Aliases for RHCG Gene

Aliases for RHCG Gene

  • Rh Family C Glycoprotein 2 3 5
  • PDRC2 2 3 4
  • RHGK 2 3 4
  • Rhesus Blood Group Family Type C Glycoprotein 3 4
  • Rhesus Blood Group, C Glycoprotein 2 3
  • Ammonium Transporter Rh Type C 3 4
  • Rh Family Type C Glycoprotein 3 4
  • Tumor-Related Protein DRC2 3 4
  • Rh Type C Glycoprotein 3 4
  • Rh Glycoprotein Kidney 3 4
  • C15orf6 3 4
  • SLC42A3 2 3
  • Chromosome 15 Open Reading Frame 6 2
  • CDRC2 4
  • RHCG 5

External Ids for RHCG Gene

Previous HGNC Symbols for RHCG Gene

  • C15orf6

Previous GeneCards Identifiers for RHCG Gene

  • GC15M086419
  • GC15M083380
  • GC15M087601
  • GC15M087744
  • GC15M087815
  • GC15M090014
  • GC15M066127

Summaries for RHCG Gene

GeneCards Summary for RHCG Gene

RHCG (Rh Family C Glycoprotein) is a Protein Coding gene. Diseases associated with RHCG include Retinohepatoendocrinologic Syndrome and Overhydrated Hereditary Stomatocytosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include ankyrin binding and ammonium transmembrane transporter activity. An important paralog of this gene is RHBG.

UniProtKB/Swiss-Prot Summary for RHCG Gene

  • Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Gene Wiki entry for RHCG Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RHCG Gene

Genomics for RHCG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RHCG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J089495 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.2 188 0.8 CREB1 CTCF PKNOX1 POLR2A EZH2 UBTF SMARCA5 ZNF444 USF1 YY1 RHCG ENSG00000173867 POLG HSALNG0108036
GH15J089498 Enhancer 1.1 ENCODE dbSUPER 600.7 -1.8 -1826 0.2 CREB1 ATF7 PRDM10 ZNF629 ZNF692 TARDBP ZHX2 JUND ZIC2 PATZ1 RHCG ENSG00000261478 TICRR
GH15J089529 Enhancer 0.4 dbSUPER 13.3 -34.7 -34722 2.7 CTCF TRIM28 ZFP37 RHCG PLIN1 FANCI GDPGP1 HSALNG0108049 piR-59769-220 ENSG00000259713 TICRR
GH15J089551 Enhancer 1 FANTOM5 Ensembl dbSUPER 3.9 -55.0 -55012 0.8 IKZF2 RCOR1 EED DPF2 RELB RUNX3 NR3C1 NBN IKZF1 NR2C1 KIF7 RHCG piR-59769-220 TICRR lnc-KIF7-4 ENSG00000259713
GH15J089526 Enhancer 0.3 dbSUPER 13.3 -30.7 -30679 0.9 KDM1A HSALNG0108049 RHCG LINC00928 ENSG00000259713 TICRR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHCG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RHCG

Top Transcription factor binding sites by QIAGEN in the RHCG gene promoter:
  • AhR
  • Arnt
  • E47
  • Ik-3
  • IRF-7A
  • MIF-1
  • MZF-1
  • NF-Y
  • Tal-1beta

Genomic Locations for RHCG Gene

Genomic Locations for RHCG Gene
25,192 bases
Minus strand
41,165 bases
Minus strand

Genomic View for RHCG Gene

Genes around RHCG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHCG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHCG Gene

Proteins for RHCG Gene

  • Protein details for RHCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ammonium transporter Rh type C
    Protein Accession:
    Secondary Accessions:
    • A8K4D4
    • Q6X3Y4

    Protein attributes for RHCG Gene

    479 amino acids
    Molecular mass:
    53179 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for RHCG Gene

neXtProt entry for RHCG Gene

Post-translational modifications for RHCG Gene

Other Protein References for RHCG Gene

Antibody Products

  • Abcam antibodies for RHCG
  • Boster Bio Antibodies for RHCG
  • Santa Cruz Biotechnology (SCBT) Antibodies for RHCG

No data available for DME Specific Peptides for RHCG Gene

Domains & Families for RHCG Gene

Gene Families for RHCG Gene

Protein Domains for RHCG Gene

  • Rhesus blood group protein signature
  • Rh-like protein/ammonium transporter

Suggested Antigen Peptide Sequences for RHCG Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93743, Homo sapiens Rhesus blood group, C glycoprotein (RHCG), mRNA (A8K4D4_HUMAN)
  • Tumor-related protein DRC2 (RHCG_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
genes like me logo Genes that share domains with RHCG: view

Function for RHCG Gene

Molecular function for RHCG Gene

UniProtKB/Swiss-Prot Function:
Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Phenotypes From GWAS Catalog for RHCG Gene

Gene Ontology (GO) - Molecular Function for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008519 ammonium transmembrane transporter activity IEA,TAS --
GO:0030506 ankyrin binding IDA 12719424
GO:0042802 identical protein binding IPI 20457942
genes like me logo Genes that share ontologies with RHCG: view
genes like me logo Genes that share phenotypes with RHCG: view

Animal Models for RHCG Gene

MGI Knock Outs for RHCG:

Animal Model Products

  • Taconic Biosciences Mouse Models for RHCG

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHCG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHCG Gene

Localization for RHCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHCG Gene

Apical cell membrane. Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHCG gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IDA 10852913
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RHCG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RHCG Gene

