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Aliases for RGS21 Gene

Aliases for RGS21 Gene

  • Regulator Of G Protein Signaling 21 2 3 5
  • Regulator Of G-Protein Signalling 21 2
  • Regulator Of G-Protein Signaling 21 2

External Ids for RGS21 Gene

Previous GeneCards Identifiers for RGS21 Gene

  • GC00U914493
  • GC01U901126
  • GC01P190552
  • GC01P163522

Summaries for RGS21 Gene

Entrez Gene Summary for RGS21 Gene

  • Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]

GeneCards Summary for RGS21 Gene

RGS21 (Regulator Of G Protein Signaling 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot for RGS21 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Additional gene information for RGS21 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS21 Gene

Genomics for RGS21 Gene

GeneHancer (GH) Regulatory Elements for RGS21 Gene

Promoters and enhancers for RGS21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I192262 Enhancer 0.6 Ensembl ENCODE 0.2 -53.4 -53414 1.4 ZNF316 JUN ENSG00000236792 RGS21
GH01I192445 Enhancer 0.6 Ensembl 0.1 +128.9 128909 0.2 CTCF ZNF654 ZNF362 TRIM22 ZNF384 REST ZBTB40 RAD21 CHAMP1 CC2D1A GC01P192448 RGS21
GH01I192439 Enhancer 0.5 ENCODE 0.1 +122.6 122572 1 SP1 JUND FOXA2 JUN REST FOSL2 FOS GC01P192448 RGS21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RGS21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS21 gene promoter:

Genomic Locations for RGS21 Gene

Genomic Locations for RGS21 Gene
50,294 bases
Plus strand

Genomic View for RGS21 Gene

Genes around RGS21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS21 Gene

Proteins for RGS21 Gene

  • Protein details for RGS21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 21
    Protein Accession:

    Protein attributes for RGS21 Gene

    152 amino acids
    Molecular mass:
    17671 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RGS21 Gene

Post-translational modifications for RGS21 Gene

No Post-translational modifications

Other Protein References for RGS21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS21 Gene

Domains & Families for RGS21 Gene

Gene Families for RGS21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS21 Gene

Suggested Antigen Peptide Sequences for RGS21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS21: view

No data available for UniProtKB/Swiss-Prot for RGS21 Gene

Function for RGS21 Gene

Molecular function for RGS21 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Phenotypes From GWAS Catalog for RGS21 Gene

Gene Ontology (GO) - Molecular Function for RGS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with RGS21: view

Phenotypes for RGS21 Gene

GenomeRNAi human phenotypes for RGS21:
genes like me logo Genes that share phenotypes with RGS21: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RGS21 Gene

Localization for RGS21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS21 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RGS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RGS21 Gene

Pathways & Interactions for RGS21 Gene

genes like me logo Genes that share pathways with RGS21: view

Gene Ontology (GO) - Biological Process for RGS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS21: view

No data available for SIGNOR curated interactions for RGS21 Gene

Drugs & Compounds for RGS21 Gene

No Compound Related Data Available

Transcripts for RGS21 Gene

mRNA/cDNA for RGS21 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGS21 Gene

Regulator of G-protein signaling 21:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS21 Gene

No ASD Table

Relevant External Links for RGS21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS21 Gene

Protein differential expression in normal tissues from HIPED for RGS21 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS21 Gene

Protein tissue co-expression partners for RGS21 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS21 Gene:


SOURCE GeneReport for Unigene cluster for RGS21 Gene:


mRNA Expression by UniProt/SwissProt for RGS21 Gene:

Tissue specificity: Expressed ubiquitously.

Evidence on tissue expression from TISSUES for RGS21 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with RGS21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS21 Gene

Orthologs for RGS21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS21 33 34
  • 99.56 (n)
(Canis familiaris)
Mammalia RGS21 33 34
  • 91.67 (n)
(Bos Taurus)
Mammalia RGS21 33 34
  • 91.23 (n)
(Mus musculus)
Mammalia Rgs21 33 16 34
  • 88.82 (n)
(Rattus norvegicus)
Mammalia LOC102551739 33
  • 88.82 (n)
(Monodelphis domestica)
Mammalia RGS21 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia RGS21 34
  • 80 (a)
(Gallus gallus)
Aves RGS21 33 34
  • 72.37 (n)
(Anolis carolinensis)
Reptilia RGS21 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs21 33
  • 67.26 (n)
(Danio rerio)
Actinopterygii rgs1 33
  • 55.97 (n)
rgs3b 34
  • 6 (a)
Species where no ortholog for RGS21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS21 Gene

Gene Tree for RGS21 (if available)
Gene Tree for RGS21 (if available)

Paralogs for RGS21 Gene

Paralogs for RGS21 Gene

(16) SIMAP similar genes for RGS21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS21: view

Variants for RGS21 Gene

Sequence variations from dbSNP and Humsavar for RGS21 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000143712 -- 192,315,121(+) G/A upstream_transcript_variant
rs1000211123 -- 192,332,439(+) T/C intron_variant
rs1000215538 -- 192,339,676(+) T/C intron_variant
rs1000411197 -- 192,332,210(+) A/T intron_variant
rs1000437879 -- 192,350,684(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS21 Gene

Variant ID Type Subtype PubMed ID
nsv548649 CNV loss 21841781
esv3362585 CNV insertion 20981092
esv3353544 CNV insertion 20981092
dgv717n54 CNV loss 21841781
dgv716n54 CNV loss 21841781
dgv715n54 CNV loss 21841781

Variation tolerance for RGS21 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS21 Gene

Disorders for RGS21 Gene

Additional Disease Information for RGS21

No disorders were found for RGS21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS21 Gene

Publications for RGS21 Gene

  1. Isolation and expression pattern of RGS21 gene, a novel RGS member. (PMID: 16302027) Li X … Mao Y (Acta biochimica Polonica 2005) 3 4 58
  2. RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells. (PMID: 15066150) von Buchholtz L … Conzelmann S (The European journal of neuroscience 2004) 2 3 58
  3. Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. (PMID: 23095746) Cohen SP … Kimple AJ (The Journal of biological chemistry 2012) 3 58
  4. Genome-wide linkage and association scans for pulse pressure in Chinese twins. (PMID: 22763476) Zhang D … Tan Q (Hypertension research : official journal of the Japanese Society of Hypertension 2012) 3 58
  5. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 44 58

Products for RGS21 Gene

Sources for RGS21 Gene

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