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Aliases for RGS14 Gene

Aliases for RGS14 Gene

  • Regulator Of G Protein Signaling 14 2 3 5
  • Regulator Of G-Protein Signalling 14 2
  • Regulator Of G-Protein Signaling 14 2

External Ids for RGS14 Gene

Previous GeneCards Identifiers for RGS14 Gene

  • GC05P177158
  • GC05P177627
  • GC05P176720
  • GC05P176765
  • GC05P176717
  • GC05P176784
  • GC05P171705

Summaries for RGS14 Gene

Entrez Gene Summary for RGS14 Gene

  • This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS14 Gene

RGS14 (Regulator Of G Protein Signaling 14) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is RGS12.

UniProtKB/Swiss-Prot for RGS14 Gene

  • Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Gene Wiki entry for RGS14 Gene

Additional gene information for RGS14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS14 Gene

Genomics for RGS14 Gene

GeneHancer (GH) Regulatory Elements for RGS14 Gene

Promoters and enhancers for RGS14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I177356 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 594.8 +0.8 779 3.7 HDGF RB1 BMI1 ZBTB40 KLF5 IRF4 RAD21 YY1 ZNF207 ZNF143 RGS14 PRELID1 MXD3 HNRNPAB SLC34A1 UIMC1 RAB24 FAM193B FAF2 GC05P176931
GH05I177368 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 56.9 +13.0 12992 5.1 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 ZNF143 ATF7 RGS14 PFN3 GRK6 F12 MXD3 RAB24 PRELID1 SLC34A1 GC05P176931
GH05I177360 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 46.2 +4.7 4719 3.3 HDGF PKNOX1 ATF1 ARNT SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 GLIS2 RGS14 RAB24 MXD3 LOC105377750 PFN3 GRK6 F12 PRELID1 DBN1 DOK3
GH05I177377 Enhancer 1.3 Ensembl ENCODE 56.5 +21.4 21356 2.2 HDGF FOXA2 MLX ARNT ARID4B DMAP1 IRF4 YY1 SLC30A9 POLR2B SLC34A1 RGS14 FAM193B NSD1 FAF2 ENSG00000247679 MXD3 ZNF346-IT1 UIMC1 LOC202181
GH05I177365 Promoter/Enhancer 1.5 Ensembl ENCODE 42.3 +9.2 9180 2.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF263 SP3 RGS14 PFN3 GRK6 F12 MXD3 PRELID1 RAB24 RMND5B SLC34A1 GC05P176931
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RGS14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RGS14 gene promoter:

Genomic Locations for RGS14 Gene

Genomic Locations for RGS14 Gene
chr5:177,357,711-177,372,601
(GRCh38/hg38)
Size:
14,891 bases
Orientation:
Plus strand
chr5:176,784,838-176,799,602
(GRCh37/hg19)

Genomic View for RGS14 Gene

Genes around RGS14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS14 Gene

Proteins for RGS14 Gene

  • Protein details for RGS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43566-RGS14_HUMAN
    Recommended name:
    Regulator of G-protein signaling 14
    Protein Accession:
    O43566
    Secondary Accessions:
    • O43565
    • Q506M1
    • Q6ZWA4
    • Q8TD62

    Protein attributes for RGS14 Gene

    Size:
    566 amino acids
    Molecular mass:
    61447 Da
    Quaternary structure:
    • Interacts with GNAO1, GNAI2 and GNAI3 (By similarity). Interacts with GNAI1 (PubMed:18434541, PubMed:21115486). Interacts (via RGS and GoLoco domains) with GNAI1; the interaction occurs in the centrosomes. Interaction with GNAI1 or GNAI3 (via active GTP- or inactive GDP-bound forms) prevents association of RGS14 with centrosomes or nuclear localization (By similarity). Interacts with RABGEF1; the interactions is GTP-dependent. Interacts with RAP2A; the interactions is GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI (By similarity). Associates with microtubules (PubMed:15917656). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts with RIC8A (via C-terminus). Interacts (via RBD 1 domain) with HRAS (active GTP-bound form preferentially). Interacts (via RBD domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary complex with RAF1. Interacts (via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation of a ternary complex with BRAF. Interacts with KRAS (active GTP-bound form preferentially), MRAS (active GTP-bound form preferentially), NRAS (active GTP-bound form preferentially) and RRAS (active GTP-bound form preferentially).
    SequenceCaution:
    • Sequence=AAB92614.1; Type=Frameshift; Positions=337, 344, 348, 539, 544; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RGS14 Gene

