This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferati... See more...

Aliases for RHOA Gene

Aliases for RHOA Gene

  • Ras Homolog Family Member A 2 3 5
  • Transforming Protein RhoA 3 4
  • RHOH12 2 3
  • ARH12 3 4
  • RHO12 3 4
  • ARHA 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Ras Homolog Gene Family, Member A 2
  • Aplysia Ras-Related Homolog 12 3
  • Small GTP Binding Protein RhoA 3
  • Rho CDNA Clone 12 4
  • Oncogene RHO H12 3
  • EC 3.6.5.2 4
  • EDFAOB 3
  • Rho12 2
  • RHOA 5
  • H12 4

External Ids for RHOA Gene

Previous HGNC Symbols for RHOA Gene

  • ARH12
  • ARHA

Previous GeneCards Identifiers for RHOA Gene

  • GC03M049357
  • GC03M049371
  • GC03M049397

Summaries for RHOA Gene

Entrez Gene Summary for RHOA Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

CIViC Summary for RHOA Gene

GeneCards Summary for RHOA Gene

RHOA (Ras Homolog Family Member A) is a Protein Coding gene. Diseases associated with RHOA include Ectodermal Dysplasia With Facial Dysmorphism And Acral, Ocular, And Brain Anomalies and Plague. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Association Between Physico-Chemical Features and Toxicity Associated Pathways. Gene Ontology (GO) annotations related to this gene include GTP binding and myosin binding. An important paralog of this gene is RHOC.

UniProtKB/Swiss-Prot Summary for RHOA Gene

  • Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:8910519, PubMed:9121475, PubMed:31570889). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:16236794, PubMed:12900402). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (PubMed:31888991). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity).
  • (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague.

Gene Wiki entry for RHOA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHOA Gene

Genomics for RHOA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RHOA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049408 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -0.3 -334 9.9 SP1 GATAD2A CTCF PRDM10 NFKBIZ KDM1A ZNF692 POLR2A BACH1 TARDBP AMT TCTA RHOA lnc-RHOA-1 WDR6 INKA1 RNA5SP130 DAG1 USP4 KLHDC8B
GH03J049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.7 +67.2 67197 16 RNF2 SP1 HNRNPL GATAD2A CTCF PRDM10 TFE3 LEF1 IKZF1 POLR2A USP4 lnc-TCTA-3 AMT WDR6 QRICH1 RBM6 ENSG00000235236 DALRD3 RHOA NICN1
GH03J050356 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -945.6 -945591 4.8 SP1 HNRNPL CREB1 PRDM10 SIX5 IKZF1 SMAD2 POLR2A LARP7 ZNF143 TMEM115 lnc-CYB561D2-2 NICN1 CYB561D2 RHOA ENSG00000272104
GH03J049265 Enhancer 0.6 Ensembl ENCODE 10.5 +146.7 146667 2.6 ZC3H11A ZFP64 ZNF781 ZNF518A ZNF697 PRDM12 WDR6 NICN1 IHO1 C3orf84 KLHDC8B CCDC71 ENSG00000223343 LAMB2 RHOA TCTA
GH03J049269 Enhancer 0.5 Ensembl ENCODE 10.5 +142.3 142342 3.3 ZIC2 ATF2 ENSG00000199546 AMT WDR6 IHO1 C3orf84 KLHDC8B CCDC71 DAG1 RNA5SP130 LAMB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHOA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RHOA

Top Transcription factor binding sites by QIAGEN in the RHOA gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • GR
  • GR-alpha
  • GR-beta
  • PPAR-gamma2
  • STAT5A

Genomic Locations for RHOA Gene

Genomic Locations for RHOA Gene
chr3:49,359,145-49,412,998
(GRCh38/hg38)
Size:
53,854 bases
Orientation:
Minus strand
chr3:49,396,578-49,450,431
(GRCh37/hg19)
Size:
53,854 bases
Orientation:
Minus strand

