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Aliases for RHBG Gene

Aliases for RHBG Gene

  • Rh Family B Glycoprotein (Gene/Pseudogene) 2 3 5
  • Rhesus Blood Group, B Glycoprotein 2 3
  • Rhesus Blood Group Family Type B Glycoprotein 4
  • Ammonium Transporter Rh Type B 3
  • Rh Family Type B Glycoprotein 4
  • Rh Family, B Glycoprotein 3
  • Rh Type B Glycoprotein 4
  • SLC42A2 3

External Ids for RHBG Gene

Previous GeneCards Identifiers for RHBG Gene

  • GC01P154207
  • GC01P152104
  • GC01P153116
  • GC01P153555
  • GC01P153152
  • GC01P154605
  • GC01P127699

Summaries for RHBG Gene

Entrez Gene Summary for RHBG Gene

  • This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for RHBG Gene

RHBG (Rh Family B Glycoprotein (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include ankyrin binding and ammonium transmembrane transporter activity. An important paralog of this gene is RHCG.

UniProtKB/Swiss-Prot for RHBG Gene

  • Functions as a specific ammonium transporter.

Gene Wiki entry for RHBG Gene

Additional gene information for RHBG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHBG Gene

Genomics for RHBG Gene

GeneHancer (GH) Regulatory Elements for RHBG Gene

Promoters and enhancers for RHBG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J156366 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 660.6 +4.5 4522 7.5 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 TCF12 SLC30A9 RHBG ISG20L2 ENSG00000246203 MSTO2P MSTO1 RRNAD1 ASH1L-AS1 YY1AP1 GON4L CCT3
GH01J156398 Enhancer 1.1 ENCODE dbSUPER 17.8 +32.6 32615 1 HDAC1 FOXA2 TAF9B RB1 NFRKB TCF12 E2F8 FOS IKZF2 ZBTB2 PIR42696 RHBG CCT3 C1orf61 TSACC ISG20L2 GC01M156396 ENSG00000237390
GH01J156474 Enhancer 1 ENCODE dbSUPER 10.8 +112.4 112399 7.7 FOXA2 RB1 SIN3A MZF1 ZNF2 RAD21 RARA EGR1 ZNF143 FOS C1orf61 MIR9-1 NAXE CCT3 RHBG MEF2D GC01M156484 ENSG00000206651 GC01M156440
GH01J156445 Enhancer 0.9 ENCODE 11.6 +80.0 79961 0.2 HDAC1 ELF3 ARID4B KLF17 SIN3A ZNF48 RAD21 RFX5 ZNF335 ZNF213 MIR9-1 CCT3 RHBG TSACC NAXE PAQR6 BCAN C1orf61 ENSG00000236947 GC01M156440
GH01J156383 Enhancer 1 ENCODE dbSUPER 8 +17.1 17112 0.1 HDGF RB1 ARID4B MZF1 SIN3A KLF14 ZNF2 RAD21 ZNF335 GLIS2 RHBG GC01M156384 CCT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RHBG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RHBG gene promoter:
  • E47
  • HNF-4alpha2
  • HNF-4alpha1
  • HEN1
  • PPAR-gamma2
  • PPAR-gamma1
  • AML1a
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for RHBG Gene

Genomic Locations for RHBG Gene
19,192 bases
Plus strand
16,009 bases
Plus strand

Genomic View for RHBG Gene

Genes around RHBG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHBG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHBG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHBG Gene

Proteins for RHBG Gene

  • Protein details for RHBG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ammonium transporter Rh type B
    Protein Accession:
    Secondary Accessions:
    • A8K475
    • Q5SZW4
    • Q5SZW6
    • Q5SZW7
    • Q6P193
    • Q6YJI2
    • Q6YJI3

    Protein attributes for RHBG Gene

    441 amino acids
    Molecular mass:
    47231 Da
    Quaternary structure:
    • Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane.
    • Sequence=AAG01086.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305}; Sequence=AAL05978.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305}; Sequence=AAN34363.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305}; Sequence=AAN34364.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305};

    Alternative splice isoforms for RHBG Gene


neXtProt entry for RHBG Gene

Post-translational modifications for RHBG Gene

Antibody Products

  • Abcam antibodies for RHBG
  • Boster Bio Antibodies for RHBG
  • Santa Cruz Biotechnology (SCBT) Antibodies for RHBG

No data available for DME Specific Peptides for RHBG Gene

Domains & Families for RHBG Gene

Gene Families for RHBG Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
  • Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
genes like me logo Genes that share domains with RHBG: view

Function for RHBG Gene

Molecular function for RHBG Gene

UniProtKB/Swiss-Prot Function:
Functions as a specific ammonium transporter.

