RGS3 Gene (Protein Coding)

Regulator Of G Protein Signaling 3

GC09P114824
GIFtS:
38
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a ... See more...

Aliases for RGS3 Gene

Aliases for RGS3 Gene

  • Regulator Of G Protein Signaling 3 2 3 5
  • Regulator Of G-Protein Signaling 3 2 3 4
  • Regulator Of G-Protein Signalling 3 2 3
  • C2PA 2 3
  • RGP3 3 4
  • FLJ20370 2
  • PDZ-RGS3 2
  • RGS3 5

External Ids for RGS3 Gene

Previous GeneCards Identifiers for RGS3 Gene

  • GC09P107022
  • GC09P107956
  • GC09P109678
  • GC09P111600
  • GC09P113303
  • GC09P115262
  • GC09P116207
  • GC09P085814
  • GC09P113448
  • GC09P113549
  • GC09P114400
  • GC09P114451
  • GC09P114457
  • GC09P114642
  • GC09P113551
  • GC09P113604
  • GC09P113737
  • GC09P113866
  • GC09P113992
  • GC09P114119
  • GC09P114252
  • GC09P114334

Summaries for RGS3 Gene

Entrez Gene Summary for RGS3 Gene

  • This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

GeneCards Summary for RGS3 Gene

RGS3 (Regulator Of G Protein Signaling 3) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot Summary for RGS3 Gene

  • Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.

Gene Wiki entry for RGS3 Gene

Additional gene information for RGS3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS3 Gene

Genomics for RGS3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for RGS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS3

Top Transcription factor binding sites by QIAGEN in the RGS3 gene promoter:
  • AP-1
  • ER-alpha
  • GR
  • GR-alpha
  • HEN1
  • Lmo2
  • Pbx1a

Genomic Locations for RGS3 Gene

Genomic Locations for RGS3 Gene
chr9:113,444,730-113,597,743
(GRCh38/hg38)
Size:
153,014 bases
Orientation:
Plus strand
chr9:116,207,011-116,360,018
(GRCh37/hg19)
Size:
153,008 bases
Orientation:
Plus strand

Genomic View for RGS3 Gene

Genes around RGS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RGS3 Gene

Proteins for RGS3 Gene

Products:

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  • Protein details for RGS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49796-RGS3_HUMAN
    Recommended name:
    Regulator of G-protein signaling 3
    Protein Accession:
    P49796
    Secondary Accessions:
    • A6NHA0
    • A8K0V1
    • B3KUB2
    • Q5VXB8
    • Q5VXC1
    • Q5VZ05
    • Q5VZ06
    • Q6ZRM5
    • Q8IUQ1
    • Q8NC47
    • Q8NFN4
    • Q8NFN5
    • Q8NFN6
    • Q8TD59
    • Q8TD68
    • Q8WV02
    • Q8WXA0

    Protein attributes for RGS3 Gene

    Size:
    1198 amino acids
    Molecular mass:
    132336 Da
    Quaternary structure:
    • Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.
    Miscellaneous:
    • [Isoform 2]: Nuclear.

    Three dimensional structures from OCA and Proteopedia for RGS3 Gene

    Alternative splice isoforms for RGS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS3 Gene

Protein Expression for RGS3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RGS3 Gene

Other Protein References for RGS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS3 Gene

Domains & Families for RGS3 Gene

Gene Families for RGS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RGS3 Gene

InterPro:
Blocks:
  • C2 domain
  • Regulator of G-protein signalling (RGS) protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for RGS3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ39521 fis, clone PUAEN2001586, highly similar to Regulator of G-protein signaling 3 (B3KUB2_HUMAN)
  • RGS3 isoform RGS3S (Q8NFN6_HUMAN)
  • RGS3 protein (Q8WV02_HUMAN)
  • RGS3 protein (Q8WVE9_HUMAN)
  • Regulator of G-protein signaling 3 (RGS3_HUMAN)
genes like me logo Genes that share domains with RGS3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS3 Gene

Function for RGS3 Gene

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Molecular function for RGS3 Gene

