Aliases for RGS7 Gene
External Ids for RGS7 Gene
Previous GeneCards Identifiers for RGS7 Gene
GeneCards Summary for RGS7 Gene
RGS7 (Regulator Of G Protein Signaling 7) is a Protein Coding gene. Diseases associated with RGS7 include Prolonged Electroretinal Response Suppression and Congenital Stationary Night Blindness. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and G-protein beta-subunit binding. An important paralog of this gene is RGS6.
UniProtKB/Swiss-Prot Summary for RGS7 Gene
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).