This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferati... See more...

Aliases for RHOA Gene

Aliases for RHOA Gene

  • Ras Homolog Family Member A 2 3 5
  • Transforming Protein RhoA 3 4
  • ARH12 3 4
  • RHO12 3 4
  • ARHA 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Ras Homolog Gene Family, Member A 2
  • Aplysia Ras-Related Homolog 12 3
  • Small GTP Binding Protein RhoA 3
  • Rho CDNA Clone 12 4
  • Oncogene RHO H12 3
  • EC 3.6.5.2 4
  • RHOH12 3
  • H12 4

External Ids for RHOA Gene

Previous HGNC Symbols for RHOA Gene

  • ARH12
  • ARHA

Previous GeneCards Identifiers for RHOA Gene

  • GC03M049357
  • GC03M049371
  • GC03M049397

Summaries for RHOA Gene

Entrez Gene Summary for RHOA Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

CIViC Summary for RHOA Gene

GeneCards Summary for RHOA Gene

RHOA (Ras Homolog Family Member A) is a Protein Coding gene. Diseases associated with RHOA include Adenocarcinoma and Peripheral T-Cell Lymphoma. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Non-Canonical Wnt Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and myosin binding. An important paralog of this gene is RHOC.

UniProtKB/Swiss-Prot Summary for RHOA Gene

  • Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:8910519, PubMed:9121475). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:16236794, PubMed:12900402). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity).
  • (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague.

Gene Wiki entry for RHOA Gene

Additional gene information for RHOA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOA Gene

Genomics for RHOA Gene

GeneHancer (GH) Regulatory Elements for RHOA Gene

Promoters and enhancers for RHOA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049408 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 -0.3 -334 9.9 SP1 CTCF LCORL RBPJ POLR2A NR2F6 MYC NFYC ETV6 ELF1 AMT RHOA TCTA lnc-RHOA-1 QRICH1 ATRIP CCDC71 SEMA3F-AS1 RBM5 USP19
GH03J049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.7 +67.2 67197 16 ZNF785 ZNF24 SP1 ZBTB40 CTCF LCORL MLX RBPJ SMARCE1 POLR2A USP4 lnc-TCTA-3 AMT QRICH1 ENSG00000235236 RBM5 IP6K2 RBM6 ATRIP WDR6
GH03J049269 Enhancer 0.5 Ensembl ENCODE 10.5 +142.3 142342 3.3 ZIC2 ATF2 ENSG00000199546 AMT WDR6 CCDC36 C3orf84 KLHDC8B CCDC71 DAG1 RNA5SP130 LAMB2
GH03J049265 Enhancer 0.5 Ensembl ENCODE 10.5 +146.7 146667 2.6 ZC3H11A ZFP64 WDR6 QRICH1 AMT RBM5 RBM6 SEMA3F-AS1 NME6 IP6K2 USP19 ATRIP
GH03J049237 Enhancer 1.3 FANTOM5 ENCODE 3.4 +173.8 173797 2.9 ZBTB40 SMARCE1 RUNX1 MYC CC2D1A NFYC ELF1 HLF L3MBTL2 MAX WDR6 AMT RBM5 RBM6 QRICH1 LAMB2 ZNF589 SEMA3F-AS1 ENSG00000235236 USP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RHOA gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • GR
  • GR-alpha
  • GR-beta
  • PPAR-gamma2
  • STAT5A

Genomic Locations for RHOA Gene

Genomic Locations for RHOA Gene
chr3:49,359,136-49,412,998
(GRCh38/hg38)
Size:
53,863 bases
Orientation:
Minus strand
chr3:49,396,578-49,450,431
(GRCh37/hg19)
Size:
53,854 bases
Orientation:
Minus strand

Genomic View for RHOA Gene

Genes around RHOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOA Gene

Proteins for RHOA Gene

  • Protein details for RHOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61586-RHOA_HUMAN
    Recommended name:
    Transforming protein RhoA
    Protein Accession:
    P61586
    Secondary Accessions:
    • P06749
    • Q53HM4
    • Q5U024
    • Q9UDJ0
    • Q9UEJ4

    Protein attributes for RHOA Gene

    Size:
    193 amino acids
    Molecular mass:
    21768 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with ARHGEF28 (By similarity). Interacts (via GTP-bound form) with RIPOR1 (via N-terminus); this interaction links RHOA to STK24 and STK26 kinases (PubMed:27807006). Interacts with RIPOR2 (via active GTP- or inactive GDP-bound forms) isoform 1 and isoform 2; these interactions are direct, block the loading of GTP to RHOA and decrease upon chemokine CCL19 stimulation in primary T lymphocytes (PubMed:25588844). Binds PRKCL1, ROCK1 and ROCK2 (PubMed:10388627, PubMed:8617235, PubMed:8641286). Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN (PubMed:10940294, PubMed:12221096, PubMed:9857026). Interacts with PLCE1 and AKAP13 (PubMed:11696353, PubMed:12900402). Interacts with DIAPH1 (PubMed:23325789). Interacts (in the constitutively activated, GTP-bound form) with DGKQ (PubMed:10066731). Interacts with RACK1; enhances RHOA activation (PubMed:20499158). Interacts with PKP4; the interaction is detected at the midbody (PubMed:17115030). Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2 (PubMed:20974804, PubMed:9121475). Interacts with ARHGDIA; this interaction inactivates and stabilizes RHOA (PubMed:20400958). Interacts with ARHGDIB. Interacts (GTP-bound form) with KCNA2 (via cytoplasmic N-terminal domain) (PubMed:9635436).
    • (Microbial infection) Interacts with yopT from Yersinia pestis.
    • (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation.

