This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydr... See more...

Aliases for RGS18 Gene

Aliases for RGS18 Gene

  • Regulator Of G Protein Signaling 18 2 3 5
  • Regulator Of G-Protein Signaling 18 2 3 4
  • RGS13 2 3 4
  • Regulator Of G-Protein Signalling 18 2 3
  • Regulator Of G-Protein Signalling 13 3
  • RGS18 5

External Ids for RGS18 Gene

Previous GeneCards Identifiers for RGS18 Gene

  • GC01P189917
  • GC01P187641
  • GC01P188594
  • GC01P189415
  • GC01P188859
  • GC01P190394
  • GC01P192127
  • GC01P163363

Summaries for RGS18 Gene

Entrez Gene Summary for RGS18 Gene

  • This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS18 Gene

RGS18 (Regulator Of G Protein Signaling 18) is a Protein Coding gene. Diseases associated with RGS18 include Discrete Subaortic Stenosis. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS4.

UniProtKB/Swiss-Prot Summary for RGS18 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

Gene Wiki entry for RGS18 Gene

Additional gene information for RGS18 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS18 Gene

Genomics for RGS18 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGS18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J192157 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 604.9 +1.4 1353 4.4 HMBOX1 CEBPB NFIC CEBPG SPI1 GABPA CHAMP1 ZBTB33 POLR2A CC2D1A RGS18 piR-57138-014 RGS21
GH01J192146 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 600.4 -10.7 -10739 2.4 CEBPB NFE2 NFIC ZBTB33 NFE2L2 RGS18 piR-55905-003 LOC105371661
GH01J192133 Enhancer 0.6 Ensembl ENCODE 16.8 -24.7 -24727 0.9 CEBPB ATF4 JUN RGS18 piR-55905-003 LOC105371661 HSALNG0009263
GH01J192108 Enhancer 0.8 Ensembl 11.7 -50.0 -49962 0.2 LEF1 IKZF1 JUND DPF2 SOX6 TCF12 EP300 CBX3 HMBOX1 EGR1 RGS18 HSALNG0009263 LOC105371661 piR-55905-003
GH01J192123 Enhancer 0.8 ENCODE 5.1 -34.4 -34427 1.7 RFX1 LEF1 IKZF1 PKNOX1 DPF2 FOXJ2 TCF12 EP300 MGA CBX3 RGS18 LOC105371661 HSALNG0009263 piR-55905-003
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS18 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS18

Top Transcription factor binding sites by QIAGEN in the RGS18 gene promoter:
  • AML1a
  • C/EBPalpha
  • E4BP4
  • FOXL1
  • GATA-1
  • HNF-3beta
  • Pbx1a
  • STAT5B

Genomic Locations for RGS18 Gene

Genomic Locations for RGS18 Gene
chr1:192,158,462-192,187,172
(GRCh38/hg38)
Size:
28,711 bases
Orientation:
Plus strand
chr1:192,127,587-192,154,945
(GRCh37/hg19)
Size:
27,359 bases
Orientation:
Plus strand

Genomic View for RGS18 Gene

Genes around RGS18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS18 Gene

Proteins for RGS18 Gene

  • Protein details for RGS18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS28-RGS18_HUMAN
    Recommended name:
    Regulator of G-protein signaling 18
    Protein Accession:
    Q9NS28
    Secondary Accessions:
    • B2RD23

    Protein attributes for RGS18 Gene

    Size:
    235 amino acids
    Molecular mass:
    27582 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RGS18 Gene

neXtProt entry for RGS18 Gene

Post-translational modifications for RGS18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS18 Gene

Domains & Families for RGS18 Gene

Gene Families for RGS18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS18 Gene

InterPro:
Blocks:
  • Regulator of G-protein signalling (RGS) protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for RGS18 Gene

GenScript: Design optimal peptide antigens:
  • Regulator of G-protein signaling 18 (RGS18_HUMAN)
genes like me logo Genes that share domains with RGS18: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS18 Gene

Function for RGS18 Gene

Molecular function for RGS18 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.

