The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bou... See more...

Aliases for RGS11 Gene

Aliases for RGS11 Gene

  • Regulator Of G Protein Signaling 11 2 3 5
  • Regulator Of G-Protein Signaling 11 2 3 4
  • Regulator Of G-Protein Signalling 11 2 3
  • RGS11 5
  • RS11 3

External Ids for RGS11 Gene

Previous GeneCards Identifiers for RGS11 Gene

  • GC16M000337
  • GC16M000259
  • GC16M000260
  • GC16M000261
  • GC16M000318

Summaries for RGS11 Gene

Entrez Gene Summary for RGS11 Gene

  • The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

GeneCards Summary for RGS11 Gene

RGS11 (Regulator Of G Protein Signaling 11) is a Protein Coding gene. Diseases associated with RGS11 include Prolonged Electroretinal Response Suppression and Bullous Retinoschisis. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and G-protein beta-subunit binding. An important paralog of this gene is RGS9.

UniProtKB/Swiss-Prot Summary for RGS11 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Gene Wiki entry for RGS11 Gene

Additional gene information for RGS11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RGS11 Gene

Genomics for RGS11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RGS11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RGS11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RGS11

Top Transcription factor binding sites by QIAGEN in the RGS11 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • CBF(2)
  • COMP1
  • Evi-1
  • Lmo2
  • NF-Y

Genomic Locations for RGS11 Gene

Genomic Locations for RGS11 Gene
chr16:268,301-275,980
(GRCh38/hg38)
Size:
7,680 bases
Orientation:
Minus strand
chr16:318,300-325,980
(GRCh37/hg19)
Size:
7,681 bases
Orientation:
Minus strand

Genomic View for RGS11 Gene

Genes around RGS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS11 Gene

Proteins for RGS11 Gene

  • Protein details for RGS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94810-RGS11_HUMAN
    Recommended name:
    Regulator of G-protein signaling 11
    Protein Accession:
    O94810
    Secondary Accessions:
    • O75883
    • Q4TT71
    • Q4TT72

    Protein attributes for RGS11 Gene

    Size:
    467 amino acids
    Molecular mass:
    52946 Da
    Quaternary structure:
    • Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).

    Alternative splice isoforms for RGS11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS11 Gene

Post-translational modifications for RGS11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RGS11 Gene

Domains & Families for RGS11 Gene

Gene Families for RGS11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RGS11 Gene

InterPro:
Blocks:
  • Regulator of G-protein signalling (RGS) protein signature
  • Gamma G-protein (transducin) signature
  • Pleckstrin putative G-protein interacting domain
ProtoNet:

Suggested Antigen Peptide Sequences for RGS11 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54669 (B7Z1X0_HUMAN)
  • cDNA FLJ58886, highly similar to Regulator of G-protein signaling 11 (B7Z285_HUMAN)
  • Regulator of G-protein signalling 11, isoform CRA_e (Q4TT70_HUMAN)
  • Regulator of G-protein signalling 11, isoform CRA_d (Q8IWC5_HUMAN)
  • Regulator of G-protein signaling 11 (RGS11_HUMAN)
genes like me logo Genes that share domains with RGS11: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RGS11 Gene

Function for RGS11 Gene

Molecular function for RGS11 Gene

UniProtKB/Swiss-Prot Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
GENATLAS Biochemistry:
negative regulator of G protein signaling 11,predominantly expressed in both brain and retina,functioning as GTPase-activating protein for G protein alpha subunits,G alpha i, G alpha o and complexing with G beta 5

Phenotypes From GWAS Catalog for RGS11 Gene

Gene Ontology (GO) - Molecular Function for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
GO:0005096 GTPase activator activity TAS 9789084
GO:0031681 G-protein beta-subunit binding IPI 12606627
genes like me logo Genes that share ontologies with RGS11: view
genes like me logo Genes that share phenotypes with RGS11: view

Animal Models for RGS11 Gene

MGI Knock Outs for RGS11:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS11

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS11 Gene

Localization for RGS11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS11 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0032991 protein-containing complex IDA 18468998
genes like me logo Genes that share ontologies with RGS11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RGS11 Gene