    Alternative splice isoforms for RGS14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS14 Gene

Post-translational modifications for RGS14 Gene

  • Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS14 Gene

No data available for DME Specific Peptides for RGS14 Gene

Domains & Families for RGS14 Gene

Gene Families for RGS14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RGS14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43566

UniProtKB/Swiss-Prot:

RGS14_HUMAN :
  • The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes.
Domain:
  • The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes.
  • The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the nucleus and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3.
  • The RBD domains are necessary for localization to the nucleus and centrosomes.
genes like me logo Genes that share domains with RGS14: view

Function for RGS14 Gene

Molecular function for RGS14 Gene

GENATLAS Biochemistry:
negative regulator of G protein signaling 14,functioning as GTPase-activating protein for G protein alpha i and q subunits with multiple transcripts,highly expressed in brain,lung,spleen,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Phenotypes From GWAS Catalog for RGS14 Gene

Gene Ontology (GO) - Molecular Function for RGS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0005057 signal transducer activity, downstream of receptor ISS,IEA --
GO:0005092 GDP-dissociation inhibitor activity IDA,IEA 15917656
GO:0005096 GTPase activator activity IDA,IEA 15917656
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with RGS14: view
genes like me logo Genes that share phenotypes with RGS14: view

Animal Models for RGS14 Gene

MGI Knock Outs for RGS14:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS14

miRNA for RGS14 Gene

miRTarBase miRNAs that target RGS14

Clone Products

  • Addgene plasmids for RGS14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS14 Gene

Localization for RGS14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS14 Gene

Nucleus. Nucleus, PML body. Cytoplasm. Membrane. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel-shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Relocalizes to the nucleus in PML nuclear bodies in response to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons. Localizes to spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS. Colocalizes with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and membranes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS14 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RGS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole ISS --
GO:0005622 intracellular IEA --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IBA,ISS --
GO:0005813 centrosome IEA,ISS --
genes like me logo Genes that share ontologies with RGS14: view

Pathways & Interactions for RGS14 Gene

genes like me logo Genes that share pathways with RGS14: view

Pathways by source for RGS14 Gene

1 KEGG pathway for RGS14 Gene
1 GeneGo (Thomson Reuters) pathway for RGS14 Gene
3 Qiagen pathways for RGS14 Gene

Gene Ontology (GO) - Biological Process for RGS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0006913 nucleocytoplasmic transport ISS,IEA --
GO:0006979 response to oxidative stress IEA,ISS --
GO:0007049 cell cycle IEA --
GO:0007051 spindle organization IMP,IEA 15917656
genes like me logo Genes that share ontologies with RGS14: view

No data available for SIGNOR curated interactions for RGS14 Gene

Drugs & Compounds for RGS14 Gene

(2) Additional Compounds for RGS14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS14: view

Transcripts for RGS14 Gene

Unigene Clusters for RGS14 Gene

Regulator of G-protein signaling 14:
Representative Sequences:

Clone Products

  • Addgene plasmids for RGS14

Alternative Splicing Database (ASD) splice patterns (SP) for RGS14 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: -
SP8: - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: -
SP12:
SP13:
SP14: -
SP15:

ExUns: 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d · 14e · 14f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13: - -
SP14:
SP15:

Relevant External Links for RGS14 Gene

GeneLoc Exon Structure for
RGS14
ECgene alternative splicing isoforms for
RGS14

Expression for RGS14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS14 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x9.8), Whole Blood (x8.4), Brain - Caudate (basal ganglia) (x7.7), and Brain - Nucleus accumbens (basal ganglia) (x7.2).

