Aliases for RGSL1 Gene

Aliases for RGSL1 Gene

  • Regulator Of G Protein Signaling Like 1 2 3 5
  • Regulator Of G-Protein Signaling Protein-Like 3 4
  • Regulator Of G-Protein Signaling Like 2 2 3
  • RGSL2 3 4
  • RGSL 3 4
  • Regulator Of G-Protein Signalling Like 1 2
  • Regulator Of G-Protein Signalling Like 2 2
  • Regulator Of G-Protein Signaling Like 1 2
  • RGSL1 5

External Ids for RGSL1 Gene

Previous HGNC Symbols for RGSL1 Gene

  • RGSL2

Previous GeneCards Identifiers for RGSL1 Gene

  • GC01U900333
  • GC01P179696
  • GC01P179189
  • GC01P180685
  • GC01P180724
  • GC01P182419
  • GC01P153658
  • GC01P182450

Summaries for RGSL1 Gene

GeneCards Summary for RGSL1 Gene

RGSL1 (Regulator Of G Protein Signaling Like 1) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by GPCR. An important paralog of this gene is AXIN2.

Additional gene information for RGSL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGSL1 Gene

Genomics for RGSL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGSL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J182408 Enhancer 0.3 Ensembl 600.7 -0.2 -191 0.4 SP1 HLF LINC00272 RGSL1 TEDDM1
GH01J182450 Promoter 0.3 EPDnew 600.3 +40.9 40935 0.1 RGSL1 TEDDM2P piR-56497-008 RNASEL
GH01J182142 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 9.6 -264.3 -264283 4.4 GATAD2A CTCF ZNF512 RFX1 IKZF1 JUND FOXA1 PRDM1 ZNF143 MTA2 GLUL TEDDM1 RNU6-152P RPL18P2 RGS16 RGSL1 RNASEL KR021980 ENSG00000232309 ZNF648
GH01J182084 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -322.5 -322492 6.6 CTCF JUND FOXA1 ZIC2 REST RAD21 TRIM22 HDAC1 ZNF341 SCRT2 ENSG00000225982 GLUL DHX9 HMGN1P4 TEDDM1 RNASEL RGSL1 NPL ZNF648 LOC105371642
GH01J182149 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 9.6 -259.6 -259554 1.5 RFX1 LEF1 JUND PKNOX1 ZNF24 DPF2 HDAC1 SOX6 FOXJ2 EP300 KR021980 GLUL TEDDM1 RNU6-152P RPL18P2 RGS16 RGSL1 RNASEL ENSG00000232309 ZNF648
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGSL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGSL1

Top Transcription factor binding sites by QIAGEN in the RGSL1 gene promoter:
  • AREB6
  • ATF6
  • CUTL1
  • Egr-3
  • GATA-1
  • ITF-2
  • NRF-2
  • NRSF form 1
  • NRSF form 2
  • Tal-1beta

Genomic Locations for RGSL1 Gene

Genomic Locations for RGSL1 Gene
chr1:182,409,192-182,560,599
(GRCh38/hg38)
Size:
151,408 bases
Orientation:
Plus strand
chr1:182,419,256-182,529,734
(GRCh37/hg19)
Size:
110,479 bases
Orientation:
Plus strand

Genomic View for RGSL1 Gene

Genes around RGSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGSL1 Gene

Proteins for RGSL1 Gene

  • Protein details for RGSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5PLK6-RGSL_HUMAN
    Recommended name:
    Regulator of G-protein signaling protein-like
    Protein Accession:
    A5PLK6
    Secondary Accessions:
    • A2A2Z0
    • A6PVM2
    • A6PVM3
    • Q0VAJ4
    • Q0VAJ5
    • Q6ZRL0
    • Q86UV0
    • Q9H084

    Protein attributes for RGSL1 Gene

    Size:
    1076 amino acids
    Molecular mass:
    125688 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RGSL1 Gene

neXtProt entry for RGSL1 Gene

Post-translational modifications for RGSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGSL1 Gene

