Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belong... See more...

Aliases for RGS2 Gene

Aliases for RGS2 Gene

  • Regulator Of G Protein Signaling 2 2 3 5
  • Regulator Of G-Protein Signaling 2 2 3 4
  • Regulator Of G-Protein Signaling 2, 24kDa 2 3
  • Cell Growth-Inhibiting Gene 31 Protein 3 4
  • G0/G1 Switch Regulatory Protein 8 3 4
  • G0S8 3 4
  • Regulator Of G-Protein Signalling 2, 24kDa 2
  • Regulator Of G-Protein Signalling 2, 24kD 2
  • G0 To G1 Switch Regulatory 8, 24kD 3
  • Cell Growth-Inhibiting Protein 31 3
  • RGS2 5

External Ids for RGS2 Gene

Previous HGNC Symbols for RGS2 Gene

  • G0S8

Previous GeneCards Identifiers for RGS2 Gene

  • GC01P190568
  • GC01P188292
  • GC01P189244
  • GC01P190066
  • GC01P189509
  • GC01P191044
  • GC01P192778
  • GC01P164013

Summaries for RGS2 Gene

Entrez Gene Summary for RGS2 Gene

  • Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

GeneCards Summary for RGS2 Gene

RGS2 (Regulator Of G Protein Signaling 2) is a Protein Coding gene. Diseases associated with RGS2 include Gitelman Syndrome and Generalized Anxiety Disorder. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and beta-tubulin binding. An important paralog of this gene is RGS3.

UniProtKB/Swiss-Prot Summary for RGS2 Gene

  • Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).

Gene Wiki entry for RGS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS2 Gene

Genomics for RGS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS2

Top Transcription factor binding sites by QIAGEN in the RGS2 gene promoter:
  • AREB6
  • C/EBPbeta
  • HSF1 (long)
  • HSF1short
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for RGS2 Gene

Genomic Locations for RGS2 Gene
chr1:192,809,039-192,812,275
(GRCh38/hg38)
Size:
3,237 bases
Orientation:
Plus strand
chr1:192,778,169-192,781,407
(GRCh37/hg19)
Size:
3,239 bases
Orientation:
Plus strand

Genomic View for RGS2 Gene

Genes around RGS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS2 Gene

Proteins for RGS2 Gene

  • Protein details for RGS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41220-RGS2_HUMAN
    Recommended name:
    Regulator of G-protein signaling 2
    Protein Accession:
    P41220
    Secondary Accessions:
    • Q6I9U5

    Protein attributes for RGS2 Gene

    Size:
    211 amino acids
    Molecular mass:
    24382 Da
    Quaternary structure:
    • Interacts with GNAQ (PubMed:18434541, PubMed:19478087, PubMed:28784619). Does not interact with GNAI1 and GNAI3 (PubMed:18434541, PubMed:19478087). Interacts with EIF2B5 (PubMed:19736320). Interacts with PRKG1 (isoform alpha) (PubMed:14608379).
    Miscellaneous:
    • [Isoform 3]: Lacks type V adenylyl cyclase (AC) inhibitory function.
    • [Isoform 4]: Lacks type V adenylyl cyclase (AC) inhibitory function.

    Three dimensional structures from OCA and Proteopedia for RGS2 Gene

    Alternative splice isoforms for RGS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS2 Gene

Post-translational modifications for RGS2 Gene

  • Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS2 Gene

Domains & Families for RGS2 Gene

Gene Families for RGS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RGS2 Gene

InterPro:
Blocks:
  • Regulator of G-protein signalling (RGS) protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for RGS2 Gene

GenScript: Design optimal peptide antigens:
  • RGS2 protein (Q49A86_HUMAN)
  • G0/G1 switch regulatory protein 8 (RGS2_HUMAN)
genes like me logo Genes that share domains with RGS2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS2 Gene

Function for RGS2 Gene

Molecular function for RGS2 Gene

UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
GENATLAS Biochemistry:
negative regulator of G-protein signaling 2,functioning as GTPase-activating protein for G protein alpha i and q subunits,C elegans EGL-10 and yeast SST2 homolog

Phenotypes From GWAS Catalog for RGS2 Gene

Gene Ontology (GO) - Molecular Function for RGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IPI 19478087
GO:0003924 GTPase activity TAS --
GO:0005096 GTPase activator activity TAS,IMP 19478087
GO:0005515 protein binding IPI 14608379
GO:0005516 calmodulin binding TAS 10747990
genes like me logo Genes that share ontologies with RGS2: view
genes like me logo Genes that share phenotypes with RGS2: view

Animal Models for RGS2 Gene

MGI Knock Outs for RGS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS2 Gene

Localization for RGS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS2 Gene

[Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus.
[Isoform 2]: Cell membrane. Cytoplasm. Nucleus, nucleolus.
[Isoform 3]: Cell membrane. Cytoplasm. Nucleus, nucleolus.
[Isoform 4]: Cell membrane. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 4
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10791963
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA,IDA 11278586
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with RGS2: view

