Aliases for RGS19 Gene
External Ids for RGS19 Gene
Previous GeneCards Identifiers for RGS19 Gene
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGS19 Gene
RGS19 (Regulator Of G Protein Signaling 19) is a Protein Coding gene. Diseases associated with RGS19 include Deafness, Autosomal Recessive 15 and Deafness, Autosomal Dominant 22. Among its related pathways are G-AlphaQ Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and G-protein alpha-subunit binding. An important paralog of this gene is RGS20.
UniProtKB/Swiss-Prot Summary for RGS19 Gene
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.