Canguilhem B … Favre G (The Journal of biological chemistry 2005) 2 3 23
- XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PMID: 12221096) Arthur WT … Wennerberg K (The Journal of biological chemistry 2002) 3 4 23
- PRK1 is targeted to endosomes by the small GTPase, RhoB. (PMID: 9478917) Mellor H … Parker PJ (The Journal of biological chemistry 1998) 3 4 23
- CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. (PMID: 7713879) Armstrong SA … Brown MS (The Journal of biological chemistry 1995) 3 4 23
- Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P … Tavitian A (Nucleic acids research 1988) 2 3 4
ExternalLinks
Products for RHOB Gene
- Custom Antibody ServicesOriGene Antibodies for RHOB
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RHOB
- Origene Custom Protein Services for RHOB
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- Browse OriGene Inhibitory RNA Products For RHOB
- OriGene qPCR primer pairs for RHOB
- OriGene qPCR primer pairs and template standards for RHOB
- OriGene CRISPR knockouts for RHOB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RHOB
- Sino Biological Human cDNA Clone for RHOB
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RHOB
- Novus Biologicals proteins and lysates for RHOB
- Browse Antibodies
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- Abcam antibodies for RHOB
- Abcam proteins for RHOB
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- VectorBuilder Custom and pre-made DNA vectors for RHOB (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RHOB (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RHOB (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RHOB CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RHOB
- Addgene plasmids for RHOB
- antibodies-online: Show 19 available RHOB Antibodies ranked by validation data
- antibodies-online: Search results for available RHOB related products ranked by validation data
- antibodies-online: Search results for available RHOB related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for RHOB
- Search Santa Cruz Biotechnology (SCBT) for RHOB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RHOB
- Horizon Cell Lines for RHOB
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RHOB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RHOB
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RHOB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOB
- Biorbyt antibodies for RHOB
Sources for RHOB Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB