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Aliases for RGS18 Gene

Aliases for RGS18 Gene

  • Regulator Of G Protein Signaling 18 2 3 5
  • Regulator Of G-Protein Signalling 18 2 3
  • Regulator Of G-Protein Signaling 18 2 3
  • RGS13 3 4
  • Regulator Of G-Protein Signalling 13 3

External Ids for RGS18 Gene

Previous GeneCards Identifiers for RGS18 Gene

  • GC01P189917
  • GC01P187641
  • GC01P188594
  • GC01P189415
  • GC01P188859
  • GC01P190394
  • GC01P163363

Summaries for RGS18 Gene

Entrez Gene Summary for RGS18 Gene

  • This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS18 Gene

RGS18 (Regulator Of G Protein Signaling 18) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS2.

UniProtKB/Swiss-Prot for RGS18 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

Gene Wiki entry for RGS18 Gene

Additional gene information for RGS18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS18 Gene

Genomics for RGS18 Gene

GeneHancer (GH) Regulatory Elements for RGS18 Gene

Promoters and enhancers for RGS18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J192157 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 654.9 +0.2 179 2 NFIC POLR2A CEBPB HMBOX1 CEBPG SPI1 GABPA RGS18 LOC105371662 GC01P191982
GH01J192146 Promoter/Enhancer 0.9 EPDnew ENCODE 650.4 -10.7 -10734 2.4 NFIC NFE2 ZBTB33 RGS18 LOC105371661 GC01P191982
GH01J192133 Enhancer 0.4 ENCODE 16.8 -24.9 -24897 0.6 ATF4 JUN RGS18 LOC105371661 GC01P191982
GH01J192123 Enhancer 0.8 ENCODE 5.1 -34.4 -34422 1.7 PKNOX1 ARNT NFRKB ZBTB40 NCOA2 CHAMP1 TCF12 ZNF592 KLF16 SMARCA4 RGS18 LOC105371661 GC01P191982
GH01J192169 Enhancer 1.1 FANTOM5 Ensembl ENCODE 2.4 +11.7 11745 2.9 PKNOX1 ARNT JUN MAX CHAMP1 ZNF316 NFE2 MAFK ZNF639 CBFA2T3 ENSG00000231767 TROVE2 ZNF101P2 RGS18 LOC105371662 GC01P191982 ENSG00000285280
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS18 gene promoter:
  • GATA-1
  • HNF-3beta
  • AML1a
  • C/EBPalpha
  • E4BP4
  • STAT5B
  • FOXL1
  • Pbx1a

Genomic Locations for RGS18 Gene

Genomic Locations for RGS18 Gene
28,716 bases
Plus strand
27,359 bases
Plus strand

Genomic View for RGS18 Gene

Genes around RGS18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS18 Gene

Proteins for RGS18 Gene

  • Protein details for RGS18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of G-protein signaling 18
    Protein Accession:
    Secondary Accessions:
    • B2RD23

    Protein attributes for RGS18 Gene

    235 amino acids
    Molecular mass:
    27582 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS18 Gene

neXtProt entry for RGS18 Gene

Post-translational modifications for RGS18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS18 Gene

Domains & Families for RGS18 Gene

Gene Families for RGS18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS18 Gene

Suggested Antigen Peptide Sequences for RGS18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS18: view

No data available for UniProtKB/Swiss-Prot for RGS18 Gene

Function for RGS18 Gene

Molecular function for RGS18 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

Gene Ontology (GO) - Molecular Function for RGS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 21685921
genes like me logo Genes that share ontologies with RGS18: view
genes like me logo Genes that share phenotypes with RGS18: view

Animal Models for RGS18 Gene

MGI Knock Outs for RGS18:

Animal Model Products

miRNA for RGS18 Gene

miRTarBase miRNAs that target RGS18

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS18 Gene

Localization for RGS18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS18 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS18 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS18: view

Pathways & Interactions for RGS18 Gene

genes like me logo Genes that share pathways with RGS18: view

Gene Ontology (GO) - Biological Process for RGS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS18: view

No data available for SIGNOR curated interactions for RGS18 Gene

Drugs & Compounds for RGS18 Gene

No Compound Related Data Available

Transcripts for RGS18 Gene

mRNA/cDNA for RGS18 Gene

Unigene Clusters for RGS18 Gene

Regulator of G-protein signaling 18:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS18 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for RGS18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RGS18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS18 Gene

This gene is overexpressed in Whole Blood (x34.5) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for RGS18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.3) and Platelet (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGS18 Gene

Protein tissue co-expression partners for RGS18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RGS18 Gene:


SOURCE GeneReport for Unigene cluster for RGS18 Gene:


mRNA Expression by UniProt/SwissProt for RGS18 Gene:

Tissue specificity: Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.

Evidence on tissue expression from TISSUES for RGS18 Gene

  • Blood(4.5)
  • Liver(4.1)
  • Nervous system(4.1)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with RGS18: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS18 Gene

Orthologs for RGS18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RGS18 34 33
  • 99.43 (n)
(Canis familiaris)
Mammalia RGS18 34 33
  • 92.62 (n)
(Bos Taurus)
Mammalia RGS18 34 33
  • 90.21 (n)
(Mus musculus)
Mammalia Rgs18 16 34 33
  • 86.52 (n)
(Rattus norvegicus)
Mammalia Rgs18 33
  • 86.52 (n)
(Monodelphis domestica)
Mammalia RGS18 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia RGS18 34
  • 70 (a)
(Gallus gallus)
Aves RGS18 34 33
  • 69.38 (n)
(Anolis carolinensis)
Reptilia RGS18 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs18 33
  • 61.62 (n)
(Danio rerio)
Actinopterygii rgs18 34 33
  • 57.48 (n)
Species where no ortholog for RGS18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS18 Gene

Gene Tree for RGS18 (if available)
Gene Tree for RGS18 (if available)
Evolutionary constrained regions (ECRs) for RGS18: view image

Paralogs for RGS18 Gene

Paralogs for RGS18 Gene

(18) SIMAP similar genes for RGS18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS18: view

Variants for RGS18 Gene

Sequence variations from dbSNP and Humsavar for RGS18 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000009884 -- 192,180,527(+) AAA/AAAA intron_variant
rs1000017093 -- 192,178,169(+) C/G intron_variant
rs1000130110 -- 192,185,193(+) G/C 3_prime_UTR_variant
rs1000159285 -- 192,186,736(+) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000293859 -- 192,159,758(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS18 Gene

Variant ID Type Subtype PubMed ID
esv2663862 CNV deletion 23128226
nsv1007060 CNV gain 25217958

Variation tolerance for RGS18 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS18 Gene

Disorders for RGS18 Gene

Additional Disease Information for RGS18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGS18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS18 Gene

Publications for RGS18 Gene

  1. Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. (PMID: 11042171) Park IK … Clarke MF (The Journal of biological chemistry 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  4. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 44 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for RGS18 Gene

Sources for RGS18 Gene

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