Free for academic non-profit institutions. Other users need a Commercial license
Aliases for RGSL1 Gene
Aliases for RGSL1 Gene
External Ids for RGSL1 Gene
- HGNC: 18636
- NCBI Entrez Gene: 353299
- Ensembl: ENSG00000121446
- OMIM®: 611012
- UniProtKB/Swiss-Prot: A5PLK6
Previous HGNC Symbols for RGSL1 Gene
- RGSL2
Previous GeneCards Identifiers for RGSL1 Gene
- GC01U900333
- GC01P179696
- GC01P179189
- GC01P180685
- GC01P180724
- GC01P182419
- GC01P153658
- GC01P182450
Summaries for RGSL1 Gene
GeneCards Summary for RGSL1 Gene
RGSL1 (Regulator Of G Protein Signaling Like 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. An important paralog of this gene is RGS12.
Additional gene information for RGSL1 Gene
- HGNC (18636)
- NCBI Entrez Gene (353299)
- Ensembl (ENSG00000121446)
- OMIM® (611012)
- UniProtKB/Swiss-Prot (A5PLK6)
- Open Targets Platform(ENSG00000121446)
- Alliance of Genome Resources
- Search for RGSL1 at DataMed
- Search for RGSL1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGSL1 Gene
Genomics for RGSL1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RGSL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RGSL1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGSL1
- Top Transcription factor binding sites by QIAGEN in the RGSL1 gene promoter:
-
- AREB6
- ATF6
- CUTL1
- Egr-3
- GATA-1
- ITF-2
- NRF-2
- NRSF form 1
- NRSF form 2
- Tal-1beta
Genomic Locations for RGSL1 Gene
Latest Assembly
- chr1:182,409,192-182,560,599
- (GRCh38/hg38)
- Size:
- 151,408 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:182,419,281-182,529,732
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 110,452 bases
- Orientation:
- Plus strand
Genomic View for RGSL1 Gene
Genes around RGSL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.3 by HGNC
- 1q25.3 by Entrez Gene
- 1q25.3 by Ensembl
RGSL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RGSL1 Gene
Proteins for RGSL1 Gene
-
Protein details for RGSL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A5PLK6-RGSL_HUMAN
- Recommended name:
- Regulator of G-protein signaling protein-like
- Protein Accession:
- A5PLK6
- A2A2Z0
- A6PVM2
- A6PVM3
- Q0VAJ4
- Q0VAJ5
- Q6ZRL0
- Q86UV0
- Q9H084
Protein attributes for RGSL1 Gene
- Size:
- 1076 amino acids
- Molecular mass:
- 125688 Da
- Quaternary structure:
- No Data Available
Protein Expression for RGSL1 Gene
Post-translational modifications for RGSL1 Gene
Other Protein References for RGSL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RGSL1
- Origene Custom Protein Services for RGSL1
Assay products for research
No data available for DME Specific Peptides for RGSL1 Gene
Domains & Families for RGSL1 Gene
Gene Families for RGSL1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for RGSL1 Gene
- GenScript: Design optimal peptide antigens:
-
- Regulator of G-protein signaling protein-like (RGSL_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGSL1 Gene
Function for RGSL1 Gene
Phenotypes From GWAS Catalog for RGSL1 Gene
Phenotypes for RGSL1 Gene
- MGI mutant phenotypes for RGSL1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RGSL1:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RGSL1 - Starting at $85 >
- * RGSL1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RGSL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RGSL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RGSL1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RGSL1
- Browse OriGene Inhibitory RNA Products For RGSL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGSL1
Clone products for research
- Applied Biological Materials (abm): Clones for RGSL1 - Starting at $45 >
- * RGSL1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RGSL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RGSL1
Cell Lines for research
-
Horizon Cell Lines for RGSL1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGSL1 Gene
Localization for RGSL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RGSL1 Gene
- Membrane. Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| endosome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RGSL1 Gene
Pathways & Interactions for RGSL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | RET signaling | ||
| 3 | Peptide ligand-binding receptors | ||
| 4 | ADP signalling through P2Y purinoceptor 12 | ||
Pathways by source for RGSL1 Gene
Interacting Proteins for RGSL1 Gene
GPS-Prot Interaction Network for RGSL1
No data available for SIGNOR curated interactions for RGSL1 Gene
Transcripts for RGSL1 Gene
mRNA/cDNA for RGSL1 Gene
- 4 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000294854 3735 nts (view in UCSC)
- ENST00000367561 2044 nts (view in UCSC)
- ENST00000415960 2084 nts (view in UCSC)
- ENST00000416676 708 nts (view in UCSC)
- ENST00000422241 731 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RGSL1 - Starting at $85 >
- * RGSL1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RGSL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RGSL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RGSL1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RGSL1
- Browse OriGene Inhibitory RNA Products For RGSL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGSL1
Clone products for research
- Applied Biological Materials (abm): Clones for RGSL1 - Starting at $45 >
- * RGSL1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RGSL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RGSL1
Relevant External Links for RGSL1 Gene
- GeneLoc Exon Structure for
- RGSL1
Expression for RGSL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for RGSL1 Gene
This gene is overexpressed in Testis (x50.6).