Genomic View for RHOA Gene

Genes around RHOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOA Gene

Proteins for RHOA Gene

  • Protein details for RHOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61586-RHOA_HUMAN
    Recommended name:
    Transforming protein RhoA
    Protein Accession:
    P61586
    Secondary Accessions:
    • P06749
    • Q53HM4
    • Q5U024
    • Q9UDJ0
    • Q9UEJ4

    Protein attributes for RHOA Gene

    Size:
    193 amino acids
    Molecular mass:
    21768 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with ARHGEF28 (By similarity). Interacts (via GTP-bound form) with RIPOR1 (via N-terminus); this interaction links RHOA to STK24 and STK26 kinases (PubMed:27807006). Interacts with RIPOR2 (via active GTP- or inactive GDP-bound forms) isoform 1 and isoform 2; these interactions are direct, block the loading of GTP to RHOA and decrease upon chemokine CCL19 stimulation in primary T lymphocytes (PubMed:25588844). Binds PRKCL1, ROCK1 and ROCK2 (PubMed:10388627, PubMed:8617235, PubMed:8641286). Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN (PubMed:10940294, PubMed:12221096, PubMed:9857026). Interacts with PLCE1 and AKAP13 (PubMed:11696353, PubMed:12900402). Interacts with DIAPH1 (PubMed:23325789). Interacts (in the constitutively activated, GTP-bound form) with DGKQ (PubMed:10066731). Interacts with RACK1; enhances RHOA activation (PubMed:20499158). Interacts with PKP4; the interaction is detected at the midbody (PubMed:17115030). Interacts (GTP-bound form preferentially) with PKN2; the interaction stimulates autophosphorylation and phosphorylation of PKN2 (PubMed:20974804, PubMed:9121475). Interacts with ARHGDIA; this interaction inactivates and stabilizes RHOA (PubMed:20400958). Interacts with ARHGDIB. Interacts (GTP-bound form) with KCNA2 (via cytoplasmic N-terminal domain) (PubMed:9635436). Interacts (GTP-bound form) with ECT2; the interaction results in allosteric activation of ECT2 (PubMed:31888991).
    • (Microbial infection) Interacts with yopT from Yersinia pestis.
    • (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation.

    Three dimensional structures from OCA and Proteopedia for RHOA Gene

neXtProt entry for RHOA Gene

Post-translational modifications for RHOA Gene

  • (Microbial infection) Substrate for botulinum ADP-ribosyltransferase.
  • (Microbial infection) Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage.
  • (Microbial infection) AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
  • (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
  • Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling (PubMed:11162591). Phosphorylation by SLK at Ser-188 in response to AGTR2 activation (By similarity).
  • Ubiquitinated by the BCR(KCTD13) and BCR(TNFAIP1) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and synaptic transmission in neurons.
  • Glycosylation at Tyr34
  • Ubiquitination at Lys135
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for RHOA

No data available for DME Specific Peptides for RHOA Gene

Domains & Families for RHOA Gene

Gene Families for RHOA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RHOA Gene

InterPro:
Blocks:
  • Ras small GTPase, Ras type
ProtoNet:

Suggested Antigen Peptide Sequences for RHOA Gene

GenScript: Design optimal peptide antigens:
  • ARHA protein (Q9BVT0_HUMAN)
  • Rho cDNA clone 12 (RHOA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61586

UniProtKB/Swiss-Prot:

RHOA_HUMAN :
  • The basic-rich region is essential for yopT recognition and cleavage.
  • Belongs to the small GTPase superfamily. Rho family.
Domain:
  • The basic-rich region is essential for yopT recognition and cleavage.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOA: view

Function for RHOA Gene

Molecular function for RHOA Gene

UniProtKB/Swiss-Prot Function:
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:8910519, PubMed:9121475, PubMed:31570889). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:16236794, PubMed:12900402). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (PubMed:31888991). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000269|PubMed:21565175, ECO:0000269|PubMed:23940119};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as ARHGEF2, ARHGEF3, ARHGEF28 and BCR (PubMed:23940119, PubMed:12221096). Inhibited by GAPs such as ARHGAP30 (PubMed:21565175). Inhibited by GDP dissociation inhibitors such as ARHGDIA (PubMed:20400958).

