Aliases for RHOB Gene

Aliases for RHOB Gene

  • Ras Homolog Family Member B 2 3 5
  • Rho-Related GTP-Binding Protein RhoB 3 4
  • Ras Homolog Gene Family, Member B 2 3
  • Rho CDNA Clone 6 3 4
  • Oncogene RHO H6 2 3
  • MST081 2 3
  • RHOH6 2 3
  • ARH6 3 4
  • ARHB 3 4
  • H6 3 4
  • Aplysia RAS-Related Homolog 6 3
  • MSTP081 3
  • RHOB 5

External Ids for RHOB Gene

Previous HGNC Symbols for RHOB Gene

  • ARH6
  • ARHB

Previous GeneCards Identifiers for RHOB Gene

  • GC02P020632
  • GC02P020568
  • GC02P020510
  • GC02P020404
  • GC02P020646

Summaries for RHOB Gene

GeneCards Summary for RHOB Gene

RHOB (Ras Homolog Family Member B) is a Protein Coding gene. Diseases associated with RHOB include Pancreatic Adenocarcinoma and Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are Guidance Cues and Growth Cone Motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot Summary for RHOB Gene

  • Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

Gene Wiki entry for RHOB Gene

Additional gene information for RHOB Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOB Gene

Genomics for RHOB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RHOB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RHOB

Top Transcription factor binding sites by QIAGEN in the RHOB gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • GR
  • GR-alpha

Genomic Locations for RHOB Gene

Genomic Locations for RHOB Gene
chr2:20,447,074-20,449,440
(GRCh38/hg38)
Size:
2,367 bases
Orientation:
Plus strand
chr2:20,646,835-20,649,201
(GRCh37/hg19)
Size:
2,367 bases
Orientation:
Plus strand

Genomic View for RHOB Gene

Genes around RHOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOB Gene

Proteins for RHOB Gene

  • Protein details for RHOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62745-RHOB_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoB
    Protein Accession:
    P62745
    Secondary Accessions:
    • B2R692
    • P01121
    • Q5U0H6
    • Q7RTN5
    • Q7RTR9
    • Q9CUV7

    Protein attributes for RHOB Gene

    Size:
    196 amino acids
    Molecular mass:
    22123 Da
    Quaternary structure:
    • Binds ROCK1 and ROCK2 (By similarity). Also binds PKN1/PRK1 (PubMed:9478917). Interacts with ARGGEF3 (PubMed:12221096). Interacts with RTKN (By similarity). Interacts with AKAP13 (PubMed:11546812). Interacts with RIPOR1 (PubMed:27807006).
    Miscellaneous:
    • RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.

    Three dimensional structures from OCA and Proteopedia for RHOB Gene

neXtProt entry for RHOB Gene

Post-translational modifications for RHOB Gene

  • Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
  • (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
  • Glycosylation at Tyr34
  • Modification sites at PhosphoSitePlus

Other Protein References for RHOB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOB Gene

Domains & Families for RHOB Gene

Gene Families for RHOB Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RHOB Gene

Suggested Antigen Peptide Sequences for RHOB Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92847, Homo sapiens ras homolog gene family, member B (ARHB), mRNA (B2R692_HUMAN)
  • MSTP081 (Q7Z4F6_HUMAN)
  • Rho cDNA clone 6 (RHOB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62745

UniProtKB/Swiss-Prot:

RHOB_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOB: view

Function for RHOB Gene

Molecular function for RHOB Gene

UniProtKB/Swiss-Prot Function:
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR).

Phenotypes From GWAS Catalog for RHOB Gene

Gene Ontology (GO) - Molecular Function for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA,TAS 3888408
GO:0005515 protein binding IPI 19637314
GO:0005525 GTP binding IBA,TAS 1400319
GO:0019003 GDP binding IEA --
genes like me logo Genes that share ontologies with RHOB: view
genes like me logo Genes that share phenotypes with RHOB: view

Animal Models for RHOB Gene

MGI Knock Outs for RHOB:

Animal Model Products

CRISPR Products

miRNA for RHOB Gene

miRTarBase miRNAs that target RHOB

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOB Gene

Localization for RHOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOB Gene

Late endosome membrane. Lipid-anchor. Cell membrane. Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOB gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endosome 5
cytosol 5
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IBA 21873635
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005770 late endosome IEA --
genes like me logo Genes that share ontologies with RHOB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOB Gene

Pathways & Interactions for RHOB Gene

PathCards logo

SuperPathways for RHOB Gene

SuperPathway Contained pathways
1 Semaphorin interactions
2 G-AlphaQ Signaling
.47
.47
.40
3 GPCR Pathway
.73
.62
.59
4 ERK Signaling
.61
.51
.49
5 Signaling by GPCR
genes like me logo Genes that share pathways with RHOB: view

