Aliases for RGS7 Gene
External Ids for RGS7 Gene
Previous GeneCards Identifiers for RGS7 Gene
GeneCards Summary for RGS7 Gene
RGS7 (Regulator Of G Protein Signaling 7) is a Protein Coding gene. Diseases associated with RGS7 include Prolonged Electroretinal Response Suppression and Congenital Stationary Night Blindness. Among its related pathways are Signaling by GPCR and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and G-protein beta-subunit binding. An important paralog of this gene is RGS6.
UniProtKB/Swiss-Prot Summary for RGS7 Gene
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).