Pathways & Interactions for RHCG Gene

genes like me logo Genes that share pathways with RHCG: view

Interacting Proteins for RHCG Gene

Gene Ontology (GO) - Biological Process for RHCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006873 cellular ion homeostasis IDA 14761968
GO:0006885 regulation of pH IEA --
GO:0015696 ammonium transport IEA,IGI 11062476
GO:0015837 amine transport NAS 10852913
GO:0030855 epithelial cell differentiation NAS 12204676
genes like me logo Genes that share ontologies with RHCG: view

No data available for SIGNOR curated interactions for RHCG Gene

Drugs & Compounds for RHCG Gene

(4) Drugs for RHCG Gene - From: DrugBank, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia N-13 Approved Pharma Transporter 0
Ammonia Approved Pharma 0
[<sup>14</sup>C]methylamine Pharma 0

(2) Additional Compounds for RHCG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHCG: view

Transcripts for RHCG Gene

mRNA/cDNA for RHCG Gene

12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHCG

Alternative Splicing Database (ASD) splice patterns (SP) for RHCG Gene

No ASD Table

Relevant External Links for RHCG Gene

GeneLoc Exon Structure for

Expression for RHCG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHCG Gene

This gene is overexpressed in Esophagus - Mucosa (x29.3), Vagina (x10.4), Cervix - Ectocervix (x6.6), and Minor Salivary Gland (x5.4).

Protein differential expression in normal tissues from HIPED for RHCG Gene

This gene is overexpressed in Cervix (21.5), Saliva (18.0), Urine (17.2), and Esophagus (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RHCG Gene

Protein tissue co-expression partners for RHCG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RHCG

SOURCE GeneReport for Unigene cluster for RHCG Gene:


mRNA Expression by UniProt/SwissProt for RHCG Gene:

Tissue specificity: Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney.

Evidence on tissue expression from TISSUES for RHCG Gene

  • Kidney(4.6)
  • Skin(2.6)
  • Blood(2.1)
  • Urine(2)
genes like me logo Genes that share expression patterns with RHCG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RHCG Gene

Orthologs for RHCG Gene

This gene was present in the common ancestor of animals.

Orthologs for RHCG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHCG 30 31
  • 99.23 (n)
(Canis familiaris)
Mammalia RHCG 30 31
  • 85.74 (n)
(Bos Taurus)
Mammalia RHCG 30 31
  • 83.22 (n)
(Rattus norvegicus)
Mammalia Rhcg 30
  • 81.7 (n)
(Mus musculus)
Mammalia Rhcg 30 17 31
  • 81.42 (n)
(Monodelphis domestica)
Mammalia RHCG 31
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RHCG 31
  • 78 (a)
(Gallus gallus)
Aves RHCG 30 31
  • 73.09 (n)
(Anolis carolinensis)
Reptilia RHCG 31
  • 71 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rhcg 30
  • 64.51 (n)
(Danio rerio)
Actinopterygii rhcga 30 31
  • 67.12 (n)
rhcgb 31
  • 62 (a)
rhcgl1 31
  • 62 (a)
wufj85f07 30
Fruit Fly
(Drosophila melanogaster)
Insecta Rh50 31 32
  • 40 (a)
(Caenorhabditis elegans)
Secernentea rhr-1 31 32
  • 38 (a)
rhr-2 31 32
  • 37 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7075 31
  • 46 (a)
-- 31
  • 45 (a)
CSA.7848 31
  • 42 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.13103 30
Species where no ortholog for RHCG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RHCG Gene

Gene Tree for RHCG (if available)
Gene Tree for RHCG (if available)
Evolutionary constrained regions (ECRs) for RHCG: view image

Paralogs for RHCG Gene

Paralogs for RHCG Gene

(10) SIMAP similar genes for RHCG Gene using alignment to 6 proteins:

  • F5H0A6_HUMAN
  • H0YM79_HUMAN
genes like me logo Genes that share paralogs with RHCG: view

Variants for RHCG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RHCG Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs17807723 - p.Arg202Cys

Additional dbSNP identifiers (rs#s) for RHCG Gene

Structural Variations from Database of Genomic Variants (DGV) for RHCG Gene

Variant ID Type Subtype PubMed ID
esv2750003 CNV deletion 23290073
esv34025 CNV loss 18971310
nsv1038140 CNV gain 25217958
nsv1141668 CNV deletion 24896259
nsv1150344 CNV deletion 26484159
nsv457245 CNV loss 19166990
nsv570386 CNV loss 21841781

Variation tolerance for RHCG Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHCG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHCG Gene

Disorders for RHCG Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHCG Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinohepatoendocrinologic syndrome
  • rhe syndrome
overhydrated hereditary stomatocytosis
  • ohst
- elite association - COSMIC cancer census association via MalaCards
Search RHCG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RHCG

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RHCG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHCG Gene

Publications for RHCG Gene

  1. Function of human Rh based on structure of RhCG at 2.1 A. (PMID: 20457942) Gruswitz F … Stroud RM (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 23
  2. Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. (PMID: 16580862) Zidi-Yahiaoui N … Mouro-Chanteloup I (Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 2006) 3 4 23
  3. Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. (PMID: 16477434) Marini AM … André B (Current genetics 2006) 3 4 23
  4. NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. (PMID: 14761968) Bakouh N … Planelles G (The Journal of biological chemistry 2004) 3 4 23
  5. RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. (PMID: 12204676) Chen BS … Wang MR (European journal of cancer (Oxford, England : 1990) 2002) 3 4 23

Products for RHCG Gene

Sources for RHCG Gene