G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the ... See more...

Aliases for RGS19 Gene

Aliases for RGS19 Gene

  • Regulator Of G Protein Signaling 19 2 3 5
  • Regulator Of G-Protein Signaling 19 2 3 4
  • GAIP 2 3 4
  • Regulator Of G-Protein Signalling 19 2 3
  • RGSGAIP 2 3
  • Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 3 Interacting Protein 3
  • G Protein Signalling Regulator 19 3
  • G Alpha Interacting Protein 3
  • G-Alpha-Interacting Protein 4
  • GNAI3IP 4
  • RGS19 5

External Ids for RGS19 Gene

Previous GeneCards Identifiers for RGS19 Gene

  • GC20M062582
  • GC20M063383
  • GC20M063430
  • GC20M062174
  • GC20M062704
  • GC20M059438

Summaries for RGS19 Gene

Entrez Gene Summary for RGS19 Gene

  • G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS19 Gene

RGS19 (Regulator Of G Protein Signaling 19) is a Protein Coding gene. Diseases associated with RGS19 include Deafness, Autosomal Recessive 15 and Deafness, Autosomal Dominant 22. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and G-protein alpha-subunit binding. An important paralog of this gene is RGS20.

UniProtKB/Swiss-Prot Summary for RGS19 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Gene Wiki entry for RGS19 Gene

Additional gene information for RGS19 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS19 Gene

Genomics for RGS19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGS19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS19

Top Transcription factor binding sites by QIAGEN in the RGS19 gene promoter:
  • STAT3

Genomic Locations for RGS19 Gene

Genomic Locations for RGS19 Gene
chr20:64,073,181-64,080,004
(GRCh38/hg38)
Size:
6,824 bases
Orientation:
Minus strand
chr20:62,704,534-62,711,324
(GRCh37/hg19)
Size:
6,791 bases
Orientation:
Minus strand

Genomic View for RGS19 Gene

Genes around RGS19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS19 Gene

Proteins for RGS19 Gene

  • Protein details for RGS19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49795-RGS19_HUMAN
    Recommended name:
    Regulator of G-protein signaling 19
    Protein Accession:
    P49795
    Secondary Accessions:
    • A8K216
    • E1P5G9
    • Q53XN0
    • Q8TD60

    Protein attributes for RGS19 Gene

    Size:
    217 amino acids
    Molecular mass:
    24636 Da
    Quaternary structure:
    • Interacts with GIPC PDZ domain.

    Three dimensional structures from OCA and Proteopedia for RGS19 Gene

neXtProt entry for RGS19 Gene

Post-translational modifications for RGS19 Gene

Other Protein References for RGS19 Gene

No data available for DME Specific Peptides for RGS19 Gene

Domains & Families for RGS19 Gene

Gene Families for RGS19 Gene

Protein Domains for RGS19 Gene

InterPro:
Blocks:
  • Regulator of G-protein signalling (RGS) protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for RGS19 Gene

GenScript: Design optimal peptide antigens:
  • RGS19 protein (Q6I9S5_HUMAN)
  • G alpha interacting protein (Q9H2T9_HUMAN)
  • G-alpha-interacting protein (RGS19_HUMAN)
genes like me logo Genes that share domains with RGS19: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS19 Gene

Function for RGS19 Gene

Molecular function for RGS19 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Phenotypes From GWAS Catalog for RGS19 Gene

Gene Ontology (GO) - Molecular Function for RGS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0003924 GTPase activity TAS --
GO:0005515 protein binding IPI 8524874
genes like me logo Genes that share ontologies with RGS19: view
genes like me logo Genes that share phenotypes with RGS19: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS19 Gene

Localization for RGS19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS19 Gene

Membrane. Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS19 gene
Compartment Confidence
plasma membrane 4
golgi apparatus 4
cytosol 3
extracellular 2
cytoskeleton 2
nucleus 2
endosome 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus TAS 9571244
GO:0005886 plasma membrane TAS --
GO:0005903 brush border IEA --
GO:0016020 membrane TAS 9571244
genes like me logo Genes that share ontologies with RGS19: view

