Aliases for RHBDF2 Gene
External Ids for RHBDF2 Gene
Previous HGNC Symbols for RHBDF2 Gene
Previous GeneCards Identifiers for RHBDF2 Gene
GeneCards Summary for RHBDF2 Gene
RHBDF2 (Rhomboid 5 Homolog 2) is a Protein Coding gene. Diseases associated with RHBDF2 include Tylosis With Esophageal Cancer and Palmoplantar Keratoderma, Nonepidermolytic, Focal 1. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and growth factor binding. An important paralog of this gene is RHBDF1.
UniProtKB/Swiss-Prot Summary for RHBDF2 Gene
Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.