Aliases for RGS19 Gene
External Ids for RGS19 Gene
Previous GeneCards Identifiers for RGS19 Gene
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGS19 Gene
RGS19 (Regulator Of G Protein Signaling 19) is a Protein Coding gene. Diseases associated with RGS19 include Deafness, Autosomal Recessive 15 and Deafness, Autosomal Dominant 22. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and G-protein alpha-subunit binding. An important paralog of this gene is RGS20.
UniProtKB/Swiss-Prot Summary for RGS19 Gene
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.