UniProtKB/Swiss-Prot Function:
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
GENATLAS Biochemistry:
negative regulator of G protein signaling 3,functioning as GTPase-activating protein for G protein alpha i and q subunits,expressed in heart,skeletal muscle,lung and other tissues,C elegans EGL-10 and yeast SST2 homolog

Phenotypes From GWAS Catalog for RGS3 Gene

Gene Ontology (GO) - Molecular Function for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
GO:0005096 GTPase activator activity TAS 9858594
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with RGS3: view
genes like me logo Genes that share phenotypes with RGS3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS3 Gene

Localization for RGS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS3 Gene

Cytoplasm. Nucleus. Cell membrane. Peripheral membrane protein. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
mitochondrion 3
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS 9858594
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RGS3: view

Pathways & Interactions for RGS3 Gene

PathCards logo

SuperPathways for RGS3 Gene

SuperPathway Contained pathways
1 EphB-EphrinB Signaling
EphB-EphrinB Signaling
.58
Ephrin-Eph Signaling
.58
Cytoskeleton remodeling Reverse signaling by ephrin B
.33
2 Signaling by GPCR
GPCR downstream signaling
.76
Signaling by GPCR
.76
Signal Transduction
.52
3 G-AlphaQ Signaling
G-AlphaI Signaling
.47
G-AlphaQ Signaling
.47
4 RET signaling
Gastrin-CREB signalling pathway via PKC and MAPK
.55
G alpha (q) signalling events
.43
5 Myometrial Relaxation and Contraction Pathways
Calcium Regulation in the Cardiac Cell
.42
Myometrial Relaxation and Contraction Pathways
.42
genes like me logo Genes that share pathways with RGS3: view

Pathways by source for RGS3 Gene

1 Sino Biological pathway for RGS3 Gene
1 KEGG pathway for RGS3 Gene
4 GeneGo (Thomson Reuters) pathways for RGS3 Gene
  • Cell adhesion Ephrins signaling
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • G-protein signaling G-Protein alpha-q signaling cascades
  • G-protein signaling G-Protein beta/gamma signaling cascades
5 Qiagen pathways for RGS3 Gene
  • cAMP Pathway
  • EphB-EphrinB Signaling
  • Ephrin-Eph Signaling
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

Gene Ontology (GO) - Biological Process for RGS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8602223
GO:0007165 signal transduction IBA 21873635
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0008277 regulation of G protein-coupled receptor signaling pathway TAS 9858594
GO:0009968 negative regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with RGS3: view

No data available for SIGNOR curated interactions for RGS3 Gene

Drugs & Compounds for RGS3 Gene

Products:

  1. Drug

(1) Drugs for RGS3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RGS3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS3: view

Transcripts for RGS3 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RGS3 Gene

13 REFSEQ mRNAs :
39 NCBI additional mRNA sequence :
32 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^
SP1: - - - - - - -
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ExUns: 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e ^ 28a · 28b ^ 29a · 29b · 29c · 29d · 29e ^ 30a · 30b · 30c ^ 31a · 31b · 31c ^ 32 ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - -
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SP25: -
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SP28: - - - - - - - -
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SP31: - - - - -
SP32: - - - -
SP33: -
SP34:
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SP37: - - - - - - - - - - - - - -
SP38:

ExUns: 33a · 33b · 33c · 33d · 33e · 33f ^ 34a · 34b · 34c · 34d · 34e · 34f · 34g · 34h · 34i · 34j · 34k · 34l ^ 35a · 35b ^ 36 ^ 37a · 37b · 37c · 37d · 37e ^
SP1:
SP2: - - - - - - - - - - - - - - - - - - - - - - - - -
SP3:
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SP5: - - - - - -
SP6: - - - - - -
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SP14: - - - - - -
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SP16: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP17: - -
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SP20: - - - - - -
SP21: - -
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SP24: - -
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SP30: -
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SP32: - - - - - -
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SP37: - - - - - -
SP38:

ExUns: 38a · 38b ^ 39a · 39b ^ 40a · 40b · 40c ^ 41a · 41b · 41c · 41d ·
SP1:
SP2: - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8: - - -
SP9:
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SP16: - - -
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SP35: -
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Relevant External Links for RGS3 Gene