Pathways & Interactions for RGS19 Gene

genes like me logo Genes that share pathways with RGS19: view

Pathways by source for RGS19 Gene

SIGNOR curated interactions for RGS19 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for RGS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS 9571244
GO:0009968 negative regulation of signal transduction IEA --
GO:0045471 response to ethanol IEA --
genes like me logo Genes that share ontologies with RGS19: view

Drugs & Compounds for RGS19 Gene

(4) Drugs for RGS19 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
opioids Pharma 0

(2) Additional Compounds for RGS19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS19: view

Transcripts for RGS19 Gene

mRNA/cDNA for RGS19 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS19

Alternative Splicing Database (ASD) splice patterns (SP) for RGS19 Gene

No ASD Table

Relevant External Links for RGS19 Gene

GeneLoc Exon Structure for
RGS19

Expression for RGS19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Blood (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for RGS19 Gene

This gene is overexpressed in Whole Blood (x24.5) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for RGS19 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.8) and Monocytes (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RGS19 Gene



Protein tissue co-expression partners for RGS19 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS19

SOURCE GeneReport for Unigene cluster for RGS19 Gene:

Hs.422336

mRNA Expression by UniProt/SwissProt for RGS19 Gene:

P49795-RGS19_HUMAN
Tissue specificity: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Evidence on tissue expression from TISSUES for RGS19 Gene

  • Nervous system(4.6)
  • Blood(4.5)
  • Liver(4.4)
  • Intestine(2.3)
  • Lymph node(2.1)
  • Spleen(2.1)
  • Bone marrow(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with RGS19: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS19 Gene

Orthologs for RGS19 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGS19 30 31
  • 99.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RGS19 30 31
  • 90.32 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RGS19 30 31
  • 88.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgs19 30
  • 84.42 (n)
Mouse
(Mus musculus)
Mammalia Rgs19 30 17 31
  • 84.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RGS19 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RGS19 30 31
  • 79.68 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGS19 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rgs19 30
  • 68.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia rgs19-prov 30
Zebrafish
(Danio rerio)
Actinopterygii rgs19 30 31
  • 72.97 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta EG:52C10.2 32
  • 71 (a)
CG5036 31
  • 39 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rgs-2 31
  • 48 (a)
ManyToMany
rgs-1 31
  • 35 (a)
ManyToMany
Species where no ortholog for RGS19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RGS19 Gene

ENSEMBL:
Gene Tree for RGS19 (if available)
TreeFam:
Gene Tree for RGS19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS19: view image

Paralogs for RGS19 Gene

(19) SIMAP similar genes for RGS19 Gene using alignment to 2 proteins:

  • RGS19_HUMAN
  • Q6I9S5_HUMAN
genes like me logo Genes that share paralogs with RGS19: view

Variants for RGS19 Gene

Additional dbSNP identifiers (rs#s) for RGS19 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS19 Gene

Variant ID Type Subtype PubMed ID
dgv4345n100 CNV gain 25217958
dgv7701n54 CNV loss 21841781
esv1008416 CNV insertion 20482838
esv2758807 CNV gain+loss 17122850
nsv1078795 CNV insertion 25765185
nsv1117295 CNV tandem duplication 24896259
nsv1125222 CNV insertion 24896259
nsv1129218 CNV insertion 24896259
nsv1149957 CNV insertion 26484159
nsv179409 CNV insertion 16902084
nsv428381 CNV gain+loss 18775914
nsv470564 CNV gain 18288195
nsv509785 CNV insertion 20534489
nsv586703 CNV loss 21841781
nsv586732 CNV loss 21841781
nsv953310 CNV deletion 24416366

Variation tolerance for RGS19 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS19 Gene

Disorders for RGS19 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RGS19 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search RGS19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGS19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RGS19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS19 Gene

Publications for RGS19 Gene

  1. GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. (PMID: 8524874) De Vries L … Farquhar MG (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 23
  2. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. (PMID: 10993892) Ogier-Denis E … Codogno P (The Journal of biological chemistry 2000) 3 4 23
  3. Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling. (PMID: 10452897) de Alba E … Tjandra N (Journal of molecular biology 1999) 3 4 23
  4. RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily. (PMID: 9748280) Wang J … Ross EM (The Journal of biological chemistry 1998) 3 4 23
  5. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41

Products for RGS19 Gene

  • Signalway ELISA kits for RGS19
  • Signalway Proteins for RGS19

Sources for RGS19 Gene