The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus ... See more...

Aliases for RGS13 Gene

Aliases for RGS13 Gene

  • Regulator Of G Protein Signaling 13 2 3 5
  • Regulator Of G-Protein Signaling 13 2 3 4
  • Regulator Of G-Protein Signalling 13 2 3
  • RGS13 5

External Ids for RGS13 Gene

Previous GeneCards Identifiers for RGS13 Gene

  • GC01P190395
  • GC01P188119
  • GC01P189071
  • GC01P189893
  • GC01P189336
  • GC01P190871
  • GC01P192605
  • GC01P163841

Summaries for RGS13 Gene

Entrez Gene Summary for RGS13 Gene

  • The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS13 Gene

RGS13 (Regulator Of G Protein Signaling 13) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RGS4.

UniProtKB/Swiss-Prot Summary for RGS13 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).

Gene Wiki entry for RGS13 Gene

Additional gene information for RGS13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS13 Gene

Genomics for RGS13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGS13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J192608 Promoter/Enhancer 1.6 EPDnew FANTOM5 ENCODE dbSUPER 611.4 -26.7 -26745 1.3 SP1 CREB1 STAT3 ZNF143 RELA RAD21 TCF12 IKZF2 RCOR1 TRIM22 RGS13 LOC107985241 RGS1 RO60 RGS2 lnc-RGS13-1 LOC105371664 ENSG00000285280
GH01J192636 Promoter 0.3 EPDnew 600.7 +0.0 1 0.1 RGS13 piR-55948-010 RGS2 ENSG00000285280
GH01J192639 Enhancer 1 FANTOM5 Ensembl ENCODE 26.9 +4.0 3960 2 RELA CEBPB ARID3A DPF2 RELB BCL11A EP300 FOSL2 NR2F1 JUNB RGS13 RGS1 RGS2 piR-55948-010 ENSG00000285280
GH01J192601 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -32.3 -32337 7.2 SP1 RXRB TCF12 IKZF2 TRIM22 PKNOX1 ARID3A PAX8 RELB RUNX3 RGS1 RGS13 RO60 RGS2 LOC107985241 lnc-UCHL5-5 LOC105371664 ENSG00000285280
GH01J192699 Enhancer 1.1 Ensembl ENCODE 10.1 +65.8 65786 4.6 GATAD2A RCOR2 RXRB IKZF2 GABPA PKNOX1 CEBPA SOX13 CEBPB TCF7 RGS13 RGS2 piR-32325-012 RPS27AP5 ENSG00000285280
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS13

Top Transcription factor binding sites by QIAGEN in the RGS13 gene promoter:
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • STAT1

Genomic Locations for RGS13 Gene

Genomic Locations for RGS13 Gene
chr1:192,636,138-192,660,311
(GRCh38/hg38)
Size:
24,174 bases
Orientation:
Plus strand
chr1:192,605,268-192,629,441
(GRCh37/hg19)
Size:
24,174 bases
Orientation:
Plus strand

Genomic View for RGS13 Gene

Genes around RGS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS13 Gene

Proteins for RGS13 Gene

  • Protein details for RGS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14921-RGS13_HUMAN
    Recommended name:
    Regulator of G-protein signaling 13
    Protein Accession:
    O14921
    Secondary Accessions:
    • Q6PGR2
    • Q8TD63
    • Q9BX45

    Protein attributes for RGS13 Gene

    Size:
    159 amino acids
    Molecular mass:
    19135 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RGS13 Gene

Post-translational modifications for RGS13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS13 Gene

Domains & Families for RGS13 Gene

Gene Families for RGS13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS13 Gene

InterPro:
Blocks:
  • Regulator of G-protein signalling (RGS) protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for RGS13 Gene

GenScript: Design optimal peptide antigens:
  • Regulator of G-protein signaling 13 (RGS13_HUMAN)
genes like me logo Genes that share domains with RGS13: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS13 Gene

Function for RGS13 Gene

Molecular function for RGS13 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).