Enzyme Numbers (IUBMB) for RHOA Gene

Phenotypes From GWAS Catalog for RHOA Gene

Gene Ontology (GO) - Molecular Function for RHOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,TAS 10436159
GO:0005515 protein binding IPI 9214622
GO:0005525 GTP binding IEA,IDA 12777804
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RHOA: view
genes like me logo Genes that share phenotypes with RHOA: view

Animal Model Products

CRISPR Products

miRNA for RHOA Gene

miRTarBase miRNAs that target RHOA

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOA Gene

Localization for RHOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOA Gene

Cell membrane. Lipid-anchor. Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex. Midbody. Cell projection, lamellipodium. Cell projection, dendrite. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. {ECO:0000250 UniProtKB:Q9QUI0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOA gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 4
nucleus 4
endoplasmic reticulum 4
endosome 4
mitochondrion 3
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RHOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005768 endosome IMP 19887681
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RHOA: view

Pathways & Interactions for RHOA Gene

genes like me logo Genes that share pathways with RHOA: view

Pathways by source for RHOA Gene

23 GeneGo (Thomson Reuters) pathways for RHOA Gene
  • Cell adhesion Ephrins signaling
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling FAK signaling
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
56 Qiagen pathways for RHOA Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for RHOA Gene
2 GeneTex pathways for RHOA Gene

Gene Ontology (GO) - Biological Process for RHOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001666 response to hypoxia IEA --
GO:0001998 angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IEA --
GO:0002363 alpha-beta T cell lineage commitment IEA --
GO:0003100 regulation of systemic arterial blood pressure by endothelin IEA --
genes like me logo Genes that share ontologies with RHOA: view

Drugs & Compounds for RHOA Gene

(69) Drugs for RHOA Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Inhibitor, Competitive HMG-CoA reductase inhibitor 582
Pravastatin Approved Pharma Inhibitor, Competitive 167
Atorvastatin Approved Pharma Inhibitor, Competitive 893
Magnesium Approved, Experimental, Investigational Pharma 0
Guanosine diphosphate Experimental Pharma Target 0

(42) Additional Compounds for RHOA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for RHOA Gene

Compound Action Cas Number
CCG-1423 RhoA inhibitor 285986-88-1
genes like me logo Genes that share compounds with RHOA: view

Transcripts for RHOA Gene

mRNA/cDNA for RHOA Gene

7 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHOA

Alternative Splicing Database (ASD) splice patterns (SP) for RHOA Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: - - -
SP4: - - -

Relevant External Links for RHOA Gene

GeneLoc Exon Structure for
RHOA

Expression for RHOA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHOA Gene

mRNA differential expression in normal tissues according to GTEx for RHOA Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for RHOA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RHOA Gene



Protein tissue co-expression partners for RHOA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RHOA

SOURCE GeneReport for Unigene cluster for RHOA Gene:

Hs.247077

Evidence on tissue expression from TISSUES for RHOA Gene

  • Nervous system(5)
  • Intestine(4.9)
  • Eye(4.9)
  • Blood(4.9)
  • Lung(4.9)
  • Skin(4.9)
  • Kidney(4.6)
  • Liver(4.4)
  • Bone(4.3)
  • Pancreas(4.2)
  • Heart(4)
  • Muscle(4)
  • Stomach(3.9)
  • Lymph node(3.6)
  • Bone marrow(3.6)
  • Spleen(3.5)
  • Adrenal gland(3.5)
  • Thyroid gland(3.3)
  • Gall bladder(2.9)
genes like me logo Genes that share expression patterns with RHOA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOA Gene