    Three dimensional structures from OCA and Proteopedia for RHOA Gene

neXtProt entry for RHOA Gene

Post-translational modifications for RHOA Gene

  • (Microbial infection) Substrate for botulinum ADP-ribosyltransferase.
  • (Microbial infection) Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage.
  • (Microbial infection) AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
  • (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
  • Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling (PubMed:11162591). Phosphorylation by SLK at Ser-188 in response to AGTR2 activation (By similarity).
  • Ubiquitinated by the BCR(KCTD13) and BCR(TNFAIP1) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and synaptic transmission in neurons.
  • Glycosylation at Tyr34
  • Ubiquitination at Lys135
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for RHOA

No data available for DME Specific Peptides for RHOA Gene

Domains & Families for RHOA Gene

Gene Families for RHOA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RHOA Gene

Suggested Antigen Peptide Sequences for RHOA Gene

GenScript: Design optimal peptide antigens:
  • ARHA protein (Q9BVT0_HUMAN)
  • Rho cDNA clone 12 (RHOA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61586

UniProtKB/Swiss-Prot:

RHOA_HUMAN :
  • The basic-rich region is essential for yopT recognition and cleavage.
  • Belongs to the small GTPase superfamily. Rho family.
Domain:
  • The basic-rich region is essential for yopT recognition and cleavage.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOA: view

Function for RHOA Gene

Molecular function for RHOA Gene

UniProtKB/Swiss-Prot Function:
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:8910519, PubMed:9121475). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:16236794, PubMed:12900402). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000269 PubMed:21565175, ECO:0000269 PubMed:23940119}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000305 PubMed:21565175, ECO:0000305 PubMed:23940119};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as ARHGEF2, ARHGEF3, ARHGEF28 and BCR (PubMed:23940119, PubMed:12221096). Inhibited by GAPs such as ARHGAP30 (PubMed:21565175). Inhibited by GDP dissociation inhibitors such as ARHGDIA (PubMed:20400958).

Enzyme Numbers (IUBMB) for RHOA Gene

Phenotypes From GWAS Catalog for RHOA Gene

Gene Ontology (GO) - Molecular Function for RHOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS,IEA 10436159
GO:0005515 protein binding IPI 9214622
GO:0005525 GTP binding IEA,IDA 12777804
GO:0017022 myosin binding IPI 15644318
GO:0019003 GDP binding IEA --
genes like me logo Genes that share ontologies with RHOA: view
genes like me logo Genes that share phenotypes with RHOA: view

Animal Model Products

CRISPR Products

miRNA for RHOA Gene

miRTarBase miRNAs that target RHOA

Clone Products

  • Addgene plasmids for RHOA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOA Gene

Localization for RHOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOA Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex. Midbody. Cell projection, lamellipodium. Cell projection, dendrite. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. {ECO:0000250 UniProtKB:Q9QUI0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOA gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4
nucleus 4
endoplasmic reticulum 4
endosome 4
extracellular 3
mitochondrion 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RHOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005768 endosome IMP 19887681
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with RHOA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHOA Gene

Pathways & Interactions for RHOA Gene

genes like me logo Genes that share pathways with RHOA: view

Pathways by source for RHOA Gene

SIGNOR curated interactions for RHOA Gene

Gene Ontology (GO) - Biological Process for RHOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001666 response to hypoxia IEA --
GO:0001998 angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IEA --
GO:0002363 alpha-beta T cell lineage commitment IEA --
GO:0003100 regulation of systemic arterial blood pressure by endothelin IEA --
genes like me logo Genes that share ontologies with RHOA: view

Drugs & Compounds for RHOA Gene

(68) Drugs for RHOA Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 568
Pravastatin Approved Pharma Competitive, Inhibitor 161
Atorvastatin Approved Pharma Competitive, Inhibitor 862
Magnesium Approved, Experimental, Investigational Pharma 0
Guanosine diphosphate Experimental Pharma Target 0

(43) Additional Compounds for RHOA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for RHOA Gene

Compound Action Cas Number
CCG-1423 RhoA inhibitor 285986-88-1
genes like me logo Genes that share compounds with RHOA: view

Transcripts for RHOA Gene

CRISPR Products

Clone Products

  • Addgene plasmids for RHOA

Alternative Splicing Database (ASD) splice patterns (SP) for RHOA Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: - - -
SP4: - - -

