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Aliases for RGS22 Gene

Aliases for RGS22 Gene

  • Regulator Of G Protein Signaling 22 2 3 5
  • Regulator Of G-Protein Signaling 22 2 3
  • Regulator Of G-Protein Signalling 22 2
  • PRTD-NY2 3
  • CT145 3

External Ids for RGS22 Gene

Previous GeneCards Identifiers for RGS22 Gene

  • GC08M101044
  • GC08M096176
  • GC08M100973

Summaries for RGS22 Gene

GeneCards Summary for RGS22 Gene

RGS22 (Regulator Of G Protein Signaling 22) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include GTPase activator activity.

UniProtKB/Swiss-Prot for RGS22 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Additional gene information for RGS22 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS22 Gene

Genomics for RGS22 Gene

GeneHancer (GH) Regulatory Elements for RGS22 Gene

Promoters and enhancers for RGS22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I100105 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 562 +25.2 25175 1.3 CTCF SIX4 SIN3A EZH2 RGS22 PIR62937 SPAG1 MIR1273A
GH08I100487 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -364.1 -364104 16.6 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 YBX1 IRF4 RNF19A SPAG1 PABPC1 ENSG00000202310 ANKRD46 ENSG00000253217 RGS22 ENSG00000254364 YWHAZ ENSG00000253666
GH08I100212 Promoter/Enhancer 1.5 Ensembl ENCODE 10.2 -82.2 -82216 2.1 PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF48 GLIS2 FOS ATF7 RUNX3 SPAG1 ENSG00000202310 ENSG00000253666 RGS22 ANKRD46 LOC105375669 ENSG00000199667
GH08I100441 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -312.5 -312549 5.2 HDGF SMAD1 RB1 NFIB YBX1 BATF RAD21 YY1 ZNF366 ATF7 RNF19A ENSG00000253666 ENSG00000253217 ANKRD46 RGS22 SPAG1 PABPC1 GC08M100437 GC08M100448 LOC105375670
GH08I100525 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.3 -396.7 -396658 4.5 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B IRF4 ETS1 YY1 ZNF207 ANKRD46 FBXO43 POLR2K ENSG00000253666 ENSG00000202310 SPAG1 RNF19A ENSG00000253217 RGS22 LOC105375674
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RGS22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS22 gene promoter:

Genomic Locations for RGS22 Gene

Genomic Locations for RGS22 Gene
170,333 bases
Minus strand

Genomic View for RGS22 Gene

Genes around RGS22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS22 Gene

Proteins for RGS22 Gene

  • Protein details for RGS22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 22
    Protein Accession:
    Secondary Accessions:
    • A8K944
    • Q569L2
    • Q86Y71
    • Q9BYZ4
    • Q9UFN6

    Protein attributes for RGS22 Gene

    1264 amino acids
    Molecular mass:
    147163 Da
    Quaternary structure:
    • Interacts with GNA11, GNA12 AND GNA13.
    • Sequence=AAG49397.1; Type=Frameshift; Positions=877, 882, 886, 891; Evidence={ECO:0000305};

    Alternative splice isoforms for RGS22 Gene


neXtProt entry for RGS22 Gene

Post-translational modifications for RGS22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS22 Gene

Domains & Families for RGS22 Gene

Gene Families for RGS22 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS22 Gene


Suggested Antigen Peptide Sequences for RGS22 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS22: view

No data available for UniProtKB/Swiss-Prot for RGS22 Gene

Function for RGS22 Gene

Molecular function for RGS22 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Phenotypes From GWAS Catalog for RGS22 Gene

Gene Ontology (GO) - Molecular Function for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with RGS22: view
genes like me logo Genes that share phenotypes with RGS22: view

Animal Model Products

miRNA for RGS22 Gene

miRTarBase miRNAs that target RGS22

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS22 Gene

Localization for RGS22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS22 Gene

Cytoplasm. Nucleus. Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS22 gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RGS22 Gene

Pathways & Interactions for RGS22 Gene

genes like me logo Genes that share pathways with RGS22: view

Pathways by source for RGS22 Gene

Interacting Proteins for RGS22 Gene

Gene Ontology (GO) - Biological Process for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS22: view

No data available for SIGNOR curated interactions for RGS22 Gene

Drugs & Compounds for RGS22 Gene

No Compound Related Data Available

Transcripts for RGS22 Gene

Unigene Clusters for RGS22 Gene

Regulator of G-protein signaling 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS22 Gene

No ASD Table

Relevant External Links for RGS22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS22 Gene

mRNA differential expression in normal tissues according to GTEx for RGS22 Gene

This gene is overexpressed in Testis (x26.8) and Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for RGS22 Gene

This gene is overexpressed in Breast (42.6), Tlymphocyte (13.0), and Monocytes (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS22 Gene

Protein tissue co-expression partners for RGS22 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS22 Gene:


SOURCE GeneReport for Unigene cluster for RGS22 Gene:


mRNA Expression by UniProt/SwissProt for RGS22 Gene:

Tissue specificity: Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level).
genes like me logo Genes that share expression patterns with RGS22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS22 Gene

Orthologs for RGS22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS22 33 34
  • 99.68 (n)
(Canis familiaris)
Mammalia RGS22 33 34
  • 88.25 (n)
(Bos Taurus)
Mammalia RGS22 33 34
  • 87.77 (n)
(Mus musculus)
Mammalia Rgs22 33 16 34
  • 79.73 (n)
(Rattus norvegicus)
Mammalia Rgs22 33
  • 79.44 (n)
(Monodelphis domestica)
Mammalia RGS22 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia RGS22 34
  • 61 (a)
(Gallus gallus)
Aves RGS22 33 34
  • 64.93 (n)
(Anolis carolinensis)
Reptilia RGS22 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs22 33
  • 59.24 (n)
(Danio rerio)
Actinopterygii LOC101884083 33
  • 49.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for RGS22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS22 Gene

Gene Tree for RGS22 (if available)
Gene Tree for RGS22 (if available)

Paralogs for RGS22 Gene

No data available for Paralogs for RGS22 Gene

Variants for RGS22 Gene

Sequence variations from dbSNP and Humsavar for RGS22 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000033630 -- 99,985,618(-) AACA/A genic_downstream_transcript_variant, intron_variant
rs1000041795 -- 100,047,084(-) C/T intron_variant
rs1000095899 -- 100,000,920(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000144869 -- 99,993,932(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000193355 -- 100,019,552(-) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS22 Gene

Variant ID Type Subtype PubMed ID
esv1068346 CNV deletion 17803354
esv1205143 CNV deletion 17803354
esv2466799 CNV deletion 19546169
esv3618185 CNV loss 21293372
nsv1030482 CNV loss 25217958
nsv1077059 CNV deletion 25765185
nsv396616 CNV deletion 16902084
nsv611814 CNV loss 21841781
nsv967622 CNV duplication 23825009

Variation tolerance for RGS22 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS22 Gene

Disorders for RGS22 Gene

Additional Disease Information for RGS22

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGS22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS22 Gene

Publications for RGS22 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 44 58
  3. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. (PMID: 18703424) Hu Y … Sha J (Biology of reproduction 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RGS22 Gene

Sources for RGS22 Gene

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