Aliases for RGS5 Gene
External Ids for RGS5 Gene
Previous GeneCards Identifiers for RGS5 Gene
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
GeneCards Summary for RGS5 Gene
RGS5 (Regulator Of G Protein Signaling 5) is a Protein Coding gene. Diseases associated with RGS5 include Hypertension, Essential. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS4.
UniProtKB/Swiss-Prot for RGS5 Gene
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).