Relevant External Links for RHOA Gene

GeneLoc Exon Structure for
RHOA
ECgene alternative splicing isoforms for
RHOA

Expression for RHOA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOA Gene

mRNA differential expression in normal tissues according to GTEx for RHOA Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for RHOA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOA Gene



Protein tissue co-expression partners for RHOA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHOA Gene:

RHOA

SOURCE GeneReport for Unigene cluster for RHOA Gene:

Hs.247077

Evidence on tissue expression from TISSUES for RHOA Gene

  • Nervous system(5)
  • Blood(4.9)
  • Eye(4.9)
  • Intestine(4.9)
  • Lung(4.9)
  • Skin(4.8)
  • Kidney(4.4)
  • Liver(4.2)
  • Bone(4)
  • Pancreas(3.9)
  • Muscle(3.8)
  • Heart(3.7)
  • Stomach(3.5)
  • Adrenal gland(3.1)
  • Bone marrow(3.1)
  • Lymph node(3.1)
  • Spleen(2.9)
  • Thyroid gland(2.3)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with RHOA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOA Gene

Orthologs for RHOA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOA 33 32
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOA 33
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOA 33
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOA 33 32
  • 95.34 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhoa 32
  • 94.13 (n)
cow
(Bos Taurus)
Mammalia RHOA 33 32
  • 93.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rhoa 17 32
  • 93.78 (n)
4930544G11Rik 33
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRHOA 33
  • 99 (a)
OneToMany
RHOA 32
  • 83.77 (n)
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 99 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rhoa.2 32
  • 77.2 (n)
Str.942 32
zebrafish
(Danio rerio)
Actinopterygii rhoaa 33
  • 93 (a)
ManyToMany
rhoab 32
  • 74.96 (n)
wufc17g01 32
fruit fly
(Drosophila melanogaster)
Insecta Rho1 33
  • 87 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rho-1 33
  • 88 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 33 32
  • 63.7 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10626g 32
  • 63.39 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR183W 32
  • 62.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11308 33
  • 86 (a)
OneToMany
Cin.5323 32
bread mold
(Neurospora crassa)
Ascomycetes NCU01484 32
  • 64.2 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rho1 32
  • 63.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5323 32
Species where no ortholog for RHOA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOA Gene

ENSEMBL:
Gene Tree for RHOA (if available)
TreeFam:
Gene Tree for RHOA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOA: view image

Paralogs for RHOA Gene

Pseudogenes.org Pseudogenes for RHOA Gene

genes like me logo Genes that share paralogs with RHOA: view

Variants for RHOA Gene

Sequence variations from dbSNP and Humsavar for RHOA Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1057519951 likely-pathogenic, Neoplasm of the breast, Lung adenocarcinoma, Adenocarcinoma of stomach, Squamous cell carcinoma of the head and neck 49,375,472(-) C/G/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1057519952 likely-pathogenic, Carcinoma of esophagus, Non-Hodgkin lymphoma, Adenocarcinoma of stomach, Neoplasm of the breast, Neoplasm of the large intestine 49,375,577(-) G/A coding_sequence_variant, intron_variant, missense_variant
rs1057519953 likely-pathogenic, Non-Hodgkin lymphoma, Carcinoma of esophagus, Neoplasm of the large intestine, Adenocarcinoma of stomach, Neoplasm of the breast 49,375,576(-) C/A/T coding_sequence_variant, intron_variant, missense_variant
rs1057519954 likely-pathogenic, Adenocarcinoma of stomach, Non-Hodgkin lymphoma, Squamous cell carcinoma of the head and neck 49,375,465(-) T/A/C/G 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1553631976 uncertain-significance, Inborn genetic diseases 49,368,509(-) A/G 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for RHOA Gene

Variant ID Type Subtype PubMed ID
esv3596125 CNV loss 21293372
nsv236940 CNV deletion 16902084
nsv237162 CNV deletion 16902084
nsv834687 CNV loss 17160897

Variation tolerance for RHOA Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOA Gene

Disorders for RHOA Gene

MalaCards: The human disease database

(14) MalaCards diseases for RHOA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adenocarcinoma
  • adenocarcinomas
peripheral t-cell lymphoma
  • peripheral t cell lymphoma
plague
  • yersiniosis
pulmonary hypertension
  • primary pulmonary hypertension
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search RHOA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHOA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RHOA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOA Gene

Publications for RHOA Gene

  1. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PMID: 12221096) Arthur WT … Wennerberg K (The Journal of biological chemistry 2002) 3 4 23 56
  2. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PMID: 11696353) Klussmann E … Rosenthal W (FEBS letters 2001) 3 4 23 56
  3. RHO binding to FAM65A regulates Golgi reorientation during cell migration. (PMID: 27807006) Mardakheh FK … Marshall CJ (Journal of cell science 2016) 3 4 56
  4. Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. (PMID: 25588844) Gao K … Wu D (Journal of cell science 2015) 3 4 56
  5. The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1. (PMID: 23940119) Dubash AD … Green KJ (The Journal of cell biology 2013) 3 4 56

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