Orthologs for RHOA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RHOA 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RHOA 31
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RHOA 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RHOA 30 31
  • 95.34 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rhoa 30
  • 94.13 (n)
Cow
(Bos Taurus)
Mammalia RHOA 30 31
  • 93.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rhoa 30 17
  • 93.78 (n)
4930544G11Rik 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CRHOA 31
  • 99 (a)
OneToMany
RHOA 30
  • 83.77 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 99 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rhoa.2 30
  • 77.2 (n)
Str.942 30
Zebrafish
(Danio rerio)
Actinopterygii rhoaa 31
  • 93 (a)
ManyToMany
rhoab 30
  • 74.96 (n)
wufc17g01 30
Fruit Fly
(Drosophila melanogaster)
Insecta Rho1 31
  • 87 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rho-1 31
  • 88 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 30 31
  • 63.7 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10626g 30
  • 63.39 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABR183W 30
  • 62.37 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11308 31
  • 86 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU01484 30
  • 64.2 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rho1 30
  • 63.33 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5323 30
Species where no ortholog for RHOA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RHOA Gene

ENSEMBL:
Gene Tree for RHOA (if available)
TreeFam:
Gene Tree for RHOA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RHOA: view image

Paralogs for RHOA Gene

Pseudogenes.org Pseudogenes for RHOA Gene

genes like me logo Genes that share paralogs with RHOA: view

Variants for RHOA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RHOA Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
695069 Pathogenic: ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIES, SOMATIC MOSAIC; neuro-ectodermal phenotype 49,375,451(-) C/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
720567 Benign: not provided 49,375,563(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
801330 Pathogenic: ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIES, SOMATIC MOSAIC 49,368,494(-) G/A MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
829804 Uncertain Significance: not provided 49,368,524(-) C/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs1057519951 Likely Pathogenic: Lung adenocarcinoma; Neoplasm of the breast; Adenocarcinoma of stomach; Squamous cell carcinoma of the head and neck. Likely Pathogenic: Lung adenocarcinoma; Neoplasm of the breast; Adenocarcinoma of stomach; Squamous cell carcinoma of the head and neck 49,375,472(-) C/GC/T MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for RHOA Gene

Structural Variations from Database of Genomic Variants (DGV) for RHOA Gene

Variant ID Type Subtype PubMed ID
esv3596125 CNV loss 21293372
nsv236940 CNV deletion 16902084
nsv237162 CNV deletion 16902084
nsv834687 CNV loss 17160897

Variation tolerance for RHOA Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHOA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOA Gene

Disorders for RHOA Gene

MalaCards: The human disease database

(48) MalaCards diseases for RHOA Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search RHOA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RHOA_HUMAN
  • Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies (EDFAOB) [MIM:618727]: A neuroectodermal syndrome characterized by linear hypopigmentation, alopecia, apparently asymptomatic leukoencephalopathy, and facial, ocular, dental and acral anomalies. Patients show no intellectual or neurologic impairment. {ECO:0000269 PubMed:31570889}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for RHOA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RHOA: view

No data available for Genatlas for RHOA Gene

Publications for RHOA Gene

  1. The armadillo protein p0071 regulates Rho signalling during cytokinesis. (PMID: 17115030) Wolf A … Hatzfeld M (Nature cell biology 2006) 3 4 23
  2. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PMID: 12221096) Arthur WT … Wennerberg K (The Journal of biological chemistry 2002) 3 4 23
  3. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. (PMID: 11696353) Klussmann E … Rosenthal W (FEBS letters 2001) 3 4 23
  4. Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome. (PMID: 31570889) Vabres P … Rivière JB (Nature genetics 2019) 3 4
  5. RHO binding to FAM65A regulates Golgi reorientation during cell migration. (PMID: 27807006) Mardakheh FK … Marshall CJ (Journal of cell science 2016) 3 4

Products for RHOA Gene

  • Addgene plasmids for RHOA

Sources for RHOA Gene