This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is a... See more...

Aliases for RGS5 Gene

Aliases for RGS5 Gene

  • Regulator Of G Protein Signaling 5 2 3 5
  • Regulator Of G-Protein Signaling 5 2 3 4
  • Regulator Of G-Protein Signalling 5 2
  • MSTP032 3
  • MSTP092 3
  • MSTP106 3
  • MSTP129 3
  • MST092 3
  • MST106 3
  • MST129 3
  • RGS5 5

External Ids for RGS5 Gene

Previous GeneCards Identifiers for RGS5 Gene

  • GC01M160750
  • GC01M158766
  • GC01M159776
  • GC01M160299
  • GC01M159843
  • GC01M161378
  • GC01M163080
  • GC01M134357

Summaries for RGS5 Gene

Entrez Gene Summary for RGS5 Gene

  • This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for RGS5 Gene

RGS5 (Regulator Of G Protein Signaling 5) is a Protein Coding gene. Diseases associated with RGS5 include Hypertension, Essential. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS3.

UniProtKB/Swiss-Prot Summary for RGS5 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).

Gene Wiki entry for RGS5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS5 Gene

Genomics for RGS5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGS5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J163320 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.4 -410 3.6 ZNF221 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 TFE3 ZNF512 NUF2 ENSG00000232995 RGS5 ENSG00000272574 RGS4 UAP1 DDR2 RGS5-AS1 NONHSAG003309.2
GH01J163200 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas 600.1 +119.9 119900 4.2 TEAD4 POLR2A YY1 RCOR1 SIN3A RFX5 CHD2 TAF1 TBP EGR2 RGS5 RGS5-AS1 RGS4 ENSG00000232995 piR-60246-012 NUF2
GH01J163195 Enhancer 0.7 ENCODE 10.9 +125.3 125301 1.7 JUND HDAC1 SOX6 EP300 TCF7L2 FOSL1 NR2F2 NFIC RCOR1 ZNF768 RGS5-AS1 RGS5 NUF2 ENSG00000232995 piR-60246-012 RGS4
GH01J163128 Enhancer 0.5 FANTOM5 4.3 +193.1 193148 0.1 ZNF316 MAFF MAFK MAFG EMSY RGS5-AS1 RGS4 RGS5 piR-61614-013 NUF2
GH01J163259 Enhancer 0.2 Ensembl 10.1 +63.0 62990 0.4 ENSG00000237756 ENSG00000232995 RGS5 NUF2 ENSG00000225755 lnc-NUF2-4 RGS4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS5

Top Transcription factor binding sites by QIAGEN in the RGS5 gene promoter:
  • aMEF-2
  • C/EBPbeta
  • FOXO3
  • FOXO3a
  • FOXO3b
  • MEF-2A
  • NF-1
  • Pax-6
  • Sox9
  • TBP

Genomic Locations for RGS5 Gene

Genomic Locations for RGS5 Gene
chr1:163,111,121-163,321,791
(GRCh38/hg38)
Size:
210,671 bases
Orientation:
Minus strand
chr1:163,080,911-163,291,577
(GRCh37/hg19)
Size:
210,667 bases
Orientation:
Minus strand

Genomic View for RGS5 Gene

Genes around RGS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS5 Gene

Proteins for RGS5 Gene

  • Protein details for RGS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15539-RGS5_HUMAN
    Recommended name:
    Regulator of G-protein signaling 5
    Protein Accession:
    O15539
    Secondary Accessions:
    • E9PMP5
    • Q53XA9
    • Q599J0

    Protein attributes for RGS5 Gene

    Size:
    181 amino acids
    Molecular mass:
    20946 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: Acts as an endogenous negative regulator of isoform 1.

    Three dimensional structures from OCA and Proteopedia for RGS5 Gene

    Alternative splice isoforms for RGS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS5 Gene

Post-translational modifications for RGS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS5 Gene

Domains & Families for RGS5 Gene

Gene Families for RGS5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS5 Gene

InterPro:
Blocks:
  • Regulator of G-protein signalling (RGS) protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for RGS5 Gene

GenScript: Design optimal peptide antigens:
  • MSTP092 (Q7LCP5_HUMAN)
  • MSTP129 (Q9H3F2_HUMAN)
  • Regulator of G-protein signaling 5 (RGS5_HUMAN)
genes like me logo Genes that share domains with RGS5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS5 Gene

Function for RGS5 Gene

Molecular function for RGS5 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).
GENATLAS Biochemistry:
negative regulator of G protein signaling 5,functioning as GTPase activating protein for G protein alpha i and q subunits,abundantly expressed in heart,lung,skeletal muscle,small intestine,C elegans EGL-10 and yeast SST2 homolog