Phenotypes From GWAS Catalog for RHBG Gene

Gene Ontology (GO) - Molecular Function for RHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008519 ammonium transmembrane transporter activity TAS --
GO:0030506 ankyrin binding IPI 15611082
genes like me logo Genes that share ontologies with RHBG: view
genes like me logo Genes that share phenotypes with RHBG: view

Animal Models for RHBG Gene

MGI Knock Outs for RHBG:

Animal Model Products

  • Taconic Biosciences Mouse Models for RHBG

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHBG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RHBG Gene

Localization for RHBG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHBG Gene

Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHBG gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 11024028
GO:0014731 spectrin-associated cytoskeleton IMP 18635543
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RHBG: view

Pathways & Interactions for RHBG Gene

genes like me logo Genes that share pathways with RHBG: view

Interacting Proteins for RHBG Gene

Selected Interacting proteins: Q9H310-RHBG_HUMAN for RHBG Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for RHBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015695 organic cation transport IBA --
GO:0015696 ammonium transport ISS --
GO:0070634 transepithelial ammonium transport IDA 18032481
GO:0072488 ammonium transmembrane transport IEA --
genes like me logo Genes that share ontologies with RHBG: view

No data available for SIGNOR curated interactions for RHBG Gene

Drugs & Compounds for RHBG Gene

(3) Drugs for RHBG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0

(1) Additional Compounds for RHBG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHBG: view

Transcripts for RHBG Gene

mRNA/cDNA for RHBG Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHBG Gene

Rh family, B glycoprotein (gene/pseudogene):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RHBG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHBG Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for RHBG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHBG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHBG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHBG Gene

This gene is overexpressed in Kidney - Cortex (x12.8), Brain - Cerebellum (x9.2), Brain - Cerebellar Hemisphere (x8.7), Ovary (x7.9), and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for RHBG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.4) and Liver (26.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RHBG Gene

Protein tissue co-expression partners for RHBG Gene

NURSA nuclear receptor signaling pathways regulating expression of RHBG Gene:


SOURCE GeneReport for Unigene cluster for RHBG Gene:


mRNA Expression by UniProt/SwissProt for RHBG Gene:

Tissue specificity: Specifically expressed in kidney. Also detected in liver and ovary.

Evidence on tissue expression from TISSUES for RHBG Gene

  • Liver(4.2)
  • Nervous system(4.1)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with RHBG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RHBG Gene

Orthologs for RHBG Gene

This gene was present in the common ancestor of animals.

Orthologs for RHBG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHBG 34 33
  • 99.34 (n)
(Bos Taurus)
Mammalia RHBG 34 33
  • 89.52 (n)
(Canis familiaris)
Mammalia RHBG 34 33
  • 87.19 (n)
(Mus musculus)
Mammalia Rhbg 16 34 33
  • 85.57 (n)
(Rattus norvegicus)
Mammalia Rhbg 33
  • 85.04 (n)
(Monodelphis domestica)
Mammalia RHBG 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia RHBG 34
  • 64 (a)
(Gallus gallus)
Aves RHBG 34
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhbg 33
  • 65.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68642 33
(Danio rerio)
Actinopterygii rhbg 34 33
  • 65.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rh50 34 35 33
  • 55.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002011 33
  • 54.7 (n)
(Caenorhabditis elegans)
Secernentea rhr-2 34 35
  • 37 (a)
rhr-1 34 35
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7075 34
  • 45 (a)
CSA.7848 34
  • 43 (a)
-- 34
  • 42 (a)
Species where no ortholog for RHBG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHBG Gene

Gene Tree for RHBG (if available)
Gene Tree for RHBG (if available)
Evolutionary constrained regions (ECRs) for RHBG: view image

Paralogs for RHBG Gene

Paralogs for RHBG Gene

genes like me logo Genes that share paralogs with RHBG: view

Variants for RHBG Gene

Sequence variations from dbSNP and Humsavar for RHBG Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000016833 -- 156,365,121(+) C/T upstream_transcript_variant
rs1000022441 -- 156,371,041(+) TTTTT/TTTT intron_variant
rs1000278758 -- 156,375,643(+) T/C intron_variant
rs1000922658 -- 156,369,444(+) C/A intron_variant
rs1001161667 -- 156,382,529(+) G/A intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RHBG Gene

Variant ID Type Subtype PubMed ID
esv3426894 CNV insertion 20981092
nsv470742 CNV loss 18288195

Variation tolerance for RHBG Gene

Gene Damage Index Score: 16.97; 97.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RHBG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHBG Gene

Disorders for RHBG Gene

Additional Disease Information for RHBG

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RHBG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHBG Gene

Publications for RHBG Gene

  1. Electroneutral ammonium transport by basolateral rhesus B glycoprotein. (PMID: 15284342) Ludewig U (The Journal of physiology 2004) 3 4 22 58
  2. Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals. (PMID: 11024028) Liu Z … Huang CH (The Journal of biological chemistry 2001) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels. (PMID: 19357182) Brown AC … Toye AM (American journal of physiology. Renal physiology 2009) 3 22 58
  5. Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1. (PMID: 18032481) Worrell RT … Matthews JB (American journal of physiology. Gastrointestinal and liver physiology 2008) 3 22 58

Products for RHBG Gene

Sources for RHBG Gene

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