Protein differential expression in normal tissues from HIPED for RGS14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.3), Brain (14.8), CD8 Tcells (10.8), and Monocytes (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RGS14 Gene



Protein tissue co-expression partners for RGS14 Gene

NURSA nuclear receptor signaling pathways regulating expression of RGS14 Gene:

RGS14

SOURCE GeneReport for Unigene cluster for RGS14 Gene:

Hs.9347

Evidence on tissue expression from TISSUES for RGS14 Gene

  • Nervous system(4.6)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with RGS14: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS14 Gene

Orthologs for RGS14 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS14 33 34
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia RGS14 33 34
  • 88.63 (n)
dog
(Canis familiaris)
Mammalia RGS14 33 34
  • 87.94 (n)
mouse
(Mus musculus)
Mammalia Rgs14 33 16 34
  • 85.57 (n)
rat
(Rattus norvegicus)
Mammalia Rgs14 33
  • 85.24 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS14 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RGS14 33 34
  • 66.4 (n)
lizard
(Anolis carolinensis)
Reptilia RGS14 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490892 33
  • 61.58 (n)
zebrafish
(Danio rerio)
Actinopterygii rgs14a 33 34
  • 53.6 (n)
RGS14 (2 of 2) 34
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta loco 34
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-7 34
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
CSA.611 34 34
  • 24 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
CSA.7262 34
  • 18 (a)
ManyToMany
-- 34
  • 17 (a)
ManyToMany
-- 34
  • 16 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
-- 34
  • 11 (a)
ManyToMany
-- 34
  • 10 (a)
ManyToMany
Species where no ortholog for RGS14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS14 Gene

ENSEMBL:
Gene Tree for RGS14 (if available)
TreeFam:
Gene Tree for RGS14 (if available)

Paralogs for RGS14 Gene

Paralogs for RGS14 Gene

(10) SIMAP similar genes for RGS14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RGS14: view

Variants for RGS14 Gene

Sequence variations from dbSNP and Humsavar for RGS14 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000037908 -- 177,369,042(+) C/T intron_variant
rs1000093969 -- 177,362,343(+) CCAGGGTCC/CC intron_variant
rs1000277260 -- 177,356,160(+) A/G upstream_transcript_variant
rs1000467003 -- 177,363,098(+) G/A intron_variant
rs1000557524 -- 177,369,300(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RGS14 Gene

Variant ID Type Subtype PubMed ID
dgv10184n54 CNV loss 21841781
dgv733n27 CNV loss 19166990
esv2759396 CNV gain 17122850
nsv1073940 CNV deletion 25765185
nsv1161311 CNV duplication 26073780
nsv1161312 CNV deletion 26073780
nsv1161313 CNV duplication 26073780
nsv428132 CNV gain 18775914
nsv471057 CNV loss 18288195
nsv509103 CNV insertion 20534489
nsv5146 CNV deletion 18451855
nsv600364 CNV loss 21841781

Variation tolerance for RGS14 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS14 Gene

Disorders for RGS14 Gene

Additional Disease Information for RGS14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RGS14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS14 Gene

Publications for RGS14 Gene

  1. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. (PMID: 17635935) Cho H … Kehrl JH (The Journal of cell biology 2007) 3 4 22 58
  2. A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. (PMID: 22396660) Urabe Y … Matsuda K (PLoS genetics 2012) 3 44 58
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58
  4. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 44 58
  5. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. (PMID: 19878719) Shu FJ … Hepler JR (Cellular signalling 2010) 3 22 58

Products for RGS14 Gene

  • Addgene plasmids for RGS14

Sources for RGS14 Gene

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