Phenotypes From GWAS Catalog for RGS5 Gene

Gene Ontology (GO) - Molecular Function for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
GO:0005096 GTPase activator activity TAS 10471929
genes like me logo Genes that share ontologies with RGS5: view
genes like me logo Genes that share phenotypes with RGS5: view

Animal Models for RGS5 Gene

MGI Knock Outs for RGS5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS5 Gene

Localization for RGS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS5 Gene

[Isoform 1]: Cytoplasm. Membrane.
[Isoform 2]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS5 gene
Compartment Confidence
plasma membrane 4
cytosol 4
extracellular 2
cytoskeleton 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RGS5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RGS5 Gene

Pathways & Interactions for RGS5 Gene

genes like me logo Genes that share pathways with RGS5: view

Pathways by source for RGS5 Gene

3 Qiagen pathways for RGS5 Gene
  • cAMP Pathway
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

Gene Ontology (GO) - Biological Process for RGS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0008277 regulation of G protein-coupled receptor signaling pathway TAS 10471929
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS5: view

No data available for SIGNOR curated interactions for RGS5 Gene

Drugs & Compounds for RGS5 Gene

(4) Drugs for RGS5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 2368
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 2338
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1414
leucovorin Approved Pharma 3692,1548

(1) Additional Compounds for RGS5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS5: view

Transcripts for RGS5 Gene

mRNA/cDNA for RGS5 Gene

5 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS5

Alternative Splicing Database (ASD) splice patterns (SP) for RGS5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6: - - - - - - -

Relevant External Links for RGS5 Gene

GeneLoc Exon Structure for
RGS5

Expression for RGS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS5 Gene

mRNA differential expression in normal tissues according to GTEx for RGS5 Gene

This gene is overexpressed in Artery - Tibial (x13.7) and Artery - Aorta (x8.3).

Protein differential expression in normal tissues from HIPED for RGS5 Gene

This gene is overexpressed in Lung (52.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGS5 Gene



Protein tissue co-expression partners for RGS5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS5

SOURCE GeneReport for Unigene cluster for RGS5 Gene:

Hs.24950

Evidence on tissue expression from TISSUES for RGS5 Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Liver(4.4)
  • Heart(3.7)
  • Muscle(3.3)
  • Pancreas(3)
  • Intestine(2.7)
  • Lung(2.6)
  • Thyroid gland(2.6)
  • Kidney(2.6)
  • Adrenal gland(2.3)
  • Lymph node(2.3)
  • Gall bladder(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with RGS5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS5 Gene

Orthologs for RGS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGS5 30 31
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RGS5 30 31
  • 94.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RGS5 30 31
  • 91.9 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rgs5 30 17 31
  • 89.69 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgs5 30
  • 88.7 (n)
Oppossum
(Monodelphis domestica)
Mammalia RGS5 31
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RGS5 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RGS5 30 31
  • 80.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGS5 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rgs5 30
  • 74.22 (n)
Zebrafish
(Danio rerio)
Actinopterygii rgs5a 30 31
  • 71.09 (n)
OneToOne
wufj30h05 30
Species where no ortholog for RGS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RGS5 Gene

ENSEMBL:
Gene Tree for RGS5 (if available)
TreeFam:
Gene Tree for RGS5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS5: view image

Paralogs for RGS5 Gene

(20) SIMAP similar genes for RGS5 Gene using alignment to 3 proteins:

  • RGS5_HUMAN
  • B1APM2_HUMAN
  • E9PS96_HUMAN
genes like me logo Genes that share paralogs with RGS5: view

Variants for RGS5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
737960 Benign: not provided 163,168,296(-) C/T SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for RGS5 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS5 Gene

Variant ID Type Subtype PubMed ID
esv3353974 CNV insertion 20981092
esv3890704 CNV loss 25118596
nsv1137820 CNV deletion 24896259
nsv946476 CNV duplication 23825009

Variation tolerance for RGS5 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS5 Gene

Disorders for RGS5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RGS5 Gene - From: OMIM, GTR, and DISEASES

Disorder Aliases PubMed IDs
hypertension, essential
  • eht
- elite association - COSMIC cancer census association via MalaCards
Search RGS5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGS5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RGS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS5 Gene

Publications for RGS5 Gene

  1. Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene. (PMID: 9747037) Seki N … Hori T (Journal of human genetics 1998) 2 3 4 23
  2. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell DB … Sullivan PF (Schizophrenia research 2008) 3 23 41
  3. Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues. (PMID: 15670159) Liang Y … Woodward DF (The FEBS journal 2005) 3 4 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41

Products for RGS5 Gene

Sources for RGS5 Gene