Aliases for RGS20 Gene
External Ids for RGS20 Gene
Previous GeneCards Identifiers for RGS20 Gene
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for RGS20 Gene
RGS20 (Regulator Of G Protein Signaling 20) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS19.
UniProtKB/Swiss-Prot for RGS20 Gene
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).