Domains & Families for RGSL1 Gene

Gene Families for RGSL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RGSL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGSL1 Gene

GenScript: Design optimal peptide antigens:
  • Regulator of G-protein signaling protein-like (RGSL_HUMAN)
genes like me logo Genes that share domains with RGSL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGSL1 Gene

Function for RGSL1 Gene

Phenotypes From GWAS Catalog for RGSL1 Gene

genes like me logo Genes that share phenotypes with RGSL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGSL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGSL1 Gene

Localization for RGSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGSL1 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGSL1 gene
Compartment Confidence
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RGSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RGSL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RGSL1 Gene

Pathways & Interactions for RGSL1 Gene

genes like me logo Genes that share pathways with RGSL1: view

Interacting Proteins for RGSL1 Gene

Gene Ontology (GO) - Biological Process for RGSL1 Gene

None

No data available for SIGNOR curated interactions for RGSL1 Gene

Drugs & Compounds for RGSL1 Gene

No Compound Related Data Available

Transcripts for RGSL1 Gene

mRNA/cDNA for RGSL1 Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGSL1

Alternative Splicing Database (ASD) splice patterns (SP) for RGSL1 Gene

No ASD Table

Relevant External Links for RGSL1 Gene

GeneLoc Exon Structure for
RGSL1

Expression for RGSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for RGSL1 Gene

This gene is overexpressed in Testis (x50.6).

Protein differential expression in normal tissues from HIPED for RGSL1 Gene

This gene is overexpressed in Liver (66.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGSL1 Gene



Protein tissue co-expression partners for RGSL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGSL1

SOURCE GeneReport for Unigene cluster for RGSL1 Gene:

Hs.121200
genes like me logo Genes that share expression patterns with RGSL1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGSL1 Gene

Orthologs for RGSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGSL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGSL1 30
  • 99.35 (n)
Dog
(Canis familiaris)
Mammalia RGSL1 30 31
  • 84.13 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RGSL1 30 31
  • 81.82 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rgsl1 30 17 31
  • 77.84 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 48 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia RGSL1 31
  • 44 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100858077 30
  • 52.68 (n)
RGSL1 31
  • 36 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGSL1 31
  • 40 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC565777 30
  • 43.41 (n)
Species where no ortholog for RGSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RGSL1 Gene

ENSEMBL:
Gene Tree for RGSL1 (if available)
TreeFam:
Gene Tree for RGSL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGSL1: view image

Paralogs for RGSL1 Gene

genes like me logo Genes that share paralogs with RGSL1: view

Variants for RGSL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGSL1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
743373 Likely Benign: not provided 182,556,042(+) C/T SYNONYMOUS_VARIANT
rs12083859 - p.Glu5Asp
rs647224 - p.Trp256Cys

Additional dbSNP identifiers (rs#s) for RGSL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGSL1 Gene

Variant ID Type Subtype PubMed ID
esv3302826 CNV tandem duplication 20981092
esv3302856 CNV tandem duplication 20981092
esv3404570 CNV insertion 20981092
nsv1068350 CNV deletion 25765185
nsv1140429 CNV tandem duplication 24896259
nsv528762 CNV loss 19592680
nsv548358 CNV gain 21841781
nsv825531 CNV loss 20364138
nsv825542 CNV gain 20364138
nsv825553 CNV gain 20364138

Variation tolerance for RGSL1 Gene

Gene Damage Index Score: 12.44; 94.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGSL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGSL1 Gene

Disorders for RGSL1 Gene

Additional Disease Information for RGSL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for RGSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGSL1 Gene

Publications for RGSL1 Gene

  1. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PMID: 20574532) Shulman JM … De Jager PL (PloS one 2010) 3 41
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Identification of 9 novel transcripts and two RGSL genes within the hereditary prostate cancer region (HPC1) at 1q25. (PMID: 12801632) Silva AP … Camargo AA (Gene 2003) 2 3

Products for RGSL1 Gene

Sources for RGSL1 Gene