Aliases for RGS22 Gene

Aliases for RGS22 Gene

  • Regulator Of G Protein Signaling 22 2 3 5
  • Regulator Of G-Protein Signaling 22 2 3 4
  • PRTD-NY2 2 3
  • CT145 2 3
  • Regulator Of G-Protein Signalling 22 2
  • DKFZP434I092 2
  • RGS22 5

External Ids for RGS22 Gene

Previous GeneCards Identifiers for RGS22 Gene

  • GC08M101044
  • GC08M096176
  • GC08M100973

Summaries for RGS22 Gene

GeneCards Summary for RGS22 Gene

RGS22 (Regulator Of G Protein Signaling 22) is a Protein Coding gene. Diseases associated with RGS22 include Hypertrophy Of Breast and Basal Cell Nevus Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot Summary for RGS22 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS22 Gene

Genomics for RGS22 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGS22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS22 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS22

Top Transcription factor binding sites by QIAGEN in the RGS22 gene promoter:
  • aMEF-2
  • C/EBPalpha
  • En-1
  • Hlf
  • HNF-3beta
  • ITF-2
  • MEF-2A
  • Pbx1a
  • Tal-1beta
  • TBP

Genomic Locations for RGS22 Gene

Genomic Locations for RGS22 Gene
chr8:99,960,936-100,131,268
(GRCh38/hg38)
Size:
170,333 bases
Orientation:
Minus strand
chr8:100,973,164-101,143,496
(GRCh37/hg19)
Size:
170,333 bases
Orientation:
Minus strand

Genomic View for RGS22 Gene

Genes around RGS22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS22 Gene

Proteins for RGS22 Gene

  • Protein details for RGS22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE09-RGS22_HUMAN
    Recommended name:
    Regulator of G-protein signaling 22
    Protein Accession:
    Q8NE09
    Secondary Accessions:
    • A8K944
    • Q569L2
    • Q86Y71
    • Q9BYZ4
    • Q9UFN6

    Protein attributes for RGS22 Gene

    Size:
    1264 amino acids
    Molecular mass:
    147163 Da
    Quaternary structure:
    • Interacts with GNA11, GNA12 AND GNA13.
    SequenceCaution:
    • Sequence=AAG49397.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 3]: May be due to competing donor splice site.

    Alternative splice isoforms for RGS22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS22 Gene

Post-translational modifications for RGS22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS22 Gene

Domains & Families for RGS22 Gene

Gene Families for RGS22 Gene

Protein Domains for RGS22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RGS22 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75004 (A8K944_HUMAN)
  • Regulator of G-protein signaling 22 (RGS22_HUMAN)
genes like me logo Genes that share domains with RGS22: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS22 Gene

Function for RGS22 Gene

Molecular function for RGS22 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Phenotypes From GWAS Catalog for RGS22 Gene

Gene Ontology (GO) - Molecular Function for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA,IPI 18703424
genes like me logo Genes that share ontologies with RGS22: view
genes like me logo Genes that share phenotypes with RGS22: view

Animal Models for RGS22 Gene

MGI Knock Outs for RGS22:
  • Rgs22 Rgs22<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for RGS22 Gene

miRTarBase miRNAs that target RGS22

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS22 Gene

Localization for RGS22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS22 Gene

Cytoplasm. Nucleus. Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS22 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18703424
GO:0005737 cytoplasm IEA,IDA 18703424
genes like me logo Genes that share ontologies with RGS22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RGS22 Gene

Pathways & Interactions for RGS22 Gene

PathCards logo

SuperPathways for RGS22 Gene

SuperPathway Contained pathways
1 Signaling by GPCR
2 G-AlphaQ Signaling
.47
.47
3 Activation of cAMP-Dependent PKA
.77
4 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with RGS22: view

Pathways by source for RGS22 Gene

3 Qiagen pathways for RGS22 Gene
  • cAMP Pathway
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

Interacting Proteins for RGS22 Gene

Gene Ontology (GO) - Biological Process for RGS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IEA --
GO:0009968 negative regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with RGS22: view

No data available for SIGNOR curated interactions for RGS22 Gene

Drugs & Compounds for RGS22 Gene

No Compound Related Data Available

Transcripts for RGS22 Gene

mRNA/cDNA for RGS22 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS22

Alternative Splicing Database (ASD) splice patterns (SP) for RGS22 Gene

No ASD Table

Relevant External Links for RGS22 Gene

GeneLoc Exon Structure for
RGS22

Expression for RGS22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for RGS22 Gene

This gene is overexpressed in Testis (x26.8) and Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for RGS22 Gene

This gene is overexpressed in Breast (42.6), Tlymphocyte (13.0), and Monocytes (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGS22 Gene



Protein tissue co-expression partners for RGS22 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS22

SOURCE GeneReport for Unigene cluster for RGS22 Gene:

Hs.120021

mRNA Expression by UniProt/SwissProt for RGS22 Gene:

Q8NE09-RGS22_HUMAN
Tissue specificity: Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level).
genes like me logo Genes that share expression patterns with RGS22: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS22 Gene

Orthologs for RGS22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS22 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGS22 30 31
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RGS22 30 31
  • 88.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RGS22 30 31
  • 87.77 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rgs22 30 17 31
  • 79.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgs22 30
  • 79.44 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RGS22 31
  • 61 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RGS22 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RGS22 30 31
  • 64.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGS22 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rgs22 30
  • 59.24 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101884083 30
  • 49.95 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToOne
Species where no ortholog for RGS22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RGS22 Gene

ENSEMBL:
Gene Tree for RGS22 (if available)
TreeFam:
Gene Tree for RGS22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS22: view image

Paralogs for RGS22 Gene

genes like me logo Genes that share paralogs with RGS22: view

Variants for RGS22 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS22 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
709879 Benign: not provided 100,064,024(-) A/G SYNONYMOUS_VARIANT
716535 Benign: not provided 99,962,441(-) A/G STOP_LOST
741405 Likely Benign: not provided 100,080,173(-) G/A SYNONYMOUS_VARIANT
776366 Benign: not provided 99,962,943(-) T/C SYNONYMOUS_VARIANT
776367 Benign: not provided 100,093,501(-) A/G SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for RGS22 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS22 Gene

Variant ID Type Subtype PubMed ID
esv1068346 CNV deletion 17803354
esv1205143 CNV deletion 17803354
esv2466799 CNV deletion 19546169
esv3618185 CNV loss 21293372
nsv1030482 CNV loss 25217958
nsv1077059 CNV deletion 25765185
nsv396616 CNV deletion 16902084
nsv611814 CNV loss 21841781
nsv967622 CNV duplication 23825009

Variation tolerance for RGS22 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS22

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS22 Gene

Disorders for RGS22 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RGS22 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypertrophy of breast
  • breasts enlarged
basal cell nevus syndrome
  • bcns
- elite association - COSMIC cancer census association via MalaCards
Search RGS22 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGS22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RGS22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS22 Gene

Publications for RGS22 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 41
  3. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. (PMID: 18703424) Hu Y … Sha J (Biology of reproduction 2008) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for RGS22 Gene

  • Signalway Proteins for RGS22

Sources for RGS22 Gene