Aliases for RGS12 Gene
External Ids for RGS12 Gene
Previous GeneCards Identifiers for RGS12 Gene
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGS12 Gene
RGS12 (Regulator Of G Protein Signaling 12) is a Protein Coding gene. Diseases associated with RGS12 include Omsk Hemorrhagic Fever and Mosaic Variegated Aneuploidy Syndrome. Among its related pathways are G-AlphaQ Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and GTPase regulator activity. An important paralog of this gene is RGS14.
UniProtKB/Swiss-Prot Summary for RGS12 Gene
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.
[Isoform 5]: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.