Phenotypes From GWAS Catalog for RGS13 Gene

Gene Ontology (GO) - Molecular Function for RGS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
genes like me logo Genes that share ontologies with RGS13: view
genes like me logo Genes that share phenotypes with RGS13: view

Animal Models for RGS13 Gene

MGI Knock Outs for RGS13:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS13

CRISPR Products

miRNA for RGS13 Gene

miRTarBase miRNAs that target RGS13

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS13 Gene

Localization for RGS13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS13 gene
Compartment Confidence
plasma membrane 4
cytosol 4
nucleus 3
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for RGS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with RGS13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RGS13 Gene

Pathways & Interactions for RGS13 Gene

PathCards logo

SuperPathways for RGS13 Gene

genes like me logo Genes that share pathways with RGS13: view

Pathways by source for RGS13 Gene

3 Qiagen pathways for RGS13 Gene
  • cAMP Pathway
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

SIGNOR curated interactions for RGS13 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RGS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0009968 negative regulation of signal transduction IEA --
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with RGS13: view

Drugs & Compounds for RGS13 Gene

No Compound Related Data Available

Transcripts for RGS13 Gene

mRNA/cDNA for RGS13 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS13

Alternative Splicing Database (ASD) splice patterns (SP) for RGS13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for RGS13 Gene

GeneLoc Exon Structure for
RGS13

Expression for RGS13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS13 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.7) and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for RGS13 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RGS13 Gene



Protein tissue co-expression partners for RGS13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS13

SOURCE GeneReport for Unigene cluster for RGS13 Gene:

Hs.497220

Evidence on tissue expression from TISSUES for RGS13 Gene

  • Lung(4.3)
  • Nervous system(4.2)
  • Lymph node(2.9)
genes like me logo Genes that share expression patterns with RGS13: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS13 Gene

Orthologs for RGS13 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGS13 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RGS13 30 31
  • 92.62 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rgs13 30 17 31
  • 85.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgs13 30
  • 84.93 (n)
Cow
(Bos Taurus)
Mammalia RGS13 31
  • 83 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RGS13 31
  • 71 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RGS13 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RGS13 30 31
  • 66.88 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RGS13 31
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rgs13 30
  • 66.67 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-117l17.5 31
  • 42 (a)
ManyToMany
rgs13 31
  • 40 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG5036 31
  • 23 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rgs-2 31
  • 31 (a)
ManyToMany
rgs-1 31
  • 25 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 18 (a)
OneToMany
Species where no ortholog for RGS13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RGS13 Gene

ENSEMBL:
Gene Tree for RGS13 (if available)
TreeFam:
Gene Tree for RGS13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS13: view image

Paralogs for RGS13 Gene

(19) SIMAP similar genes for RGS13 Gene using alignment to 1 proteins:

  • RGS13_HUMAN
genes like me logo Genes that share paralogs with RGS13: view

Variants for RGS13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS13 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs16834603 - p.Leu150Phe

Additional dbSNP identifiers (rs#s) for RGS13 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS13 Gene

Variant ID Type Subtype PubMed ID
esv1739511 CNV deletion 17803354
esv2283787 CNV deletion 18987734
esv2720762 CNV deletion 23290073
esv2720773 CNV deletion 23290073
esv2720784 CNV deletion 23290073
esv2720795 CNV deletion 23290073
esv2720807 CNV deletion 23290073
esv3003020 CNV deletion 24192839
esv3424496 CNV insertion 20981092
esv3544289 CNV deletion 23714750
esv991606 CNV deletion 20482838
nsv1133927 CNV deletion 24896259
nsv466994 CNV loss 19166990
nsv467005 CNV gain 19166990
nsv548658 CNV loss 21841781
nsv548659 CNV gain 21841781
nsv548660 CNV gain 21841781

Variation tolerance for RGS13 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS13

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS13 Gene

Disorders for RGS13 Gene

Additional Disease Information for RGS13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for RGS13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS13 Gene

Publications for RGS13 Gene

  1. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41
  2. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 41
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Functional characterization of the G protein regulator RGS13. (PMID: 11875076) Johnson EN … Druey KM (The Journal of biological chemistry 2002) 2 3

Products for RGS13 Gene

Sources for RGS13 Gene