This gene is overexpressed in Liver (66.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGSL1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGSL1
SOURCE GeneReport for Unigene cluster for RGSL1 Gene:
Hs.121200Primer products for research
-
OriGene qPCR primer pairs for RGSL1
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGSL1 Gene
Orthologs for RGSL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RGSL1 29 |
|
||
| Dog (Canis familiaris) |
Mammalia | RGSL1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RGSL1 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rgsl1 29 16 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | RGSL1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LOC100858077 29 |
|
||
| RGSL1 30 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | RGSL1 30 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | LOC565777 29 |
|
- Species where no ortholog for RGSL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for RGSL1 Gene
- ENSEMBL:
- Gene Tree for RGSL1 (if available)
- TreeFam:
- Gene Tree for RGSL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RGSL1: view image
- Alliance of Genome Resources:
- Additional Orthologs for RGSL1
Paralogs for RGSL1 Gene
Variants for RGSL1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGSL1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs769739061 | Likely Benign: not provided | 182,556,042(+) |
C/T NM_001137669.2(RGSL1):c.3216C>T (p.Ile1072=) |
SYNONYMOUS | |
| rs12083859 | -- |
p.Glu5Asp |
|||
| rs647224 | -- |
p.Trp256Cys |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3302826 | CNV | tandem duplication | 20981092 |
| esv3302856 | CNV | tandem duplication | 20981092 |
| esv3404570 | CNV | insertion | 20981092 |
| nsv1068350 | CNV | deletion | 25765185 |
| nsv1140429 | CNV | tandem duplication | 24896259 |
| nsv528762 | CNV | loss | 19592680 |
| nsv548358 | CNV | gain | 21841781 |
| nsv825531 | CNV | loss | 20364138 |
| nsv825542 | CNV | gain | 20364138 |
| nsv825553 | CNV | gain | 20364138 |
Gene Damage Index Score:
12.44;
94.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RGSL1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGSL1 Gene
Disorders for RGSL1 Gene
Additional Disease Information for RGSL1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for RGSL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGSL1 Gene
Publications for RGSL1 Gene
- Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PMID: 20574532) Shulman JM … De Jager PL (PloS one 2010) 3 40
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Identification of 9 novel transcripts and two RGSL genes within the hereditary prostate cancer region (HPC1) at 1q25. (PMID: 12801632) Silva AP … Camargo AA (Gene 2003) 2 3
ExternalLinks
Products for RGSL1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RGSL1
- Origene Custom Protein Services for RGSL1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RGSL1
- Browse OriGene Inhibitory RNA Products For RGSL1
- OriGene qPCR primer pairs for RGSL1
- OriGene CRISPR knockouts for RGSL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RGSL1
- Sino Biological Human cDNA Clone for RGSL1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for RGSL1 (AFLGC-RGSL1)
- VectorBuilder Custom and pre-made DNA vectors for RGSL1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RGSL1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RGSL1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RGSL1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RGSL1
- antibodies-online: Search results for available RGSL1 related products ranked by validation data
- antibodies-online: Search results for available RGSL1 related products ranked by validation data
- antibodies-online: Search results for available RGSL1 related products ranked by validation data
- Horizon Cell Lines for RGSL1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RGSL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RGSL1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RGSL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGSL1
- Biorbyt antibodies for RGSL1
Sources for RGSL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources