Aliases for RGSL1 Gene
Aliases for RGSL1 Gene
External Ids for RGSL1 Gene
- HGNC: 18636
- Entrez Gene: 353299
- Ensembl: ENSG00000121446
- OMIM: 611012
- UniProtKB: A5PLK6
Previous HGNC Symbols for RGSL1 Gene
- RGSL2
Previous GeneCards Identifiers for RGSL1 Gene
- GC01U900333
- GC01P179696
- GC01P179189
- GC01P180685
- GC01P180724
- GC01P182419
- GC01P153658
- GC01P182450
Summaries for RGSL1 Gene
GeneCards Summary for RGSL1 Gene
RGSL1 (Regulator Of G Protein Signaling Like 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 12.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGSL1 Gene
Genomics for RGSL1 Gene
GeneHancer (GH) Regulatory Elements for RGSL1 Gene
Promoters and enhancers for RGSL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RGSL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RGSL1 gene promoter:
Regulatory Element Products
Genomic Locations for RGSL1 Gene
Genomic Locations for RGSL1 Gene
- chr1:182,409,192-182,560,599
- (GRCh38/hg38)
- Size:
- 151,408 bases
- Orientation:
- Plus strand
- chr1:182,419,256-182,529,734
- (GRCh37/hg19)
Genomic View for RGSL1 Gene
Genes around RGSL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.3 by Ensembl
- 1q25.3 by Entrez Gene
- 1q25.3 by HGNC
RGSL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RGSL1 Gene
Proteins for RGSL1 Gene
-
Protein details for RGSL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A5PLK6-RGSL_HUMAN
- Recommended name:
- Regulator of G-protein signaling protein-like
- Protein Accession:
- A5PLK6
- A2A2Z0
- A6PVM2
- A6PVM3
- Q0VAJ4
- Q0VAJ5
- Q6ZRL0
- Q86UV0
- Q9H084
Protein attributes for RGSL1 Gene
- Size:
- 1076 amino acids
- Molecular mass:
- 125688 Da
- Quaternary structure:
- No Data Available
Protein Expression for RGSL1 Gene
Post-translational modifications for RGSL1 Gene
No Post-translational modifications
Other Protein References for RGSL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for RGSL1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RGSL1
- Origene Custom Protein Services for RGSL1
- Search GeneTex for Proteins for RGSL1
Assay Products
No data available for DME Specific Peptides for RGSL1 Gene
Domains & Families for RGSL1 Gene
Gene Families for RGSL1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for RGSL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for RGSL1 Gene
Function for RGSL1 Gene
Phenotypes From GWAS Catalog for RGSL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IBA | -- |
Phenotypes for RGSL1 Gene
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for RGSL1 in any vector
- XM_011509502.1
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- XM_011509495.1
- XM_011509498.1
- XM_011509501.1
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- NM_001137669.1
- XM_011509490.1
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- XM_011509496.1
- XM_011509499.1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RGSL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RGSL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available RGSL1 gene related products
- orf clones - Search results for available RGSL1 gene related products
- Applied Biological Materials Clones for RGSL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RGSL1
-
ViGene Biosciences adenoviral particle packaged cDNA for RGSL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RGSL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RGSL1 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGSL1 Gene
Localization for RGSL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RGSL1 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005886 | plasma membrane | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RGSL1 Gene
Pathways & Interactions for RGSL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | RET signaling | ||
| 3 | Peptide ligand-binding receptors | ||
| 4 | ADP signalling through P2Y purinoceptor 12 | ||
Pathways by source for RGSL1 Gene
Interacting Proteins for RGSL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
No data available for SIGNOR curated interactions for RGSL1 Gene
Transcripts for RGSL1 Gene
mRNA/cDNA for RGSL1 Gene
- (19) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (21) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RGSL1 Gene
- Regulator of G-protein signaling like 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RGSL1
- genomics-online: gRNA clones - Search results for available RGSL1 gene related products
- Applied Biological Materials CRISPR for RGSL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RGSL1
- GenScript: Design CRISPR guide RNA sequences for RGSL1
miRNA Products
- Search ViGene Biosciences for RGSL1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for RGSL1
- Browse OriGene Inhibitory RNA Products For RGSL1
- genomics-online: shRNA clones - Search results for available RGSL1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RGSL1 gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for RGSL1 in any vector
- XM_011509502.1
- XM_011509487.1
- XM_011509505.1
- XM_005245137.1
- XM_011509492.1
- XM_011509495.1
- XM_011509498.1
- XM_011509501.1
- XM_011509486.1
- XM_011509504.1
- XM_011509489.1
- XM_011509491.1
- XM_011509494.1
- XM_011509497.1
- XM_011509500.1
- XM_011509485.1
- XM_011509503.1
- XM_011509488.1
- NM_001137669.1
- XM_011509490.1
- XM_011509493.1
- XM_011509496.1
- XM_011509499.1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RGSL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RGSL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available RGSL1 gene related products
- orf clones - Search results for available RGSL1 gene related products
- Applied Biological Materials Clones for RGSL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RGSL1 Gene
mRNA differential expression in normal tissues according to GTEx for RGSL1 Gene
This gene is overexpressed in Testis (x50.6).
