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The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
RGS16 (Regulator Of G Protein Signaling 16) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and calmodulin binding. An important paralog of this gene is RGS8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003924 | GTPase activity | TAS | -- |
GO:0005096 | GTPase activator activity | TAS,IDA | 18434541 |
GO:0005515 | protein binding | IPI | 21784977 |
GO:0005516 | calmodulin binding | TAS | 10747990 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 10791963 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031224 | intrinsic component of membrane | IEA,ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | G-AlphaQ Signaling |
G-AlphaI Signaling
.47
|
G-AlphaQ Signaling
.47
|
3 | Myometrial Relaxation and Contraction Pathways | ||
4 | Activation of cAMP-Dependent PKA |
cAMP Pathway
.77
|
|
5 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007186 | G protein-coupled receptor signaling pathway | IEA,TAS | -- |
GO:0007601 | visual perception | TAS | 9469939 |
GO:0008277 | regulation of G protein-coupled receptor signaling pathway | TAS | 10747990 |
GO:0009968 | negative regulation of signal transduction | IEA | -- |
GO:0043547 | positive regulation of GTPase activity | IEA,IDA | 18434541 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||
SP2: | - | - | - | ||||||||||||||||
SP3: | - | ||||||||||||||||||
SP4: | |||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RGS16 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RGS16 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RGS16 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rgs16 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rgs16 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | RGS16 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RGS16 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RGS16 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RGS16 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rgs16 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.32778 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rgs5b 30 |
|
||
rgs16 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1144566 | - |
p.His137Arg |
No disorders were found for RGS16 Gene.