Pathways & Interactions for RGS11 Gene

genes like me logo Genes that share pathways with RGS11: view

Pathways by source for RGS11 Gene

1 GeneGo (Thomson Reuters) pathway for RGS11 Gene
  • G-protein signaling G-Protein alpha-i signaling cascades
3 Qiagen pathways for RGS11 Gene
  • cAMP Pathway
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

Gene Ontology (GO) - Biological Process for RGS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0008277 regulation of G protein-coupled receptor signaling pathway TAS 9789084
GO:0009968 negative regulation of signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RGS11: view

No data available for SIGNOR curated interactions for RGS11 Gene

Drugs & Compounds for RGS11 Gene

No Compound Related Data Available

Transcripts for RGS11 Gene

mRNA/cDNA for RGS11 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RGS11

Alternative Splicing Database (ASD) splice patterns (SP) for RGS11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5: -

Relevant External Links for RGS11 Gene

GeneLoc Exon Structure for
RGS11

Expression for RGS11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RGS11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS11 Gene

This gene is overexpressed in Brain - Cerebellum (x8.3) and Brain - Cerebellar Hemisphere (x6.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RGS11

SOURCE GeneReport for Unigene cluster for RGS11 Gene:

Hs.65756

Evidence on tissue expression from TISSUES for RGS11 Gene

  • Nervous system(4.8)
  • Eye(2)
genes like me logo Genes that share expression patterns with RGS11: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS11 Gene

Orthologs for RGS11 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RGS11 30 31
  • 93.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RGS11 30 31
  • 83.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rgs11 30
  • 82.59 (n)
Mouse
(Mus musculus)
Mammalia Rgs11 30 17 31
  • 81.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RGS11 30 31
  • 81.32 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RGS11 31
  • 69 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RGS11 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RGS11 30
  • 75.68 (n)
-- 31
  • 71 (a)
OneToMany
-- 31
  • 68 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia RGS11 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rgs9 30
  • 69.66 (n)
Zebrafish
(Danio rerio)
Actinopterygii rgs11 30 31
  • 65.49 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000232 30
  • 54.56 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG7095 32
  • 41 (a)
CG42450 31
  • 14 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea eat-16 31
  • 30 (a)
ManyToMany
Species where no ortholog for RGS11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RGS11 Gene

ENSEMBL:
Gene Tree for RGS11 (if available)
TreeFam:
Gene Tree for RGS11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RGS11: view image

Paralogs for RGS11 Gene

(14) SIMAP similar genes for RGS11 Gene using alignment to 7 proteins:

  • RGS11_HUMAN
  • B7Z1X0_HUMAN
  • B7Z285_HUMAN
  • H7C5Z0_HUMAN
  • L8ECA7_HUMAN
  • Q4TT70_HUMAN
  • Q8IWC5_HUMAN
genes like me logo Genes that share paralogs with RGS11: view

Variants for RGS11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RGS11 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs739999 - p.Met427Thr
rs9806942 - p.Val351Met

Additional dbSNP identifiers (rs#s) for RGS11 Gene

Structural Variations from Database of Genomic Variants (DGV) for RGS11 Gene

Variant ID Type Subtype PubMed ID
dgv1479e59 CNV duplication 20981092
dgv32n68 CNV loss 17160897
esv2422427 CNV duplication 17116639
esv3570031 CNV gain 25503493
esv3637561 CNV loss 21293372
esv3637562 CNV gain 21293372
esv3637563 CNV gain 21293372
nsv570947 CNV loss 21841781
nsv827477 CNV gain 20364138
nsv952896 CNV deletion 24416366

Variation tolerance for RGS11 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.01; 90.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RGS11 Gene

Human Gene Mutation Database (HGMD)
RGS11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS11 Gene

Disorders for RGS11 Gene

MalaCards: The human disease database

(8) MalaCards diseases for RGS11 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search RGS11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RGS11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RGS11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RGS11 Gene

Publications for RGS11 Gene

  1. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. (PMID: 9789084) Snow BE … Siderovski DP (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 41
  3. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. (PMID: 20627871) Wang J … Wu X (Carcinogenesis 2010) 3 41
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4

Products for RGS11 Gene

  • Signalway Proteins for RGS11

Sources for RGS11 Gene