Pathways & Interactions for RGS2 Gene

genes like me logo Genes that share pathways with RGS2: view

Pathways by source for RGS2 Gene

2 GeneGo (Thomson Reuters) pathways for RGS2 Gene
  • G-protein signaling G-Protein alpha-q signaling cascades
  • G-protein signaling G-Protein alpha-s signaling cascades
3 Qiagen pathways for RGS2 Gene
  • cAMP Pathway
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

SIGNOR curated interactions for RGS2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RGS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006417 regulation of translation IEA --
GO:0007049 cell cycle IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with RGS2: view

Drugs & Compounds for RGS2 Gene

(10) Drugs for RGS2 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
antipsychotics Pharma 0

(3) Additional Compounds for RGS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS2: view

Transcripts for RGS2 Gene

mRNA/cDNA for RGS2 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS2

Alternative Splicing Database (ASD) splice patterns (SP) for RGS2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for RGS2 Gene

GeneLoc Exon Structure for
RGS2

Expression for RGS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS2 Gene

This gene is overexpressed in Whole Blood (x8.2) and Esophagus - Muscularis (x5.1).

Protein differential expression in normal tissues from HIPED for RGS2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGS2 Gene



Protein tissue co-expression partners for RGS2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS2

SOURCE GeneReport for Unigene cluster for RGS2 Gene:

Hs.78944

mRNA Expression by UniProt/SwissProt for RGS2 Gene:

P41220-RGS2_HUMAN
Tissue specificity: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).

Evidence on tissue expression from TISSUES for RGS2 Gene

  • Nervous system(3.7)
  • Blood(3.6)
  • Adrenal gland(3.2)
  • Bone marrow(3)
  • Eye(3)
  • Intestine(2.9)
  • Pancreas(2.9)
  • Muscle(2.9)
  • Spleen(2.9)
  • Heart(2.8)
  • Lung(2.7)
  • Kidney(2.6)
  • Skin(2.5)
  • Liver(2.4)
  • Lymph node(2.3)
  • Gall bladder(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RGS2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS2 Gene

Orthologs for RGS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGS2 30 31
  • 99.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RGS2 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RGS2 30 31
  • 91.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgs2 30
  • 89.57 (n)
Mouse
(Mus musculus)
Mammalia Rgs2 30 17 31
  • 89.42 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RGS2 31
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RGS2 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RGS2 30 31
  • 70.49 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGS2 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rgs2 30
  • 70.62 (n)
Str.15616 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.27466 30
Zebrafish
(Danio rerio)
Actinopterygii rgs2 31
  • 39 (a)
OneToOne
Species where no ortholog for RGS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RGS2 Gene

ENSEMBL:
Gene Tree for RGS2 (if available)
TreeFam:
Gene Tree for RGS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS2: view image

Paralogs for RGS2 Gene

(17) SIMAP similar genes for RGS2 Gene using alignment to 2 proteins:

  • RGS2_HUMAN
  • Q49A86_HUMAN
genes like me logo Genes that share paralogs with RGS2: view

Variants for RGS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
712093 Likely Benign: not provided 192,810,203(+) C/A MISSENSE_VARIANT
rs141030117 -. - p.Gln2Leup.Gln2Arg
rs148489044 Uncertain Significance: not specified. - 192,809,139(+) G/Ap.Gly23Asp MISSENSE_VARIANT
rs547204431 Likely Pathogenic: not provided 192,810,432(+) G/T SPLICE_DONOR_VARIANT
rs112707798 - p.Gln196Arg

Additional dbSNP identifiers (rs#s) for RGS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS2 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV loss 19166990
nsv548658 CNV loss 21841781
nsv548660 CNV gain 21841781
nsv952595 CNV duplication 24416366

Variation tolerance for RGS2 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS2 Gene

Human Gene Mutation Database (HGMD)
RGS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS2 Gene

Disorders for RGS2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RGS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gitelman syndrome
  • gtlmns
generalized anxiety disorder
  • anxiety generalized
panic disorder
  • panic disorder 1
anxiety
  • anxiety disorder
agoraphobia
  • fear of open spaces
- elite association - COSMIC cancer census association via MalaCards
Search RGS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RGS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS2 Gene

Publications for RGS2 Gene

  1. Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population. (PMID: 16003176) Yang J … Miyata T (Journal of hypertension 2005) 3 4 23 41
  2. [Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population]. (PMID: 20140863) Zhang J … Chang J (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2010) 3 23 41
  3. Association analysis between functional polymorphism of the rs4606 SNP in the RGS2 gene and antipsychotic-induced Parkinsonism in Japanese patients with schizophrenia: results from the Juntendo University Schizophrenia Projects (JUSP). (PMID: 19931593) Higa M … Arai H (Neuroscience letters 2010) 3 23 41
  4. Further evidence for association of the RGS2 gene with antipsychotic-induced parkinsonism: protective role of a functional polymorphism in the 3'-untranslated region. (PMID: 18347610) Greenbaum L … Lerer B (The pharmacogenomics journal 2009) 3 23 41
  5. Polymorphism C1114G of gene encoding the cardiac regulator of G-protein signaling 2 may be associated with number of episodes of neurally mediated syncope. (PMID: 19427970) Lelonek M … Goch JH (Archives of medical research 2009) 3 23 41

Products for RGS2 Gene

Sources for RGS2 Gene