Phenotypes From GWAS Catalog for RGS18 Gene

Gene Ontology (GO) - Molecular Function for RGS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 21685921
genes like me logo Genes that share ontologies with RGS18: view
genes like me logo Genes that share phenotypes with RGS18: view

Animal Models for RGS18 Gene

MGI Knock Outs for RGS18:

Animal Model Products

CRISPR Products

miRNA for RGS18 Gene

miRTarBase miRNAs that target RGS18

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS18

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS18 Gene

Localization for RGS18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS18 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS18 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RGS18: view

Pathways & Interactions for RGS18 Gene

genes like me logo Genes that share pathways with RGS18: view

Pathways by source for RGS18 Gene

1 GeneGo (Thomson Reuters) pathway for RGS18 Gene
  • G-protein signaling G-Protein alpha-i signaling cascades
3 Qiagen pathways for RGS18 Gene
  • cAMP Pathway
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

Gene Ontology (GO) - Biological Process for RGS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0008277 regulation of G protein-coupled receptor signaling pathway IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS18: view

No data available for SIGNOR curated interactions for RGS18 Gene

Drugs & Compounds for RGS18 Gene

No Compound Related Data Available

Transcripts for RGS18 Gene

mRNA/cDNA for RGS18 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS18

Alternative Splicing Database (ASD) splice patterns (SP) for RGS18 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for RGS18 Gene

GeneLoc Exon Structure for
RGS18

Expression for RGS18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS18 Gene

This gene is overexpressed in Whole Blood (x34.5) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for RGS18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.3) and Platelet (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGS18 Gene



Protein tissue co-expression partners for RGS18 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS18

SOURCE GeneReport for Unigene cluster for RGS18 Gene:

Hs.440890

mRNA Expression by UniProt/SwissProt for RGS18 Gene:

Q9NS28-RGS18_HUMAN
Tissue specificity: Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.

Evidence on tissue expression from TISSUES for RGS18 Gene

  • Blood(4.6)
  • Nervous system(4.3)
  • Liver(4.2)
  • Spleen(2.6)
  • Bone marrow(2.3)
  • Heart(2.2)
  • Lymph node(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with RGS18: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS18 Gene

Orthologs for RGS18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS18 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGS18 30 31
  • 99.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RGS18 30 31
  • 92.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RGS18 30 31
  • 90.21 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rgs18 30 17 31
  • 86.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgs18 30
  • 86.52 (n)
Oppossum
(Monodelphis domestica)
Mammalia RGS18 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RGS18 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RGS18 30 31
  • 69.38 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGS18 31
  • 62 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rgs18 30
  • 61.62 (n)
Zebrafish
(Danio rerio)
Actinopterygii rgs18 30 31
  • 57.48 (n)
OneToOne
Species where no ortholog for RGS18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RGS18 Gene

ENSEMBL:
Gene Tree for RGS18 (if available)
TreeFam:
Gene Tree for RGS18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS18: view image

Paralogs for RGS18 Gene

(18) SIMAP similar genes for RGS18 Gene using alignment to 1 proteins:

  • RGS18_HUMAN
genes like me logo Genes that share paralogs with RGS18: view

Variants for RGS18 Gene

Additional dbSNP identifiers (rs#s) for RGS18 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS18 Gene

Variant ID Type Subtype PubMed ID
esv2663862 CNV deletion 23128226
nsv1007060 CNV gain 25217958

Variation tolerance for RGS18 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS18

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS18 Gene

Disorders for RGS18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RGS18 Gene - From: DISEASES

Disorder Aliases PubMed IDs
discrete subaortic stenosis
- elite association - COSMIC cancer census association via MalaCards
Search RGS18 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGS18

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RGS18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS18 Gene

Publications for RGS18 Gene

  1. Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. (PMID: 11042171) Park IK … Clarke MF (The Journal of biological chemistry 2001) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41
  4. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 41
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4

Products for RGS18 Gene

Sources for RGS18 Gene