The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectivel... See more...

Aliases for RGS20 Gene

Aliases for RGS20 Gene

  • Regulator Of G Protein Signaling 20 2 3 5
  • Regulator Of G-Protein Signaling 20 2 3 4
  • RGSZ1 2 3 4
  • ZGAP1 2 3 4
  • Regulator Of Gz-Selective Protein Signaling 1 3 4
  • Gz-Selective GTPase-Activating Protein 3 4
  • Regulator Of G-Protein Signalling 20 2 3
  • Regulator Of G-Protein Signaling Z1 3 4
  • G(Z)GAP 3 4
  • Gz-GAP 3 4
  • Regulator Of G-Protein Signaling 20 Variant 2 3
  • RGS20 5

External Ids for RGS20 Gene

Previous GeneCards Identifiers for RGS20 Gene

  • GC08P054063
  • GC08P054703
  • GC08P054488
  • GC08P054814
  • GC08P054926
  • GC08P054764
  • GC08P050231

Summaries for RGS20 Gene

Entrez Gene Summary for RGS20 Gene

  • The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for RGS20 Gene

RGS20 (Regulator Of G Protein Signaling 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS19.

UniProtKB/Swiss-Prot Summary for RGS20 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Gene Wiki entry for RGS20 Gene

Additional gene information for RGS20 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS20 Gene

Genomics for RGS20 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGS20 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS20 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS20

Top Transcription factor binding sites by QIAGEN in the RGS20 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-1
  • Pax-2
  • Pax-2a
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • ZIC2

Genomic Locations for RGS20 Gene

Genomic Locations for RGS20 Gene
chr8:53,851,795-53,959,304
(GRCh38/hg38)
Size:
107,510 bases
Orientation:
Plus strand
chr8:54,764,368-54,871,863
(GRCh37/hg19)
Size:
107,496 bases
Orientation:
Plus strand

Genomic View for RGS20 Gene

Genes around RGS20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS20 Gene

Proteins for RGS20 Gene

  • Protein details for RGS20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76081-RGS20_HUMAN
    Recommended name:
    Regulator of G-protein signaling 20
    Protein Accession:
    O76081
    Secondary Accessions:
    • Q96BG9

    Protein attributes for RGS20 Gene

    Size:
    388 amino acids
    Molecular mass:
    43692 Da
    Quaternary structure:
    • Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity).

    Alternative splice isoforms for RGS20 Gene

neXtProt entry for RGS20 Gene

Post-translational modifications for RGS20 Gene

  • Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).
  • N- and O-glycosylated in synapsomal membranes.
  • Serine phosphorylated in synapsomal membranes.
  • Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS20 Gene

Domains & Families for RGS20 Gene

Gene Families for RGS20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RGS20 Gene

InterPro:
Blocks:
  • Regulator of G-protein signalling (RGS) protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for RGS20 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ37184 fis, clone BRALZ2001559, highly similar to Regulator of G-protein signaling 20 (B3KSW4_HUMAN)
  • Regulator of Gz-selective protein signaling 1 (RGS20_HUMAN)
genes like me logo Genes that share domains with RGS20: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS20 Gene

Function for RGS20 Gene

Molecular function for RGS20 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Phenotypes From GWAS Catalog for RGS20 Gene

Gene Ontology (GO) - Molecular Function for RGS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
GO:0005096 GTPase activator activity TAS 9748279
GO:0005515 protein binding IPI 20859254
genes like me logo Genes that share ontologies with RGS20: view
genes like me logo Genes that share phenotypes with RGS20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS20

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS20

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS20 Gene

Localization for RGS20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS20 Gene

Membrane. Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS20 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3
golgi apparatus 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RGS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IMP 10791963
GO:0005802 trans-Golgi network IMP 10791963
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RGS20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RGS20 Gene

Pathways & Interactions for RGS20 Gene

genes like me logo Genes that share pathways with RGS20: view

Pathways by source for RGS20 Gene

3 Qiagen pathways for RGS20 Gene
  • cAMP Pathway
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

Gene Ontology (GO) - Biological Process for RGS20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0008277 regulation of G protein-coupled receptor signaling pathway TAS 9748279
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS20: view

No data available for SIGNOR curated interactions for RGS20 Gene

Drugs & Compounds for RGS20 Gene

(1) Drugs for RGS20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for RGS20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS20: view

Transcripts for RGS20 Gene

mRNA/cDNA for RGS20 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS20

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - - - - - - -
SP9:

Relevant External Links for RGS20 Gene

GeneLoc Exon Structure for
RGS20

Expression for RGS20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS20 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x9.1), Brain - Caudate (basal ganglia) (x8.6), Brain - Putamen (basal ganglia) (x7.6), and Brain - Amygdala (x5.5).

