Free for academic non-profit institutions. Other users need a Commercial license
RHOB (Ras Homolog Family Member B) is a Protein Coding gene. Diseases associated with RHOB include Pancreatic Adenocarcinoma and Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are Guidance Cues and Growth Cone Motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RHOA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IBA,TAS | 3888408 |
GO:0005515 | protein binding | IPI | 19637314 |
GO:0005525 | GTP binding | IBA,TAS | 1400319 |
GO:0019003 | GDP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005768 | endosome | IEA | -- |
GO:0005769 | early endosome | IEA | -- |
GO:0005770 | late endosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Semaphorin interactions | ||
2 | G-AlphaQ Signaling |
G-AlphaI Signaling
.47
G-AlphaQ Signaling
.47
|
Thrombin Signaling
.40
|
3 | GPCR Pathway |
Ras Pathway
.73
GPCR Pathway
.62
|
Pancreatic Adenocarcinoma
.59
|
4 | ERK Signaling |
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
|
ILK Signaling
.49
|
5 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000281 | mitotic cytokinesis | IMP | 16236794 |
GO:0001525 | angiogenesis | IEA | -- |
GO:0006886 | intracellular protein transport | IEA | -- |
GO:0006915 | apoptotic process | TAS | 19637314 |
GO:0007015 | actin filament organization | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
botulinum toxin type a | Approved, Investigational | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RHOB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RHOB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RHOB 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rhob 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rhob 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RHOB 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | CRHOB 31 |
|
OneToOne | |
RHOB 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | RHOB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rhob 30 |
|
||
Str.7519 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | rhoac 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Rho1 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | rho-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RHO1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11308 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
pancreatic adenocarcinoma |
|
|
cardiomyopathy, familial hypertrophic, 1 |
|
|
breast cancer |
|
|
hypercholesterolemia, familial, 4 |
|
|
lung cancer |
|