This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of t... See more...

Aliases for RGS17 Gene

Aliases for RGS17 Gene

  • Regulator Of G Protein Signaling 17 2 3 5
  • Regulator Of G-Protein Signaling 17 2 3 4
  • RGSZ2 2 3 4
  • RGS-17 2 3
  • Regulator Of G-Protein Signalling 17 2
  • HRGS17 3
  • RGS17 5

External Ids for RGS17 Gene

Previous GeneCards Identifiers for RGS17 Gene

  • GC06M152892
  • GC06M153227
  • GC06M153286
  • GC06M153362
  • GC06M153423
  • GC06M153331
  • GC06M150894

Summaries for RGS17 Gene

Entrez Gene Summary for RGS17 Gene

  • This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS17 Gene

RGS17 (Regulator Of G Protein Signaling 17) is a Protein Coding gene. Diseases associated with RGS17 include Jejunal Somatostatinoma and Substance Dependence. Among its related pathways are G-AlphaQ Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS20.

UniProtKB/Swiss-Prot Summary for RGS17 Gene

  • Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Gene Wiki entry for RGS17 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS17 Gene

Genomics for RGS17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGS17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J153129 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.3 283 2.8 ZNF600 ZBTB10 ZNF639 ZEB1 KLF7 SIN3A REST KLF9 ZNF610 SP2 RGS17 lnc-VIP-3 piR-54131-002 MTRF1L
GH06J153089 Enhancer 1 FANTOM5 ENCODE 18 +39.5 39549 3.8 JUND TRIM22 IRF4 SMARCA5 BATF IKZF1 BHLHE40 TRIM28 SPI1 OSR2 RGS17 MTRF1L piR-54131-002
GH06J153117 Enhancer 0.9 Ensembl ENCODE 18.1 +12.5 12530 1.5 BCL11A CEBPB EP300 IRF4 NFE2 JUND NFE2L2 BATF ELF1 ZNF24 RGS17 piR-54131-002 MTRF1L
GH06J153111 Enhancer 0.4 Ensembl ENCODE 19.1 +20.6 20583 1.8 YY1 RGS17 piR-54131-002 MTRF1L
GH06J153059 Enhancer 0.7 Ensembl ENCODE 10.2 +72.0 72035 2.5 CTCF MAFF SMC3 ZNF316 NFE2 MAFK NFE2L2 MAFG FOS RAD21 RGS17 piR-54131-002 MTRF1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS17

Top Transcription factor binding sites by QIAGEN in the RGS17 gene promoter:
  • AML1a
  • AP-1
  • Egr-4
  • Elk-1
  • Pbx1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • S8
  • STAT1

Genomic Locations for RGS17 Gene

Latest Assembly
chr6:153,004,459-153,131,284
(GRCh38/hg38)
Size:
126,826 bases
Orientation:
Minus strand

Previous Assembly
chr6:153,325,594-153,452,417
(GRCh37/hg19 by Entrez Gene)
Size:
126,824 bases
Orientation:
Minus strand

chr6:153,325,594-153,452,384
(GRCh37/hg19 by Ensembl)
Size:
126,791 bases
Orientation:
Minus strand

Genomic View for RGS17 Gene

Genes around RGS17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS17 Gene

Proteins for RGS17 Gene

  • Protein details for RGS17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGC6-RGS17_HUMAN
    Recommended name:
    Regulator of G-protein signaling 17
    Protein Accession:
    Q9UGC6
    Secondary Accessions:
    • Q5TF49
    • Q8TD61
    • Q9UJS8

    Protein attributes for RGS17 Gene

    Size:
    210 amino acids
    Molecular mass:
    24359 Da
    Quaternary structure:
    • Interacts with GNAI1 and GNAQ (PubMed:18434541). Interacts with GNAZ and GNAI2. Interacts with OPRM1. Forms a complex with mu-opioid receptors and G(alpha)z/i2 subunits, including GNAZ and GNAI2; the formation of this complex results in mu-opioid receptor desensitization (By similarity).