Protein differential expression in normal tissues from HIPED for RGS20 Gene

This gene is overexpressed in Lung (55.5) and Liver (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RGS20 Gene



Protein tissue co-expression partners for RGS20 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS20

SOURCE GeneReport for Unigene cluster for RGS20 Gene:

Hs.368733

mRNA Expression by UniProt/SwissProt for RGS20 Gene:

O76081-RGS20_HUMAN
Tissue specificity: Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.

Evidence on tissue expression from TISSUES for RGS20 Gene

  • Nervous system(4.5)
  • Eye(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with RGS20: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS20 Gene

Orthologs for RGS20 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS20 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGS20 30 31
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RGS20 30 31
  • 84.13 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RGS20 31
  • 80 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RGS20 30 31
  • 78.8 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgs20 30
  • 78.61 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RGS20 31
  • 74 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Rgs20 30 17 31
  • 73.17 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RGS20 30 31
  • 80.49 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGS20 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rgs20 30
  • 76.42 (n)
Zebrafish
(Danio rerio)
Actinopterygii rgs20 30 31
  • 71.12 (n)
OneToOne
Dr.11071 30
Fruit Fly
(Drosophila melanogaster)
Insecta EG:52C10.2 32
  • 61 (a)
CG5036 31
  • 43 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rgs-2 30 31
  • 61.19 (n)
ManyToMany
rgs-1 31
  • 36 (a)
ManyToMany
Species where no ortholog for RGS20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RGS20 Gene

ENSEMBL:
Gene Tree for RGS20 (if available)
TreeFam:
Gene Tree for RGS20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS20: view image

Paralogs for RGS20 Gene

(18) SIMAP similar genes for RGS20 Gene using alignment to 5 proteins:

  • RGS20_HUMAN
  • B3KSW4_HUMAN
  • E5RGA3_HUMAN
  • E5RH54_HUMAN
  • H9NIM5_HUMAN
genes like me logo Genes that share paralogs with RGS20: view

Variants for RGS20 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS20 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
754436 Likely Benign: not provided 53,939,667(+) G/A MISSENSE_VARIANT,INTRON_VARIANT
776334 Benign: not provided 53,954,097(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
778397 Benign: not provided 53,879,428(+) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for RGS20 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS20 Gene

Variant ID Type Subtype PubMed ID
esv2737005 CNV deletion 23290073
esv2759617 CNV gain 17122850
esv3576573 CNV gain 25503493
esv3617246 CNV gain 21293372
nsv1078614 CNV duplication 25765185
nsv1110515 CNV duplication 24896259
nsv1120561 CNV tandem duplication 24896259
nsv1124340 CNV deletion 24896259
nsv1146126 CNV insertion 26484159
nsv951430 CNV deletion 24416366
nsv958513 CNV insertion 24416366

Variation tolerance for RGS20 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS20 Gene

Disorders for RGS20 Gene

Additional Disease Information for RGS20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for RGS20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS20 Gene

Publications for RGS20 Gene

  1. RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily. (PMID: 9748280) Wang J … Ross EM (The Journal of biological chemistry 1998) 2 3 4 23
  2. RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20. (PMID: 11735229) Barker SA … Ross EM (Genomics 2001) 3 4 23
  3. RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. (PMID: 9748279) Glick JL … Casey PJ (The Journal of biological chemistry 1998) 2 3 4
  4. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 41
  5. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension. (PMID: 18360038) Kohara K … Miki T (Hypertension research : official journal of the Japanese Society of Hypertension 2008) 3 41

Products for RGS20 Gene

  • Signalway Proteins for RGS20

Sources for RGS20 Gene