This gene is overexpressed in Liver (66.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGSL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of RGSL1 Gene:
RGSL1SOURCE GeneReport for Unigene cluster for RGSL1 Gene:
Hs.121200Primer Products
-
OriGene qPCR primer pairs for RGSL1
- genomics-online: primer clones - Search results for available RGSL1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGSL1 Gene
Orthologs for RGSL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RGSL1 33 |
|
||
| dog (Canis familiaris) |
Mammalia | RGSL1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RGSL1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Rgsl1 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | RGSL1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100858077 33 |
|
||
| RGSL1 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | RGSL1 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | LOC565777 33 |
|
- Species where no ortholog for RGSL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for RGSL1 Gene
No data available for Paralogs for RGSL1 Gene
Variants for RGSL1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000031543 | -- | 182,457,333(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000066014 | -- | 182,516,014(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000080951 | -- | 182,470,135(+) | C/G | intron_variant | |
| rs1000104361 | -- | 182,495,773(+) | C/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000145100 | -- | 182,516,270(+) | G/A | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv825553 | CNV | gain | 20364138 |
| nsv825542 | CNV | gain | 20364138 |
| nsv825531 | CNV | loss | 20364138 |
| nsv548358 | CNV | gain | 21841781 |
| nsv528762 | CNV | loss | 19592680 |
| nsv1140429 | CNV | tandem duplication | 24896259 |
| nsv1068350 | CNV | deletion | 25765185 |
| esv3404570 | CNV | insertion | 20981092 |
| esv3302856 | CNV | tandem duplication | 20981092 |
| esv3302826 | CNV | tandem duplication | 20981092 |
Gene Damage Index Score:
12.44;
94.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RGSL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RGSL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGSL1 Gene
Disorders for RGSL1 Gene
Additional Disease Information for RGSL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for RGSL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGSL1 Gene
Publications for RGSL1 Gene
- Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PMID: 20574532) Shulman JM … De Jager PL (PloS one 2010) 3 44 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Identification of 9 novel transcripts and two RGSL genes within the hereditary prostate cancer region (HPC1) at 1q25. (PMID: 12801632) Silva AP … Camargo AA (Gene 2003) 2 3 58
Products for RGSL1 Gene
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- GenScript: Next-day shipping of latest version cDNA ORF clones for RGSL1 in any vector
- XM_011509499.1
- XM_011509496.1
- XM_011509493.1
- XM_011509490.1
- NM_001137669.1
- XM_011509488.1
- XM_011509503.1
- XM_011509485.1
- XM_011509500.1
- XM_011509497.1
- XM_011509494.1
- XM_011509491.1
- XM_011509489.1
- XM_011509504.1
- XM_011509486.1
- XM_011509501.1
- XM_011509498.1
- XM_011509495.1
- XM_011509492.1
- XM_005245137.1
- XM_011509505.1
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- XM_011509502.1
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for RGSL1
- VectorBuilder custom plasmid, inducible vectors for RGSL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RGSL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available RGSL1 related products ranked by validation data
- antibodies-online: Search results for available RGSL1 related products ranked by validation data
- antibodies-online: Search results for available RGSL1 related products ranked by validation data
- Search GeneTex for Antibodies for RGSL1
- Search GeneTex for Proteins for RGSL1
- ViGene Biosciences adenoviral particle packaged cDNA for RGSL1 gene
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- Search ViGene Biosciences for RGSL1
- Horizon Cell Lines for RGSL1
- genomics-online: cdna clones - Search results for available RGSL1 gene related products
- orf clones - Search results for available RGSL1 gene related products
- genomics-online: gRNA clones - Search results for available RGSL1 gene related products
- genomics-online: primer clones - Search results for available RGSL1 gene related products
- genomics-online: shRNA clones - Search results for available RGSL1 gene related products
Sources for RGSL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew