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Aliases for RGS16 Gene

Aliases for RGS16 Gene

  • Regulator Of G Protein Signaling 16 2 3 5
  • Retinally Abundant Regulator Of G-Protein Signaling 3 4
  • Regulator Of G-Protein Signalling 16 2 3
  • Regulator Of G-Protein Signaling 16 2 3
  • Retinal-Specific RGS 3 4
  • A28-RGS14P 3 4
  • HRGS-R 3 4
  • RGS-R 3 4
  • A28-RGS14 3
  • RGSR 4

External Ids for RGS16 Gene

Previous GeneCards Identifiers for RGS16 Gene

  • GC01M180093
  • GC01M177996
  • GC01M179088
  • GC01M179807
  • GC01M179299
  • GC01M180835
  • GC01M182567
  • GC01M153804

Summaries for RGS16 Gene

Entrez Gene Summary for RGS16 Gene

  • The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS16 Gene

RGS16 (Regulator Of G Protein Signaling 16) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and calmodulin binding. An important paralog of this gene is RGS8.

UniProtKB/Swiss-Prot for RGS16 Gene

  • Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).

Gene Wiki entry for RGS16 Gene

Additional gene information for RGS16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS16 Gene

Genomics for RGS16 Gene

GeneHancer (GH) Regulatory Elements for RGS16 Gene

Promoters and enhancers for RGS16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I182600 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.4 1432 4 HDGF PKNOX1 CLOCK SMAD1 SIN3A FEZF1 ZNF2 YY1 ZNF213 E2F8 RGS16 DHX9 RNASEL LAMC1-AS1 HMGN1P4 LAMC1 LAMC2 GC01M182527
GH01I182142 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +457.8 457766 7.8 PKNOX1 FOXA2 ARNT YY1 ZNF143 DEK REST ZNF592 SMARCA4 GLIS1 GLUL TEDDM1 RNU6-152P RPL18P2 RGS16 RGSL1 RNASEL ENSG00000232309 GC01M182183 LINC01344
GH01I182633 Enhancer 1.1 ENCODE dbSUPER 12.2 -29.6 -29643 1.4 PKNOX1 CLOCK NEUROD1 SIN3A FEZF1 ZNF2 ZNF213 FOS TSHZ1 ZNF488 RGS16 RGS8 GC01M182641 GC01P182625
GH01I182613 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 7 -11.2 -11219 3.4 PKNOX1 FEZF1 ZNF2 IRF4 YY1 ZNF766 ZNF213 ZNF207 ZNF143 KLF13 LINC01686 HMGN1P4 DHX9 LAMC1-AS1 SMG7-AS1 RGS16 GC01P182625
GH01I182632 Enhancer 1 Ensembl ENCODE dbSUPER 11.7 -28.3 -28288 0.2 ZNF687 NR2F1 CEBPB CBFA2T3 CEBPG ELF1 DPF2 IKZF1 NR2C1 ATF7 RGS16 RGS8 GC01P182625 GC01M182641
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RGS16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS16 gene promoter:

Genomic Locations for RGS16 Gene

Genomic Locations for RGS16 Gene
chr1:182,598,623-182,604,413
(GRCh38/hg38)
Size:
5,791 bases
Orientation:
Minus strand
chr1:182,567,758-182,573,548
(GRCh37/hg19)

Genomic View for RGS16 Gene

Genes around RGS16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS16 Gene

Proteins for RGS16 Gene

  • Protein details for RGS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15492-RGS16_HUMAN
    Recommended name:
    Regulator of G-protein signaling 16
    Protein Accession:
    O15492
    Secondary Accessions:
    • B2R4M4
    • Q5VYN9
    • Q99701

    Protein attributes for RGS16 Gene

    Size:
    202 amino acids
    Molecular mass:
    22749 Da
    Quaternary structure:
    • Interacts with GNAI1 and GNAQ (PubMed:18434541). Interacts with GNAI2, GNAI3 and GNAO1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RGS16 Gene

neXtProt entry for RGS16 Gene

Post-translational modifications for RGS16 Gene

  • Palmitoylated on Cys-2 and/or Cys-12.
  • Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS16 Gene

Domains & Families for RGS16 Gene

Gene Families for RGS16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS16 Gene

Suggested Antigen Peptide Sequences for RGS16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS16: view

No data available for UniProtKB/Swiss-Prot for RGS16 Gene

Function for RGS16 Gene

Molecular function for RGS16 Gene

GENATLAS Biochemistry:
negative regulator of G-protein signaling 16,23kDa,functioning as GTPase activating protein for G protein alpha i and q subunits,abundantly expressed in retina,p53 target gene,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).

Phenotypes From GWAS Catalog for RGS16 Gene

Gene Ontology (GO) - Molecular Function for RGS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 18434541
GO:0005515 protein binding IPI 21784977
GO:0005516 calmodulin binding TAS 10747990
genes like me logo Genes that share ontologies with RGS16: view
genes like me logo Genes that share phenotypes with RGS16: view

Animal Models for RGS16 Gene

MGI Knock Outs for RGS16:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RGS16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS16 Gene

Localization for RGS16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS16 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS16 gene
Compartment Confidence
plasma membrane 4
cytosol 4
mitochondrion 2
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RGS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10791963
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0031224 intrinsic component of membrane ISS,IEA --
genes like me logo Genes that share ontologies with RGS16: view

Pathways & Interactions for RGS16 Gene

genes like me logo Genes that share pathways with RGS16: view

SIGNOR curated interactions for RGS16 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RGS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,ISS --
GO:0007601 visual perception TAS 9469939
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 10747990
GO:0009968 negative regulation of signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA,IDA 18434541
genes like me logo Genes that share ontologies with RGS16: view

Drugs & Compounds for RGS16 Gene

(4) Drugs for RGS16 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for RGS16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS16: view

Transcripts for RGS16 Gene

mRNA/cDNA for RGS16 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(220) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RGS16 Gene

Regulator of G-protein signaling 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RGS16

Alternative Splicing Database (ASD) splice patterns (SP) for RGS16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for RGS16 Gene

GeneLoc Exon Structure for
RGS16
ECgene alternative splicing isoforms for
RGS16

Expression for RGS16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS16 Gene

This gene is overexpressed in Thyroid (x4.4).

Protein differential expression in normal tissues from HIPED for RGS16 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS16 Gene



Protein tissue co-expression partners for RGS16 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS16 Gene:

RGS16

SOURCE GeneReport for Unigene cluster for RGS16 Gene:

Hs.413297

mRNA Expression by UniProt/SwissProt for RGS16 Gene:

O15492-RGS16_HUMAN
Tissue specificity: Abundantly expressed in retina with lower levels of expression in most other tissues.

Evidence on tissue expression from TISSUES for RGS16 Gene

  • Nervous system(4.7)
  • Lung(4.5)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with RGS16: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS16 Gene

Orthologs for RGS16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RGS16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS16 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia RGS16 33 34
  • 88.45 (n)
cow
(Bos Taurus)
Mammalia RGS16 33 34
  • 87.29 (n)
mouse
(Mus musculus)
Mammalia Rgs16 33 16 34
  • 84.91 (n)
rat
(Rattus norvegicus)
Mammalia Rgs16 33
  • 84.76 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS16 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RGS16 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS16 33 34
  • 75 (n)
lizard
(Anolis carolinensis)
Reptilia RGS16 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs16 33
  • 60.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32778 33
zebrafish
(Danio rerio)
Actinopterygii rgs5b 33
  • 60 (n)
rgs16 34
  • 44 (a)
ManyToMany
Species where no ortholog for RGS16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RGS16 Gene

ENSEMBL:
Gene Tree for RGS16 (if available)
TreeFam:
Gene Tree for RGS16 (if available)

Paralogs for RGS16 Gene

Paralogs for RGS16 Gene

(19) SIMAP similar genes for RGS16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS16: view

Variants for RGS16 Gene

Sequence variations from dbSNP and Humsavar for RGS16 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000005165 -- 182,604,678(-) G/A upstream_transcript_variant
rs1001125357 -- 182,605,817(-) T/C upstream_transcript_variant
rs1001417214 -- 182,606,254(-) A/C upstream_transcript_variant
rs1001949693 -- 182,600,208(-) C/G 3_prime_UTR_variant
rs1002647252 -- 182,604,407(-) G/A/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS16 Gene

Variant ID Type Subtype PubMed ID
esv1010175 CNV deletion 20482838
nsv548358 CNV gain 21841781
nsv825531 CNV loss 20364138

Variation tolerance for RGS16 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS16 Gene

Disorders for RGS16 Gene

Additional Disease Information for RGS16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGS16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS16 Gene

Publications for RGS16 Gene

  1. Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene. (PMID: 9469939) Snow BE … Siderovski DP (Gene 1998) 2 3 4 22 58
  2. Association of RGS2 and RGS5 variants with schizophrenia symptom severity. (PMID: 18262772) Campbell DB … Sullivan PF (Schizophrenia research 2008) 3 22 44 58
  3. RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation. (PMID: 11602604) Derrien A … Druey KM (The Journal of biological chemistry 2001) 3 4 22 58
  4. The p53 tumor suppressor targets a novel regulator of G protein signaling. (PMID: 9223279) Buckbinder L … Kley N (Proceedings of the National Academy of Sciences of the United States of America 1997) 3 4 22 58
  5. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 44 58

Products for RGS16 Gene

  • Addgene plasmids for RGS16

Sources for RGS16 Gene

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