GeneLoc Exon Structure for
RGS3

Expression for RGS3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS3 Gene

mRNA expression in normal human tissues for RGS3 Gene
mRNA expression by BioGPS for RGS3 GenemRNA expression by GTEx for RGS3 Gene

Protein differential expression in normal tissues from HIPED for RGS3 Gene

This gene is overexpressed in NK cells (24.7), Peripheral blood mononuclear cells (17.3), and CD8 Tcells (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RGS3 Gene



Protein tissue co-expression partners for RGS3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS3

SOURCE GeneReport for Unigene cluster for RGS3 Gene:

Hs.494875

Evidence on tissue expression from TISSUES for RGS3 Gene

  • Nervous system(4.8)
  • Kidney(4.5)
  • Liver(4.3)
  • Muscle(2.8)
  • Heart(2.7)
  • Skin(2.4)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with RGS3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS3 Gene

Orthologs for RGS3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia RGS3 30 31
  • 99.42 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia RGS3 30 31
  • 87.93 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia RGS3 31
  • 87 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Rgs3 30
  • 83.95 (n)
Mouse
(Mus musculus)
 Mammalia Rgs3 30 17 31
  • 83.52 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia RGS3 31
  • 69 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia RGS3 31
  • 68 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves RGS3 30 31
  • 73.91 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia RGS3 31
  • 77 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii si:ch211-154e10.1 30
  • 59.98 (n)
RGS3 31
  • 41 (a)
 OneToOne
Species where no ortholog for RGS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RGS3 Gene

ENSEMBL:
Gene Tree for RGS3 (if available)
TreeFam:
Gene Tree for RGS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS3: view image

Paralogs for RGS3 Gene

Paralogs for RGS3 Gene

(20) SIMAP similar genes for RGS3 Gene using alignment to 8 proteins:

  • RGS3_HUMAN
  • B3KUB2_HUMAN
  • C9J582_HUMAN
  • C9J6G2_HUMAN
  • H7BXY1_HUMAN
  • H7C539_HUMAN
  • Q5VXC0_HUMAN
  • Q8WVE9_HUMAN
genes like me logo Genes that share paralogs with RGS3: view

Variants for RGS3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS3 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
770753 Benign: not provided 113,583,688(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
774431 Benign: not provided 113,584,235(+) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
rs16933949 - p.Arg129Lys
rs41305473 - p.Arg809Gln

Additional dbSNP identifiers (rs#s) for RGS3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS3 Gene

Variant ID Type Subtype PubMed ID
dgv12854n54 CNV loss 21841781
esv1750461 CNV deletion 17803354
esv2738955 CNV deletion 23290073
nsv415849 CNV deletion 16902084
nsv466508 CNV loss 19166990
nsv472386 CNV novel sequence insertion 20440878
nsv473478 CNV novel sequence insertion 20440878
nsv478450 CNV novel sequence insertion 20440878
nsv526579 CNV loss 19592680
nsv615215 CNV loss 21841781
nsv950929 CNV deletion 24416366
nsv972443 CNV duplication 23825009

Variation tolerance for RGS3 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS3 Gene

Disorders for RGS3 Gene

Additional Disease Information for RGS3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for RGS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS3 Gene

Publications for RGS3 Gene

  1. Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation. (PMID: 11294858) Shi CS … Kehrl JH (The Journal of biological chemistry 2001) 3 4 23
  2. Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. (PMID: 10749886) Dulin NO … Dunn MJ (The Journal of biological chemistry 2000) 3 4 23
  3. RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. (PMID: 9858594) Dulin NO … Dunn MJ (Molecular and cellular biology 1999) 3 4 23
  4. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PMID: 8602223) Druey KM … Kehrl JH (Nature 1996) 2 3 4
  5. Genomic assessment of follicular marker genes as pregnancy predictors for human IVF. (PMID: 19778949) Hamel M … Sirard MA (Molecular human reproduction 2010) 3 23

ExternalLinks

View latest publications for RGS3 gene in Mastermind

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