    Three dimensional structures from OCA and Proteopedia for RGS17 Gene

neXtProt entry for RGS17 Gene

Post-translational modifications for RGS17 Gene

  • N- and O-glycosylated in synapsomal membranes.
  • Serine phosphorylated in synapsomal membranes.
  • Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS17 Gene

No data available for DME Specific Peptides for RGS17 Gene

Domains & Families for RGS17 Gene

Gene Families for RGS17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS17 Gene

InterPro:
Blocks:
  • Regulator of G-protein signalling (RGS) protein signature

Suggested Antigen Peptide Sequences for RGS17 Gene

GenScript: Design optimal peptide antigens:
  • Regulator of G-protein signaling 17 (RGS17_HUMAN)
genes like me logo Genes that share domains with RGS17: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS17 Gene

Function for RGS17 Gene

Molecular function for RGS17 Gene

UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Phenotypes From GWAS Catalog for RGS17 Gene

Gene Ontology (GO) - Molecular Function for RGS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RGS17: view
genes like me logo Genes that share phenotypes with RGS17: view

miRNA for RGS17 Gene

miRTarBase miRNAs that target RGS17

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RGS17 Gene

Localization for RGS17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS17 Gene

Membrane. Cell junction, synapse, synaptosome. Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS17 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 3
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RGS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with RGS17: view

Pathways & Interactions for RGS17 Gene

genes like me logo Genes that share pathways with RGS17: view

Pathways by source for RGS17 Gene

3 Qiagen pathways for RGS17 Gene
  • cAMP Pathway
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

Gene Ontology (GO) - Biological Process for RGS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS17: view

No data available for SIGNOR curated interactions for RGS17 Gene

Drugs & Compounds for RGS17 Gene

(1) Drugs for RGS17 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
antidepressants Pharma 0
genes like me logo Genes that share compounds with RGS17: view

Transcripts for RGS17 Gene

mRNA/cDNA for RGS17 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS17

Alternative Splicing Database (ASD) splice patterns (SP) for RGS17 Gene

No ASD Table

Relevant External Links for RGS17 Gene

GeneLoc Exon Structure for
RGS17

Expression for RGS17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS17 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.9) and Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for RGS17 Gene

This gene is overexpressed in Heart (37.9) and Fetal Brain (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGS17 Gene



Protein tissue co-expression partners for RGS17 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS17

SOURCE GeneReport for Unigene cluster for RGS17 Gene:

Hs.166313

mRNA Expression by UniProt/SwissProt for RGS17 Gene:

Q9UGC6-RGS17_HUMAN
Tissue specificity: Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.

Evidence on tissue expression from TISSUES for RGS17 Gene

  • Nervous system(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with RGS17: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS17 Gene

Orthologs for RGS17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGS17 29 30
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RGS17 29 30
  • 94.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RGS17 29 30
  • 94.17 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RGS17 30
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgs17 29
  • 88.25 (n)
Mouse
(Mus musculus)
Mammalia Rgs17 29 16 30
  • 87.3 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RGS17 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RGS17 29 30
  • 86.51 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGS17 30
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rgs17 29
  • 79.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii rgs17 29 30
  • 65.1 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta EG:52C10.2 31
  • 67 (a)
CG5036 29 30
  • 63.29 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007127 29
  • 60.2 (n)
Worm
(Caenorhabditis elegans)
Secernentea rgs-2 30
  • 48 (a)
ManyToMany
rgs-1 30
  • 34 (a)
ManyToMany
Species where no ortholog for RGS17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RGS17 Gene

ENSEMBL:
Gene Tree for RGS17 (if available)
TreeFam:
Gene Tree for RGS17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS17: view image
Alliance of Genome Resources:
Additional Orthologs for RGS17

Paralogs for RGS17 Gene

(19) SIMAP similar genes for RGS17 Gene using alignment to 1 proteins:

  • RGS17_HUMAN

Pseudogenes.org Pseudogenes for RGS17 Gene

genes like me logo Genes that share paralogs with RGS17: view

Variants for RGS17 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RGS17 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RGS17 Gene

Variant ID Type Subtype PubMed ID
esv1484621 CNV insertion 17803354
esv2667419 CNV deletion 23128226
esv2732913 CNV deletion 23290073
esv2732914 CNV deletion 23290073
esv2732915 CNV deletion 23290073
esv3611290 CNV loss 21293372
esv3611292 CNV gain 21293372
esv3611293 CNV loss 21293372
nsv1074023 CNV deletion 25765185
nsv1117448 CNV tandem duplication 24896259
nsv1128281 CNV deletion 24896259
nsv1137162 CNV deletion 24896259
nsv1140713 CNV deletion 24896259

Variation tolerance for RGS17 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS17
Leiden Open Variation Database (LOVD)
RGS17

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS17 Gene

Disorders for RGS17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RGS17 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
jejunal somatostatinoma
  • jejunal delta cell somatostatin producing tumor
substance dependence
- elite association - COSMIC cancer census association via MalaCards
Search RGS17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGS17

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RGS17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS17 Gene

Publications for RGS17 Gene

  1. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. (PMID: 15096504) Mao H … Albert PR (The Journal of biological chemistry 2004) 3 4 22
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 40
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 40
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 40

Products for RGS17 Gene

Sources for RGS17 Gene