Pathways by source for RHOB Gene

1 KEGG pathway for RHOB Gene
1 GeneGo (Thomson Reuters) pathway for RHOB Gene
  • G-protein signaling_RhoB regulation pathway
1 R&D Systems pathway for RHOB Gene
33 Qiagen pathways for RHOB Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C
1 Cell Signaling Technology pathway for RHOB Gene

SIGNOR curated interactions for RHOB Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 16236794
GO:0001525 angiogenesis IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006915 apoptotic process TAS 19637314
GO:0007015 actin filament organization IBA 21873635
genes like me logo Genes that share ontologies with RHOB: view

Drugs & Compounds for RHOB Gene

(9) Drugs for RHOB Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
botulinum toxin type a Approved, Investigational Pharma Target 0

(10) Additional Compounds for RHOB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHOB: view

Transcripts for RHOB Gene

mRNA/cDNA for RHOB Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOB

Alternative Splicing Database (ASD) splice patterns (SP) for RHOB Gene

No ASD Table

Relevant External Links for RHOB Gene

GeneLoc Exon Structure for
RHOB

Expression for RHOB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOB Gene

This gene is overexpressed in Artery - Tibial (x4.6).

Protein differential expression in normal tissues from HIPED for RHOB Gene

This gene is overexpressed in Frontal cortex (21.9), Brain (19.9), and Fetal Brain (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOB Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RHOB

SOURCE GeneReport for Unigene cluster for RHOB Gene:

Hs.502876

Evidence on tissue expression from TISSUES for RHOB Gene

  • Nervous system(5)
  • Kidney(4.8)
  • Intestine(3.9)
  • Lung(3.9)
  • Liver(3.8)
  • Muscle(3.6)
  • Pancreas(3.6)
  • Heart(3.6)
  • Blood(3.3)
  • Skin(3.2)
  • Adrenal gland(3.1)
  • Stomach(3)
  • Eye(3)
  • Spleen(2.9)
  • Lymph node(2.7)
  • Bone marrow(2.6)
  • Thyroid gland(2.6)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with RHOB: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOB Gene

Orthologs for RHOB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RHOB 30 31
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RHOB 30 31
  • 96.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RHOB 30 31
  • 96.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rhob 30
  • 95.07 (n)
Mouse
(Mus musculus)
Mammalia Rhob 30 17 31
  • 94.9 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RHOB 31
  • 92 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 78 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves CRHOB 31
  • 97 (a)
OneToOne
RHOB 30
  • 90.31 (n)
Lizard
(Anolis carolinensis)
Reptilia RHOB 31
  • 93 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rhob 30
  • 84.69 (n)
Str.7519 30
Zebrafish
(Danio rerio)
Actinopterygii rhoac 31
  • 84 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Rho1 31
  • 82 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rho-1 31
  • 80 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 31
  • 60 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11308 31
  • 79 (a)
OneToMany
Species where no ortholog for RHOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RHOB Gene

ENSEMBL:
Gene Tree for RHOB (if available)
TreeFam:
Gene Tree for RHOB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOB: view image

Paralogs for RHOB Gene

Variants for RHOB Gene

Additional dbSNP identifiers (rs#s) for RHOB Gene

Structural Variations from Database of Genomic Variants (DGV) for RHOB Gene

Variant ID Type Subtype PubMed ID
dgv56n68 CNV loss 17160897
esv29979 CNV loss 17803354
nsv455830 CNV loss 19166990
nsv482049 CNV gain 20164927
nsv581166 CNV loss 21841781

Variation tolerance for RHOB Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOB Gene

Human Gene Mutation Database (HGMD)
RHOB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RHOB Gene

Disorders for RHOB Gene

MalaCards: The human disease database

(7) MalaCards diseases for RHOB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatic adenocarcinoma
  • adenocarcinoma of the pancreas
cardiomyopathy, familial hypertrophic, 1
  • fhc
breast cancer
  • breast lobular carcinoma
hypercholesterolemia, familial, 4
  • fhcl4
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search RHOB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RHOB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOB Gene

Publications for RHOB Gene

  1. RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. (PMID: 16278215) Canguilhem B … Favre G (The Journal of biological chemistry 2005) 2 3 23
  2. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PMID: 12221096) Arthur WT … Wennerberg K (The Journal of biological chemistry 2002) 3 4 23
  3. PRK1 is targeted to endosomes by the small GTPase, RhoB. (PMID: 9478917) Mellor H … Parker PJ (The Journal of biological chemistry 1998) 3 4 23
  4. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. (PMID: 7713879) Armstrong SA … Brown MS (The Journal of biological chemistry 1995) 3 4 23
  5. Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P … Tavitian A (Nucleic acids research 1988) 2 3 4

Products for RHOB Gene

Sources for RHOB Gene